DE60324607D1 - PYRROLO (2,1-C) (1,4) BENZODIAZEPINE DIMERE AS ANTITUMPHANT AND METHOD THEREFOR - Google Patents

PYRROLO (2,1-C) (1,4) BENZODIAZEPINE DIMERE AS ANTITUMPHANT AND METHOD THEREFOR

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Publication number
DE60324607D1
DE60324607D1 DE60324607T DE60324607T DE60324607D1 DE 60324607 D1 DE60324607 D1 DE 60324607D1 DE 60324607 T DE60324607 T DE 60324607T DE 60324607 T DE60324607 T DE 60324607T DE 60324607 D1 DE60324607 D1 DE 60324607D1
Authority
DE
Germany
Prior art keywords
pyrrolo
antitumphant
dimere
benzodiazepine
method therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60324607T
Other languages
German (de)
Inventor
Ahmed Kamal
Peram Surakattula Reddy
Depatla Rajasekhar Reddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Council of Scientific and Industrial Research CSIR
Original Assignee
Council of Scientific and Industrial Research CSIR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Council of Scientific and Industrial Research CSIR filed Critical Council of Scientific and Industrial Research CSIR
Application granted granted Critical
Publication of DE60324607D1 publication Critical patent/DE60324607D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention provides Analogues of 1, 1'-{[(bisalkane-1,N-diyl)piperazine]dioxy}bis(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one] of formula (VI) where n = 2 to 10; a pharmaceutical composition comprising the above analogs and a process of preparing these analogues.
DE60324607T 2003-03-31 2003-03-31 PYRROLO (2,1-C) (1,4) BENZODIAZEPINE DIMERE AS ANTITUMPHANT AND METHOD THEREFOR Expired - Lifetime DE60324607D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2003/001164 WO2004087716A1 (en) 2003-03-31 2003-03-31 Pyrrolo[(2,1-c)(1,4) benzodiazepines dimers as antitumour agents and process thereof

Publications (1)

Publication Number Publication Date
DE60324607D1 true DE60324607D1 (en) 2008-12-18

Family

ID=33104923

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60324607T Expired - Lifetime DE60324607D1 (en) 2003-03-31 2003-03-31 PYRROLO (2,1-C) (1,4) BENZODIAZEPINE DIMERE AS ANTITUMPHANT AND METHOD THEREFOR

Country Status (6)

Country Link
EP (1) EP1608663B1 (en)
AT (1) ATE413407T1 (en)
AU (1) AU2003215810B2 (en)
CA (1) CA2520897C (en)
DE (1) DE60324607D1 (en)
WO (1) WO2004087716A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2374964T3 (en) * 2006-01-25 2012-02-23 Sanofi CYTOTOXIC AGENTS UNDERSTANDING NEW TOMAIMYCIN DERIVATIVES.
JP2009526778A (en) * 2006-02-13 2009-07-23 カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ Bis-pyrrolo [2,1-c] [1,4] benzodiazepine-anthraquinone conjugate as antitumor agent and method for producing the same
ES2435779T3 (en) * 2007-07-19 2013-12-23 Sanofi Cytotoxic agents comprising new tomaimycin derivatives and their therapeutic use
JP5657395B2 (en) * 2008-03-05 2015-01-21 カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチＣｏｕｎｃｉｌ Ｏｆ Ｓｃｉｅｎｔｉｆｉｃ ＆ Ｉｎｄｕｓｔｒｉａｌ Ｒｅｓｅａｒｃｈ Quinazoline-binding pyrrolo [2,1-c] [1,4] benzodiazepine hybrid as an effective anticancer agent and method for producing the same
WO2009113084A1 (en) * 2008-03-11 2009-09-17 Council Of Scientific & Industrial Research C2-fluoro substituted piperazine linked pyrrolo[2,1-c][1,4] benzodiazepine dimers and a process for the preparation thereof
EP2262809A1 (en) * 2008-03-26 2010-12-22 Council Of Scientific & Industrial Research Benzophenone-piperazine linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential anticancer agents and process for the preparation thereof
SG10201706294VA (en) 2009-02-05 2017-09-28 Immunogen Inc Novel benzodiazepine derivatives
JP5941058B2 (en) * 2010-12-06 2016-06-29 カウンシル・オヴ・サイエンティフィック・アンド・インダストリアル・リサーチ Pyrrolo [2,1-c] [1,4] benzodiazepine-linked imidazo [1,5-a] pyridine conjugates as potential antitumor agents and methods for their preparation
KR20140010067A (en) 2011-02-15 2014-01-23 이뮤노젠 아이엔씨 Methods of preparation of conjugates
US9504694B2 (en) 2015-03-19 2016-11-29 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepines
AU2016297087B2 (en) 2015-07-21 2021-02-18 Immunogen, Inc Methods of preparing cytotoxic benzodiazepine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9205051D0 (en) * 1992-03-09 1992-04-22 Cancer Res Campaign Tech Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them

Also Published As

Publication number Publication date
AU2003215810B2 (en) 2009-06-18
AU2003215810A1 (en) 2004-10-25
ATE413407T1 (en) 2008-11-15
EP1608663B1 (en) 2008-11-05
CA2520897A1 (en) 2004-10-14
CA2520897C (en) 2010-08-24
WO2004087716A1 (en) 2004-10-14
EP1608663A1 (en) 2005-12-28

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