DE68918681D1 - Glycosidasehemmer. - Google Patents
Glycosidasehemmer.Info
- Publication number
- DE68918681D1 DE68918681D1 DE68918681T DE68918681T DE68918681D1 DE 68918681 D1 DE68918681 D1 DE 68918681D1 DE 68918681 T DE68918681 T DE 68918681T DE 68918681 T DE68918681 T DE 68918681T DE 68918681 D1 DE68918681 D1 DE 68918681D1
- Authority
- DE
- Germany
- Prior art keywords
- glycosidase inhibitors
- glycosidase
- allitol
- dideoxy
- imino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/288,735 US4894388A (en) | 1988-12-22 | 1988-12-22 | Glycosidase inhibitors and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68918681D1 true DE68918681D1 (de) | 1994-11-10 |
DE68918681T2 DE68918681T2 (de) | 1995-03-30 |
Family
ID=23108416
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68918681T Expired - Fee Related DE68918681T2 (de) | 1988-12-22 | 1989-12-21 | Glycosidasehemmer. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4894388A (de) |
EP (1) | EP0375651B1 (de) |
JP (1) | JP2948847B2 (de) |
AT (1) | ATE112558T1 (de) |
CA (1) | CA2006269C (de) |
DE (1) | DE68918681T2 (de) |
ES (1) | ES2064487T3 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5043416A (en) * | 1988-09-26 | 1991-08-27 | Monsanto Company | Method of inhibiting virus |
US5013842A (en) * | 1990-01-22 | 1991-05-07 | Monsanto Company | Synthesis of chiral pyrrolidine and piperidine glycosidase inhibitors |
US5863903A (en) * | 1994-03-09 | 1999-01-26 | Novo Nordisk A/S | Use of hydroxy alkyl piperidine and pyrrolidine compounds to treat diabetes |
EP0749423B1 (de) * | 1994-03-09 | 2003-06-18 | Novo Nordisk A/S | Piperidine und pyrrolidine |
US5650413A (en) * | 1995-06-07 | 1997-07-22 | Glycodesign Inc. | Derivatives of swainsonine, processes for their preparation and their use as therapeutic agents |
EP0884050A1 (de) | 1995-09-08 | 1998-12-16 | Novo Nordisk A/S | Verwendung von 3,4-dihydroxy-2-hydroxymethylpyrrolidin zur behandlung von diabetes |
US6048870A (en) * | 1996-10-01 | 2000-04-11 | Glycodesign | 3, 5, and/or 6 substituted analogues of swainsonine processes for their preparation and their use as therapeutic agents |
CA2286766A1 (en) | 1997-04-15 | 1998-10-22 | Glycodesign Inc. | Alkaloid halide salts of swainsonine and methods of use |
EP1023290A1 (de) * | 1997-10-24 | 2000-08-02 | Glycodesign Inc. | Synthese von swainsoninsalzen |
US7256005B2 (en) | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
DE60037664T2 (de) * | 1999-08-10 | 2008-12-24 | The Chancellor, Masters And Scholars Of The University Of Oxford | Langkettige n-alkyl verbindungen und deren oxa-derivate zur verwendung als anitvirale mittel |
CA2616537A1 (en) | 2005-07-27 | 2007-02-01 | University Of Florida Research Foundation, Inc. | Small compounds that correct protein misfolding and uses thereof |
EP2049126A2 (de) | 2006-08-02 | 2009-04-22 | United Therapeutics Corporation | Liposomen-behandlung von virusinfektionen |
WO2008063727A2 (en) * | 2006-08-21 | 2008-05-29 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
WO2009118658A2 (en) * | 2008-03-26 | 2009-10-01 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
WO2010109330A2 (en) * | 2009-03-27 | 2010-09-30 | University Of Oxford | Cholesterol level lowering liposomes |
IN2012DN00352A (de) | 2009-06-16 | 2015-08-21 | Bikam Pharmaceuticals Inc | |
WO2012174064A1 (en) | 2011-06-14 | 2012-12-20 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
EP2768307B1 (de) | 2011-10-19 | 2020-03-18 | Bikam Pharmaceuticals, Inc. | Opsinbindende liganden, zusammensetzungen damit und anwendungsverfahren dafür |
EP2944628B1 (de) | 2011-11-30 | 2017-01-04 | Bikam Pharmaceuticals, Inc. | Opsinbindende liganden, zusammensetzungen und verfahren zur verwendung |
WO2013081642A1 (en) | 2011-12-01 | 2013-06-06 | Bikam Pharmaceuticals, Inc. | Opsin-binding ligands, compositions and methods of use |
CN107613990B (zh) * | 2015-03-27 | 2021-03-26 | 康奈尔大学 | 烟酰胺单核苷酸的有效合成 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3312716A (en) * | 1964-08-11 | 1967-04-04 | Aldrich Chem Co Inc | 4-hydroxy-3-pyrrolidinemethanols |
US4999360A (en) * | 1987-12-21 | 1991-03-12 | Monsanto Company | Method of inhibiting virus |
-
1988
- 1988-12-22 US US07/288,735 patent/US4894388A/en not_active Expired - Lifetime
-
1989
- 1989-12-21 ES ES89870215T patent/ES2064487T3/es not_active Expired - Lifetime
- 1989-12-21 AT AT89870215T patent/ATE112558T1/de not_active IP Right Cessation
- 1989-12-21 CA CA002006269A patent/CA2006269C/en not_active Expired - Fee Related
- 1989-12-21 DE DE68918681T patent/DE68918681T2/de not_active Expired - Fee Related
- 1989-12-21 EP EP89870215A patent/EP0375651B1/de not_active Expired - Lifetime
- 1989-12-21 JP JP1332491A patent/JP2948847B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2006269A1 (en) | 1990-06-22 |
JPH02212470A (ja) | 1990-08-23 |
EP0375651A1 (de) | 1990-06-27 |
EP0375651B1 (de) | 1994-10-05 |
JP2948847B2 (ja) | 1999-09-13 |
DE68918681T2 (de) | 1995-03-30 |
CA2006269C (en) | 1998-09-15 |
US4894388A (en) | 1990-01-16 |
ES2064487T3 (es) | 1995-02-01 |
ATE112558T1 (de) | 1994-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |