DE60208018D1 - Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-bisphosphonsäure - Google Patents

Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-bisphosphonsäure

Info

Publication number: DE60208018D1
Authority: DE; Germany
Prior art keywords: hydroxybutylidene; amino; acid; preparing; bisphosphonic acid
Prior art date: 2001-05-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60208018T

Other languages

English (en)

Other versions

DE60208018T2 (de

Inventor

Kadir Dabak

Evren Ozarslan

Filiz Sahbaz

Tuncer Aslan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Zentiva Kinyasal Urunleri Sanayi ve Ticaret AS

Original Assignee

EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi ve Ticaret AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-10

Filing date

2002-05-08

Publication date

2006-01-19

2002-05-08 Application filed by EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi ve Ticaret AS filed Critical EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi ve Ticaret AS

2006-01-19 Application granted granted Critical

2006-01-19 Publication of DE60208018D1 publication Critical patent/DE60208018D1/de

2006-07-13 Publication of DE60208018T2 publication Critical patent/DE60208018T2/de

2022-05-09 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000002253 acid Substances 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 1
239000010775 animal oil Substances 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000003995 emulsifying agent Substances 0.000 abstract 1
229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
238000005954 phosphonylation reaction Methods 0.000 abstract 1
FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 1
239000010773 plant oil Substances 0.000 abstract 1
ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1
150000003626 triacylglycerols Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

DE60208018T 2001-05-10 2002-05-08 Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-bisphosphonsäure Expired - Lifetime DE60208018T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
TR200101250		2001-05-10
TR2001/01250A TR200101250A2 (tr)	2001-05-10	2001-05-10	4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
PCT/TR2002/000018 WO2002090367A1 (en)	2001-05-10	2002-05-08	Process for the preparation of 4-amino-1-hydroxybutylidene-1, 1-biphosphonic acid

Publications (2)

Publication Number	Publication Date
DE60208018D1 true DE60208018D1 (de)	2006-01-19
DE60208018T2 DE60208018T2 (de)	2006-07-13

Family

ID=21623110

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60208018T Expired - Lifetime DE60208018T2 (de)	2001-05-10	2002-05-08	Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-bisphosphonsäure

Country Status (9)

Country	Link
US (1)	US7009071B2 (de)
EP (1)	EP1390373B9 (de)
JP (1)	JP3911287B2 (de)
AT (1)	ATE312836T1 (de)
CA (1)	CA2445428C (de)
DE (1)	DE60208018T2 (de)
ES (1)	ES2254691T3 (de)
TR (1)	TR200101250A2 (de)
WO (1)	WO2002090367A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR0215413A (pt) *	2001-12-24	2004-12-14	Teva Pharma	Formula dosada com um comprimido central de ingrediente ativo encapado em uma capa anular prensada de material em pó ou granulado e processo e conjunto de ferramentas para a sua produção
US20040052843A1 (en) *	2001-12-24	2004-03-18	Lerner E. Itzhak	Controlled release dosage forms
WO2003097655A1 (en) *	2002-05-17	2003-11-27	Teva Pharmaceutical Industries Ltd.	Use of certain diluents for making bisphosphonic acids
HUP0300227A2 (hu) *	2003-01-28	2004-09-28	Richter Gedeon Vegyészeti Gyár Rt.	Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
PT1656386E (pt)	2003-08-21	2010-03-05	Sun Pharmaceuticals Ind Ltd	Processo para a preparação de compostos de ácido bifosfónico
US8003820B2 (en)	2005-10-20	2011-08-23	Dr. Reddy's Laboratories Limited	Process for preparing bisphosphonic acids
EP1798236A1 (de) *	2005-12-13	2007-06-20	EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S.	Verfahren zur Herstellung von 3-Pyridyl-1-hydroxyethyliden-1,1- bisphosphosonsäure und Hydrate davon
ES2323728T3 (es)	2005-12-27	2009-07-23	Ipca Laboratories Limited	Proceso mejorado para la fabricacion de 4-amino-hidroxibutilideno-1,1-bisfosfonico y sus sales.
WO2007083240A2 (en) *	2006-01-20	2007-07-26	Aurobindo Pharma Limited	An improved process for the preparation of bisphosphonic acids
WO2007096896A1 (en) *	2006-02-20	2007-08-30	Alembic Limited	An improved process for the preparation of biphosphonic derivatives
CA2646418A1 (en) *	2006-03-21	2007-09-27	Albemarle Corporation	Process for manufacturing bisphosphonic acids
CA2689504A1 (en) *	2007-06-19	2008-12-24	Albemarle Corporation	Processes for manufacturing bisphosphonic acids
WO2010003704A2 (en)	2008-07-11	2010-01-14	Synthon B.V.	Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
EP2470549B1 (de)	2009-08-28	2014-07-16	Synthon B.V.	Verfahren zur herstellung von hydroxyalkyliden-1,1-biphosphonsäuren

