DE60322237D1 - 6h-thienä2,3-büpyrrolderivate als antagonisten des gonadotropin-freisetzenden hormons (gnrh) - Google Patents

6h-thienä2,3-büpyrrolderivate als antagonisten des gonadotropin-freisetzenden hormons (gnrh)

Info

Publication number
DE60322237D1
DE60322237D1 DE60322237T DE60322237T DE60322237D1 DE 60322237 D1 DE60322237 D1 DE 60322237D1 DE 60322237 T DE60322237 T DE 60322237T DE 60322237 T DE60322237 T DE 60322237T DE 60322237 D1 DE60322237 D1 DE 60322237D1
Authority
DE
Germany
Prior art keywords
thienä2
büpyrrol
gonadotropine
gnrh
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60322237T
Other languages
English (en)
Inventor
Kevin Michael Foote
Zbigniew Matusiak
Macclesfield Dossetter
Jean Claude Arnould
Maryannick Andree Lamorlette
Benedicte Delouvrie
Annie Hamon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE60322237D1 publication Critical patent/DE60322237D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
DE60322237T 2002-08-21 2003-08-19 6h-thienä2,3-büpyrrolderivate als antagonisten des gonadotropin-freisetzenden hormons (gnrh) Expired - Fee Related DE60322237D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02292074 2002-08-21
PCT/GB2003/003631 WO2004018480A1 (en) 2002-08-21 2003-08-19 6h-thieno`2, 3-b!pyrrole derivatives as antagonists of gonadotropin releasing hormone (gnrh)

Publications (1)

Publication Number Publication Date
DE60322237D1 true DE60322237D1 (de) 2008-08-28

Family

ID=31896979

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60322237T Expired - Fee Related DE60322237D1 (de) 2002-08-21 2003-08-19 6h-thienä2,3-büpyrrolderivate als antagonisten des gonadotropin-freisetzenden hormons (gnrh)

Country Status (10)

Country Link
US (3) US7132442B2 (de)
EP (1) EP1543012B1 (de)
JP (1) JP2006501232A (de)
AR (1) AR041029A1 (de)
AT (1) ATE401331T1 (de)
AU (1) AU2003255818A1 (de)
DE (1) DE60322237D1 (de)
ES (1) ES2308018T3 (de)
TW (1) TW200407127A (de)
WO (1) WO2004018480A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200407127A (en) * 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds
WO2005012311A1 (en) 2003-07-31 2005-02-10 Wyeth N-sulfonylheterocyclopyrrolylalkylamine compounds as 5-hydroxytryptamine-6 ligands
GB0403781D0 (en) * 2004-02-20 2004-03-24 Astrazeneca Ab Chemical compounds
WO2005080402A1 (en) * 2004-02-20 2005-09-01 Astrazeneca Ab Thienopyroles as antagonists of gnrh
TW200600513A (en) * 2004-06-30 2006-01-01 Bristol Myers Squibb Co A method for preparing pyrrolotriazine compounds
TW200637553A (en) * 2004-12-14 2006-11-01 Shionogi & Co Indlomorphinane derivatives having a carboxy group at 6' position
AU2010295461B2 (en) * 2009-09-17 2016-03-03 Vertex Pharmaceuticals Incorporated Process for preparing azabicyclic compounds
CN102875535B (zh) * 2011-07-12 2016-06-08 上海药明康德新药开发有限公司 1,5-[(取代)-甲桥]-四氢-1H-吡咯[1,2-c]-咪唑-3(2H)-酮衍生物及制备方法
JP2016525071A (ja) 2013-08-07 2016-08-22 カディラ ヘルスケア リミテッド ヤーヌスキナーゼのインヒビターとしてのｎ−シアノメチルアミド

