AT7110U3 - Verfahren zur herstellung von amlodipinmaleat - Google Patents

Verfahren zur herstellung von amlodipinmaleat Download PDF

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Publication number
AT7110U3
AT7110U3 AT0093503U AT9352003U AT7110U3 AT 7110 U3 AT7110 U3 AT 7110U3 AT 0093503 U AT0093503 U AT 0093503U AT 9352003 U AT9352003 U AT 9352003U AT 7110 U3 AT7110 U3 AT 7110U3
Authority
AT
Austria
Prior art keywords
amlodipinmaleat
production
Prior art date
Application number
AT0093503U
Other languages
English (en)
Other versions
AT7110U9 (de
AT7110U2 (de
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29740325&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT7110(U3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of AT7110U2 publication Critical patent/AT7110U2/de
Application granted granted Critical
Publication of AT7110U9 publication Critical patent/AT7110U9/de
Publication of AT7110U3 publication Critical patent/AT7110U3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT0093503U 2000-12-29 2003-12-29 Verfahren zur herstellung von amlodipinmaleat AT7110U9 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25861200P 2000-12-29 2000-12-29
US80934301A 2001-03-16 2001-03-16
BE2001/0709A BE1014452A6 (nl) 2000-12-29 2001-11-05 Werkwijze voor het maken van amlodipinemaleaat.

Publications (3)

Publication Number Publication Date
AT7110U2 AT7110U2 (de) 2004-10-25
AT7110U9 AT7110U9 (de) 2004-11-25
AT7110U3 true AT7110U3 (de) 2005-05-25

Family

ID=29740325

Family Applications (3)

Application Number Title Priority Date Filing Date
AT01972796T ATE300520T1 (de) 2000-12-29 2001-08-15 Verfahren zur herstellung amlodipinmaleat
AT0093503U AT7110U9 (de) 2000-12-29 2003-12-29 Verfahren zur herstellung von amlodipinmaleat
AT0093403U AT7109U3 (de) 2000-12-29 2003-12-29 Verfahren zur herstellung von amlodipinmaleat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT01972796T ATE300520T1 (de) 2000-12-29 2001-08-15 Verfahren zur herstellung amlodipinmaleat

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT0093403U AT7109U3 (de) 2000-12-29 2003-12-29 Verfahren zur herstellung von amlodipinmaleat

Country Status (25)

Country Link
US (2) US6600047B2 (de)
EP (1) EP1309555B1 (de)
CN (1) CN1272319C (de)
AP (1) AP2003002820A0 (de)
AT (3) ATE300520T1 (de)
BE (1) BE1014452A6 (de)
BR (1) BR0116557A (de)
CA (1) CA2433288C (de)
DE (2) DE60112305T2 (de)
DK (3) DK1309555T3 (de)
ES (1) ES2243553T3 (de)
FI (1) FI6788U1 (de)
HK (2) HK1055965A1 (de)
HR (1) HRP20030526A2 (de)
IL (1) IL156692A0 (de)
IS (1) IS6834A (de)
MA (1) MA25984A1 (de)
MX (1) MXPA03005885A (de)
NO (1) NO20032518L (de)
NZ (1) NZ526506A (de)
PL (1) PL362660A1 (de)
PT (1) PT1309555E (de)
RS (1) RS53403A (de)
SI (1) SI1309555T1 (de)
WO (1) WO2002053542A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0116553A (pt) * 2000-12-29 2004-02-03 Pfizer Ltd Composto, composição farmacêutica para tratamento de angina ou hipertensão, processo, processo para tratamento ou prevenção de angina ou hipertensão, composição de ingredientes farmaceuticamente ativos, composição farmacêutica para tratamento ou prevenção de angina ou hipertensão e processo para tratar ou prevenir angina ou hipertensão
CN1272319C (zh) * 2000-12-29 2006-08-30 辉瑞有限公司 制备氨氯地平马来酸盐的工艺、所制得的氨氯地平马来酸盐、其药物组合物和用途
EP1309554A1 (de) * 2000-12-29 2003-05-14 Synthon Licensing, Ltd. Amid-derivat von amlodipin
MXPA03005882A (es) * 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
US6653481B2 (en) * 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
GB0114709D0 (en) * 2001-06-15 2001-08-08 Pfizer Ltd Stabilised formulations of amlodipine maleate
US20030027848A1 (en) * 2001-06-15 2003-02-06 Anne Billotte Stabilized formulations
US20030180354A1 (en) * 2001-10-17 2003-09-25 Dr. Reddy's Laboratories Limited Amlodipine maleate formulations
KR100538641B1 (ko) * 2002-07-30 2005-12-22 씨제이 주식회사 암로디핀의 유기산염
KR100496436B1 (ko) 2002-07-30 2005-06-20 씨제이 주식회사 암로디핀의 유기산염
KR100467669B1 (ko) 2002-08-21 2005-01-24 씨제이 주식회사 암로디핀의 유기산염
AU2003253460A1 (en) * 2002-09-19 2004-04-08 Cj Corporation Crystalline organic acid salt of amlodipine
EP1407773A1 (de) * 2002-10-08 2004-04-14 Council of Scientific and Industrial Research Verfahren zur Herstellung von s(-)Amlodipin-Salzen
US20040072879A1 (en) * 2002-10-10 2004-04-15 Dr. Reddy's Laboratories Limited Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine)
AU2002368531A1 (en) * 2002-12-30 2004-07-22 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Isolation of dihydropyridine derivative and preparation salts thereof
WO2005023769A1 (en) * 2003-09-04 2005-03-17 Cipla Limited Process for the preparation of amlodipine salts
EP1687273A1 (de) * 2003-11-20 2006-08-09 Council Of Scientific And Industrial Research Verfahren zur herstellung chiraler amlodipinsalze
US20060030602A1 (en) * 2004-03-16 2006-02-09 Sepracor Inc. (S)-amlodipine malate
WO2008057972A1 (en) * 2006-11-02 2008-05-15 Millennium Pharmaceuticals, Inc. Methods of synthesizing pharmaceutical salts of a factor xa inhibitor
KR100843400B1 (ko) * 2006-11-14 2008-07-04 씨제이제일제당 (주) 결정성 ｓ-(-)-암로디핀 말레익산 염 무수물 및 이의제조방법
US20090062352A1 (en) * 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched amlodipine
CN102344409B (zh) * 2011-07-20 2013-04-03 海南锦瑞制药股份有限公司 一种氨氯地平晶体、其与贝那普利药用组合物及制备方法
CN102382041B (zh) * 2011-12-02 2016-01-20 东北制药集团股份有限公司 一种马来酸氨氯地平的制备方法
CN103044314A (zh) * 2013-01-06 2013-04-17 先声药业有限公司 马来酸氨氯地平的制备方法
CN104529877A (zh) * 2015-01-22 2015-04-22 华东理工常熟研究院有限公司 氨氯地平-癸酸离子液体及其制备方法和用途
CA3038989A1 (en) 2016-10-07 2018-04-12 Silvergate Pharmaceuticals, Inc. Amlodipine formulations
CN108358833A (zh) * 2018-03-15 2018-08-03 上海峰林生物科技有限公司 一种马来酸氨氯地平的合成工艺
JP7456933B2 (ja) 2018-04-11 2024-03-27 シルバーゲイト ファーマシューティカルズ，インク． アムロジピン製剤
CN109651236A (zh) * 2019-01-24 2019-04-19 浙江尖峰药业有限公司 门冬氨酸氨氯地平的晶型及其制备和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572909A (en) * 1982-03-11 1986-02-25 Pfizer Inc. 2-(Secondary aminoalkoxymethyl) dihydropyridine derivatives as anti-ischaemic and antihypertensive agents
WO1999025689A1 (en) * 1997-11-14 1999-05-27 A/S Gea Farmaceutisk Fabrik Process for the preparation of acetal derivatives of 1,4-dihydropyridines
WO1999025688A1 (en) * 1997-11-14 1999-05-27 A/S Gea Farmaceutisk Fabrik Process for the preparation of 1,4-dihydropyridines and compounds used in this process

