DE68926333D1 - Bacillus-Stämme - Google Patents

Bacillus-Stämme

Info

Publication number
DE68926333D1
DE68926333D1 DE68926333T DE68926333T DE68926333D1 DE 68926333 D1 DE68926333 D1 DE 68926333D1 DE 68926333 T DE68926333 T DE 68926333T DE 68926333 T DE68926333 T DE 68926333T DE 68926333 D1 DE68926333 D1 DE 68926333D1
Authority
DE
Germany
Prior art keywords
proteolytically active
bacillus strains
residual protease
epr gene
mutation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68926333T
Other languages
English (en)
Other versions
DE68926333T2 (de
Inventor
Alan Sloma
Cathy Faye Rudolf
Janice Pero
Gerald A Rufo
Barbara J Sullivan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OmniGene Bioproducts Inc
Original Assignee
OmniGene Bioproducts Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27402569&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE68926333(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by OmniGene Bioproducts Inc filed Critical OmniGene Bioproducts Inc
Publication of DE68926333D1 publication Critical patent/DE68926333D1/de
Application granted granted Critical
Publication of DE68926333T2 publication Critical patent/DE68926333T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Polishing Bodies And Polishing Tools (AREA)
  • Materials For Medical Uses (AREA)
DE68926333T 1988-11-18 1989-11-17 Bacillus-Stämme Expired - Lifetime DE68926333T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27342388A 1988-11-18 1988-11-18
US34742889A 1989-05-04 1989-05-04
US39652189A 1989-08-21 1989-08-21

Publications (2)

Publication Number Publication Date
DE68926333D1 true DE68926333D1 (de) 1996-05-30
DE68926333T2 DE68926333T2 (de) 1996-11-28

Family

ID=27402569

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68926333T Expired - Lifetime DE68926333T2 (de) 1988-11-18 1989-11-17 Bacillus-Stämme

Country Status (8)

Country Link
US (3) US5620880A (de)
EP (1) EP0369817B1 (de)
JP (1) JP3210315B2 (de)
AT (1) ATE137265T1 (de)
AU (1) AU4476689A (de)
CA (1) CA2003078A1 (de)
DE (1) DE68926333T2 (de)
DK (1) DK577989A (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143846A (en) * 1988-03-17 1992-09-01 The General Hospital Corporation Protease deficient bacterial hosts
US5294542A (en) * 1991-03-19 1994-03-15 Omnigene, Inc. Residual protease-III
US5429950A (en) * 1992-03-30 1995-07-04 Genencor International, Inc. Heterologous gene expression in bacillus subtilis: fusion approach
US5792623A (en) * 1992-04-06 1998-08-11 Immuno Aktiengesellschaft Method for producing activated blood factors with a protease and a detergent
AT397390B (de) * 1992-04-06 1994-03-25 Immuno Ag Verfahren zur spaltung von proteinen
WO1997003185A1 (en) * 1995-07-07 1997-01-30 Novo Nordisk A/S Production of proteins using bacillus incapable of sporulation
GB9708452D0 (en) * 1997-04-26 1997-06-18 Univ Newcastle Improved prokaryotic expression of protein
JP2001510050A (ja) * 1997-07-15 2001-07-31 ジェネンコア インターナショナル インコーポレーテッド グラム陽性微生物からのプロテアーゼ
AU8487098A (en) * 1997-07-15 1999-02-10 Genencor International B.V. Proteases from gram-positive organisms
US6723550B1 (en) 1997-07-15 2004-04-20 Genencor International, Inc. Proteases from gram-positive organisms
US6300117B1 (en) 1997-09-15 2001-10-09 Genencor International, Inc. Proteases from gram-positive organisms
GB9719636D0 (en) * 1997-09-15 1997-11-19 Genencor Int Bv Proteases from gram-positive organisms
US6521440B1 (en) 1997-09-15 2003-02-18 Genencor International, Inc. Proteases from gram-positive organisms
GB9719637D0 (en) * 1997-09-15 1997-11-19 Genencor Int Bv Proteases from gram-positive organisms
GB9724629D0 (en) * 1997-11-20 1998-01-21 Genencor Int Bv Alpha/beta hydrolase-fold enzymes
US6465186B1 (en) 1997-12-30 2002-10-15 Genecor International, Inc. Proteases from gram positive organisms
GB9727470D0 (en) * 1997-12-30 1998-02-25 Genencor Int Bv Proteases from gram positive organisms
GB9727466D0 (en) * 1997-12-30 1998-02-25 Genencor Int Bv Proteases from gram positive organisms
US6489108B1 (en) * 1997-12-30 2002-12-03 Genencor International, Inc. Proteases from gram positive organisms
US6599731B1 (en) 1997-12-30 2003-07-29 Genencor International, Inc. Proteases from gram positive organisms
GB9727468D0 (en) * 1997-12-30 1998-02-25 Genencor Int Bv Proteases from gram positive organisms
GB9727471D0 (en) * 1997-12-30 1998-02-25 Genencor Int Bv Proteases from gram positive organisms
US6528255B1 (en) * 1997-12-30 2003-03-04 Genencor International, Inc. Proteases from gram positive organisms
GB9727464D0 (en) * 1997-12-30 1998-02-25 Genencor Int Bv Proteases from gram positive organisms
US6558939B1 (en) 1999-08-31 2003-05-06 Novozymes, A/S Proteases and variants thereof
US7217554B2 (en) 1999-08-31 2007-05-15 Novozymes A/S Proteases and variants thereof
NZ531394A (en) 1999-08-31 2005-10-28 Novozymes As Residual protease II (RPII) and variants thereof useful in detergent compositions
GB0116798D0 (en) * 2001-07-10 2001-08-29 Secr Defence Expression system
FI112666B (fi) * 2001-11-06 2003-12-31 Ipsat Therapies Oy Itiöimätön Bacillus subtilis, sen valmistus ja käyttö
DK1495128T3 (da) * 2002-03-29 2014-08-11 Genencor Int Forstærket proteinekspression i Bacillus
DK1995319T3 (da) * 2002-04-10 2011-12-05 Novozymes As Forbedret bacillusværtscelle
CN1659282A (zh) * 2002-04-10 2005-08-24 诺维信公司 地衣芽孢杆菌的突变宿主细胞
TW200521103A (en) * 2003-11-21 2005-07-01 Toshiba Kk High thermally conductive aluminum nitride sintered product
CN102250861A (zh) 2004-02-13 2011-11-23 诺维信公司 蛋白酶变体
EP1766000A1 (de) * 2004-06-21 2007-03-28 Novozymes A/S Verbesserte verfahren zur herstellung heterologer proteasen
JP4485341B2 (ja) 2004-12-20 2010-06-23 花王株式会社 組換え微生物
DK1944365T3 (da) 2005-10-13 2012-04-30 Kao Corp Hidtil ukendt bacillus subtilis mutantstamme
US7932520B2 (en) * 2006-04-07 2011-04-26 Chimei Innolux Corporation Organic light emitting device and method of fabricating the same
TWI303535B (en) * 2006-04-07 2008-11-21 Chi Mei El Corp Organic light emitting device and method of fabricating the same
JP2008231063A (ja) * 2007-03-22 2008-10-02 Takano Foods Kk 納豆菌ワクチン
JP2012513771A (ja) 2008-12-31 2012-06-21 ソレイ リミテッド ライアビリティ カンパニー Ｃｃｋ放出能力が増強されたタンパク質加水分解組成物
CN102387711A (zh) 2008-12-31 2012-03-21 索莱有限责任公司 蛋白质水解产物组合物
EP2585618B1 (de) 2010-06-22 2014-04-23 Novozymes A/S Enzymatisches enthaaren von tierhäuten
CN103561589A (zh) 2011-02-23 2014-02-05 索莱有限责任公司 具有增强的cck和glp-1释放活性的蛋白水解产物组合物
US20170335360A1 (en) * 2014-10-30 2017-11-23 Merck Sharp & Dohme Corp. Bacillus megaterium recombinant protein expression system
CN113249287B (zh) * 2021-07-07 2021-09-24 中国科学院天津工业生物技术研究所 一株表达d-阿洛酮糖3-差向异构酶的枯草芽孢杆菌工程菌株及其应用
WO2023117970A1 (en) * 2021-12-20 2023-06-29 Basf Se Method for improved production of intracellular proteins in bacillus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2966911D1 (en) * 1978-07-04 1984-05-24 Novo Industri As Microbial protease preparation suitable for admixture to washing compositions and process for preparing it
US4828994A (en) * 1984-09-21 1989-05-09 Genex Corporation Bacillus strains with reduced extracellular protease levels
US5585253A (en) * 1989-11-27 1996-12-17 The Regents Of The University Of California Extracellular serine protease and a Bacillus subtilis alkaline neutral an serine protease mutant strain

Also Published As

Publication number Publication date
EP0369817A2 (de) 1990-05-23
AU4476689A (en) 1990-05-24
DK577989A (da) 1990-05-19
ATE137265T1 (de) 1996-05-15
JPH0367582A (ja) 1991-03-22
EP0369817A3 (de) 1991-07-31
CA2003078A1 (en) 1990-05-18
DE68926333T2 (de) 1996-11-28
US5874278A (en) 1999-02-23
EP0369817B1 (de) 1996-04-24
JP3210315B2 (ja) 2001-09-17
US5620880A (en) 1997-04-15
US5589383A (en) 1996-12-31
DK577989D0 (da) 1989-11-17

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Legal Events

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8363 Opposition against the patent