DE60307856D1 - Antitumorverbindung und ihre therapeutischen verwendungen - Google Patents
Antitumorverbindung und ihre therapeutischen verwendungenInfo
- Publication number
- DE60307856D1 DE60307856D1 DE60307856T DE60307856T DE60307856D1 DE 60307856 D1 DE60307856 D1 DE 60307856D1 DE 60307856 T DE60307856 T DE 60307856T DE 60307856 T DE60307856 T DE 60307856T DE 60307856 D1 DE60307856 D1 DE 60307856D1
- Authority
- DE
- Germany
- Prior art keywords
- antitumoric
- connection
- therapeutic uses
- fgf
- men2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2002MI001620A ITMI20021620A1 (it) | 2002-07-23 | 2002-07-23 | Composto ad ativita' antitumorale |
ITMI20021620 | 2002-07-23 | ||
PCT/EP2003/007963 WO2004009083A1 (en) | 2002-07-23 | 2003-07-22 | Antitumor compound and therapeutic uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60307856D1 true DE60307856D1 (de) | 2006-10-05 |
DE60307856T2 DE60307856T2 (de) | 2007-04-12 |
Family
ID=30130912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60307856T Expired - Lifetime DE60307856T2 (de) | 2002-07-23 | 2003-07-22 | Antitumorverbindung und ihre therapeutischen verwendungen |
Country Status (12)
Country | Link |
---|---|
US (2) | US20060258731A1 (de) |
EP (1) | EP1534271B1 (de) |
JP (1) | JP2005537277A (de) |
CN (1) | CN1668298A (de) |
AT (1) | ATE337001T1 (de) |
AU (1) | AU2003251437A1 (de) |
CA (1) | CA2493202A1 (de) |
DE (1) | DE60307856T2 (de) |
ES (1) | ES2271649T3 (de) |
IT (1) | ITMI20021620A1 (de) |
MX (1) | MXPA05000781A (de) |
WO (1) | WO2004009083A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005068424A1 (en) * | 2004-01-20 | 2005-07-28 | Cell Therapeutics Europe S.R.L. | Indolinone derivatives as receptor tyrosine kinase ihibitors |
WO2006119148A2 (en) * | 2005-04-29 | 2006-11-09 | The Ohio State University Research Foundation | Keratinocyte growth factor receptor - tyrosine specific inhibitors for the prevention of cancer metastatis |
BRPI0716555A2 (pt) * | 2006-09-07 | 2013-09-24 | Astrazeneca Ab | mÉtodos para prever a probabilidade de que um paciente É um candidato para tratamento com uma droga de ret responderÁ ao citado tratamento, e para tratar um paciente, iniciador direto mutante de arms, e, kit diagnàstico |
CA2952692C (en) | 2008-09-22 | 2020-04-28 | Array Biopharma Inc. | Substituted imidazo[1,2b]pyridazine compounds |
AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
PL3699181T3 (pl) | 2014-11-16 | 2023-05-22 | Array Biopharma, Inc. | Postać krystaliczna wodorosiarczanu (s)-n-(5-((r)-2-(2,5-difluorofenylo) - pirolidyn-1-ylo)-pirazolo[1,5-a]pirimidyn-3-ylo)-3-hydroksypirolidyno-1-karboksyamidu |
MX2018000577A (es) | 2015-07-16 | 2018-09-05 | Array Biopharma Inc | Compuestos de pirazolo[1,5-a]piridina sustituidos como inhibidores de la ret quinasa. |
SG11201803438XA (en) | 2015-10-26 | 2018-05-30 | Univ Colorado Regents | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
KR20180129911A (ko) | 2016-04-04 | 2018-12-05 | 록쏘 온콜로지, 인코포레이티드 | 소아암을 치료하는 방법 |
SG11201808559PA (en) | 2016-04-04 | 2018-10-30 | Loxo Oncology Inc | Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