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JPH04356029A (ja) 1990-07-02 1992-12-09 Japan Synthetic Rubber Co Ltd 非線形光学素子
JPH04179949A (ja) 1990-11-15 1992-06-26 Fuji Photo Film Co Ltd 新規な色素形成カプラーおよび該カプラーを用いたハロゲン化銀カラー写真感光材料
WO1997021704A1 (en) 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1997021707A1 (en) 1995-12-14 1997-06-19 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6200957B1 (en) 1995-12-14 2001-03-13 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
JP3092947B2 (ja) 1995-12-14 2000-09-25 メルク エンド カンパニー インコーポレーテッド ゴナドトロピン放出ホルモン拮抗剤
SK77598A3 (en) 1995-12-14 1999-01-11 Merck & Co Inc Nonpeptide derivatives, pharmaceutical composition containing them and their use
EP0986385A4 (de) 1997-06-05 2001-05-16 Merck & Co Inc Antagonisten des gonadorelins
AU7806998A (en) 1997-06-05 1998-12-21 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6156772A (en) 1997-06-05 2000-12-05 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1998055470A1 (en) 1997-06-05 1998-12-10 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
AU728811B2 (en) 1997-06-05 2001-01-18 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
AU729663B2 (en) 1997-06-05 2001-02-08 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
CA2308454A1 (en) 1997-10-28 1999-05-06 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
AU1197299A (en) 1997-10-28 1999-05-17 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
JP2002503661A (ja) 1998-02-11 2002-02-05 メルク エンド カムパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモン拮抗薬
EP1068195A1 (de) 1998-02-11 2001-01-17 Merck & Co., Inc. Antagonisten des "gonadotropin releasing hormone"
JP2002510630A (ja) 1998-04-02 2002-04-09 メルク エンド カムパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモン拮抗薬
AU3368299A (en) 1998-04-02 1999-10-25 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1999051595A1 (en) 1998-04-02 1999-10-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
CA2325995A1 (en) 1998-04-02 1999-10-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1999051596A1 (en) 1998-04-02 1999-10-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
EP1067930A4 (de) 1998-04-02 2002-09-18 Merck & Co Inc Antagonisten des gonadoliberins
CA2367116A1 (en) 1999-03-10 2000-09-14 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone
AU3514200A (en) 1999-03-10 2000-09-28 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone
JP2002539124A (ja) * 1999-03-10 2002-11-19 メルク エンド カムパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモン拮抗薬としての６−アザインドール化合物
JP2002538205A (ja) 1999-03-10 2002-11-12 メルク エンド カムパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモン拮抗薬としての６−アザインドール化合物
AU3868800A (en) 1999-03-10 2000-09-28 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone
WO2000053181A1 (en) 1999-03-10 2000-09-14 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone
WO2002000216A1 (en) * 2000-06-28 2002-01-03 Teva Pharmaceutical Industries Ltd. Carvedilol
BR0113987A (pt) 2000-09-22 2003-08-12 Akzo Nobel Nv Composto heteromático bicìclico, ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de derivados heteroaromáticos bicìclicos ou de um sal ou solvato farmaceuticamente aceitável dos mesmos
SE0100566D0 (sv) 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
SE0101692D0 (sv) 2001-05-14 2001-05-14 Astrazeneca Ab Compounds
AU2003267551A1 (en) * 2002-08-21 2004-03-11 Astrazeneca Ab Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone
TW200407127A (en) 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds

Also Published As

Publication number Publication date
US7132442B2 (en) 2006-11-07
US7268158B2 (en) 2007-09-11
EP1543012B1 (de) 2008-07-16
US7547722B2 (en) 2009-06-16
TW200407127A (en) 2004-05-16
US20060004082A1 (en) 2006-01-05
US20060235067A1 (en) 2006-10-19
WO2004018480A1 (en) 2004-03-04
EP1543012A1 (de) 2005-06-22
AR041029A1 (es) 2005-04-27
ATE401331T1 (de) 2008-08-15
AU2003255818A1 (en) 2004-03-11
ES2308018T3 (es) 2008-12-01
US20080045517A1 (en) 2008-02-21
JP2006501232A (ja) 2006-01-12

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee