DE68929304D1 - Oligoribonukleotid-Derivate und Verwendung davon als Antiviral-Arzneimittel - Google Patents
Oligoribonukleotid-Derivate und Verwendung davon als Antiviral-ArzneimittelInfo
- Publication number
- DE68929304D1 DE68929304D1 DE68929304T DE68929304T DE68929304D1 DE 68929304 D1 DE68929304 D1 DE 68929304D1 DE 68929304 T DE68929304 T DE 68929304T DE 68929304 T DE68929304 T DE 68929304T DE 68929304 D1 DE68929304 D1 DE 68929304D1
- Authority
- DE
- Germany
- Prior art keywords
- antiviral drugs
- oligoribonucleotide derivatives
- oligoribonucleotide
- derivatives
- antiviral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10494388 | 1988-04-27 | ||
JP13896688 | 1988-06-06 | ||
JP16814288 | 1988-07-06 | ||
JP22788788 | 1988-09-12 | ||
JP23848188 | 1988-09-22 | ||
JP2437289 | 1989-02-02 | ||
JP1064058A JP2976436B2 (ja) | 1988-04-27 | 1989-03-16 | 新規オリゴリボヌクレオチド誘導体及び抗ウイルス剤への使用 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68929304D1 true DE68929304D1 (de) | 2001-07-19 |
DE68929304T2 DE68929304T2 (de) | 2002-04-25 |
Family
ID=27564029
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1989629304 Expired - Lifetime DE68929304T2 (de) | 1988-04-27 | 1989-04-13 | Oligoribonukleotid-Derivate und Verwendung davon als Antiviral-Arzneimittel |
DE1989629361 Expired - Lifetime DE68929361T2 (de) | 1988-04-27 | 1989-04-13 | Oligoribonukleotid-Derivate und Verwendung davon als Antiviral Arzneimittel |
DE1989629306 Expired - Lifetime DE68929306T2 (de) | 1988-04-27 | 1989-04-13 | H-Phosphonat Ribonucleotid-Derivate |
DE1989627417 Expired - Lifetime DE68927417T2 (de) | 1988-04-27 | 1989-04-13 | Oligoribonukleotid-Derivate und ihre Anwendung als antivirale Mittel |
DE1989629305 Expired - Lifetime DE68929305T2 (de) | 1988-04-27 | 1989-04-13 | Oligoribonukleotid-Derivate und Verwendung davon als Antiviral Arzneimittel |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1989629361 Expired - Lifetime DE68929361T2 (de) | 1988-04-27 | 1989-04-13 | Oligoribonukleotid-Derivate und Verwendung davon als Antiviral Arzneimittel |
DE1989629306 Expired - Lifetime DE68929306T2 (de) | 1988-04-27 | 1989-04-13 | H-Phosphonat Ribonucleotid-Derivate |
DE1989627417 Expired - Lifetime DE68927417T2 (de) | 1988-04-27 | 1989-04-13 | Oligoribonukleotid-Derivate und ihre Anwendung als antivirale Mittel |
DE1989629305 Expired - Lifetime DE68929305T2 (de) | 1988-04-27 | 1989-04-13 | Oligoribonukleotid-Derivate und Verwendung davon als Antiviral Arzneimittel |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP0339842B1 (de) |
DE (5) | DE68929304T2 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4958013A (en) * | 1989-06-06 | 1990-09-18 | Northwestern University | Cholesteryl modified oligonucleotides |
DK0497875T3 (da) | 1989-10-24 | 2000-07-03 | Gilead Sciences Inc | 2'-modificerede oligonukleotider |
US6005087A (en) | 1995-06-06 | 1999-12-21 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
US6399754B1 (en) | 1991-12-24 | 2002-06-04 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides |
US5859221A (en) * | 1990-01-11 | 1999-01-12 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
US5623065A (en) * | 1990-08-13 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Gapped 2' modified oligonucleotides |
US5955589A (en) * | 1991-12-24 | 1999-09-21 | Isis Pharmaceuticals Inc. | Gapped 2' modified oligonucleotides |
US5872232A (en) * | 1990-01-11 | 1999-02-16 | Isis Pharmaceuticals Inc. | 2'-O-modified oligonucleotides |
US6034233A (en) * | 1990-05-04 | 2000-03-07 | Isis Pharmaceuticals Inc. | 2'-O-alkylated oligoribonucleotides and phosphorothioate analogs complementary to portions of the HIV genome |
US6262241B1 (en) | 1990-08-13 | 2001-07-17 | Isis Pharmaceuticals, Inc. | Compound for detecting and modulating RNA activity and gene expression |
ES2259177T3 (es) | 1990-08-13 | 2006-09-16 | Isis Pharmaceuticals, Inc. | Oligonucleotidos modificados en el azucar que detectan y modulan la expresion genica. |
EP0558749A1 (de) * | 1990-11-20 | 1993-09-08 | Sankyo Company Limited | Antisense-nukleinsäurederivate |
US5965722A (en) * | 1991-05-21 | 1999-10-12 | Isis Pharmaceuticals, Inc. | Antisense inhibition of ras gene with chimeric and alternating oligonucleotides |
US7015315B1 (en) * | 1991-12-24 | 2006-03-21 | Isis Pharmaceuticals, Inc. | Gapped oligonucleotides |
US7119184B2 (en) | 1991-08-12 | 2006-10-10 | Isis Pharmaceuticals, Inc. | Oligonucleotides having A-DNA form and B-DNA form conformational geometry |
US6307040B1 (en) * | 1992-03-05 | 2001-10-23 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides that detect and modulate gene expression |
US5525719A (en) * | 1991-08-30 | 1996-06-11 | Chemgenes Corporation | N-protected-2'-O-methyl-and N-protected-3'-O-methyl-ribonucleosides and their phosphoramidite derivatives |
US5700922A (en) * | 1991-12-24 | 1997-12-23 | Isis Pharmaceuticals, Inc. | PNA-DNA-PNA chimeric macromolecules |
ATE515510T1 (de) * | 1991-12-24 | 2011-07-15 | Isis Pharmaceuticals Inc | Durch dna-abschnitte unterbrochene modifizierte oligonukleotide |
US6277603B1 (en) | 1991-12-24 | 2001-08-21 | Isis Pharmaceuticals, Inc. | PNA-DNA-PNA chimeric macromolecules |
US5856455A (en) * | 1991-12-24 | 1999-01-05 | Isis Pharmaceuticals, Inc. | Gapped 2'-modified oligonucleotides |
TW244371B (de) * | 1992-07-23 | 1995-04-01 | Tri Clover Inc | |
US5652355A (en) * | 1992-07-23 | 1997-07-29 | Worcester Foundation For Experimental Biology | Hybrid oligonucleotide phosphorothioates |
US6346614B1 (en) | 1992-07-23 | 2002-02-12 | Hybridon, Inc. | Hybrid oligonucleotide phosphorothioates |
US6015886A (en) * | 1993-05-24 | 2000-01-18 | Chemgenes Corporation | Oligonucleotide phosphate esters |
US5869248A (en) * | 1994-03-07 | 1999-02-09 | Yale University | Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences |
DE4427219A1 (de) * | 1994-08-01 | 1996-02-08 | Max Planck Gesellschaft | Nukleinsäure zur Initiation der Aktivität von RNase H bzw. reverser Transkriptase |
US6057153A (en) * | 1995-01-13 | 2000-05-02 | Yale University | Stabilized external guide sequences |
AU5359496A (en) | 1995-03-06 | 1996-09-23 | Isis Pharmaceuticals, Inc. | Improved process for the synthesis of 2'-o-substituted pyrimidines and oligomeric compounds therefrom |
US6166197A (en) * | 1995-03-06 | 2000-12-26 | Isis Pharmaceuticals, Inc. | Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions |
CA2749312A1 (en) | 1996-02-14 | 1997-08-21 | Novartis Ag | Sugar-modified gapped oligonucleotides |
US5856099A (en) * | 1996-05-21 | 1999-01-05 | Isis Pharmaceuticals, Inc. | Antisense compositions and methods for modulating type I interleukin-1 receptor expression |
US9096636B2 (en) * | 1996-06-06 | 2015-08-04 | Isis Pharmaceuticals, Inc. | Chimeric oligomeric compounds and their use in gene modulation |
US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
US6610478B1 (en) | 1996-08-16 | 2003-08-26 | Yale University | Phenotypic conversion of cells mediated by external guide sequences |
US6172217B1 (en) | 1996-12-27 | 2001-01-09 | Isis Pharmaceuticals Inc. | Method of synthesizing phosphorothioate oligonucleotides |
US6576752B1 (en) | 1997-02-14 | 2003-06-10 | Isis Pharmaceuticals, Inc. | Aminooxy functionalized oligomers |
US6172209B1 (en) | 1997-02-14 | 2001-01-09 | Isis Pharmaceuticals Inc. | Aminooxy-modified oligonucleotides and methods for making same |
US6127533A (en) | 1997-02-14 | 2000-10-03 | Isis Pharmaceuticals, Inc. | 2'-O-aminooxy-modified oligonucleotides |
US20030036516A1 (en) * | 1997-09-10 | 2003-02-20 | Sudhir Agrawal | Method for using oligonucleotides having modified cpg dinucleotides |
BR0314236A (pt) | 2002-09-13 | 2005-08-09 | Replicor Inc | Formulação de oligonucleotìdeo, composição farmacêutica, kit, composto antiviral, preparação de oligonucleotìdeo e métodos para seleção de um oligonucleotìdeo antiviral para uso como um agente antiviral, para profilaxia ou tratamento de uma infecção viral em um paciente, para tratamento profilático de câncer causado por oncovìrus, para identificação de um composto que altera a ligação de um oligonucleotìdeo a pelo menos um componente viral, para purificação da ligação de oligonucleotìdeos a pelo menos um componente viral e para enriquecimento de oligonucleotìdeos a partir de um agrupamento de oligonucleotìdeos |
ES2911034T3 (es) | 2006-08-08 | 2022-05-17 | Univ Bonn Rheinische Friedrich Wilhelms | Estructura y uso de oligonucleótidos 5' fosfato |
US7820810B2 (en) | 2007-03-19 | 2010-10-26 | Isis Pharmaceuticals, Inc. | Process for the synthesis of 2′-O-substituted purine nulceosides |
WO2009141146A1 (en) | 2008-05-21 | 2009-11-26 | Gunther Hartmann | 5' triphosphate oligonucleotide with blunt end and uses thereof |
EP2508530A1 (de) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Reinigung von triphosphorylierten Oligonucleotiden mit Einfang-Tags |
EP2712870A1 (de) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Neuartige RIG-I-Liganden und Herstellungsverfahren dafür |
US20160068894A1 (en) | 2013-04-04 | 2016-03-10 | Georgia State University Research Foundation, Inc. | RNA Microchip Detection Using Nanoparticle-Assisted Signal Amplification |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2567892B1 (fr) * | 1984-07-19 | 1989-02-17 | Centre Nat Rech Scient | Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons |
JPS61291595A (ja) * | 1985-06-19 | 1986-12-22 | Ajinomoto Co Inc | 2′−o−メチル化rnaの製造法 |
-
1989
- 1989-04-13 EP EP19890303700 patent/EP0339842B1/de not_active Expired - Lifetime
- 1989-04-13 DE DE1989629304 patent/DE68929304T2/de not_active Expired - Lifetime
- 1989-04-13 DE DE1989629361 patent/DE68929361T2/de not_active Expired - Lifetime
- 1989-04-13 DE DE1989629306 patent/DE68929306T2/de not_active Expired - Lifetime
- 1989-04-13 DE DE1989627417 patent/DE68927417T2/de not_active Expired - Lifetime
- 1989-04-13 DE DE1989629305 patent/DE68929305T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0339842A2 (de) | 1989-11-02 |
EP0339842A3 (de) | 1994-03-09 |
DE68929306T2 (de) | 2002-05-02 |
DE68929304T2 (de) | 2002-04-25 |
DE68929305D1 (de) | 2001-07-19 |
DE68927417T2 (de) | 1997-03-20 |
DE68929361T2 (de) | 2002-06-20 |
DE68929361D1 (de) | 2002-01-31 |
DE68929305T2 (de) | 2002-05-02 |
DE68929306D1 (de) | 2001-07-19 |
DE68927417D1 (de) | 1996-12-12 |
EP0339842B1 (de) | 1996-11-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |