DE60335743D1 - Verbindungen und verfahren zur erhöhung der neurogenese - Google Patents
Verbindungen und verfahren zur erhöhung der neurogeneseInfo
- Publication number
- DE60335743D1 DE60335743D1 DE60335743T DE60335743T DE60335743D1 DE 60335743 D1 DE60335743 D1 DE 60335743D1 DE 60335743 T DE60335743 T DE 60335743T DE 60335743 T DE60335743 T DE 60335743T DE 60335743 D1 DE60335743 D1 DE 60335743D1
- Authority
- DE
- Germany
- Prior art keywords
- agents
- neurogenesis
- increasing
- compounds
- intracellular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000004766 neurogenesis Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title 1
- 230000003834 intracellular effect Effects 0.000 abstract 3
- 230000003028 elevating effect Effects 0.000 abstract 2
- 230000001737 promoting effect Effects 0.000 abstract 2
- 230000001537 neural effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42791202P | 2002-11-20 | 2002-11-20 | |
PCT/IB2003/005311 WO2004045592A2 (en) | 2002-11-20 | 2003-11-20 | Compounds and methods for increasing neurogenesis |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60335743D1 true DE60335743D1 (de) | 2011-02-24 |
Family
ID=32326612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60335743T Expired - Lifetime DE60335743D1 (de) | 2002-11-20 | 2003-11-20 | Verbindungen und verfahren zur erhöhung der neurogenese |
Country Status (14)
Country | Link |
---|---|
US (1) | US20050009847A1 (de) |
EP (1) | EP1583541B1 (de) |
JP (2) | JP5420813B2 (de) |
AT (1) | ATE494904T1 (de) |
AU (1) | AU2003280117B2 (de) |
CA (1) | CA2506850C (de) |
CY (1) | CY1111386T1 (de) |
DE (1) | DE60335743D1 (de) |
DK (1) | DK1583541T3 (de) |
ES (1) | ES2359720T3 (de) |
HK (1) | HK1091112A1 (de) |
PT (1) | PT1583541E (de) |
SI (1) | SI1583541T1 (de) |
WO (1) | WO2004045592A2 (de) |
Families Citing this family (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7691145B2 (en) * | 1999-10-22 | 2010-04-06 | Facet Solutions, Inc. | Prostheses, systems and methods for replacement of natural facet joints with artificial facet joint surfaces |
JP3993560B2 (ja) * | 2001-08-30 | 2007-10-17 | ステム セル セラピューティクス インコーポレイテッド | 神経幹細胞の分化およびその治療用途 |
EP1430114B1 (de) | 2001-09-14 | 2012-01-18 | Stem Cell Therapeutics Inc. | Prolaktin-induzierte zunahme an neuronalen stammzellen und dessen therapeutische anwendung |
US20030054551A1 (en) * | 2001-09-18 | 2003-03-20 | Stem Cell Therapeutics Inc. | Effect of growth hormone and IGF-1 on neural stem cells |
US7368115B2 (en) * | 2002-07-31 | 2008-05-06 | Stem Cell Therapeutics Inc. | Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (PACAP) |
FR2856595B1 (fr) * | 2003-06-27 | 2008-05-30 | Exonhit Therapeutics Sa | Methodes et compositions pour le traitement de deficits cognitifs. |
US20070111932A1 (en) * | 2003-07-31 | 2007-05-17 | Stem Cell Therapeutics Inc. | Method of enhancing and/or inducing neuronal migration using erythropoietin |
CA2546843C (en) * | 2003-11-20 | 2015-01-06 | Neuronova Ab | Compounds and methods for increasing neurogenesis |
CA2556266A1 (en) | 2004-02-13 | 2005-08-25 | Stem Cell Therapeutics Corp. | Use of luteinizing hormone (lh), and chorionic gonadotropin (hcg) for proliferation of neural stem cells and neurogenesis |
ATE534664T1 (de) | 2004-05-24 | 2011-12-15 | Inst Cardiologie Montreal | Markierte adrenomedullinderivate und deren verwendung zur bilddarstellung und therapie |
US8475764B2 (en) | 2004-05-24 | 2013-07-02 | Institut De Cardiologie De Montreal | Labelled adrenomedullin derivatives and their use for imaging and therapy |
EP1619251A1 (de) | 2004-07-22 | 2006-01-25 | Prosensa B.V. | Ein mRNA Spleisvariant des Doublecortin-ähnlichen Kinasegens und dessen Anwendung in Krebsdiagnosis und Krebstherapie |
EP1850840A2 (de) * | 2005-01-13 | 2007-11-07 | Sirtris Pharmaceuticals, Inc. | Neue zusammensetzungen zur vorbeugung und behandlung von neurodegenerativen und blutgerinnungserkrankungen |
US7741431B2 (en) * | 2005-02-01 | 2010-06-22 | The United States Of America As Represented By The Secretary Of The Army | Liposomes containing novel targeting and/or fusogenic peptides, preparations containing them and therapeutic use thereof |
US20090220587A1 (en) * | 2005-02-01 | 2009-09-03 | United State Army | Liposomal drug delivery constructs targeted by lipid-conjugated peptide ligands |
DE102005036094A1 (de) * | 2005-08-01 | 2007-02-08 | B.R.A.H.M.S Ag | In vitro Verfahren zur Diagnose von neurodegenerativen Erkrankungen |
EP2258358A3 (de) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
AU2006297041A1 (en) | 2005-09-27 | 2007-04-05 | Stem Cell Therapeutics Corp. | Oligodendrocyte precursor cell proliferation regulated by prolactin |
EP1940389A2 (de) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation von neurogenese durch pde-hemmung |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
JP5050195B2 (ja) * | 2006-02-14 | 2012-10-17 | 国立大学法人 岡山大学 | 神経細胞分化誘導剤 |
JP5424291B2 (ja) * | 2006-03-03 | 2014-02-26 | 独立行政法人国立循環器病研究センター | 骨髄細胞の動員剤および動員方法 |
US20100216734A1 (en) * | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
WO2007104035A1 (en) * | 2006-03-08 | 2007-09-13 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
JP2009149524A (ja) * | 2006-03-16 | 2009-07-09 | Kyushu Univ | アルツハイマー病の予防・治療剤 |
WO2007106986A1 (en) * | 2006-03-17 | 2007-09-27 | Stem Cell Therapeutics Corp. | Dosing regimes for lh or hcg and epo for treatment of neurological disorders |
US20100009983A1 (en) * | 2006-05-09 | 2010-01-14 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
US7858611B2 (en) | 2006-05-09 | 2010-12-28 | Braincells Inc. | Neurogenesis by modulating angiotensin |
AU2007249399A1 (en) * | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
US20090197823A1 (en) * | 2006-05-09 | 2009-08-06 | Braincells, Inc. | Aliskiren modulation of neurogenesis |
KR100838013B1 (ko) * | 2006-06-07 | 2008-06-12 | 제일약품주식회사 | 인간배아줄기세포로부터 단계적 선별법을 통해 고수율로신경전구세포, 신경세포 및 기능성 도파민신경세포를생성하는 방법 |
MX2009002496A (es) * | 2006-09-08 | 2009-07-10 | Braincells Inc | Combinaciones que contienen un derivado de 4-acilaminopiridina. |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
EP2066355A2 (de) * | 2006-09-19 | 2009-06-10 | Braincells, Inc. | Kombination aus einem durch einen peroxisom-proliferator aktivierten rezeptor-mittel und einem zweiten neurogenen mittel zur behandlung von erkrankungen des nervensystems sowie zur förderung von neuraler differenzierung und neurogenese |
CA2672524C (en) * | 2006-12-14 | 2016-08-23 | Neuronova Ab | Treatment of disease or injury of the nervous system using agents that decrease the activity of the melanocortin 4 receptor |
WO2008083204A2 (en) * | 2006-12-28 | 2008-07-10 | Braincells, Inc. | Modulation of neurogenesis by melatoninergic ligands |
EP2125017A2 (de) * | 2007-01-11 | 2009-12-02 | Braincells, Inc. | Neurogenese-modulation durch verwendung von modafinil |
US20080188457A1 (en) * | 2007-02-02 | 2008-08-07 | Braincells, Inc. | Modulation of Neurogenesis with Biguanides and GSK3-beta Agents |
CA2686760C (en) * | 2007-05-11 | 2016-10-11 | Institut De Cardiologie De Montreal | Labelled adrenomedullin derivatives and their use for imaging and therapy |
CA2694696A1 (en) * | 2007-07-27 | 2009-02-05 | Immuneregen Biosciences, Inc. | Methods and compositions for stimulating the proliferation or differentiation of stem cells with substance p or an analog thereof |
KR20100057641A (ko) * | 2007-09-11 | 2010-05-31 | 몬도바이오테크 래보래토리즈 아게 | 인터메딘 47 및 53 펩티드의 치료적 용도 |
WO2009033809A2 (en) * | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Use of a peptide as a therapeutic agent |
CA2698992A1 (en) * | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Use of a peptide as a therapeutic agent |
EP2187929A2 (de) * | 2007-09-11 | 2010-05-26 | Mondobiotech Laboratories AG | Verwendung eines peptids als therapeutisches mittel |
JP2011509981A (ja) * | 2008-01-18 | 2011-03-31 | サントル ナショナル ドゥ ラ ルシェルシュ スィヤンティフィック(セーエヌエルエス) | 神経障害性疼痛の治療に使用される化合物 |
FR2926464B1 (fr) * | 2008-01-18 | 2012-01-20 | Centre Nat Rech Scient | Composes utilisables pour le traitement de douleurs neuropathiques |
WO2009123877A1 (en) * | 2008-03-21 | 2009-10-08 | Braincells, Inc. | A method of treating a nervous system disorder by modulation of neurogenesis with mcc-257 |
JPWO2009136587A1 (ja) * | 2008-05-08 | 2011-09-08 | 株式会社カネカ | 抗疲労組成物 |
WO2010019450A2 (en) * | 2008-08-09 | 2010-02-18 | Nyles Bauer | Synergizing active compounds for treating inflammation and other conditions |
GB0815315D0 (en) * | 2008-08-21 | 2008-09-24 | Univ Leiden | Organ protection |
LT2349324T (lt) | 2008-10-17 | 2017-12-27 | Sanofi-Aventis Deutschland Gmbh | Insulino ir glp-1 agonisto derinys |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
PL2408446T3 (pl) | 2009-03-20 | 2020-03-31 | Hg&H Pharmaceuticals (Pty) Limited | Zastosowanie kompozycji farmaceutycznych zawierających mesembrenon |
ES2702461T3 (es) | 2009-03-20 | 2019-03-01 | Hg&H Pharmaceuticals Pty Ltd | Extracto de Sceletium y usos del mismo |
CN102458399B (zh) | 2009-04-30 | 2014-04-23 | 美国中西部大学 | centhaquin的新制药用途 |
MX2011012043A (es) * | 2009-05-13 | 2012-03-29 | Protein Delivery Solutions Llc | Sistema farmaceutico para suministro transmembrana. |
PL2498801T3 (pl) | 2009-11-13 | 2018-08-31 | Sanofi Aventis Deutschland | Kompozycja farmaceutyczna zawierająca desPro<sup>36</sup>eksendyno-4(1-39)-Lys6-NH2 i metioninę |
ES2534191T3 (es) | 2009-11-13 | 2015-04-20 | Sanofi-Aventis Deutschland Gmbh | Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina |
ES2688072T3 (es) * | 2010-05-11 | 2018-10-30 | Mallinckrodt Ard Ip Limited | ACTH para el tratamiento de la esclerosis lateral amiotrófica |
CA2801281C (en) * | 2010-06-16 | 2018-07-10 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Acetyl-carnitine for use in a method for increasing neurogenesis in neural tissue |
HUE031181T2 (en) | 2010-08-30 | 2017-06-28 | Sanofi Aventis Deutschland | Use of AVE0010 for the manufacture of a medicament for the treatment of type 2 diabetes |
HUE029393T2 (en) | 2010-08-31 | 2017-03-28 | Bionure Farma S L | Neurotrophin receptor agonists and their use as medicaments |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
WO2013002879A1 (en) * | 2011-06-29 | 2013-01-03 | President And Fellows Of Harvard College | Small molecule cd38 inhibitors and methods of using same |
US9193710B2 (en) | 2011-08-29 | 2015-11-24 | Sanford-Burnham Medical Research Institute | Benzodiazepinones as modulators of metabotropic glutamate receptor functions and neurological uses thereof |
CN108079281A (zh) | 2011-08-29 | 2018-05-29 | 赛诺菲-安万特德国有限公司 | 用于2型糖尿病患者中的血糖控制的药物组合 |
AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
JP2016503771A (ja) | 2012-12-21 | 2016-02-08 | サノフイ | エキセンジン−4誘導体 |
BR112016000431A8 (pt) * | 2013-07-08 | 2018-01-23 | Univ Midwestern | composições e métodos para o tratamento de distúrbios neuropsiquiátricos usando um agonista do receptor de endotelina-b |
EP3080150B1 (de) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4-peptidanaloga als duale glp-1/gip-rezeptoragonisten |
EP3080149A1 (de) | 2013-12-13 | 2016-10-19 | Sanofi | Duale glp-1-/glucagon-rezeptoragonisten |
EP3080154B1 (de) | 2013-12-13 | 2018-02-07 | Sanofi | Duale glp-1/gip-rezeptoragonisten |
WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
US9950039B2 (en) | 2014-12-12 | 2018-04-24 | Sanofi-Aventis Deutschland Gmbh | Insulin glargine/lixisenatide fixed ratio formulation |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
JP6820868B2 (ja) * | 2015-06-22 | 2021-01-27 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 動物において神経新生を増強するための組成物及び方法 |
AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
EP3438249A4 (de) * | 2016-03-31 | 2019-10-30 | Ajinomoto Co., Inc. | Medium für neurale stammzellen zur verbesserung der neuralen differenzierungsfähigkeit |
JP7029707B2 (ja) * | 2016-10-17 | 2022-03-04 | 国立大学法人 熊本大学 | cAMPの増加をメカニズムとする有機酸血症における神経障害治療薬剤 |
KR102026156B1 (ko) * | 2018-03-16 | 2019-09-27 | (주)메디노 | 신경줄기세포의 신경분화 방법 |
JP2021532070A (ja) * | 2018-06-21 | 2021-11-25 | ボード オブ リージェンツ オブ ザ ネバダ システム オブ ハイヤー エデュケーション オン ビハーフ オブ ザ ユニバーシティー オブ ネバダ リノ | 向知性薬を用いて神経変性疾患を治療するための疾患修飾方法 |
WO2021011878A1 (en) * | 2019-07-18 | 2021-01-21 | Venturis Therapeutics, Inc. | Method of treating parkinson's disease |
JP2022104448A (ja) * | 2020-12-28 | 2022-07-08 | 純一 今村 | 認知症治療薬 |
CN113121641B (zh) * | 2021-03-11 | 2022-11-01 | 武汉英纳氏药业有限公司 | 一类多功能多肽及其在医药领域的应用 |
CN115869459A (zh) * | 2021-09-27 | 2023-03-31 | 广州图微科创生物科技有限公司 | 促伤口愈合的多肽水凝胶及其制备方法与应用 |
CN115887619B (zh) * | 2021-09-30 | 2024-03-26 | 四川大学 | 中脑星形胶质细胞源性神经营养因子的用途及药物组合物 |
WO2024030977A2 (en) * | 2022-08-03 | 2024-02-08 | Sightstream Biotherapeutics, Inc. | Novel melanocortin analogs |
Family Cites Families (8)
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---|---|---|---|---|
EP0734251B1 (de) * | 1993-12-17 | 2009-10-14 | Novavax, Inc. | Verfahren zur übertragung eines biologisch aktiven materials an eine zelle |
US5968829A (en) * | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
US6268352B1 (en) * | 1998-09-02 | 2001-07-31 | The Regents Of The University Of California | Promoters of neural regeneration |
US6284539B1 (en) * | 1998-10-09 | 2001-09-04 | Neuralstem Biopharmaceuticals, Ltd. | Method for generating dopaminergic cells derived from neural precursors |
US6610540B1 (en) * | 1998-11-18 | 2003-08-26 | California Institute Of Technology | Low oxygen culturing of central nervous system progenitor cells |
DE60137414D1 (de) * | 2000-05-05 | 2009-03-05 | Univ City | Zusammensetzungen zur stimulierung der regeneration und der wiederherstellung des nervensystems durch regulierung der arginase 1- und polyamin-synthese |
WO2002083877A1 (en) * | 2001-04-11 | 2002-10-24 | Stem Cell Therapeutics Inc. | Production of tyrosine hydroxylase positive neurons |
EP1385938A1 (de) * | 2001-04-23 | 2004-02-04 | Nsgene A/S | Methode und kulturmedium zur herstellung von neuronalenzellen ausdrücken tyrosin hydroxylase |
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2003
- 2003-11-20 WO PCT/IB2003/005311 patent/WO2004045592A2/en active Application Filing
- 2003-11-20 EP EP03772495A patent/EP1583541B1/de not_active Revoked
- 2003-11-20 CA CA2506850A patent/CA2506850C/en not_active Expired - Fee Related
- 2003-11-20 JP JP2004553032A patent/JP5420813B2/ja not_active Expired - Fee Related
- 2003-11-20 US US10/718,071 patent/US20050009847A1/en not_active Abandoned
- 2003-11-20 PT PT03772495T patent/PT1583541E/pt unknown
- 2003-11-20 DK DK03772495.2T patent/DK1583541T3/da active
- 2003-11-20 AT AT03772495T patent/ATE494904T1/de active
- 2003-11-20 AU AU2003280117A patent/AU2003280117B2/en not_active Ceased
- 2003-11-20 ES ES03772495T patent/ES2359720T3/es not_active Expired - Lifetime
- 2003-11-20 DE DE60335743T patent/DE60335743D1/de not_active Expired - Lifetime
- 2003-11-20 SI SI200331983T patent/SI1583541T1/sl unknown
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2006
- 2006-04-10 HK HK06104339.6A patent/HK1091112A1/xx not_active IP Right Cessation
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2010
- 2010-06-18 JP JP2010139986A patent/JP5421194B2/ja not_active Expired - Fee Related
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2011
- 2011-04-11 CY CY20111100370T patent/CY1111386T1/el unknown
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JP2006514630A (ja) | 2006-05-11 |
AU2003280117B2 (en) | 2009-09-10 |
ES2359720T3 (es) | 2011-05-26 |
DK1583541T3 (da) | 2011-04-11 |
CA2506850C (en) | 2014-05-13 |
JP5421194B2 (ja) | 2014-02-19 |
PT1583541E (pt) | 2011-04-06 |
HK1091112A1 (en) | 2007-01-12 |
JP5420813B2 (ja) | 2014-02-19 |
US20050009847A1 (en) | 2005-01-13 |
WO2004045592A2 (en) | 2004-06-03 |
EP1583541A2 (de) | 2005-10-12 |
JP2010195841A (ja) | 2010-09-09 |
SI1583541T1 (sl) | 2011-08-31 |
EP1583541B1 (de) | 2011-01-12 |
AU2003280117A1 (en) | 2004-06-15 |
CY1111386T1 (el) | 2015-08-05 |
CA2506850A1 (en) | 2004-06-03 |
ATE494904T1 (de) | 2011-01-15 |
WO2004045592A3 (en) | 2004-11-04 |
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