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294969A (en) * 1979-01-29 1981-10-13 Merck & Co., Inc. Process for producing 2-bromo-3,5-disubstituted pyridines
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
GR851819B (de) * 1984-08-17 1985-11-26 Wyeth John & Brother Ltd
IT1201454B (it) * 1985-08-19 1989-02-02 Boehringer Biochemia Srl 1,4-diidropiridine-2-sostituite
GB8608335D0 (en) 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
FR2602231B1 (fr) * 1986-08-04 1988-10-28 Adir Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US4983740A (en) 1986-08-04 1991-01-08 Adir Et Compagnie Process for 1,4-dihydropyridine compounds
GB8710493D0 (en) 1987-05-02 1987-06-03 Pfizer Ltd Dihydropyridines
US5155120A (en) 1991-01-14 1992-10-13 Pfizer Inc Method for treating congestive heart failure
WO1993006082A1 (en) 1991-09-13 1993-04-01 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropyridines
US5389654A (en) 1992-11-26 1995-02-14 Lek, Tovarna, Farmacevtskih In Kemicnih . . . 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate
HU221810B1 (hu) 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
PL189666B1 (pl) * 1998-04-09 2005-09-30 Adamed Sp Z Oo Sposób otrzymywania benzenosulfonianu amlodypiny
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
ES2151850B1 (es) 1998-10-26 2001-08-16 Esteve Quimica Sa Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente.
GB9827431D0 (en) 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel compound
GB9827387D0 (en) 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel process
CN1272319C (zh) * 2000-12-29 2006-08-30 辉瑞有限公司 制备氨氯地平马来酸盐的工艺、所制得的氨氯地平马来酸盐、其药物组合物和用途
EP1309554A1 (de) * 2000-12-29 2003-05-14 Synthon Licensing, Ltd. Amid-derivat von amlodipin
EP1309556B1 (de) * 2000-12-29 2004-11-24 Pfizer Limited Amlodipinfumarat
ATE315026T1 (de) * 2000-12-29 2006-02-15 Pfizer Ltd Amlodipin-hemimaleat
BR0116553A (pt) * 2000-12-29 2004-02-03 Pfizer Ltd Composto, composição farmacêutica para tratamento de angina ou hipertensão, processo, processo para tratamento ou prevenção de angina ou hipertensão, composição de ingredientes farmaceuticamente ativos, composição farmacêutica para tratamento ou prevenção de angina ou hipertensão e processo para tratar ou prevenir angina ou hipertensão

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572909A (en) * 1982-03-11 1986-02-25 Pfizer Inc. 2-(Secondary aminoalkoxymethyl) dihydropyridine derivatives as anti-ischaemic and antihypertensive agents
WO1999025689A1 (en) * 1997-11-14 1999-05-27 A/S Gea Farmaceutisk Fabrik Process for the preparation of acetal derivatives of 1,4-dihydropyridines
WO1999025688A1 (en) * 1997-11-14 1999-05-27 A/S Gea Farmaceutisk Fabrik Process for the preparation of 1,4-dihydropyridines and compounds used in this process

Also Published As

Publication number Publication date
NO20032518L (no) 2003-06-26
AP2003002820A0 (en) 2003-06-30
CA2433288A1 (en) 2002-07-11
US20020086888A1 (en) 2002-07-04
FI6788U1 (fi) 2005-09-14
RS53403A (en) 2006-10-27
EP1309555A1 (de) 2003-05-14
FIU20030476U0 (fi) 2003-12-17
WO2002053542A1 (en) 2002-07-11
ATE300520T1 (de) 2005-08-15
DE20115704U1 (de) 2002-02-14
US6600047B2 (en) 2003-07-29
DK200300344U1 (da) 2003-12-12
ES2243553T3 (es) 2005-12-01
AT7109U3 (de) 2005-05-25
AT7110U9 (de) 2004-11-25
PL362660A1 (en) 2004-11-02
AT7109U2 (de) 2004-10-25
DK200300345U3 (da) 2004-03-12
CA2433288C (en) 2006-06-13
CN1505614A (zh) 2004-06-16
NZ526506A (en) 2004-11-26
DE60112305T2 (de) 2006-05-24
MXPA03005885A (es) 2005-04-19
AT7110U2 (de) 2004-10-25
SI1309555T1 (sl) 2005-12-31
US20030199559A1 (en) 2003-10-23
DK1309555T3 (da) 2005-10-24
IS6834A (is) 2003-05-30
HK1064671A1 (en) 2005-02-04
IL156692A0 (en) 2004-01-04
DK200300344U4 (da) 2005-09-09
BR0116557A (pt) 2003-10-28
HK1055965A1 (en) 2004-01-30
EP1309555B1 (de) 2005-07-27
MA25984A1 (fr) 2003-12-31
BE1014452A6 (nl) 2003-10-07
CN1272319C (zh) 2006-08-30
DE60112305D1 (de) 2005-09-01
HRP20030526A2 (en) 2005-06-30
PT1309555E (pt) 2005-10-31
NO20032518D0 (no) 2003-06-04

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