DE60222734D1 - Mikropartikel und Verfahren zur deren Herstellung - Google Patents
Mikropartikel und Verfahren zur deren HerstellungInfo
- Publication number
- DE60222734D1 DE60222734D1 DE60222734T DE60222734T DE60222734D1 DE 60222734 D1 DE60222734 D1 DE 60222734D1 DE 60222734 T DE60222734 T DE 60222734T DE 60222734 T DE60222734 T DE 60222734T DE 60222734 D1 DE60222734 D1 DE 60222734D1
- Authority
- DE
- Germany
- Prior art keywords
- active substance
- microparticles
- suspension
- polymer
- nano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000011859 microparticle Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000013543 active substance Substances 0.000 abstract 4
- 229920000642 polymer Polymers 0.000 abstract 3
- 239000000725 suspension Substances 0.000 abstract 3
- 239000002105 nanoparticle Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02005393A EP1344520B1 (de) | 2002-03-15 | 2002-03-15 | Mikropartikel und Verfahren zur deren Herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60222734D1 true DE60222734D1 (de) | 2007-11-15 |
DE60222734T2 DE60222734T2 (de) | 2008-07-17 |
Family
ID=27763347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60222734T Expired - Lifetime DE60222734T2 (de) | 2002-03-15 | 2002-03-15 | Mikropartikel und Verfahren zur deren Herstellung |
Country Status (7)
Country | Link |
---|---|
US (1) | US8802148B2 (de) |
EP (1) | EP1344520B1 (de) |
AT (1) | ATE374598T1 (de) |
AU (1) | AU2003230658A1 (de) |
DE (1) | DE60222734T2 (de) |
ES (1) | ES2292655T3 (de) |
WO (1) | WO2003077887A1 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE374598T1 (de) * | 2002-03-15 | 2007-10-15 | Alrise Biosystems Gmbh | Mikropartikel und verfahren zur deren herstellung |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
DE10351087A1 (de) * | 2003-10-31 | 2005-05-25 | Bayer Technology Services Gmbh | Feste Wirkstoff-Formulierung |
FR2869801B1 (fr) * | 2004-05-05 | 2008-09-12 | Ethypharm Sa | Procede de preparation de compositions a liberation prolongee et utilisation de ces compositions pour le traitement des affections chroniques du systeme nerveux central (snc) |
ES2492641T3 (es) * | 2005-12-22 | 2014-09-10 | Novartis Ag | Formulación de liberación sostenida que comprende octreótida y dos o más polímeros de poliláctida-co-glicólido |
JP5419699B2 (ja) * | 2006-10-31 | 2014-02-19 | エボニック コーポレイション | 球状化されたポリマー粒子 |
US8946200B2 (en) * | 2006-11-02 | 2015-02-03 | Southwest Research Institute | Pharmaceutically active nanosuspensions |
CA2580589C (en) * | 2006-12-19 | 2016-08-09 | Fio Corporation | Microfluidic detection system |
US8360321B2 (en) | 2007-04-02 | 2013-01-29 | Fio Corporation | System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology |
JP2010530912A (ja) | 2007-06-22 | 2010-09-16 | フィオ コーポレイション | 量子ドットをドープしたポリマーマイクロビーズの製造システム及び方法 |
CN101809433A (zh) * | 2007-07-09 | 2010-08-18 | Fio公司 | 用于增强试样中靶分子荧光检测的***和方法 |
CA2689705C (en) * | 2007-07-23 | 2012-03-13 | Fio Corporation | A method and system for collating, storing, analyzing and enabling access to collected and analyzed data associated with biological and environmental test subjects |
CA2702367C (en) | 2007-10-12 | 2012-08-21 | Fio Corporation | Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto |
US8404850B2 (en) * | 2008-03-13 | 2013-03-26 | Southwest Research Institute | Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors |
US8652506B2 (en) * | 2008-06-05 | 2014-02-18 | Boston Scientific Scimed, Inc. | Bio-degradable block co-polymers for controlled release |
EP2321810A4 (de) | 2008-06-25 | 2014-09-17 | Fio Corp | Biogefahr-alarmsystem |
US8722706B2 (en) * | 2008-08-15 | 2014-05-13 | Southwest Research Institute | Two phase bioactive formulations of bis-quaternary pyridinium oxime sulfonate salts |
WO2010022519A1 (en) | 2008-08-29 | 2010-03-04 | Fio Corporation | A single-use handheld diagnostic test device, and an associated system and method for testing biological and environmental test samples |
US8309134B2 (en) * | 2008-10-03 | 2012-11-13 | Southwest Research Institute | Modified calcium phosphate nanoparticle formation |
CA2749660C (en) | 2009-01-13 | 2017-10-31 | Fio Corporation | A handheld diagnostic test device and method for use with an electronic device and a test cartridge in a rapid diagnostic test |
US8410455B2 (en) * | 2009-04-17 | 2013-04-02 | University Of Florida Research Foundation, Inc. | Excitation-intensity-dependent, color-tunable, dual emitting nanocrystals |
US9028873B2 (en) * | 2010-02-08 | 2015-05-12 | Southwest Research Institute | Nanoparticles for drug delivery to the central nervous system |
WO2011163469A1 (en) | 2010-06-23 | 2011-12-29 | Teva Pharmaceutical Industries Ltd. | Hydrated form of anti-inflammatory roflumilast-n-oxide |
GB201016436D0 (en) | 2010-09-30 | 2010-11-17 | Q Chip Ltd | Method of making solid beads |
GB201016433D0 (en) | 2010-09-30 | 2010-11-17 | Q Chip Ltd | Apparatus and method for making solid beads |
US8652366B2 (en) * | 2010-11-01 | 2014-02-18 | Board Of Regents, The University Of Texas System | Aerosol-mediated particle synthesis |
JP6505705B2 (ja) * | 2013-12-05 | 2019-04-24 | アルライズ バイオシステムズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 経口投与用製剤の製造方法 |
US11154510B2 (en) | 2015-06-11 | 2021-10-26 | Alrise Biosystems Gmbh | Process for the preparation of drug loaded microparticles |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2653255B2 (ja) * | 1990-02-13 | 1997-09-17 | 武田薬品工業株式会社 | 長期徐放型マイクロカプセル |
GB9211268D0 (en) * | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
JP3277342B2 (ja) * | 1992-09-02 | 2002-04-22 | 武田薬品工業株式会社 | 徐放性マイクロカプセルの製造法 |
GB9412273D0 (en) * | 1994-06-18 | 1994-08-10 | Univ Nottingham | Administration means |
DE19508049C2 (de) * | 1995-02-23 | 1997-02-06 | Schering Ag | Verwendung von Methylenmalondiesterderivaten zur Herstellung von gasenthaltenden Mikropartikeln |
DE19510690A1 (de) * | 1995-03-14 | 1996-09-19 | Schering Ag | Polymere Nano- und/oder Mikropartikel, Verfahren zu deren Herstellung, sowie Verwendung in medizinischen Diagnostik und Therapie |
DE19545257A1 (de) * | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
DE19611769A1 (de) * | 1996-03-14 | 1997-09-18 | Schering Ag | Mikropartikel, Verfahren zu deren Herstellung, sowie deren Verwendung in der Ultraschall Diagnostik |
US5858531A (en) * | 1996-10-24 | 1999-01-12 | Bio Syntech | Method for preparation of polymer microparticles free of organic solvent traces |
US20030049320A1 (en) * | 2000-12-18 | 2003-03-13 | Wockhardt Limited | Novel in-situ forming controlled release microcarrier delivery system |
CA2432900C (en) * | 2000-12-21 | 2007-09-11 | Nektar Therapeutics | Induced phase transition method for the production of microparticles containing hydrophilic active agents |
US20040126900A1 (en) * | 2001-04-13 | 2004-07-01 | Barry Stephen E | High affinity peptide- containing nanoparticles |
US7081489B2 (en) * | 2001-08-09 | 2006-07-25 | Florida State University Research Foundation | Polymeric encapsulation of nanoparticles |
ATE374598T1 (de) * | 2002-03-15 | 2007-10-15 | Alrise Biosystems Gmbh | Mikropartikel und verfahren zur deren herstellung |
-
2002
- 2002-03-15 AT AT02005393T patent/ATE374598T1/de active
- 2002-03-15 DE DE60222734T patent/DE60222734T2/de not_active Expired - Lifetime
- 2002-03-15 ES ES02005393T patent/ES2292655T3/es not_active Expired - Lifetime
- 2002-03-15 EP EP02005393A patent/EP1344520B1/de not_active Expired - Lifetime
-
2003
- 2003-03-14 US US10/506,952 patent/US8802148B2/en active Active
- 2003-03-14 WO PCT/US2003/007954 patent/WO2003077887A1/en not_active Application Discontinuation
- 2003-03-14 AU AU2003230658A patent/AU2003230658A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE374598T1 (de) | 2007-10-15 |
WO2003077887A1 (en) | 2003-09-25 |
ES2292655T3 (es) | 2008-03-16 |
US20050106257A1 (en) | 2005-05-19 |
US8802148B2 (en) | 2014-08-12 |
AU2003230658A1 (en) | 2003-09-29 |
DE60222734T2 (de) | 2008-07-17 |
EP1344520A1 (de) | 2003-09-17 |
EP1344520B1 (de) | 2007-10-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8381 | Inventor (new situation) |
Inventor name: ALBAYRAK, CELAL DR., 82152 PLANEGG, DE |
|
8364 | No opposition during term of opposition |