DE60002347D1 - Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure und ihres trihydratisierten mononatriumsalzes - Google Patents

Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure und ihres trihydratisierten mononatriumsalzes

Info

Publication number: DE60002347D1
Authority: DE; Germany
Prior art keywords: amino; trihydratized; hydroxybutyliden; mononatrium; salts
Prior art date: 1999-08-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE60002347T

Other languages

English (en)

Other versions

DE60002347T2 (de

Inventor

I Llado Jordi E- Girona Bosch

Lista Eugenia Pagans

Miguel M Del Carmen Onrubia

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Medichem SA

Original Assignee

Medichem SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-06

Filing date

2000-07-17

Publication date

2003-05-28

2000-07-17 Application filed by Medichem SA filed Critical Medichem SA

2003-05-28 Publication of DE60002347D1 publication Critical patent/DE60002347D1/de

2004-02-12 Application granted granted Critical

2004-02-12 Publication of DE60002347T2 publication Critical patent/DE60002347T2/de

2020-07-18 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 title abstract 2
239000002253 acid Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 2
229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
IZDROVVXIHRYMH-UHFFFAOYSA-N methanesulfonic anhydride Chemical compound CS(=O)(=O)OS(C)(=O)=O IZDROVVXIHRYMH-UHFFFAOYSA-N 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DE60002347T 1999-08-06 2000-07-17 Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure und ihres trihydratisierten mononatriumsalzes Expired - Fee Related DE60002347T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
ES009901806A ES2153794B1 (es)	1999-08-06	1999-08-06	Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
ES9901806		1999-08-06
PCT/ES2000/000254 WO2001010874A1 (es)	1999-08-06	2000-07-17	Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada

Publications (2)

Publication Number	Publication Date
DE60002347D1 true DE60002347D1 (de)	2003-05-28
DE60002347T2 DE60002347T2 (de)	2004-02-12

Family

ID=8309563

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60002347T Expired - Fee Related DE60002347T2 (de)	1999-08-06	2000-07-17	Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure und ihres trihydratisierten mononatriumsalzes

Country Status (18)

Country	Link
US (1)	US6573401B1 (de)
EP (1)	EP1205484B1 (de)
KR (1)	KR100688287B1 (de)
AT (1)	ATE238317T1 (de)
AU (1)	AU5987300A (de)
BR (1)	BR0013031A (de)
CA (1)	CA2380841C (de)
CR (1)	CR6575A (de)
DE (1)	DE60002347T2 (de)
DK (1)	DK1205484T3 (de)
ES (2)	ES2153794B1 (de)
HU (1)	HUP0202196A3 (de)
IL (1)	IL148000A (de)
MX (1)	MXPA02001293A (de)
PL (1)	PL191733B1 (de)
PT (1)	PT1205484E (de)
SI (1)	SI1205484T1 (de)
WO (1)	WO2001010874A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040052843A1 (en) *	2001-12-24	2004-03-18	Lerner E. Itzhak	Controlled release dosage forms
KR100897837B1 (ko) *	2001-12-24	2009-05-15	테바 파마슈티컬 인더스트리즈 리미티드	분말 또는 과립 물질의 압착된 환상체 내에 싸인 활성성분의 코어 정제를 갖는 제형과, 이의 제조 방법 및 툴링
ITMI20020908A1 (it)	2002-04-29	2003-10-29	Chemi Spa	Processo di preparazione di sodio alendronato
WO2003097655A1 (en) *	2002-05-17	2003-11-27	Teva Pharmaceutical Industries Ltd.	Use of certain diluents for making bisphosphonic acids
HUP0300227A2 (hu) *	2003-01-28	2004-09-28	Richter Gedeon Vegyészeti Gyár Rt.	Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
US20050113343A1 (en) *	2003-10-14	2005-05-26	Pliva - Research And Development Ltd.	Solid-state form of alendronate sodium and preparation thereof
EP1883644A2 (de) *	2005-05-06	2008-02-06	Medichem, S.A.	Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof
EP1891081B1 (de) *	2005-06-13	2014-08-20	Jubilant Organosys Limited	Verfahren zur herstellung von bisphosphonsäuren und formen davon
US8003820B2 (en) *	2005-10-20	2011-08-23	Dr. Reddy's Laboratories Limited	Process for preparing bisphosphonic acids
WO2007083240A2 (en)	2006-01-20	2007-07-26	Aurobindo Pharma Limited	An improved process for the preparation of bisphosphonic acids
US8076483B2 (en) *	2006-05-11	2011-12-13	M/S. Ind Swift Laboratories Limited	Process for the preparation of pure risedronic acid or salts
US8779135B2 (en)	2009-10-02	2014-07-15	Straitmark Holding Ag	Method for the manufacture of aminohydroxy diphosphonic acids

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3016289A1 (de)	1980-04-28	1981-10-29	Henkel KGaA, 4000 Düsseldorf	Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4639338A (en) *	1984-08-06	1987-01-27	Ciba-Geigy Corporation	Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de) *	1984-09-21	1986-04-03	Henkel KGaA, 4000 Düsseldorf	4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it)	1984-10-29	1988-11-16	Gentili Ist Spa	Procedimento per la preparazione di acidi difosfonici
US4922007A (en) *	1989-06-09	1990-05-01	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en)	1990-06-20	1991-05-28	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
GB2248061A (en) *	1990-09-18	1992-03-25	Merck & Co Inc	Amino-hydroxy-alkylidene bis phosphonic acids
US5039819A (en)	1990-09-18	1991-08-13	Merck & Co., Inc.	Diphosphonate intermediate for preparing an antihypercalcemic agent
IT1246992B (it) *	1991-01-08	1994-12-12	Gentili Ist Spa	Procedimento per la preparazione di acidi difosfonici e loro sali
US5510517A (en) *	1993-08-25	1996-04-23	Merck & Co., Inc.	Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
TW257765B (de)	1993-08-25	1995-09-21	Merck & Co Inc
CA2197267C (en) *	1997-02-11	2000-02-08	Yong Tao	Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
IL144941A0 (en) *	1999-02-17	2002-06-30	Teva Pharma	Novel process for preparing alendronic acid

1999
- 1999-08-06 ES ES009901806A patent/ES2153794B1/es not_active Expired - Fee Related
2000
- 2000-07-17 AU AU59873/00A patent/AU5987300A/en not_active Abandoned
- 2000-07-17 US US10/048,267 patent/US6573401B1/en not_active Expired - Fee Related
- 2000-07-17 IL IL14800000A patent/IL148000A/xx not_active IP Right Cessation
- 2000-07-17 EP EP00945957A patent/EP1205484B1/de not_active Expired - Lifetime
- 2000-07-17 WO PCT/ES2000/000254 patent/WO2001010874A1/es active IP Right Grant
- 2000-07-17 HU HU0202196A patent/HUP0202196A3/hu unknown
- 2000-07-17 CA CA002380841A patent/CA2380841C/en not_active Expired - Fee Related
- 2000-07-17 AT AT00945957T patent/ATE238317T1/de not_active IP Right Cessation
- 2000-07-17 MX MXPA02001293A patent/MXPA02001293A/es active IP Right Grant
- 2000-07-17 DK DK00945957T patent/DK1205484T3/da active
- 2000-07-17 PT PT00945957T patent/PT1205484E/pt unknown
- 2000-07-17 ES ES00945957T patent/ES2194753T3/es not_active Expired - Lifetime
- 2000-07-17 PL PL354033A patent/PL191733B1/pl not_active IP Right Cessation
- 2000-07-17 DE DE60002347T patent/DE60002347T2/de not_active Expired - Fee Related
- 2000-07-17 KR KR1020027001589A patent/KR100688287B1/ko not_active IP Right Cessation
- 2000-07-17 SI SI200030140T patent/SI1205484T1/xx unknown
- 2000-07-17 BR BR0013031-1A patent/BR0013031A/pt not_active Application Discontinuation
2002
- 2002-01-31 CR CR6575A patent/CR6575A/es unknown

Also Published As

Publication number	Publication date
AU5987300A (en)	2001-03-05
HUP0202196A3 (en)	2002-12-28
PL191733B1 (pl)	2006-06-30
EP1205484A1 (de)	2002-05-15
EP1205484B1 (de)	2003-04-23
BR0013031A (pt)	2002-04-16
WO2001010874A1 (es)	2001-02-15
CA2380841A1 (en)	2001-02-15
ES2153794A1 (es)	2001-03-01
MXPA02001293A (es)	2002-07-22
HUP0202196A2 (en)	2002-10-28
IL148000A0 (en)	2002-09-12
PL354033A1 (en)	2003-12-15
US6573401B1 (en)	2003-06-03
CA2380841C (en)	2009-09-15
DE60002347T2 (de)	2004-02-12
DK1205484T3 (da)	2003-08-11
PT1205484E (pt)	2003-08-29
KR100688287B1 (ko)	2007-02-28
ES2194753T3 (es)	2003-12-01
ATE238317T1 (de)	2003-05-15
IL148000A (en)	2005-12-18
KR20020024320A (ko)	2002-03-29
ES2153794B1 (es)	2001-10-16
SI1205484T1 (en)	2003-12-31
CR6575A (es)	2002-08-16

Legal Events

Date	Code	Title	Description
2004-05-19	8364	No opposition during term of opposition
2011-05-19	8339	Ceased/non-payment of the annual fee

Publication	Publication Date	Title
ATE128470T1 (de)	1995-10-15	Verbessertes verfahren zur herstellung von salzen der 4-amino-1-hydroxybutyliden-1,1- bisphosphonsäure.
ATE233270T1 (de)	2003-03-15	Verfahren zur herstellung von dialkylphosphinsäuren
DE60002347D1 (de)	2003-05-28	Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure und ihres trihydratisierten mononatriumsalzes
ATE451380T1 (de)	2009-12-15	Verfahren zur herstellung von bisphosphonsäureverbindungen
DE50003162D1 (de)	2003-09-11	Verfahren zur Herstellung von Dialkylphosphinsäuren und deren Salzen
DE50001357D1 (de)	2003-04-10	Verfahren zur Herstellung von Phosphinsäureestern
ATE213249T1 (de)	2002-02-15	Verfahren zur herstellung von n- phosphonomethyliminodiessigesäure.
DE69920676D1 (de)	2004-11-04	Verfahren zur Herstellung von Amin-Umsetzungsprodukt-Teilchen
ATE413409T1 (de)	2008-11-15	Verfahren zur herstellung von ä1-hydroxy-2-(3- pyridinyl)ethylidenübisphosphonsäure und dem hemipentahydrat-mononatriumsalz davon
ATE302190T1 (de)	2005-09-15	Verfahren zur herstellung von chinolinderivaten und zwischenprodukten davon
ATE316975T1 (de)	2006-02-15	Verfahren zur herstellung von ethanbis(methylphosphinsäure)
DE50005649D1 (de)	2004-04-22	Verfahren zur Herstellung von Alkylphosphonsäuren
DE60015563D1 (de)	2004-12-09	Verfahren zur herstellung von benzoperhydroisoindolen
ATE121410T1 (de)	1995-05-15	Verfahren zur herstellung von diphosphonsäuren und salzen davon.
ATE155789T1 (de)	1997-08-15	Verfahren zur herstellung von aminomethanphosphonsäure
AT399877B (de)	1995-08-25	Neues verfahren zur herstellung von ceftriaxon
DE69914493D1 (de)	2004-03-04	Verfahren zur herstellung von 2-hydroxy-6-trifluormethylpyridin
DE50003163D1 (de)	2003-09-11	Verfahren zur Herstellung von Alkylphosphonigsäureestern
ATE247084T1 (de)	2003-08-15	Verfahren zur herstellung von hydroxamsäuren
DE50001638D1 (de)	2003-05-08	Verfahren zur herstellung von 4,6-dichlorpyrimidin