DE60321208D1 - Verfahren zur herstellung von 2,6-diamino-4,5,6,7-tetrahydrobenzothiazol - Google Patents
Verfahren zur herstellung von 2,6-diamino-4,5,6,7-tetrahydrobenzothiazolInfo
- Publication number
- DE60321208D1 DE60321208D1 DE60321208T DE60321208T DE60321208D1 DE 60321208 D1 DE60321208 D1 DE 60321208D1 DE 60321208 T DE60321208 T DE 60321208T DE 60321208 T DE60321208 T DE 60321208T DE 60321208 D1 DE60321208 D1 DE 60321208D1
- Authority
- DE
- Germany
- Prior art keywords
- tetrahydrobenzothiazole
- diamino
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0225701A GB2394951A (en) | 2002-11-04 | 2002-11-04 | One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole |
| PCT/GB2003/004734 WO2004041797A1 (en) | 2002-11-04 | 2003-11-03 | Process for preparing 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60321208D1 true DE60321208D1 (de) | 2008-07-03 |
Family
ID=9947186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60321208T Expired - Lifetime DE60321208D1 (de) | 2002-11-04 | 2003-11-03 | Verfahren zur herstellung von 2,6-diamino-4,5,6,7-tetrahydrobenzothiazol |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7285669B2 (de) |
| EP (1) | EP1562921B1 (de) |
| JP (1) | JP4708792B2 (de) |
| KR (1) | KR101086844B1 (de) |
| CN (1) | CN100551918C (de) |
| AP (1) | AP1882A (de) |
| AT (1) | ATE396180T1 (de) |
| AU (1) | AU2003278396B2 (de) |
| BR (1) | BR0315919A (de) |
| CA (1) | CA2505179C (de) |
| DE (1) | DE60321208D1 (de) |
| EC (1) | ECSP055835A (de) |
| GB (1) | GB2394951A (de) |
| HR (1) | HRPK20050403B3 (de) |
| IS (1) | IS7882A (de) |
| MA (1) | MA27534A1 (de) |
| MX (1) | MXPA05004815A (de) |
| NO (1) | NO20052189L (de) |
| NZ (1) | NZ539953A (de) |
| PL (1) | PL376543A1 (de) |
| PT (1) | PT1562921E (de) |
| RU (1) | RU2305097C2 (de) |
| TN (1) | TNSN05125A1 (de) |
| WO (1) | WO2004041797A1 (de) |
| ZA (1) | ZA200503548B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0221513D0 (en) * | 2002-09-17 | 2002-10-23 | Generics Uk Ltd | Novel compounds and processes |
| WO2006012277A2 (en) * | 2004-06-30 | 2006-02-02 | Amr Technology, Inc. | Biocatalytic process for preparing enantiomerically enriched pramipexole |
| WO2006003677A1 (en) * | 2004-07-01 | 2006-01-12 | Alembic Limited | Improved process for the preparation of biologically active tetrahydrobenzthiazole derivative |
| US8518926B2 (en) | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| ATE537826T1 (de) | 2006-05-16 | 2012-01-15 | Knopp Neurosciences Inc | Zusammensetzungen aus r(+)- und s(-)-pramipexol sowie verfahren zu ihrer anwendung |
| US8524695B2 (en) | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| SI22446A (sl) * | 2007-02-07 | 2008-08-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek za sintezo pramipeksola in njegovih farmacevtsko sprejemljivih soli |
| WO2008104847A2 (en) * | 2007-02-26 | 2008-09-04 | Wockhardt Research Centre | Processes for the preparation of pramipexole and salts thereof |
| US8519148B2 (en) | 2007-03-14 | 2013-08-27 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
| CN101429173B (zh) * | 2007-11-09 | 2012-12-05 | 重庆医药工业研究院有限责任公司 | 一种普拉克索中间体2,6-二氨基-4,5,6,7-四氢-苯并噻唑的制备方法 |
| US20110190356A1 (en) | 2008-08-19 | 2011-08-04 | Knopp Neurosciences Inc. | Compositions and Methods of Using (R)- Pramipexole |
| WO2011021214A2 (en) * | 2009-08-07 | 2011-02-24 | Msn Laboratories Limited | Improved process for the preparation of (s)-2-amino-4,5,6,7-tetrahydro-6 - (propylamino) benzothiazole and its pharmaceutically acceptable salts |
| WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| PT3019167T (pt) | 2013-07-12 | 2021-03-04 | Knopp Biosciences Llc | Tratamento de níveis elevados de eosinófilos e/ou basófilos |
| US9642840B2 (en) | 2013-08-13 | 2017-05-09 | Knopp Biosciences, Llc | Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders |
| AU2014306597B2 (en) | 2013-08-13 | 2018-05-17 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
| CN104311507A (zh) * | 2013-10-09 | 2015-01-28 | 安徽万邦医药科技有限公司 | (6s)-2,6-二氨基-4,5,6,7-四氢苯并噻唑的制备方法 |
| CN103613562B (zh) * | 2013-11-25 | 2015-09-30 | 浙江美诺华药物化学有限公司 | 一种普拉克索的制备方法 |
| CN107573301B (zh) * | 2017-11-08 | 2020-08-11 | 江苏长青农化股份有限公司 | 一种三环唑中间体的制备方法 |
| CN109232471B (zh) * | 2018-10-31 | 2022-05-10 | 安徽省庆云医药股份有限公司 | 一种盐酸普拉克索的制备方法 |
| CN111362884A (zh) * | 2018-12-26 | 2020-07-03 | 江苏神龙药业股份有限公司 | 一种2,6-二氨基-4,5,6,7-四氢-苯并噻唑的工业化制备方法 |
| CN110734413A (zh) * | 2019-12-02 | 2020-01-31 | 山东铂源药业有限公司 | 一种普拉克索中间体2,6-二氨基-4,5,6,7-四氢苯并噻唑的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3447075A1 (de) * | 1984-12-22 | 1986-07-03 | Dr. Karl Thomae Gmbh, 7950 Biberach | Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arzneimittel |
| EP0186087B1 (de) * | 1984-12-22 | 1989-08-23 | Dr. Karl Thomae GmbH | Tetrahydro-benzthiazole, deren Herstellung und deren Verwendung als Zwischenprodukte oder als Arnzneimittel |
| ES2187249B1 (es) * | 2000-09-18 | 2004-09-16 | Synthon Bv | Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles. |
-
2002
- 2002-11-04 GB GB0225701A patent/GB2394951A/en not_active Withdrawn
-
2003
- 2003-11-03 AU AU2003278396A patent/AU2003278396B2/en not_active Ceased
- 2003-11-03 WO PCT/GB2003/004734 patent/WO2004041797A1/en active IP Right Grant
- 2003-11-03 BR BR0315919-1A patent/BR0315919A/pt not_active IP Right Cessation
- 2003-11-03 NZ NZ539953A patent/NZ539953A/en not_active IP Right Cessation
- 2003-11-03 CA CA2505179A patent/CA2505179C/en not_active Expired - Fee Related
- 2003-11-03 RU RU2005117364/04A patent/RU2305097C2/ru not_active IP Right Cessation
- 2003-11-03 AT AT03769701T patent/ATE396180T1/de not_active IP Right Cessation
- 2003-11-03 PT PT03769701T patent/PT1562921E/pt unknown
- 2003-11-03 AP AP2005003306A patent/AP1882A/xx active
- 2003-11-03 EP EP03769701A patent/EP1562921B1/de not_active Expired - Lifetime
- 2003-11-03 CN CNB2003801082013A patent/CN100551918C/zh not_active Expired - Fee Related
- 2003-11-03 US US10/533,637 patent/US7285669B2/en not_active Expired - Fee Related
- 2003-11-03 JP JP2004549326A patent/JP4708792B2/ja not_active Expired - Fee Related
- 2003-11-03 DE DE60321208T patent/DE60321208D1/de not_active Expired - Lifetime
- 2003-11-03 PL PL376543A patent/PL376543A1/pl not_active IP Right Cessation
- 2003-11-03 MX MXPA05004815A patent/MXPA05004815A/es active IP Right Grant
- 2003-11-03 ZA ZA200503548A patent/ZA200503548B/en unknown
- 2003-11-03 KR KR1020057007963A patent/KR101086844B1/ko not_active IP Right Cessation
-
2005
- 2005-05-04 NO NO20052189A patent/NO20052189L/no unknown
- 2005-05-04 TN TNP2005000125A patent/TNSN05125A1/en unknown
- 2005-05-05 HR HR20050403A patent/HRPK20050403B3/xx not_active IP Right Cessation
- 2005-06-02 IS IS7882A patent/IS7882A/is unknown
- 2005-06-02 MA MA28311A patent/MA27534A1/fr unknown
- 2005-06-03 EC EC2005005835A patent/ECSP055835A/es unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |