DE60229055D1 - Verfahren zur produktion von iohexol hoher reinheit - Google Patents

Verfahren zur produktion von iohexol hoher reinheit

Info

Publication number: DE60229055D1
Authority: DE; Germany
Prior art keywords: iohexol; production; high purity; propanol; methoxy
Prior art date: 2001-04-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60229055T

Other languages

English (en)

Inventor

Stefano Turchetta

Pietro Massardo

Valentina Aromatario

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Chemi SpA

Original Assignee

Chemi SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-11

Filing date

2002-04-09

Publication date

2008-11-06

2002-04-09 Application filed by Chemi SpA filed Critical Chemi SpA

2008-11-06 Application granted granted Critical

2008-11-06 Publication of DE60229055D1 publication Critical patent/DE60229055D1/de

2022-04-10 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 title abstract 2
229960001025 iohexol Drugs 0.000 title abstract 2
ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 abstract 2
238000000746 purification Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE60229055T 2001-04-11 2002-04-09 Verfahren zur produktion von iohexol hoher reinheit Expired - Lifetime DE60229055D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2001MI000773A ITMI20010773A1 (it)	2001-04-11	2001-04-11	Processo per la produzione di ioexolo ad elevata purezza
PCT/IB2002/001256 WO2002083623A1 (en)	2001-04-11	2002-04-09	Process for the production of high purity iohexol

Publications (1)

Publication Number	Publication Date
DE60229055D1 true DE60229055D1 (de)	2008-11-06

Family

ID=11447479

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60229055T Expired - Lifetime DE60229055D1 (de)	2001-04-11	2002-04-09	Verfahren zur produktion von iohexol hoher reinheit

Country Status (11)

Country	Link
US (1)	US6897339B2 (de)
EP (1)	EP1395546B1 (de)
JP (1)	JP4231293B2 (de)
AT (1)	ATE409178T1 (de)
CA (1)	CA2443730C (de)
CZ (1)	CZ303728B6 (de)
DE (1)	DE60229055D1 (de)
ES (1)	ES2314047T3 (de)
IT (1)	ITMI20010773A1 (de)
PT (1)	PT1395546E (de)
WO (1)	WO2002083623A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE520688C2 (sv) *	2000-04-11	2003-08-12	Bone Support Ab	Ett injicerbart ersättningsmaterial för benmineral
SE517168C2 (sv) *	2000-07-17	2002-04-23	Bone Support Ab	En komposition för ett injicerbart ersättningsmaterial för benmineral
SE522098C2 (sv) *	2001-12-20	2004-01-13	Bone Support Ab	Ett nytt benmineralsubstitut
SE0300620D0 (sv) *	2003-03-05	2003-03-05	Bone Support Ab	A new bone substitute composition
NO20033058D0 (no) *	2003-07-03	2003-07-03	Amersham Health As	Prosess
SE0302983D0 (sv) *	2003-11-11	2003-11-11	Bone Support Ab	Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed
DE602005001873T2 (de) *	2004-03-03	2008-04-24	Chemi S.P.A., Cinisello Balsamo	Amorphe 3-Pyridyl-1-Hydroxyethyliden-1,1-Bisphosphonsäure Mononatriumsalz und Verfahren zu deren Herstellung
SE527528C2 (sv)	2004-06-22	2006-04-04	Bone Support Ab	Anordning för framställning av härdbar massa samt användning av anordningen
NO20043305D0 (no) *	2004-08-09	2004-08-09	Amersham Health As	Preparation of lodixanol
NO338295B1 (no) *	2004-08-09	2016-08-08	Ge Healthcare As	Fremstilling av iodixanol.
NO20053676D0 (no) *	2005-07-29	2005-07-29	Amersham Health As	Crystallisation Process
NO20053687D0 (no)	2005-07-29	2005-07-29	Amersham Health As	Crystallisation Process.
PT103391B (pt) *	2005-11-24	2008-10-30	Hovione Farmaciencia S A	Processo para fabrico de lohexol
US9180137B2 (en)	2010-02-09	2015-11-10	Bone Support Ab	Preparation of bone cement compositions
WO2013065064A1 (en) *	2011-10-31	2013-05-10	Sequent Scientific Limited	A process for preparation of l-(6-methylpyridin-3-yl)-2-[4-(meth.ylsulfonyi)phenyl]ethanone field of invention
US9403757B2 (en) *	2012-11-12	2016-08-02	Ge Healthcare As	Preparation of intermediates of X-ray contrast agents
PL2958603T3 (pl)	2013-02-20	2018-10-31	Bone Support Ab	Ulepszone zestalanie utwardzalnego materiału zastępczego kości
JP6571100B2 (ja)	2014-03-04	2019-09-04	大塚製薬株式会社	イオヘキソール粉末及びそれを使用する方法
CN114933546B (zh) *	2022-05-23	2023-12-22	浙江海洲制药有限公司	一种适用于碘海醇大生产的纯化方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1548594A (en) *	1976-06-11	1979-07-18	Nyegaard & Co As	Triiodoisophthalic acid amides
DK162045C (da) *	1982-10-01	1992-02-10	Nyegaard & Co As	Trijodbenzenderivater, fremgangsmaade til fremstilling deraf og radiologiske praeparater indeholdende saadanne forbindelser
US5204086A (en) *	1982-10-01	1993-04-20	Nycomed Imaging As	X-ray contrast agent
IL94718A (en) *	1989-07-05	1994-10-21	Schering Ag	Non-ionic carboxamide contrast agent and method of preparation
GB9618056D0 (en) *	1996-08-29	1996-10-09	Nycomed Imaging As	Process
GB9618055D0 (en) *	1996-08-29	1996-10-09	Nycomed Imaging As	Process
PT101919B (pt) *	1996-09-30	2000-01-31	Hovione Sociedade Quimica Sa	Um processo para a purificacao de tohexol
GB9720969D0 (en) *	1997-10-02	1997-12-03	Nycomed Imaging As	Process

2001
- 2001-04-11 IT IT2001MI000773A patent/ITMI20010773A1/it unknown
2002
- 2002-04-09 EP EP02720366A patent/EP1395546B1/de not_active Expired - Lifetime
- 2002-04-09 AT AT02720366T patent/ATE409178T1/de not_active IP Right Cessation
- 2002-04-09 PT PT02720366T patent/PT1395546E/pt unknown
- 2002-04-09 JP JP2002581380A patent/JP4231293B2/ja not_active Expired - Lifetime
- 2002-04-09 CZ CZ20032757A patent/CZ303728B6/cs not_active IP Right Cessation
- 2002-04-09 CA CA2443730A patent/CA2443730C/en not_active Expired - Lifetime
- 2002-04-09 US US10/474,535 patent/US6897339B2/en not_active Expired - Lifetime
- 2002-04-09 DE DE60229055T patent/DE60229055D1/de not_active Expired - Lifetime
- 2002-04-09 WO PCT/IB2002/001256 patent/WO2002083623A1/en active IP Right Grant
- 2002-04-09 ES ES02720366T patent/ES2314047T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1395546A1 (de)	2004-03-10
PT1395546E (pt)	2008-12-30
JP4231293B2 (ja)	2009-02-25
ES2314047T3 (es)	2009-03-16
JP2004525182A (ja)	2004-08-19
CA2443730A1 (en)	2002-10-24
EP1395546B1 (de)	2008-09-24
ITMI20010773A0 (it)	2001-04-11
ATE409178T1 (de)	2008-10-15
US20040106828A1 (en)	2004-06-03
US6897339B2 (en)	2005-05-24
ITMI20010773A1 (it)	2002-10-11
WO2002083623A1 (en)	2002-10-24
CZ303728B6 (cs)	2013-04-10
CA2443730C (en)	2011-11-08
CZ20032757A3 (en)	2004-03-17

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Legal Events

Date	Code	Title	Description
2009-10-15	8364	No opposition during term of opposition