DE68923362T2 - Wachstumsregelfaktoren für neuriten. - Google Patents
Wachstumsregelfaktoren für neuriten.Info
- Publication number
- DE68923362T2 DE68923362T2 DE68923362T DE68923362T DE68923362T2 DE 68923362 T2 DE68923362 T2 DE 68923362T2 DE 68923362 T DE68923362 T DE 68923362T DE 68923362 T DE68923362 T DE 68923362T DE 68923362 T2 DE68923362 T2 DE 68923362T2
- Authority
- DE
- Germany
- Prior art keywords
- proteins
- metalloproteases
- present
- neurites
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/06—Chelate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26794188A | 1988-11-04 | 1988-11-04 | |
US07/401,212 US5684133A (en) | 1988-11-04 | 1989-08-30 | Neurite growth regulatory factors, antibodies thereto, and pharmaceutical compositions |
PCT/EP1989/001321 WO1990005191A1 (en) | 1988-11-04 | 1989-11-02 | Neurite growth regulatory factors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68923362D1 DE68923362D1 (de) | 1995-08-10 |
DE68923362T2 true DE68923362T2 (de) | 1996-03-28 |
Family
ID=26952762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68923362T Expired - Lifetime DE68923362T2 (de) | 1988-11-04 | 1989-11-02 | Wachstumsregelfaktoren für neuriten. |
Country Status (8)
Country | Link |
---|---|
US (2) | US6025333A (de) |
EP (1) | EP0396719B1 (de) |
KR (1) | KR100196540B1 (de) |
AT (1) | ATE124726T1 (de) |
AU (2) | AU652537B2 (de) |
DE (1) | DE68923362T2 (de) |
DK (1) | DK160190A (de) |
WO (1) | WO1990005191A1 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5250414A (en) * | 1988-11-04 | 1993-10-05 | Erziehungsdirektion Of The Canton Zurich | Diagnostic methods using neurite growth regulatory factors |
AU652537B2 (en) * | 1988-11-04 | 1994-09-01 | Erziehungsdirektion Of The Canton Zurich | Neurite growth regulatory factors |
WO1993000427A2 (en) * | 1991-06-24 | 1993-01-07 | Erziehungsdirektion Of The Canton Zurich | Neurite growth regulatory factors |
AU679167B2 (en) * | 1991-09-20 | 1997-06-26 | Amgen, Inc. | Glial derived neurotrophic factor |
AU5891394A (en) * | 1993-02-11 | 1994-08-29 | Erziehungsdirektion Of The Canton Zurich | A combination of neurotrophin and antibody directed toward myelin-associated neurite growth inhibitory protein promotes central nervous system regeneration |
HUP9900060A3 (en) * | 1995-04-19 | 2001-08-28 | Acorda Therapeutics New York | Cns neurite outgrowth modulators, and compositions, cells and methods embodying and using same |
US6576607B1 (en) | 1995-04-19 | 2003-06-10 | Acorda Therapeutics | Methods using CNS neurite outgrowth modulators |
US6576441B1 (en) | 1995-12-06 | 2003-06-10 | Sumitomo Pharmaceuticals Company, Limited | Semaphorin Z and gene encoding the same |
AU4136797A (en) | 1996-09-11 | 1998-04-02 | Sumitomo Pharmaceuticals Company, Limited | Novel semaphorin gene: semaphorin y |
EP0945505A4 (de) | 1996-10-09 | 2002-11-27 | Sumitomo Pharma | Neues semaphorin-gen: semaphorin w |
EP0960888A4 (de) | 1996-11-15 | 2002-10-16 | Sumitomo Pharma | Neue semaphorin-gene (i) |
JP2002518010A (ja) | 1998-06-16 | 2002-06-25 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 94個のヒト分泌タンパク質 |
CN1721444A (zh) * | 1998-11-06 | 2006-01-18 | 苏黎世大学 | Nogo基因的核苷酸序列和蛋白序列以及基于其的方法 |
US7119165B2 (en) * | 2000-01-12 | 2006-10-10 | Yale University | Nogo receptor-mediated blockade of axonal growth |
NZ520065A (en) | 2000-01-12 | 2006-02-24 | Univ Yale | Nogo receptor-mediated blockade of axonal growth |
ATE458815T1 (de) * | 2000-10-06 | 2010-03-15 | Univ Yale | Homologe des nogo rezeptors |
EP1805209A4 (de) * | 2004-10-01 | 2008-04-02 | Univ Yale | Nogo-a polypeptidfragmente, variante von nogo receptor-1 polypeptiden und verwendung |
US20060217324A1 (en) * | 2005-01-24 | 2006-09-28 | Juergen Soutschek | RNAi modulation of the Nogo-L or Nogo-R gene and uses thereof |
