DE60223227D1 - BenzoÄbÄthiophenderivate und Verfahren zu deren Herstellung - Google Patents

BenzoÄbÄthiophenderivate und Verfahren zu deren Herstellung

Info

Publication number
DE60223227D1
DE60223227D1 DE60223227T DE60223227T DE60223227D1 DE 60223227 D1 DE60223227 D1 DE 60223227D1 DE 60223227 T DE60223227 T DE 60223227T DE 60223227 T DE60223227 T DE 60223227T DE 60223227 D1 DE60223227 D1 DE 60223227D1
Authority
DE
Germany
Prior art keywords
thiophene
bromomethyl
halogen atom
benzoäbäthiophenderivate
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60223227T
Other languages
English (en)
Other versions
DE60223227T2 (de
DE60223227T8 (de
Inventor
Hirosi Saitoh
Naoki Tsuchiya
Tsuyoshi Mizuno
Tomohide Ida
Yoshiyuki Sawai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Pharma Ltd
Original Assignee
Teijin Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Pharma Ltd filed Critical Teijin Pharma Ltd
Application granted granted Critical
Publication of DE60223227D1 publication Critical patent/DE60223227D1/de
Publication of DE60223227T2 publication Critical patent/DE60223227T2/de
Publication of DE60223227T8 publication Critical patent/DE60223227T8/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60223227T 2001-02-22 2002-02-22 Benzo[b]thiophenderivate und Verfahren zu deren Herstellung Active DE60223227T8 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2001046275 2001-02-22
JP2001046275 2001-02-22
JP2001135927 2001-05-07
JP2001135927 2001-05-07
PCT/JP2002/001611 WO2002066457A1 (fr) 2001-02-22 2002-02-22 Derive benzo[b]thiophene et procede de production correspondant

Publications (3)

Publication Number Publication Date
DE60223227D1 true DE60223227D1 (de) 2007-12-13
DE60223227T2 DE60223227T2 (de) 2008-08-14
DE60223227T8 DE60223227T8 (de) 2008-11-27

Family

ID=26609879

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60223227T Active DE60223227T8 (de) 2001-02-22 2002-02-22 Benzo[b]thiophenderivate und Verfahren zu deren Herstellung

Country Status (16)

Country Link
US (1) US6884896B2 (de)
EP (2) EP1362854B1 (de)
JP (1) JP3999128B2 (de)
KR (1) KR100922485B1 (de)
CN (1) CN100457750C (de)
AT (1) ATE376830T1 (de)
AU (1) AU2002233698B2 (de)
CA (1) CA2406913C (de)
DE (1) DE60223227T8 (de)
ES (1) ES2292712T3 (de)
HK (1) HK1057215A1 (de)
NO (1) NO328158B1 (de)
NZ (1) NZ522150A (de)
PL (1) PL358494A1 (de)
PT (1) PT1362854E (de)
WO (1) WO2002066457A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1944415B (zh) * 2001-02-22 2011-04-13 帝人株式会社 苯并[b]噻吩衍生物及其制备方法
CL2004001034A1 (es) * 2003-05-14 2005-03-28 Teijin Pharma Ltd Formas cristalinas de acido 4-(1-((,etilbenzotiofen-3-il)me til)benzimidazol-2-iltio)butanoico; procedimiento de preparacion de las formas cristalinas; composicion farmaceutica; y su uso para el tratamiento de enfermedades inflamatorias, alergicas, r
AU2004266536A1 (en) * 2003-08-22 2005-03-03 Teijin Pharma Limited Drug containing chymase inhibitor as the active ingredient
US7169807B2 (en) * 2004-04-09 2007-01-30 Allergan, Inc. 10-Hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists
DE102004021637A1 (de) * 2004-05-03 2005-12-01 Merck Patent Gmbh Dihydrobenzothiophene
US20080015240A1 (en) * 2004-11-12 2008-01-17 Mitsuru Teramoto Acid Salt of Benzimidazole Derivative and Crystal Thereof
KR20080058435A (ko) 2005-10-27 2008-06-25 데이진 화-마 가부시키가이샤 벤조[ｂ]티오펜 유도체 및 그 제조 방법
TW200734320A (en) 2005-10-27 2007-09-16 Teijin Pharma Ltd 3-Hydroxymethylbenzo [b] thiophen derivatives and a process for producing 3-hydroxymethylbenzo [b] thiophen derivatives
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
NO2944633T3 (de) 2012-11-14 2018-06-30
EP3444243B1 (de) * 2016-03-31 2020-09-02 FUJIFILM Toyama Chemical Co., Ltd. Verfahren zur herstellung von 5-(bromomethyl)-1-benzothiophen

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1174411A (en) 1966-03-02 1969-12-17 Aspro Nicholas Ltd Novel Benzothiophen Compounds, Compositions containing them and processes for their manufacture
US3910955A (en) * 1970-12-21 1975-10-07 Aspro Nicholas Ltd Benzothiophene-ethylamines
US4255196A (en) * 1979-02-23 1981-03-10 Rohm And Haas Company Lithographic ink of reduced volatile solvent content for reducing atmospheric pollution
ES2173182T3 (es) * 1994-04-11 2002-10-16 Chugai Pharmaceutical Co Ltd Derivado de 4,6-dl-butil-2,3-dihidrobenzotiofenos como antioxidantes de ldl.
WO2000003997A1 (fr) 1998-07-15 2000-01-27 Teijin Limited Derives de thiobenzimidazole
PT1078923E (pt) * 1999-08-02 2006-07-31 Hoffmann La Roche Processo para a preparacao de derivados de benzotiofeno
DK1249450T3 (da) * 2000-01-17 2008-02-11 Teijin Pharma Ltd Benzimidazolderivater som human chymase-inhibitorer
JP2001199968A (ja) 2000-01-18 2001-07-24 Teijin Ltd アミノベンズイミダゾール誘導体
GB0001439D0 (en) * 2000-01-21 2000-03-08 R P Adam Limited Method of controlling microbiological activity in water storage tanks and apparatus for use in such method
KR20030031486A (ko) * 2001-05-07 2003-04-21 데이진 가부시키가이샤 3-히드록시메틸벤조[ｂ]티오펜 유도체 및 그의 제조 방법

Also Published As

Publication number Publication date
EP1362854A4 (de) 2004-06-09
DE60223227T2 (de) 2008-08-14
NO20025053L (no) 2002-11-29
ES2292712T3 (es) 2008-03-16
US6884896B2 (en) 2005-04-26
PL358494A1 (en) 2004-08-09
CA2406913C (en) 2011-04-19
KR20030005293A (ko) 2003-01-17
HK1057215A1 (en) 2004-03-19
PT1362854E (pt) 2008-01-21
WO2002066457A1 (fr) 2002-08-29
NZ522150A (en) 2006-03-31
JPWO2002066457A1 (ja) 2004-06-17
CA2406913A1 (en) 2002-08-29
NO328158B1 (no) 2009-12-21
EP1362854A1 (de) 2003-11-19
CN100457750C (zh) 2009-02-04
JP3999128B2 (ja) 2007-10-31
DE60223227T8 (de) 2008-11-27
AU2002233698B2 (en) 2007-11-08
NO20025053D0 (no) 2002-10-21
EP1792614A1 (de) 2007-06-06
KR100922485B1 (ko) 2009-10-20
ATE376830T1 (de) 2007-11-15
CN1461301A (zh) 2003-12-10
EP1362854B1 (de) 2007-10-31
US20030176490A1 (en) 2003-09-18

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Legal Events

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8364 No opposition during term of opposition