DE60312543D1 - Herstellung von codein aus morphin - Google Patents

Herstellung von codein aus morphin

Info

Publication number: DE60312543D1
Authority: DE; Germany
Prior art keywords: codeine; approximately; reaction mixture; hydrocarbon solvent; morphine
Prior art date: 2002-10-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE60312543T

Other languages

English (en)

Other versions

DE60312543T2 (de

Inventor

Lloyd P Hill

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mallinckrodt Inc

Original Assignee

Mallinckrodt International Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-21

Filing date

2003-10-14

Publication date

2007-04-26

2003-10-14 Application filed by Mallinckrodt International Corp filed Critical Mallinckrodt International Corp

2007-04-26 Application granted granted Critical

2007-04-26 Publication of DE60312543D1 publication Critical patent/DE60312543D1/de

2007-11-15 Publication of DE60312543T2 publication Critical patent/DE60312543T2/de

2023-10-15 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 title abstract 9
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title abstract 6
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 title abstract 5
229960005181 morphine Drugs 0.000 title abstract 3
238000002360 preparation method Methods 0.000 title abstract 2
239000004215 Carbon black (E152) Substances 0.000 abstract 4
229960004126 codeine Drugs 0.000 abstract 4
229930195733 hydrocarbon Natural products 0.000 abstract 4
150000002430 hydrocarbons Chemical class 0.000 abstract 4
239000011541 reaction mixture Substances 0.000 abstract 4
239000002904 solvent Substances 0.000 abstract 4
JLTDJTHDQAWBAV-UHFFFAOYSA-N N,N-dimethylaniline Chemical compound CN(C)C1=CC=CC=C1 JLTDJTHDQAWBAV-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
HGPQAWTZLJXCTC-SSTWWWIQSA-N (4r,4ar,7s,7ar,12bs)-7,9-dimethoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline Chemical compound C([C@@H](N(CC1)C)[C@@H]2C=C[C@@H]3OC)C4=CC=C(OC)C5=C4[C@@]21[C@H]3O5 HGPQAWTZLJXCTC-SSTWWWIQSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000001816 cooling Methods 0.000 abstract 1
229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
239000012022 methylating agents‎ Substances 0.000 abstract 1
239000011707 mineral Substances 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
238000010992 reflux Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE60312543T 2002-10-21 2003-10-14 Herstellung von codein aus morphin Expired - Fee Related DE60312543T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US10/274,702 US6579985B1 (en)	2002-10-21	2002-10-21	Preparation of codeine from morphine
US274702		2002-10-21
PCT/US2003/032698 WO2004037826A2 (en)	2002-10-21	2003-10-14	Preparation of codeine from morphine

Publications (2)

Publication Number	Publication Date
DE60312543D1 true DE60312543D1 (de)	2007-04-26
DE60312543T2 DE60312543T2 (de)	2007-11-15

Family

ID=23049276

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60312543T Expired - Fee Related DE60312543T2 (de)	2002-10-21	2003-10-14	Herstellung von codein aus morphin

Country Status (11)

Country	Link
US (1)	US6579985B1 (de)
EP (1)	EP1560833B1 (de)
JP (1)	JP2006505588A (de)
CN (1)	CN1692117A (de)
AT (1)	ATE356819T1 (de)
AU (1)	AU2003279287B2 (de)
CA (1)	CA2502935A1 (de)
DE (1)	DE60312543T2 (de)
ES (1)	ES2282689T3 (de)
MX (1)	MXPA05004162A (de)
WO (1)	WO2004037826A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6949645B1 (en)	2004-05-20	2005-09-27	Acura Pharmaceuticals, Inc.	Process for the production of opiates
US6972332B1 (en) *	2004-05-20	2005-12-06	Acura Pharmaceuticals, Inc.	Process for the production of opiates
CN101528269A (zh) *	2006-08-16	2009-09-09	奥斯拜客斯制药有限公司	阿片样物质止痛剂的制备和应用
CA2905112A1 (en)	2013-03-15	2014-09-18	The Board Of Trustees Of The Leland Stanford Junior University	Benzylisoquinoline alkaloids (bia) producing microbes, and methods of making and using the same
EP3770267A1 (de)	2013-11-04	2021-01-27	The Board of Trustees of the Leland Stanford Junior University	Mikroben zur herstellung von vorläufern von benzylisochinolin-alkaloid (bia) sowie verfahren zur herstellung und verwendung davon
CA2983445A1 (en)	2015-05-08	2016-11-17	The Board Of Trustees Of The Leland Stanford Junior University	Methods of producing epimerases and benzylisoquinoline alkaloids
CN110261194B (zh) *	2019-06-06	2022-02-22	深圳砺剑防卫技术有限公司	一种毒品探测设备校验品的制备方法及毒品探测设备校验品
TR2021022252A2 (tr) *	2021-12-31	2022-01-21	Toprak Mahsulleri Ofisi Genel Mueduerluegue	Kodei̇n kamphosulfonat üreti̇mi̇ne dai̇r yeni̇ bi̇r yöntem

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3679327D1 (de) *	1986-11-25	1991-06-20	Council Scient Ind Res	Verfahren zur herstellung von codein aus morphin.
CS277517B6 (en) *	1990-12-12	1993-02-17	Slovakofarma S P	Process for purifying codeine being prepared by morphine methylation
US6204337B1 (en) *	1996-11-19	2001-03-20	The Board Of Regents Of The University And Community College System Of Neveda	Solid-phase synthesis of codeine from morphine

2002
- 2002-10-21 US US10/274,702 patent/US6579985B1/en not_active Expired - Lifetime
2003
- 2003-10-14 JP JP2004546881A patent/JP2006505588A/ja not_active Withdrawn
- 2003-10-14 CN CN200380100724.3A patent/CN1692117A/zh active Pending
- 2003-10-14 AT AT03770770T patent/ATE356819T1/de not_active IP Right Cessation
- 2003-10-14 DE DE60312543T patent/DE60312543T2/de not_active Expired - Fee Related
- 2003-10-14 MX MXPA05004162A patent/MXPA05004162A/es active IP Right Grant
- 2003-10-14 CA CA002502935A patent/CA2502935A1/en not_active Abandoned
- 2003-10-14 WO PCT/US2003/032698 patent/WO2004037826A2/en active IP Right Grant
- 2003-10-14 ES ES03770770T patent/ES2282689T3/es not_active Expired - Lifetime
- 2003-10-14 AU AU2003279287A patent/AU2003279287B2/en not_active Ceased
- 2003-10-14 EP EP03770770A patent/EP1560833B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2006505588A (ja)	2006-02-16
ATE356819T1 (de)	2007-04-15
WO2004037826A2 (en)	2004-05-06
DE60312543T2 (de)	2007-11-15
US6579985B1 (en)	2003-06-17
MXPA05004162A (es)	2005-06-22
EP1560833B1 (de)	2007-03-14
EP1560833A2 (de)	2005-08-10
WO2004037826A3 (en)	2004-07-01
AU2003279287A1 (en)	2004-05-13
AU2003279287B2 (en)	2009-01-29
CA2502935A1 (en)	2004-05-06
ES2282689T3 (es)	2007-10-16
CN1692117A (zh)	2005-11-02

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Legal Events

Date	Code	Title	Description
2007-07-19	8327	Change in the person/name/address of the patent owner	Owner name: MALLINCKRODT, INC., ST. LOUIS, MO., US
2008-04-03	8364	No opposition during term of opposition
2010-08-19	8339	Ceased/non-payment of the annual fee