WO2007008732A2 (en) * | 2005-07-07 | 2007-01-18 | Yale University | Compositions and methods for suppressing axonal growth inhibition |
US7772200B2 (en) | 2005-07-21 | 2010-08-10 | Alnylam Pharmaceuticals, Inc. | iRNA agents targeted to the Rho-A gene |
CA2619406A1 (en) * | 2005-08-25 | 2007-03-01 | Biogen Idec Ma Inc. | Nogo receptor polypeptides and polypeptide fragments and uses thereof |
KR100756423B1 (ko) | 2005-10-27 | 2007-09-07 | 한국과학기술연구원 | 성선자극호르몬 수용체를 바이오마커로 이용한 마이엘린의탐색방법 |
BRPI0618609A2 (pt) * | 2005-11-16 | 2011-09-06 | Novartis Ag | biomarcadores para tratamento com anticorpo anti-nogo-a em danos à medula espinhal |
JP2009538282A (ja) * | 2006-05-15 | 2009-11-05 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 乏突起膠細胞の生存を促進させるためのNogo受容体−1(NgR1)アンタゴニストの使用 |
CN101969999B (zh) * | 2006-11-21 | 2017-03-22 | 雅培制药有限公司 | 抗nogo‑66受体(ngr)的中和单克隆抗体及其用途 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4287184A (en) * | 1977-11-23 | 1981-09-01 | The Massachusetts General Hospital | Process for healing wounds |
US4407744A (en) * | 1977-11-23 | 1983-10-04 | Young David M | Process for obtaining nerve growth factor |
US4230691A (en) * | 1978-05-23 | 1980-10-28 | The Massachusetts General Hospital | Nerve growth factor antibody and process |
CA1173823A (en) * | 1980-08-26 | 1984-09-04 | Leonard M. Hjelmeland | Nondenaturing zwitterionic detergent for membrane biochemistry |
US4444760A (en) * | 1983-06-17 | 1984-04-24 | Merck & Co., Inc. | Purification and characterization of a protein fibroblast growth factor |
EP0155433A1 (de) * | 1984-03-23 | 1985-09-25 | Adriano Fontana | Immunsuppressionsfaktor |
CA1341401C (en) * | 1984-03-23 | 2002-11-26 | Adriano Fontana | Immunosuppressant factor derived from human glioblastoma cells |
US4803163A (en) * | 1984-06-04 | 1989-02-07 | E. I. Du Pont De Nemours And Company | Preparation of a protein fraction exhibiting cell growth-inhibiting activity |
EP0233838A3 (de) * | 1986-02-04 | 1990-01-31 | Incyte Pharmaceuticals, Inc. | Neuriten stimulierender Faktor und Prozess für seine Herstellung |
US4923696A (en) * | 1987-05-04 | 1990-05-08 | Baylor College Of Medicine | Method to prepare a neurotrophic composition |
US5250414A (en) * | 1988-11-04 | 1993-10-05 | Erziehungsdirektion Of The Canton Zurich | Diagnostic methods using neurite growth regulatory factors |
AU652537B2 (en) * | 1988-11-04 | 1994-09-01 | Erziehungsdirektion Of The Canton Zurich | Neurite growth regulatory factors |
-
1989
- 1989-11-02 AU AU45280/89A patent/AU652537B2/en not_active Expired
- 1989-11-02 WO PCT/EP1989/001321 patent/WO1990005191A1/en active IP Right Grant
- 1989-11-02 EP EP89912786A patent/EP0396719B1/de not_active Expired - Lifetime
- 1989-11-02 KR KR1019900701436A patent/KR100196540B1/ko not_active IP Right Cessation
- 1989-11-02 DE DE68923362T patent/DE68923362T2/de not_active Expired - Lifetime
- 1989-11-02 AT AT89912786T patent/ATE124726T1/de not_active IP Right Cessation
-
1990
- 1990-07-03 DK DK160190A patent/DK160190A/da not_active IP Right Cessation
-
1994
- 1994-09-30 AU AU74354/94A patent/AU680932B2/en not_active Ceased
-
1995
- 1995-06-05 US US08/462,312 patent/US6025333A/en not_active Expired - Fee Related
- 1995-06-05 US US08/464,509 patent/US6103232A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0396719B1 (de) | 1995-07-05 |
DE68923362D1 (de) | 1995-08-10 |
AU680932B2 (en) | 1997-08-14 |
AU7435494A (en) | 1994-12-15 |
US6025333A (en) | 2000-02-15 |
EP0396719A1 (de) | 1990-11-14 |
US6103232A (en) | 2000-08-15 |
DK160190A (da) | 1990-09-03 |
WO1990005191A1 (en) | 1990-05-17 |
DK160190D0 (da) | 1990-07-03 |
KR100196540B1 (ko) | 1999-06-15 |
ATE124726T1 (de) | 1995-07-15 |
KR900702050A (ko) | 1990-12-05 |
AU4528089A (en) | 1990-05-28 |
AU652537B2 (en) | 1994-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |