DE60209362D1 - 3-substituierte chinolin-4-carbonsäureamidderivate als nk-3- und nk-2-rezeptorantagonisten - Google Patents

3-substituierte chinolin-4-carbonsäureamidderivate als nk-3- und nk-2-rezeptorantagonisten

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Publication number
DE60209362D1
DE60209362D1 DE60209362T DE60209362T DE60209362D1 DE 60209362 D1 DE60209362 D1 DE 60209362D1 DE 60209362 T DE60209362 T DE 60209362T DE 60209362 T DE60209362 T DE 60209362T DE 60209362 D1 DE60209362 D1 DE 60209362D1
Authority
DE
Germany
Prior art keywords
chinolin
substituted
carboxylic acid
receptor antagonists
acid amid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60209362T
Other languages
English (en)
Other versions
DE60209362T2 (de
Inventor
Carlo Farina
Stefania Gagliardi
Arnaldo Giardina
Marisa Martinelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
GlaxoSmithKline SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0109123.0A external-priority patent/GB0109123D0/en
Priority claimed from GB0205649A external-priority patent/GB0205649D0/en
Application filed by GlaxoSmithKline SpA filed Critical GlaxoSmithKline SpA
Publication of DE60209362D1 publication Critical patent/DE60209362D1/de
Application granted granted Critical
Publication of DE60209362T2 publication Critical patent/DE60209362T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D487/04—Ortho-condensed systems

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DE60209362T 2001-04-11 2002-04-11 3-substituierte chinolin-4-carbonsäureamidderivate als nk-3- und nk-2-rezeptorantagonisten Expired - Fee Related DE60209362T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0109123.0A GB0109123D0 (en) 2001-04-11 2001-04-11 Novel compounds
GB0109123 2001-04-11
GB0205649A GB0205649D0 (en) 2002-03-11 2002-03-11 Novel compounds
GB0205649 2002-03-11
PCT/EP2002/004070 WO2002083664A1 (en) 2001-04-11 2002-04-11 3-substituted quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists

Publications (2)

Publication Number Publication Date
DE60209362D1 true DE60209362D1 (de) 2006-04-27
DE60209362T2 DE60209362T2 (de) 2006-10-26

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Application Number Title Priority Date Filing Date
DE60209362T Expired - Fee Related DE60209362T2 (de) 2001-04-11 2002-04-11 3-substituierte chinolin-4-carbonsäureamidderivate als nk-3- und nk-2-rezeptorantagonisten
DE60208178T Expired - Fee Related DE60208178T2 (de) 2001-04-11 2002-04-11 Chinolin-4-carboxamidderivate als nk-3 und nk-2 rezeptor antagonisten

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DE60208178T Expired - Fee Related DE60208178T2 (de) 2001-04-11 2002-04-11 Chinolin-4-carboxamidderivate als nk-3 und nk-2 rezeptor antagonisten

Country Status (7)

Country Link
US (5) US20040152726A1 (de)
EP (3) EP1377567B1 (de)
JP (2) JP2004525184A (de)
AT (2) ATE318266T1 (de)
DE (2) DE60209362T2 (de)
ES (2) ES2254688T3 (de)
WO (2) WO2002083663A1 (de)

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BRPI0510365A (pt) 2004-04-28 2007-11-06 Takeda Pharmaceutical composto, método de produção de um composto, antagonista do receptor nk2, pró-droga, agente farmacêutico, métodos para antagonizar um recpetor nk2 e para evitar ou tratar doenças gastrintestinais funcionais, e, uso do composto ou uma pró-droga do mesmo
GB0417702D0 (en) * 2004-08-09 2004-09-08 Merck Sharp & Dohme New uses
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GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
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WO2008153027A1 (ja) * 2007-06-11 2008-12-18 Takeda Pharmaceutical Company Limited ピロロキノリン誘導体およびその用途
WO2009072643A1 (en) 2007-12-03 2009-06-11 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound and use thereof
WO2009128262A1 (ja) * 2008-04-15 2009-10-22 武田薬品工業株式会社 キノロン誘導体およびその用途
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EP1377567A1 (de) 2004-01-07
EP1659120A1 (de) 2006-05-24
WO2002083664A1 (en) 2002-10-24
DE60208178D1 (de) 2006-01-26
ATE313539T1 (de) 2006-01-15
DE60208178T2 (de) 2006-08-24
ES2254688T3 (es) 2006-06-16
US20050176762A1 (en) 2005-08-11
ATE318266T1 (de) 2006-03-15
US20070259882A1 (en) 2007-11-08
EP1385839B1 (de) 2006-02-22
EP1377567B1 (de) 2005-12-21
JP2004525183A (ja) 2004-08-19
US20070161647A1 (en) 2007-07-12
DE60209362T2 (de) 2006-10-26
WO2002083663A1 (en) 2002-10-24
US20040152726A1 (en) 2004-08-05
US20060229315A1 (en) 2006-10-12
ES2259096T3 (es) 2006-09-16
EP1385839A1 (de) 2004-02-04
JP2004525184A (ja) 2004-08-19

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