DE60229393D1 - Überbrückte piperidinderivate als melanocortin-rezeptor-agonisten - Google Patents
Überbrückte piperidinderivate als melanocortin-rezeptor-agonistenInfo
- Publication number
- DE60229393D1 DE60229393D1 DE60229393T DE60229393T DE60229393D1 DE 60229393 D1 DE60229393 D1 DE 60229393D1 DE 60229393 T DE60229393 T DE 60229393T DE 60229393 T DE60229393 T DE 60229393T DE 60229393 D1 DE60229393 D1 DE 60229393D1
- Authority
- DE
- Germany
- Prior art keywords
- piperidine derivatives
- receptor agonists
- melanocortin receptor
- bridged piperidine
- agonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- 239000000336 melanocortin receptor agonist Substances 0.000 title 1
- 102000008316 Type 4 Melanocortin Receptor Human genes 0.000 abstract 2
- 108010021436 Type 4 Melanocortin Receptor Proteins 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 2
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 206010057671 Female sexual dysfunction Diseases 0.000 abstract 1
- 101000978418 Homo sapiens Melanocortin receptor 4 Proteins 0.000 abstract 1
- 102000004378 Melanocortin Receptors Human genes 0.000 abstract 1
- 108090000950 Melanocortin Receptors Proteins 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 102000057094 human MC4R Human genes 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30635901P | 2001-07-18 | 2001-07-18 | |
PCT/US2002/022258 WO2003007949A1 (en) | 2001-07-18 | 2002-07-12 | Bridged piperidine derivatives as melanocortin receptor agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60229393D1 true DE60229393D1 (de) | 2008-11-27 |
Family
ID=23184940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60229393T Expired - Lifetime DE60229393D1 (de) | 2001-07-18 | 2002-07-12 | Überbrückte piperidinderivate als melanocortin-rezeptor-agonisten |
Country Status (8)
Country | Link |
---|---|
US (1) | US7115628B2 (de) |
EP (1) | EP1411940B1 (de) |
JP (1) | JP4336196B2 (de) |
AT (1) | ATE411021T1 (de) |
AU (1) | AU2002320494B2 (de) |
CA (1) | CA2453609C (de) |
DE (1) | DE60229393D1 (de) |
WO (1) | WO2003007949A1 (de) |
Families Citing this family (91)
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CA2439149C (en) | 2001-02-28 | 2012-04-24 | Merck & Co., Inc. | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
EP1383501B1 (de) | 2001-02-28 | 2007-04-04 | Merck & Co., Inc. | Acylierte piperidinderivate als melanocortin-4-rezeptoragonisten |
US6977264B2 (en) | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
-
2002
- 2002-07-12 US US10/483,913 patent/US7115628B2/en not_active Expired - Fee Related
- 2002-07-12 EP EP02750014A patent/EP1411940B1/de not_active Expired - Lifetime
- 2002-07-12 JP JP2003513556A patent/JP4336196B2/ja not_active Expired - Fee Related
- 2002-07-12 AU AU2002320494A patent/AU2002320494B2/en not_active Ceased
- 2002-07-12 AT AT02750014T patent/ATE411021T1/de not_active IP Right Cessation
- 2002-07-12 WO PCT/US2002/022258 patent/WO2003007949A1/en active Application Filing
- 2002-07-12 DE DE60229393T patent/DE60229393D1/de not_active Expired - Lifetime
- 2002-07-12 CA CA2453609A patent/CA2453609C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7115628B2 (en) | 2006-10-03 |
CA2453609C (en) | 2010-05-04 |
EP1411940A4 (de) | 2005-03-09 |
EP1411940A1 (de) | 2004-04-28 |
CA2453609A1 (en) | 2003-01-30 |
EP1411940B1 (de) | 2008-10-15 |
ATE411021T1 (de) | 2008-10-15 |
JP4336196B2 (ja) | 2009-09-30 |
JP2004538281A (ja) | 2004-12-24 |
US20040180923A1 (en) | 2004-09-16 |
AU2002320494B2 (en) | 2006-06-29 |
WO2003007949A1 (en) | 2003-01-30 |
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Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US |