DE60309019D1 - Verfahren zur herstellung von peptidamiden durch seitenkettenanknüpfung an einer festphase - Google Patents

Verfahren zur herstellung von peptidamiden durch seitenkettenanknüpfung an einer festphase

Info

Publication number
DE60309019D1
DE60309019D1 DE60309019T DE60309019T DE60309019D1 DE 60309019 D1 DE60309019 D1 DE 60309019D1 DE 60309019 T DE60309019 T DE 60309019T DE 60309019 T DE60309019 T DE 60309019T DE 60309019 D1 DE60309019 D1 DE 60309019D1
Authority
DE
Germany
Prior art keywords
peptidamides
production
solid phase
chain
solid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60309019T
Other languages
English (en)
Other versions
DE60309019T2 (de
Inventor
John Evans
Steven Simpkin
Alfred Wellings
Eric Atherton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Diosynth Biotechnologies UK Ltd
Original Assignee
Avecia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0210184A external-priority patent/GB0210184D0/en
Priority claimed from GBGB0210183.0A external-priority patent/GB0210183D0/en
Priority claimed from GB0210185A external-priority patent/GB0210185D0/en
Application filed by Avecia Ltd filed Critical Avecia Ltd
Application granted granted Critical
Publication of DE60309019D1 publication Critical patent/DE60309019D1/de
Publication of DE60309019T2 publication Critical patent/DE60309019T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/003General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by transforming the C-terminal amino acid to amides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/75Fibrinogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18Fluorenes; Hydrogenated fluorenes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE60309019T 2002-05-03 2003-05-02 Verfahren zur herstellung von peptidamiden durch seitenkettenanknüpfung an einer festphase Expired - Lifetime DE60309019T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0210184A GB0210184D0 (en) 2002-05-03 2002-05-03 Process
GBGB0210183.0A GB0210183D0 (en) 2002-05-03 2002-05-03 Process
GB0210185A GB0210185D0 (en) 2002-05-03 2002-05-03 Process
GB0210183 2002-05-03
GB0210184 2002-05-03
GB0210185 2002-05-03
PCT/GB2003/001949 WO2003093302A2 (en) 2002-05-03 2003-05-02 Process for the synthesis of peptides amides by side-chain attachement to a solid phase

Publications (2)

Publication Number Publication Date
DE60309019D1 true DE60309019D1 (de) 2006-11-23
DE60309019T2 DE60309019T2 (de) 2007-05-16

Family

ID=29407323

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60309019T Expired - Lifetime DE60309019T2 (de) 2002-05-03 2003-05-02 Verfahren zur herstellung von peptidamiden durch seitenkettenanknüpfung an einer festphase

Country Status (9)

Country Link
US (1) US7691968B2 (de)
EP (1) EP1504022B1 (de)
JP (1) JP2006501150A (de)
AT (1) ATE342273T1 (de)
AU (1) AU2003227907A1 (de)
CA (1) CA2484594C (de)
DE (1) DE60309019T2 (de)
MX (1) MXPA04010910A (de)
WO (1) WO2003093302A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2369872T3 (es) * 2004-04-08 2011-12-07 Millennium Pharmaceuticals, Inc. Procesos para la preparación de eptifibatide y los compuestos intermedios pertinentes.
ATE451384T1 (de) * 2004-06-14 2009-12-15 Usv Ltd Verfahren zur herstellung von peptiden
US7897724B2 (en) * 2004-10-10 2011-03-01 Usv, Ltd. Solid phase Fmoc chemistry process to prepare peptides
CN101111510B (zh) * 2004-10-19 2011-09-14 隆萨股份公司 树脂上肽环化
PT1737889E (pt) 2004-10-19 2010-12-13 Lonza Ag Método para síntese de péptidos em fase sólida
JP2008534628A (ja) * 2005-05-03 2008-08-28 ノベタイド,リミティド ペプチド誘導体の製造のための方法
CN1858060B (zh) * 2005-05-08 2010-09-29 周达明 固相多肽合成依非巴特的制备方法
NL2000126C2 (nl) * 2005-07-15 2008-01-29 Solvay Werkwijze voor de vervaardiging van eptifibatide.
WO2008040536A1 (en) * 2006-10-05 2008-04-10 Lonza Ag Method for peptide synthesis
US8815807B2 (en) 2008-06-03 2014-08-26 President And Fellows Of Harvard College Peptides and peptide compositions having osteoinductive activity
WO2009150657A1 (en) * 2008-06-09 2009-12-17 Natco Pharma Limited Improved process for preparation of eptifibatide by fmoc solid phase synthesis
WO2014147129A1 (en) 2013-03-21 2014-09-25 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
SG11201506804VA (en) 2013-03-21 2015-09-29 Sanofi Aventis Deutschland Synthesis of hydantoin containing peptide products
GB201310921D0 (en) * 2013-06-19 2013-07-31 Chemical & Biopharmaceutical Lab Of Patras S A Peptide-resin conjugate and use thereof
GB201315335D0 (en) 2013-08-29 2013-10-09 Of Singapore Amino diacids containing peptide modifiers
CN107108696B (zh) * 2014-12-26 2021-01-15 深圳华大生命科学研究院 芋螺毒素肽κ-CPTx-btl05、其制备方法及应用
CN110498834A (zh) * 2018-05-16 2019-11-26 深圳翰宇药业股份有限公司 一种依替巴肽固相制备的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4033940A (en) * 1975-11-12 1977-07-05 Armour Pharmaceutical Company Cyclization of peptides
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5780595A (en) * 1989-06-16 1998-07-14 Cor Therapeutics, Inc. Platelet aggregation inhibitors
GB9112825D0 (en) * 1991-06-14 1991-07-31 Ici Plc Process for making peptides
US6008058A (en) * 1993-06-18 1999-12-28 University Of Louisville Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis
GB9313330D0 (en) * 1993-06-28 1993-08-11 Fujisawa Pharmaceutical Co New compound and its preparation
WO2000026262A2 (en) * 1998-11-05 2000-05-11 Mitokor Functionalized polymeric substrates for binding molecular moieties
CA2423933A1 (en) * 2000-10-17 2002-04-25 Applied Research Systems Ars Holding N.V. Pharmaceutically active sulfanilide derivatives

Also Published As

Publication number Publication date
US20050266520A1 (en) 2005-12-01
CA2484594C (en) 2012-06-26
AU2003227907A8 (en) 2003-11-17
CA2484594A1 (en) 2003-11-13
ATE342273T1 (de) 2006-11-15
EP1504022A2 (de) 2005-02-09
DE60309019T2 (de) 2007-05-16
WO2003093302A2 (en) 2003-11-13
EP1504022B1 (de) 2006-10-11
JP2006501150A (ja) 2006-01-12
AU2003227907A1 (en) 2003-11-17
WO2003093302A3 (en) 2004-01-08
US7691968B2 (en) 2010-04-06
MXPA04010910A (es) 2005-01-25

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Owner name: AVECIA BIOLOGICS LTD., BLACKLEY, MANCHESTER, GB

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Representative=s name: HOFFMANN & EITLE, 81925 MUENCHEN

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