DE60335093D1 - Verwendung von nichtantibakteriellen tetrazyklin-analoga und ihren formulierungen für die behandlung von bakteriellen exotoxinen - Google Patents

Verwendung von nichtantibakteriellen tetrazyklin-analoga und ihren formulierungen für die behandlung von bakteriellen exotoxinen

Info

Publication number: DE60335093D1
Authority: DE; Germany
Prior art keywords: tetrazyklin; exotoxines; antibibterial; analogues; bacterial
Prior art date: 2002-03-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60335093T

Other languages

English (en)

Inventor

Lorne M Golub

Stephen G Walker

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Research Foundation of State University of New York

Original Assignee

Research Foundation of State University of New York

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-29

Filing date

2003-03-27

Publication date

2011-01-05

2003-03-27 Application filed by Research Foundation of State University of New York filed Critical Research Foundation of State University of New York

2011-01-05 Application granted granted Critical

2011-01-05 Publication of DE60335093D1 publication Critical patent/DE60335093D1/de

2023-03-28 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title abstract 2
230000001580 bacterial effect Effects 0.000 title 1
OFVLGDICTFRJMM-WESIUVDSSA-N tetracycline Chemical class C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 title 1
OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 abstract 2
239000002095 exotoxin Substances 0.000 abstract 2
231100000776 exotoxin Toxicity 0.000 abstract 2
241000894006 Bacteria Species 0.000 abstract 1
102000000584 Calmodulin Human genes 0.000 abstract 1
108010041952 Calmodulin Proteins 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
102000005741 Metalloproteases Human genes 0.000 abstract 1
108010006035 Metalloproteases Proteins 0.000 abstract 1
239000004098 Tetracycline Substances 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229960002180 tetracycline Drugs 0.000 abstract 1
229930101283 tetracycline Natural products 0.000 abstract 1
235000019364 tetracycline Nutrition 0.000 abstract 1
150000003522 tetracyclines Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Toxicology (AREA)
Oncology (AREA)
Microbiology (AREA)
Mycology (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Plant Pathology (AREA)
Pest Control & Pesticides (AREA)
Agronomy & Crop Science (AREA)
Engineering & Computer Science (AREA)
Dentistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DE60335093T 2002-03-29 2003-03-27 Verwendung von nichtantibakteriellen tetrazyklin-analoga und ihren formulierungen für die behandlung von bakteriellen exotoxinen Expired - Lifetime DE60335093D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US36847802P	2002-03-29	2002-03-29
PCT/US2003/009570 WO2003082011A1 (en)	2002-03-29	2003-03-27	Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins

Publications (1)

Publication Number	Publication Date
DE60335093D1 true DE60335093D1 (de)	2011-01-05

Family

ID=28675499

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60335093T Expired - Lifetime DE60335093D1 (de)	2002-03-29	2003-03-27	Verwendung von nichtantibakteriellen tetrazyklin-analoga und ihren formulierungen für die behandlung von bakteriellen exotoxinen

Country Status (11)

Country	Link
US (2)	US20040014731A1 (de)
EP (2)	EP1496742B1 (de)
JP (1)	JP2005521701A (de)
KR (1)	KR20040094833A (de)
AT (1)	ATE489081T1 (de)
AU (1)	AU2003226112B9 (de)
CA (1)	CA2475202A1 (de)
DE (1)	DE60335093D1 (de)
ES (1)	ES2359346T3 (de)
NZ (1)	NZ534950A (de)
WO (1)	WO2003082011A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2803922C (en)	2003-04-07	2015-09-15	Supernus Pharmaceuticals, Inc.	Once daily formulations of tetracyclines
US20060252731A1 (en) *	2005-05-06	2006-11-09	Pfeiffer David F	Methods of treating recurrent aphthous stomatitis
WO2007011699A2 (en) *	2005-07-15	2007-01-25	Research Foundation Of State University Of New York	Use of non-antibacterial tetracycline formulations for inhibiting bacterial spores
US20070015738A1 (en) *	2005-07-15	2007-01-18	Walker Stephen G	Use of non-antibacterial tetracycline formulations for inhibiting bacterial spores from becoming infectious vegetative cells
US8440646B1 (en) *	2006-10-11	2013-05-14	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds for treatment of Bacillus anthracis infections
MX2017012073A (es) *	2015-03-24	2018-02-21	Paratek Pharm Innc	Compuestos de minociclina para biodefensas.
WO2023133096A1 (en) *	2022-01-04	2023-07-13	The Research Foundation For The State University Of New York	Cmt-3 formulations and methods of using the same

Family Cites Families (24)

* Cited by examiner, † Cited by third party
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FR1430859A (de) *	1960-05-23	1966-05-25
GB1034934A (en) *	1962-10-29	1966-07-06	American Cyanamid Co	New tetracycline compounds and manufacture thereof
DE2011281A1 (en) *	1970-03-10	1971-09-16	Leningradskij Nautschno-Issledowatelskij Institut Antibiotikow, Leningrad (Sowjetunion)	Polyantibiotic with antimicrobial activity
US4666897A (en)	1983-12-29	1987-05-19	Research Foundation Of State University	Inhibition of mammalian collagenolytic enzymes by tetracyclines
US4935412A (en)	1983-12-29	1990-06-19	The Research Foundation Of State University Of New York	Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
US4704383A (en)	1983-12-29	1987-11-03	The Research Foundation Of State University Of New York	Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
US4925833A (en)	1983-12-29	1990-05-15	The Research Foundation Of State University Of New York	Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis
EP0256713A3 (de) *	1986-08-06	1989-02-15	Merck & Co. Inc.	Therapeutische, menschliche Antipseudomonas-Aeruginosa-Antikörper
US5308839A (en) *	1989-12-04	1994-05-03	The Research Foundation Of State University Of New York	Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline
US5045538A (en)	1990-06-28	1991-09-03	The Research Foundation Of State University Of New York	Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines
DK0599397T3 (da)	1992-11-17	1996-09-16	Univ New York State Res Found	Tetracycliner, herunder non-mikrobielle, kemisk-modificerede tetracycliner, inhiberer overdreven collagentværbinding ved diabetes
US5523297A (en)	1993-03-02	1996-06-04	The Research Foundation Of State University Of New York	Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US6043231A (en)	1993-03-02	2000-03-28	The Research Foundation Of State Univ. Of New York	Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
EP0736302A3 (de) *	1995-03-23	1997-06-04	Stichting Rega V Z W	Proteaseinhibitoren, eine DNA-Konstruktion zur Expression einer Protease und ein Verfahren zur Messung der Protease und/oder Proteaseinhibitoren
US5744453A (en) *	1996-01-05	1998-04-28	Mintz; Clifford S.	Polyamine conjugates for treatment of infection
US6245735B1 (en) *	1996-07-29	2001-06-12	The Brigham And Women's Hospital, Inc.	Methods and products for treating pseudomonas infection
US5789395A (en)	1996-08-30	1998-08-04	The Research Foundation Of State University Of New York	Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
US6063775A (en) *	1997-04-29	2000-05-16	Berman; Charles L.	Retardation of metalloproteinase incidental to HIV and/or AIDS
US6277061B1 (en) *	1998-03-31	2001-08-21	The Research Foundation Of State University Of New York	Method of inhibiting membrane-type matrix metalloproteinase
US6015804A (en) *	1998-09-11	2000-01-18	The Research Foundation Of State University Of New York	Method of using tetracycline compounds to enhance interleukin-10 production
US6384081B2 (en) *	1998-10-09	2002-05-07	Charles L. Berman	Treatment of diseases of the eye characterized by the formation of metalloproteinase
EP1137410B1 (de) *	1998-11-18	2006-08-16	Collagenex Pharmaceuticals, Inc.	Neue 4-dedimethylaminotetracyclinderivate
US6506740B1 (en) *	1998-11-18	2003-01-14	Robert A. Ashley	4-dedimethylaminotetracycline derivatives
US6172040B1 (en) *	1999-05-28	2001-01-09	A. Satyanarayan Naidu	Immobilized lactoferrin antimicrobial agents and the use thereof

2003
- 2003-03-27 US US10/400,737 patent/US20040014731A1/en not_active Abandoned
- 2003-03-27 JP JP2003579565A patent/JP2005521701A/ja active Pending
- 2003-03-27 WO PCT/US2003/009570 patent/WO2003082011A1/en active Application Filing
- 2003-03-27 DE DE60335093T patent/DE60335093D1/de not_active Expired - Lifetime
- 2003-03-27 EP EP03745650A patent/EP1496742B1/de not_active Expired - Lifetime
- 2003-03-27 CA CA002475202A patent/CA2475202A1/en not_active Abandoned
- 2003-03-27 KR KR10-2004-7014877A patent/KR20040094833A/ko not_active Application Discontinuation
- 2003-03-27 AU AU2003226112A patent/AU2003226112B9/en not_active Ceased
- 2003-03-27 AT AT03745650T patent/ATE489081T1/de not_active IP Right Cessation
- 2003-03-27 ES ES03745650T patent/ES2359346T3/es not_active Expired - Lifetime
- 2003-03-27 EP EP10174817.6A patent/EP2250887B1/de not_active Expired - Lifetime
- 2003-03-27 NZ NZ534950A patent/NZ534950A/en not_active IP Right Cessation
2007
- 2007-08-06 US US11/890,546 patent/US20080233151A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1496742B1 (de)	2010-11-24
EP1496742A4 (de)	2007-04-11
EP1496742A1 (de)	2005-01-19
US20040014731A1 (en)	2004-01-22
EP2250887A2 (de)	2010-11-17
NZ534950A (en)	2006-04-28
EP2250887A3 (de)	2010-11-24
EP2250887B1 (de)	2013-04-24
CA2475202A1 (en)	2003-10-09
ATE489081T1 (de)	2010-12-15
WO2003082011A1 (en)	2003-10-09
AU2003226112B2 (en)	2008-05-01
JP2005521701A (ja)	2005-07-21
KR20040094833A (ko)	2004-11-10
AU2003226112B9 (en)	2008-06-05
AU2003226112A1 (en)	2003-10-13
US20080233151A1 (en)	2008-09-25
ES2359346T3 (es)	2011-05-20

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