DE60209289D1 - Laktonisierungsverfahren bei der Herstellung von Statinen - Google Patents

Laktonisierungsverfahren bei der Herstellung von Statinen

Info

Publication number
DE60209289D1
DE60209289D1 DE60209289T DE60209289T DE60209289D1 DE 60209289 D1 DE60209289 D1 DE 60209289D1 DE 60209289 T DE60209289 T DE 60209289T DE 60209289 T DE60209289 T DE 60209289T DE 60209289 D1 DE60209289 D1 DE 60209289D1
Authority
DE
Germany
Prior art keywords
present
simvastatin
statins
production
processing method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60209289T
Other languages
English (en)
Other versions
DE60209289T2 (de
Inventor
Kwang-Hyeg Lee
Jin-Wan Kim
Kwang-Do Choi
Sang-Ho Lee
Hong-Suk Cho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CJ CheilJedang Corp
Original Assignee
CJ Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CJ Corp filed Critical CJ Corp
Application granted granted Critical
Publication of DE60209289D1 publication Critical patent/DE60209289D1/de
Publication of DE60209289T2 publication Critical patent/DE60209289T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60209289T 2001-12-03 2002-12-03 Laktonisierungsverfahren bei der Herstellung von Statinen Expired - Lifetime DE60209289T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR2001075991 2001-12-03
KR10-2001-0075991A KR100423892B1 (ko) 2001-12-03 2001-12-03 스타틴의 제조에 있어서 새로운 락톤화 방법

Publications (2)

Publication Number Publication Date
DE60209289D1 true DE60209289D1 (de) 2006-04-27
DE60209289T2 DE60209289T2 (de) 2006-08-10

Family

ID=36129249

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60209289T Expired - Lifetime DE60209289T2 (de) 2001-12-03 2002-12-03 Laktonisierungsverfahren bei der Herstellung von Statinen

Country Status (12)

Country Link
US (1) US6906204B2 (de)
EP (1) EP1316552B1 (de)
JP (1) JP3802481B2 (de)
KR (1) KR100423892B1 (de)
CN (1) CN1197854C (de)
AT (1) ATE318264T1 (de)
AU (1) AU2002311322B8 (de)
BR (1) BR0204943A (de)
CA (1) CA2413235C (de)
DE (1) DE60209289T2 (de)
MX (1) MXPA02011967A (de)
WO (1) WO2003048149A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100502834B1 (ko) * 2002-03-25 2005-07-20 보령제약 주식회사 개선된 락톤화 반응에 의한 심바스타틴의 제조방법 및이의 정제방법
ATE414071T1 (de) * 2004-03-30 2008-11-15 Lupin Ltd Verbessertes verfahren zur herstellung von 4- hydroxypyran-2-onderivaten
EP2597092A1 (de) 2011-11-24 2013-05-29 Sterling Biotech Limited Verfahren zum Reinigen von Lovastatin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2053000C (en) * 1990-10-15 1995-08-29 Michael J. Conder Biosynthetic production of 6(r)-[2-(8(s)-hydroxy-2(s), 6(r)-dimethyl-1,2,6,7,8,8a(r)-hexahydronaphthyl)-ethyl]-4 (r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one triol acid by enzymatic hydrolysis of lovastatin acid using an enzyme derived from__lonostachys compactiuscula
NZ245713A (en) * 1992-02-10 1994-12-22 Novopharm Ltd Production of the antibiotic lovastatin from genetically engineered aspergillus strains
DE69813538T2 (de) 1997-01-28 2004-04-01 Plus Chemicals B.V. Verfahren zur herstellung von halbsynthetischen statinen vianeue zwischenprodukte
IN186880B (de) * 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
IN186879B (de) * 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
CA2388182A1 (en) 1999-10-27 2001-05-03 Merck & Co., Inc. Lactonization process
SK702003A3 (en) * 2001-05-18 2003-12-02 Aurobindo Pharma Ltd A process for lactonization to produce simvastatin

Also Published As

Publication number Publication date
CN1197854C (zh) 2005-04-20
CA2413235A1 (en) 2003-06-03
DE60209289T2 (de) 2006-08-10
KR20030045340A (ko) 2003-06-11
US20030109723A1 (en) 2003-06-12
CN1425661A (zh) 2003-06-25
BR0204943A (pt) 2004-06-15
EP1316552B1 (de) 2006-02-22
MXPA02011967A (es) 2004-07-16
JP2003183271A (ja) 2003-07-03
ATE318264T1 (de) 2006-03-15
CA2413235C (en) 2006-05-30
JP3802481B2 (ja) 2006-07-26
AU2002311322B8 (en) 2005-10-27
AU2002311322B2 (en) 2005-06-30
WO2003048149A1 (en) 2003-06-12
KR100423892B1 (ko) 2004-03-22
US6906204B2 (en) 2005-06-14
EP1316552A1 (de) 2003-06-04

Similar Documents

Publication Publication Date Title
DE60226203D1 (de) Laktonisierung im Verfahren zur Herstellung von Statinen
ATE353081T1 (de) Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten
ATE195973T1 (de) Enzymatische verfahren zur resolution von enantiomeren-mischungen nützlich wie zwischenprodukte zur herstellung von taxanen
ATE494274T1 (de) Verfahren zum herstellen von 2-dihalogenacyl-3- amino-acryls ureestern und 3-dihalogenmethyl- pyrazol-4-carbons ureestern
ATE231850T1 (de) Isochroman verbindungen und verfahren zu deren produktion
ATE444747T1 (de) Verfahren zur herstellung von expoxybutanol- zwischenprodukten
CY1112350T1 (el) Διαδικασια παραγωγης ενος οπτικα ενεργου οξοεπτενοϊκου οξινου εστερα
NO20062656L (no) Fremgangsmate for fremstilling av statiner
ATE543793T1 (de) Verfahren zur herstellung von benzoesäureestern
DE60105113D1 (de) Verfahren zur Herstellung von einem Kristallepoxid
IT1312331B1 (it) Procedimento per la produzione di diamminodifenilmetano e suoiomologhi superiori.
DE60209289D1 (de) Laktonisierungsverfahren bei der Herstellung von Statinen
DE602004017217D1 (de) Verfahren zur herstellung von alkenylierten hydroxylierten aromatischen verbindungen, von chromanverbindungen und deren acylierten derivaten
CA2676424A1 (en) Taxane derivatives and processes for the preparation thereof
DE60203200D1 (de) Synthese von vicinalen Difluoraromaten und Zwischenprodukte davon
ATE496907T1 (de) Verfahren zur herstellung von cilostazol
DE60312214D1 (de) Verfahren zur herstellung von(4e)-5-chloro-2-isopropyl-4-pentensäureester und optischaktivem isomer davon
ATE223414T1 (de) Prozess zur herstellung von zwischebprodukten für imidazodeazepinen
RU2003128953A (ru) Деградация эпотилонов
DE60039533D1 (de) Verbessertes verfahren zur herstellung von 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin
ATE156819T1 (de) Verfahren zur herstellung einer oxazolidincarbon säure nützlich für die herstellung von therapeutischen taxoiden
ATE423089T1 (de) Verfahren zur herstellung von butantriol- derivaten
ATE267167T1 (de) Verfahren zur herstellung von 7-azabicyclo (4.1.0)-hept-3-ene-3-carbonsäureestern
DE60225199D1 (de) Verfahren zur Herstellung von Michael-addukten
RU2003127743A (ru) Способ получения производного хинолинкарбоксальдегида и промежуточных соединений

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: CJ CHEILJEDANG CORP., SEOUL, KR