DE68908440T2 - Synthese von Trichostatin. - Google Patents

Synthese von Trichostatin.

Info

Publication number: DE68908440T2
Authority: DE; Germany
Prior art keywords: trichostatin; synthesis
Prior art date: 1988-03-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE89302169T

Other languages

English (en)

Other versions

DE68908440D1 (en

Inventor

Koshi Life Science Rese Koseki

Kenji Mori

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Japan Tobacco Inc

Original Assignee

Japan Tobacco Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-04

Filing date

1989-03-03

Publication date

1993-12-23

1989-03-03 Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc

1993-09-23 Publication of DE68908440D1 publication Critical patent/DE68908440D1/de

1993-12-23 Application granted granted Critical

1993-12-23 Publication of DE68908440T2 publication Critical patent/DE68908440T2/de

2009-03-04 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
229930185603 trichostatin Natural products 0.000 title 1
RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/76—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/44—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE89302169T 1988-03-04 1989-03-03 Synthese von Trichostatin. Expired - Lifetime DE68908440T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP63049595A JPH01224381A (ja)	1988-03-04	1988-03-04	トリコスタチン酸、トリコスタチンａの新規な合成中間体、及びトリコスタチン酸、トリコスタチンａの製造方法。

Publications (2)

Publication Number	Publication Date
DE68908440D1 DE68908440D1 (en)	1993-09-23
DE68908440T2 true DE68908440T2 (de)	1993-12-23

Family

ID=12835588

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE89302169T Expired - Lifetime DE68908440T2 (de)	1988-03-04	1989-03-03	Synthese von Trichostatin.

Country Status (4)

Country	Link
US (1)	US4946999A (de)
EP (1)	EP0331524B1 (de)
JP (1)	JPH01224381A (de)
DE (1)	DE68908440T2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0775593A (ja) *	1993-09-08	1995-03-20	Suntory Ltd	蛋白質の製造方法
US6777217B1 (en)	1996-03-26	2004-08-17	President And Fellows Of Harvard College	Histone deacetylases, and uses related thereto
EP0827946A1 (de) *	1996-09-04	1998-03-11	Vrije Universiteit Brussel	Inhibitoren der Differenzierung von Zellen, insbesondere von Kupffer-Sternzellen
US20030129724A1 (en)	2000-03-03	2003-07-10	Grozinger Christina M.	Class II human histone deacetylases, and uses related thereto
US7244853B2 (en)	2001-05-09	2007-07-17	President And Fellows Of Harvard College	Dioxanes and uses thereof
US20070021612A1 (en) *	2004-11-04	2007-01-25	University Of Notre Dame Du Lac	Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof
US7235688B1 (en)	2004-11-04	2007-06-26	University Of Notre Dame Du Lac	Process for preparing histone deacetylase inhibitors and intermediates thereof
WO2006102557A2 (en)	2005-03-22	2006-09-28	The President And Fellows Of Harvard College	Treatment of protein degradation disorders
CN1939898B (zh) *	2005-09-29	2010-10-13	中国科学院上海药物研究所	一种组蛋白脱乙酰酶抑制剂的手性全合成方法
JP5409015B2 (ja)	2006-02-14	2014-02-05	プレジデントアンドフェロウズオブハーバードカレッジ	ヒストンデアセチラーゼ阻害剤
CN101400362B (zh)	2006-02-14	2016-10-12	哈佛大学校长及研究员协会	双官能组蛋白去乙酰化酶抑制剂
JP5497431B2 (ja)	2006-05-03	2014-05-21	プレジデントアンドフェローズオブハーバードカレッジ	ヒストンデアセチラーゼおよびチューブリンデアセチラーゼ阻害剤
US8088951B2 (en) *	2006-11-30	2012-01-03	Massachusetts Institute Of Technology	Epigenetic mechanisms re-establish access to long-term memory after neuronal loss
JP5665740B2 (ja)	2008-07-23	2015-02-04	プレジデントアンドフェローズオブハーバードカレッジ	デアセチラーゼ阻害剤およびその使用
WO2010138802A2 (en) *	2009-05-28	2010-12-02	Cornell University	Compositions and their use for removing cholesterol
US8716344B2 (en)	2009-08-11	2014-05-06	President And Fellows Of Harvard College	Class- and isoform-specific HDAC inhibitors and uses thereof
US20110237832A1 (en) *	2010-03-29	2011-09-29	University Of Notre Dame Du Lac	Synthesis of hdac inhibitors: trichostatin a and analogues
US10669528B2 (en)	2015-06-25	2020-06-02	Children's Medical Center Corporation	Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
WO2017161001A1 (en)	2016-03-15	2017-09-21	Children's Medical Center Corporation	Methods and compositions relating to hematopoietic stem cell expansion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3867434A (en) *	1971-11-04	1975-02-18	Rorer Inc William H	Phenyl butyric acids and derivatives thereof
US3868406A (en) *	1970-08-03	1975-02-25	Zoecon Corp	P-alkenyloxybenzoic acid esters useful for the control of insects
US4243819A (en) *	1978-02-16	1981-01-06	Zoecon Corporation	Substituted amino acids
US4218478A (en) *	1979-01-05	1980-08-19	Ruiko Oiwa	Trichostatin as an antiprotozoal agent
US4218378A (en) *	1979-05-01	1980-08-19	The Upjohn Company	11a-Methano-TXA compounds
US4608390A (en) *	1985-04-26	1986-08-26	Abbott Laboratories	Lipoxygenase inhibiting compounds

