DE60304037D1 - Pluripotenzdeterminierender faktor und deren anwendung - Google Patents
Pluripotenzdeterminierender faktor und deren anwendungInfo
- Publication number
- DE60304037D1 DE60304037D1 DE60304037T DE60304037T DE60304037D1 DE 60304037 D1 DE60304037 D1 DE 60304037D1 DE 60304037 T DE60304037 T DE 60304037T DE 60304037 T DE60304037 T DE 60304037T DE 60304037 D1 DE60304037 D1 DE 60304037D1
- Authority
- DE
- Germany
- Prior art keywords
- maintain
- pluripotency
- factors
- confer
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Developmental Biology & Embryology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Reproductive Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Gynecology & Obstetrics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0202149.1A GB0202149D0 (en) | 2002-01-30 | 2002-01-30 | Pluripotency determining factors and uses thereof |
GB0202149 | 2002-01-30 | ||
PCT/GB2003/000366 WO2003064463A2 (en) | 2002-01-30 | 2003-01-30 | Pluripotency determining factors and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60304037D1 true DE60304037D1 (de) | 2006-05-11 |
DE60304037T2 DE60304037T2 (de) | 2006-11-09 |
Family
ID=9930054
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60320599T Expired - Lifetime DE60320599T2 (de) | 2002-01-30 | 2003-01-30 | Pluripotenzdeterminierende Faktoren und deren Anwendung |
DE60304037T Expired - Lifetime DE60304037T2 (de) | 2002-01-30 | 2003-01-30 | Pluripotenzdeterminierender faktor und deren anwendungen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60320599T Expired - Lifetime DE60320599T2 (de) | 2002-01-30 | 2003-01-30 | Pluripotenzdeterminierende Faktoren und deren Anwendung |
Country Status (11)
Country | Link |
---|---|
US (2) | US7687266B2 (de) |
EP (2) | EP1698639B1 (de) |
JP (1) | JP2005536183A (de) |
KR (1) | KR20040093699A (de) |
CN (1) | CN1646562A (de) |
AT (2) | ATE393167T1 (de) |
DE (2) | DE60320599T2 (de) |
DK (2) | DK1698639T3 (de) |
ES (1) | ES2308616T3 (de) |
GB (1) | GB0202149D0 (de) |
WO (1) | WO2003064463A2 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4268169B2 (ja) * | 2003-01-31 | 2009-05-27 | 伸弥 山中 | 胚性幹細胞の自己複製決定因子 |
WO2004072226A2 (en) * | 2003-02-13 | 2004-08-26 | Reprocell Inc. | Marker for undifferentiated state of cell and composition and method for separation and preparation of stem cells |
ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
US7682828B2 (en) * | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
WO2006025802A1 (en) * | 2004-09-03 | 2006-03-09 | Agency For Science, Technology And Research | Method for maintaining pluripotency of stem/progenitor cells |
US8192988B2 (en) * | 2004-10-22 | 2012-06-05 | University Of Central Florida Research Foundation, Inc. | Methods for increasing potency of adult mesenchymal stem cells |
US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
US8759090B2 (en) * | 2006-10-30 | 2014-06-24 | University Of Central Florida Research Foundation, Inc. | Stem cell banking system |
GB0701062D0 (en) * | 2007-01-19 | 2007-02-28 | Evocell Ltd | Biological materials and uses thereof |
SG193653A1 (en) | 2007-03-23 | 2013-10-30 | Wisconsin Alumni Res Found | Somatic cell reprogramming |
EP2145000A4 (de) | 2007-04-07 | 2010-05-05 | Whitehead Biomedical Inst | Neuprogammierung von körperzellen |
WO2009032456A2 (en) * | 2007-08-01 | 2009-03-12 | Primegen Biotech Llc | Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state |
US7615374B2 (en) | 2007-09-25 | 2009-11-10 | Wisconsin Alumni Research Foundation | Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions |
ES2587395T3 (es) | 2008-06-04 | 2016-10-24 | Cellular Dynamics International, Inc. | Procedimientos para la producción de células IPS usando un enfoque no vírico |
CN105671065A (zh) | 2008-06-13 | 2016-06-15 | 怀特黑德生物医学研究所 | 细胞编程和重编程 |
JP2012500005A (ja) | 2008-08-12 | 2012-01-05 | セルラー ダイナミクス インターナショナル, インコーポレイテッド | iPS細胞を生成するための方法 |
WO2011094538A1 (en) * | 2010-01-29 | 2011-08-04 | The Board Of Trustees Of The Leland Stanford Junior University | Depletion of teratoma-forming pluripotent stem cells |
US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
WO2013086008A1 (en) | 2011-12-05 | 2013-06-13 | Factor Bioscience Inc. | Methods and products for transfecting cells |
US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
US9884076B2 (en) | 2012-06-05 | 2018-02-06 | Capricor, Inc. | Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy |
EP3563859B1 (de) | 2012-08-13 | 2021-10-13 | Cedars-Sinai Medical Center | Von kardiosphären abgeleitete exosomen zur geweberegeneration |
EP3786298A1 (de) | 2012-11-01 | 2021-03-03 | Factor Bioscience Inc. | Verfahren und produkte zur expression von proteinen in zellen |
CN103609526B (zh) * | 2013-10-16 | 2015-10-07 | 中国科学院生物物理研究所 | 线粒体蛋白质翻译因子Guf1在雄性不育研究中的应用 |
EP3099801B1 (de) | 2014-01-31 | 2020-03-18 | Factor Bioscience Inc. | Synthetische rna zur verwendung in der behandlung von epidermolysis bullosa dystrophica |
WO2016054591A1 (en) | 2014-10-03 | 2016-04-07 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
US11241505B2 (en) | 2015-02-13 | 2022-02-08 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
WO2017123662A1 (en) | 2016-01-11 | 2017-07-20 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
CA3033788A1 (en) | 2016-08-17 | 2018-02-22 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
WO2018057542A1 (en) | 2016-09-20 | 2018-03-29 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
WO2018167283A1 (en) | 2017-03-17 | 2018-09-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling |
EP3612191A4 (de) | 2017-04-19 | 2020-12-30 | Cedars-Sinai Medical Center | Verfahren und zusammensetzungen zur behandlung von skelettmuskeldystrophie |
EP3727351A4 (de) | 2017-12-20 | 2021-10-06 | Cedars-Sinai Medical Center | Manipulierte extrazelluläre vesikel für verbesserte freisetzung in gewebe |
US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996022693A1 (en) | 1995-01-24 | 1996-08-01 | The Board Of Regents Of The University Of Texas System | Self-renewing pluripotent hematopoietic stem cell compositions, methods of use, and culture systems therefor |
WO1997030151A1 (en) | 1996-02-16 | 1997-08-21 | The University Of Edinburgh | Cytokine expressed by dia/lif-deficient embryonic stem cells for the inhibition of differentiation |
US6159950A (en) * | 1998-10-16 | 2000-12-12 | Cornell Research Foundation, Inc. | Method of modulating hair growth |
US7005252B1 (en) | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
US6436703B1 (en) * | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
EP1402256A4 (de) * | 2001-05-31 | 2006-09-13 | Chiron Corp | P-cadherin als ziel einer antikrebstherapie |
-
2002
- 2002-01-30 GB GBGB0202149.1A patent/GB0202149D0/en not_active Ceased
-
2003
- 2003-01-30 DE DE60320599T patent/DE60320599T2/de not_active Expired - Lifetime
- 2003-01-30 ES ES06005029T patent/ES2308616T3/es not_active Expired - Lifetime
- 2003-01-30 WO PCT/GB2003/000366 patent/WO2003064463A2/en active IP Right Grant
- 2003-01-30 KR KR10-2004-7011810A patent/KR20040093699A/ko not_active Application Discontinuation
- 2003-01-30 AT AT06005029T patent/ATE393167T1/de not_active IP Right Cessation
- 2003-01-30 AT AT03734758T patent/ATE320446T1/de not_active IP Right Cessation
- 2003-01-30 DK DK06005029T patent/DK1698639T3/da active
- 2003-01-30 DE DE60304037T patent/DE60304037T2/de not_active Expired - Lifetime
- 2003-01-30 US US10/502,972 patent/US7687266B2/en not_active Expired - Fee Related
- 2003-01-30 EP EP06005029A patent/EP1698639B1/de not_active Expired - Lifetime
- 2003-01-30 CN CNA038076519A patent/CN1646562A/zh active Pending
- 2003-01-30 DK DK03734758T patent/DK1470155T3/da active
- 2003-01-30 EP EP03734758A patent/EP1470155B1/de not_active Expired - Lifetime
- 2003-01-30 JP JP2003564083A patent/JP2005536183A/ja active Pending
-
2008
- 2008-08-12 US US12/222,580 patent/US20100144039A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2003064463B1 (en) | 2004-02-12 |
JP2005536183A (ja) | 2005-12-02 |
ATE393167T1 (de) | 2008-05-15 |
DK1698639T3 (da) | 2008-07-14 |
US20050255573A1 (en) | 2005-11-17 |
EP1470155A2 (de) | 2004-10-27 |
WO2003064463A3 (en) | 2003-12-11 |
US7687266B2 (en) | 2010-03-30 |
EP1698639B1 (de) | 2008-04-23 |
DE60304037T2 (de) | 2006-11-09 |
WO2003064463A2 (en) | 2003-08-07 |
ATE320446T1 (de) | 2006-04-15 |
DE60320599T2 (de) | 2009-10-29 |
DE60320599D1 (de) | 2008-06-05 |
DK1470155T3 (da) | 2006-07-24 |
GB0202149D0 (en) | 2002-03-20 |
EP1470155B1 (de) | 2006-03-15 |
US20100144039A1 (en) | 2010-06-10 |
KR20040093699A (ko) | 2004-11-08 |
EP1698639A3 (de) | 2006-12-06 |
EP1698639A2 (de) | 2006-09-06 |
ES2308616T3 (es) | 2008-12-01 |
CN1646562A (zh) | 2005-07-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURG |
|
8364 | No opposition during term of opposition |