JP7443057B2 (ja) | 2016-05-18 | 2024-03-05 | ロクソ オンコロジー, インコーポレイテッド | (S)-N-(5-((R)-2-(2,5-ジフルオロフェニル)ピロリジン-1-イル)-ピラゾロ[1,5-a]ピリミジン-3-イル)-3-ヒドロキシピロリジン-1-カルボキサミドの調製 |
TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
EP3571203B1 (de) | 2017-01-18 | 2023-06-07 | Array BioPharma Inc. | Substituierte pyrazolo[1,5-a]pyrazin verbindungen als ret kinase inhibitoren |
WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
TWI812649B (zh) | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
JP7061195B2 (ja) | 2018-01-18 | 2022-04-27 | アレイ バイオファーマ インコーポレイテッド | RETキナーゼ阻害剤としての置換ピラゾロ[3,4-d]ピリミジン化合物 |
CN111971286B (zh) | 2018-01-18 | 2023-04-14 | 阿雷生物药品公司 | 作为RET激酶抑制剂的取代的吡咯并[2,3-d]嘧啶化合物 |
US11472802B2 (en) | 2018-01-18 | 2022-10-18 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors |
WO2020055672A1 (en) | 2018-09-10 | 2020-03-19 | Array Biopharma Inc. | Fused heterocyclic compounds as ret kinase inhibitors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5502072A (en) * | 1993-11-26 | 1996-03-26 | Pfizer Inc. | Substituted oxindoles |
US6147106A (en) * | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
US6130238A (en) * | 1997-06-20 | 2000-10-10 | Sugen, Inc. | 3-(cyclohexanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors |
GB9716557D0 (en) * | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
US6133305A (en) * | 1997-09-26 | 2000-10-17 | Sugen, Inc. | 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity |
NZ520640A (en) * | 2000-02-15 | 2005-04-29 | Upjohn Co | Pyrrole substituted 2-indolinone protein kinase inhibitors |
-
2002
- 2002-07-23 IT IT2002MI001620A patent/ITMI20021620A1/it unknown
-
2003
- 2003-07-22 AU AU2003251437A patent/AU2003251437A1/en not_active Abandoned
- 2003-07-22 EP EP03765081A patent/EP1534271B1/de not_active Expired - Lifetime
- 2003-07-22 DE DE60307856T patent/DE60307856T2/de not_active Expired - Lifetime
- 2003-07-22 CA CA002493202A patent/CA2493202A1/en not_active Abandoned
- 2003-07-22 US US10/522,081 patent/US20060258731A1/en not_active Abandoned
- 2003-07-22 MX MXPA05000781A patent/MXPA05000781A/es active IP Right Grant
- 2003-07-22 ES ES03765081T patent/ES2271649T3/es not_active Expired - Lifetime
- 2003-07-22 CN CNA038173352A patent/CN1668298A/zh active Pending
- 2003-07-22 JP JP2004522542A patent/JP2005537277A/ja active Pending
- 2003-07-22 AT AT03765081T patent/ATE337001T1/de not_active IP Right Cessation
- 2003-07-22 WO PCT/EP2003/007963 patent/WO2004009083A1/en active IP Right Grant
-
2008
- 2008-11-13 US US12/313,033 patent/US20090130229A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2493202A1 (en) | 2004-01-29 |
EP1534271A1 (de) | 2005-06-01 |
JP2005537277A (ja) | 2005-12-08 |
US20060258731A1 (en) | 2006-11-16 |
DE60307856T2 (de) | 2007-04-12 |
MXPA05000781A (es) | 2005-09-21 |
AU2003251437A8 (en) | 2004-02-09 |
ITMI20021620A1 (it) | 2004-01-23 |
EP1534271B1 (de) | 2006-08-23 |
WO2004009083A8 (en) | 2005-02-03 |
WO2004009083A1 (en) | 2004-01-29 |
ATE337001T1 (de) | 2006-09-15 |
AU2003251437A1 (en) | 2004-02-09 |
ES2271649T3 (es) | 2007-04-16 |
US20090130229A1 (en) | 2009-05-21 |
CN1668298A (zh) | 2005-09-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |