DE60308435D1 - Verfahren zur Umwandlung von Dihidroisoxazol Derivate in Gamma-Hydroxaminsäurederivate, z.B Monatins - Google Patents

Verfahren zur Umwandlung von Dihidroisoxazol Derivate in Gamma-Hydroxaminsäurederivate, z.B Monatins

Info

Publication number
DE60308435D1
DE60308435D1 DE60308435T DE60308435T DE60308435D1 DE 60308435 D1 DE60308435 D1 DE 60308435D1 DE 60308435 T DE60308435 T DE 60308435T DE 60308435 T DE60308435 T DE 60308435T DE 60308435 D1 DE60308435 D1 DE 60308435D1
Authority
DE
Germany
Prior art keywords
derivatives
gamma
dihidroisoxazole
monatin
conversion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60308435T
Other languages
English (en)
Other versions
DE60308435T2 (de
Inventor
Yusuke Amino
Shigeru Kawahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Application granted granted Critical
Publication of DE60308435D1 publication Critical patent/DE60308435D1/de
Publication of DE60308435T2 publication Critical patent/DE60308435T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60308435T 2002-04-01 2003-03-10 Verfahren zur Umwandlung von Dihidroisoxazol Derivate in Gamma-Hydroxaminsäurederivate, z.B Monatins Expired - Lifetime DE60308435T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002098515 2002-04-01
JP2002098515A JP2003292484A (ja) 2002-04-01 2002-04-01 γ−ヒドロキシアミノ酸誘導体及びモナティン類の製造方法

Publications (2)

Publication Number Publication Date
DE60308435D1 true DE60308435D1 (de) 2006-11-02
DE60308435T2 DE60308435T2 (de) 2007-05-03

Family

ID=28035889

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60308435T Expired - Lifetime DE60308435T2 (de) 2002-04-01 2003-03-10 Verfahren zur Umwandlung von Dihidroisoxazol Derivate in Gamma-Hydroxaminsäurederivate, z.B Monatins

Country Status (6)

Country Link
US (1) US7329427B2 (de)
EP (1) EP1350791B1 (de)
JP (1) JP2003292484A (de)
AT (1) ATE340174T1 (de)
CA (1) CA2423691C (de)
DE (1) DE60308435T2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4991091B2 (ja) * 2001-11-30 2012-08-01 味の素株式会社 モナティンの非天然型立体異性体塩の結晶及びその使用
US7297800B2 (en) 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
JP4196832B2 (ja) * 2001-12-27 2008-12-17 味の素株式会社 グルタミン酸化合物及びそれらの製造中間体の製造方法並びにそのための新規中間体
JP2003292484A (ja) 2002-04-01 2003-10-15 Ajinomoto Co Inc γ−ヒドロキシアミノ酸誘導体及びモナティン類の製造方法
US8372989B2 (en) 2002-04-23 2013-02-12 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US7572607B2 (en) 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
ATE463568T1 (de) 2002-08-26 2010-04-15 Ajinomoto Kk Neue aldolasen und verfahren zur herstellung von substituierter alpha-ketosäure
JP4544154B2 (ja) * 2002-12-09 2010-09-15 味の素株式会社 変異型ｄ−アミノトランスフェラーゼおよびこれを用いた光学活性グルタミン酸誘導体の製造方法
JP4770174B2 (ja) * 2003-01-09 2011-09-14 味の素株式会社 グルタミン酸誘導体及びピログルタミン酸誘導体の製造方法並びに新規製造中間体
WO2005014839A2 (en) * 2003-08-01 2005-02-17 Cargill, Incorporated Monatin tabletop sweetener compositions and methods of making same
ATE360370T1 (de) * 2003-08-14 2007-05-15 Cargill Inc Monatinhaltige kaugummizusammensetzungen und verfahren zu ihrer herstellung
US20050106305A1 (en) * 2003-08-25 2005-05-19 Cargill, Inc. Beverage compositions comprising monatin and methods of making same
EP1678313B1 (de) 2003-10-21 2011-02-16 Cargill, Incorporated Herstellung von monatin und monatinvorstufen
JP5113978B2 (ja) * 2003-11-21 2013-01-09 味の素株式会社 グルタミン酸誘導体の有機アミン塩及びその利用
JP5319885B2 (ja) * 2004-02-27 2013-10-16 味の素株式会社 モナティンの製造方法
US7935377B2 (en) * 2004-06-04 2011-05-03 Ajinomoto Co., Inc. Crystals of free (2R, 4R)-monatin and use thereof
CA2506247C (en) * 2004-06-07 2012-02-21 Ajinomoto Co., Inc. Novel aldolase, and method for producing optically active ihog and monatin
RU2007116971A (ru) * 2004-10-05 2008-11-27 Адзиномото Ко., Инк. (Jp) Способ получения производного аминокислоты из гидроксииминокислоты
CA2583434A1 (en) * 2004-10-15 2006-04-20 Ajinomoto Co., Inc. Sweetener composition comprising monatin or a salt thereof and method for preserving monatin
WO2006113897A2 (en) 2005-04-20 2006-10-26 Cargill, Incorporated Products and methods for in vivo secretion of monatin
US8158389B2 (en) 2005-04-20 2012-04-17 Cargill, Incorporated Products and methods for in vivo secretion of monatin
US8076108B2 (en) 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
US7582455B2 (en) 2005-04-26 2009-09-01 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
EP2361976B1 (de) * 2005-04-26 2016-05-25 Cargill, Incorporated Polypeptide und Biosynthesewege zur Herstellung von Stereoisomeren von Monatin und ihren Vorläufern
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
MX2008011477A (es) 2006-03-07 2008-09-23 Cargill Inc Aldolasas, acidos nucleicos que las codifican y metodos para hacerlas y usarlas.
JP2009538145A (ja) 2006-05-24 2009-11-05 カーギル・インコーポレイテッド 平衡反応の収量を増加させるための方法およびシステム
US20090198072A1 (en) * 2006-05-24 2009-08-06 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US8076107B2 (en) * 2007-10-01 2011-12-13 Cargill, Incorporated Production of monatin stereoisomers
US8003361B2 (en) 2007-10-01 2011-08-23 Cargill Incorporated Production of monatin enantiomers
US8367847B2 (en) 2007-10-01 2013-02-05 Cargill, Incorporated Production of monatin enantiomers
EP2107053A1 (de) * 2008-03-11 2009-10-07 Ajinomoto Co., Inc. Hydratkristalle von (2R,4R)-Monatin Mononatrium-Salz

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2240105B (en) * 1990-01-19 1993-06-09 Technology Finance Corp Process for the production of 3-(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl) indole
US5994559A (en) * 1998-08-06 1999-11-30 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Synthesis of monatin-A high intensity natural sweetener
JP2002060382A (ja) * 2000-08-22 2002-02-26 Ajinomoto Co Inc モナティンの立体異性体及びその使用、並びにモナティン類の製造方法及びそのための中間体
JP2003292484A (ja) 2002-04-01 2003-10-15 Ajinomoto Co Inc γ−ヒドロキシアミノ酸誘導体及びモナティン類の製造方法

Also Published As

Publication number Publication date
CA2423691C (en) 2010-09-14
CA2423691A1 (en) 2003-10-01
US7329427B2 (en) 2008-02-12
DE60308435T2 (de) 2007-05-03
JP2003292484A (ja) 2003-10-15
EP1350791B1 (de) 2006-09-20
US20030228403A1 (en) 2003-12-11
ATE340174T1 (de) 2006-10-15
EP1350791A1 (de) 2003-10-08

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