DE627272C - Process for obtaining the female sex hormone - Google Patents
Process for obtaining the female sex hormoneInfo
- Publication number
- DE627272C DE627272C DEA72796D DEA0072796D DE627272C DE 627272 C DE627272 C DE 627272C DE A72796 D DEA72796 D DE A72796D DE A0072796 D DEA0072796 D DE A0072796D DE 627272 C DE627272 C DE 627272C
- Authority
- DE
- Germany
- Prior art keywords
- obtaining
- sex hormone
- female sex
- benzene
- urine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
Verfahren zur Gewinnung des weiblichen Sexualhormons Es ist bekannt, die Sexuall%ormone aus frischen oder getro ckneten menschlichen oder tierischen Organen durch Extraktion mit Benzol zu gewinnen. Auch weiß man, daß der Harn schwangerer Frauen stark hormonhaltig ist. Gemäß vorliegender Erftadung wird nun der Harn schwangerer Frauen oder trächtiger Kühe zwecks Gewinnung des Sexualhormons mit Benzol extrahiert. Der Erfolg dieses Verfahrens war nicht ohne weiteres zu erwarten, da nach Angaben in der neueren Literatur das in Wasser gelöste Hormon nach dem Eindampfen in Benzol nicht mehr löslich ist (vgl. Klinische Wochenschrift i927., S.392, linke Spalte).Method of obtaining the female sex hormone It is known the sexual% ormone from fresh or dried human or animal Obtain organs by extraction with benzene. It is also known that the urine is pregnant Women have high levels of hormones. According to the present charge, the urine is now becoming more pregnant Women or pregnant cows are extracted with benzene to obtain the sex hormone. The success of this procedure was not to be expected without further ado, according to information in recent literature the hormone dissolved in water after evaporation in benzene is no longer soluble (see Klinische Wochenschrift 1927., p.392, left column).
Zur Erläuterung der Ausführung des Verfahrens dienen folgende Beispiele: ;Beispiel I 5 1 Harnf einer schwangeren Frau werden mit 2 1 Benzol 3 Stunden auf der Schüttelmaschine geschüttelt. Die entstandene Emulsion wird mit einem weiteren Liter Benzol und 0,5 ccm Eisessig eine Nacht bei Zimmertemperatur sich selbst überlassen. Nach Abscheiden von der wässerigen Phase wird die Benzollösung im Vakuum konzentriert und der Rückstand in der Eindampfschale mit kleinem. Mengen warmen Wassers wiederholt verrieben, bis eine Menge von Zoo ccm Wasser erreicht ist. Die Lösung enthält das Hormon in einer zur subkutanen Injektion geeigneten Form; gegebienenfalls kann eine weitere Reinigung vorgenommen werden. Beispiel II 5 1 Harn einer trächtigen Kuh werden in der in Beispiel I beschriebenen Weise behandelt. Das Endprodukt beträgt 2ioccm wässeriger Lösung und ist zur subkutanen Injektion geeignet; unter Umständen kann man eine weitere Reinigung vornehmen.The following examples serve to explain the execution of the method: Example I 5 1 urine of a pregnant woman are shaken with 2 1 benzene for 3 hours on the shaking machine. The resulting emulsion is left to stand for one night at room temperature with another liter of benzene and 0.5 cc of glacial acetic acid. After the aqueous phase has separated off, the benzene solution is concentrated in vacuo and the residue in the evaporation dish with a small. Amounts of warm water rubbed in repeatedly until an amount of zoo cc of water is reached. The solution contains the hormone in a form suitable for subcutaneous injection; If necessary, further cleaning can be carried out. Example II 5 1 urine from a pregnant cow is treated in the manner described in Example I. The end product is 2 ounces of aqueous solution and is suitable for subcutaneous injection; it may be possible to carry out further cleaning.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEA72796D DE627272C (en) | 1928-02-14 | 1928-02-14 | Process for obtaining the female sex hormone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEA72796D DE627272C (en) | 1928-02-14 | 1928-02-14 | Process for obtaining the female sex hormone |
Publications (1)
Publication Number | Publication Date |
---|---|
DE627272C true DE627272C (en) | 1936-03-11 |
Family
ID=6945667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DEA72796D Expired DE627272C (en) | 1928-02-14 | 1928-02-14 | Process for obtaining the female sex hormone |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE627272C (en) |
-
1928
- 1928-02-14 DE DEA72796D patent/DE627272C/en not_active Expired
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