1988
- 1988-03-04 JP JP63049595A patent/JPH01224381A/ja active Pending
1989
- 1989-02-22 US US07/313,505 patent/US4946999A/en not_active Expired - Fee Related
- 1989-03-03 DE DE89302169T patent/DE68908440T2/de not_active Expired - Lifetime
- 1989-03-03 EP EP89302169A patent/EP0331524B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0331524A3 (en)	1990-01-17
DE68908440D1 (en)	1993-09-23
EP0331524B1 (de)	1993-08-18
JPH01224381A (ja)	1989-09-07
EP0331524A2 (de)	1989-09-06
US4946999A (en)	1990-08-07

Legal Events

Date	Code	Title	Description
1994-09-15	8364	No opposition during term of opposition
1999-04-08	8339	Ceased/non-payment of the annual fee

Publication	Publication Date	Title
DE68923255D1 (de)	1995-08-03	Synthese von Methylaluminoxanen.
DE69330129T2 (de)	2001-08-02	Synthese von 1,4,7-thiazacyclononan-derivaten
DE68908440T2 (de)	1993-12-23	Synthese von Trichostatin.
ATE123037T1 (de)	1995-06-15	Synthese von carbonylverbindungen.
DE69605282T2 (de)	2000-07-13	Synthese von cyclopropylacetylen
DE68929060D1 (de)	1999-09-30	Synthese von 1,2-Dioxetanen und Zwischenprodukte dafür
DE69126089D1 (de)	1997-06-19	Synthese von Trans-1,4-Polybutadien
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NO904210D0 (no)	1990-09-27	Syntese av hydrokarbylaminer.
DE3689304T2 (de)	1994-05-19	Synthese von Verbindungen vom Podophylotoxintyp.
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DE69226706T2 (de)	1999-04-15	Synthese von smektit-tonmineralen
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DE69006345D1 (de)	1994-03-10	Totale Synthese von Erbstatin-Analogen.
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DE69410814T2 (de)	1998-11-12	Synthese von sphingosinen
ES2023930B3 (es)	1992-02-16	Sintesis de ditioles.
DE3586143T2 (de)	1992-12-03	Synthese von zeolithischem material.
DE69707656T2 (de)	2002-08-08	Synthese von cycloalkyldiarylphosphin
DE69708273T2 (de)	2002-07-25	Synthese von cycloalkyldiarylphosphin
DE69205144D1 (de)	1995-11-02	Synthese von n-Perfluoroctylbromid.
ATE134370T1 (de)	1996-03-15	Stereo- und enantioselektive synthese von 5- substituierten-3-methylen-2- tetrahydrofuranmethanolen
DE69318738T2 (de)	1998-09-24	Katalytische Synthese von Alkylmorpholinonen
ATE53987T1 (de)	1990-07-15	Synthese von silicophosphoaluminaten.