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3016289A1 (de) *	1980-04-28	1981-10-29	Henkel KGaA, 4000 Düsseldorf	Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
DE3434667A1 (de) *	1984-09-21	1986-04-03	Henkel KGaA, 4000 Düsseldorf	4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) *	1984-10-29	1988-11-16	Gentili Ist Spa	Procedimento per la preparazione di acidi difosfonici
TW198039B (de) *	1988-11-28	1993-01-11	Ciba Geigy Ag
US4922007A (en) *	1989-06-09	1990-05-01	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) *	1990-06-20	1991-05-28	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
CA2197267C (en) *	1997-02-11	2000-02-08	Yong Tao	Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
BR0010112A (pt) *	1999-02-17	2001-12-26	Teva Pharma	Processo para preparação de ácido alendrÈnico

2001
- 2001-05-10 TR TR2001/01250A patent/TR200101250A2/xx unknown
2002
- 2002-05-08 EP EP02736468A patent/EP1390373B9/de not_active Expired - Lifetime
- 2002-05-08 WO PCT/TR2002/000018 patent/WO2002090367A1/en active IP Right Grant
- 2002-05-08 CA CA002445428A patent/CA2445428C/en not_active Expired - Fee Related
- 2002-05-08 US US10/473,600 patent/US7009071B2/en not_active Expired - Fee Related
- 2002-05-08 JP JP2002587445A patent/JP3911287B2/ja not_active Expired - Fee Related
- 2002-05-08 DE DE60208018T patent/DE60208018T2/de not_active Expired - Lifetime
- 2002-05-08 ES ES02736468T patent/ES2254691T3/es not_active Expired - Lifetime
- 2002-05-08 AT AT02736468T patent/ATE312836T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2445428A1 (en)	2002-11-14
CA2445428C (en)	2006-05-02
DE60208018T2 (de)	2006-07-13
US20040152916A1 (en)	2004-08-05
EP1390373B1 (de)	2005-12-14
US7009071B2 (en)	2006-03-07
ES2254691T3 (es)	2006-06-16
JP3911287B2 (ja)	2007-05-09
EP1390373B9 (de)	2006-08-16
EP1390373A1 (de)	2004-02-25
ATE312836T1 (de)	2005-12-15
JP2004528382A (ja)	2004-09-16
TR200101250A2 (tr)	2003-04-21
WO2002090367A1 (en)	2002-11-14

Legal Events

Date	Code	Title	Description
2007-01-04	8364	No opposition during term of opposition
2007-09-20	8380	Miscellaneous part iii	Free format text: DIE VERTRETER SIND HINZUZUFUEGEN: WUESTHOFF & WUESTHOFF PATENT- UND RECHTSANWAELTE, 81541 MUENCHEN
2008-03-13	8327	Change in the person/name/address of the patent owner	Owner name: ECZACIBASI-ZENTIVA KIMYASAL URUNLER SANAYI VE , TR
2010-01-07	8327	Change in the person/name/address of the patent owner	Owner name: ZENTIVA KIMYASAL URUNLER SANAYI VE TICARET A.S, TR

Publication	Publication Date	Title
DE60208018D1 (de)	2006-01-19	Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-bisphosphonsäure
ATE220404T1 (de)	2002-07-15	Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-biphosphonsäure
ATE451380T1 (de)	2009-12-15	Verfahren zur herstellung von bisphosphonsäureverbindungen
ATE236171T1 (de)	2003-04-15	Verfahren zur herstellung von phosphodiestern
ATE508134T1 (de)	2011-05-15	Amorphe form das natriumsalzes der ibandronsäure
ATE298756T1 (de)	2005-07-15	Salz eines melamin-kondensationsproduktes und einer phophorenthaltenden säure
DK0391329T3 (da)	1995-04-10	Fremgangsmåde til fremstilling af alkylphosphonsyrlingdiestere og/eller dialkylphosphinsyrlingestere
DE59906740D1 (de)	2003-10-02	Verfahren zur Herstellung von Phosphonigsäureestern
DE50103200D1 (de)	2004-09-16	Verfahren zur Herstellung von Alkenylphosphonsäure-Derivaten
DE60002347D1 (de)	2003-05-28	Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure und ihres trihydratisierten mononatriumsalzes
DE69528405T2 (de)	2003-06-18	Phosphorylierungsreagens, Verfahren und Verwendung
HUP0300227A2 (hu)	2004-09-28	Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
DK0693074T3 (da)	1998-02-16	Fremgangsmåde til fremstilling af aminomethanphosphonsyre
DE3864927D1 (de)	1991-10-24	Verfahren zur herstellung von aminomethylenphosphonalkylphosphinaten.
ATE74136T1 (de)	1992-04-15	Verfahren zur herstellung substituierter diarylphosphide.
ATE150755T1 (de)	1997-04-15	Neue 2-saccharinylmethyl und 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphate, phosphonate und phosphinate, brauchbar als proteolytische enzyme- inhibitoren und zusammensetzungen und methode zur verwendung davon
ATE425171T1 (de)	2009-03-15	Verbesserter herstellungsprozess von 4-amino- hydroxybutyliden-1,1-bisphosphonischer säure und ihrer salze
MX9307454A (es)	1994-08-31	Novedosos 2-sacarinilmetil fosfatos, fosfonatos y fosfinatos utiles como inhibidores de enzima proteolitica y composiciones y metodos de uso de los mismos.
DE50003163D1 (de)	2003-09-11	Verfahren zur Herstellung von Alkylphosphonigsäureestern
ATE251594T1 (de)	2003-10-15	Verfahren zur herstellung von mononatriumtrihydrogenpyrophosphat