DE602007012247D1 - Prodrugs von 5-amino-3-(3'-deoxy-beta-d-ribofuranosyl)-thiazolä4,5-düpyrimidin-2,7-dion - Google Patents

Prodrugs von 5-amino-3-(3'-deoxy-beta-d-ribofuranosyl)-thiazolä4,5-düpyrimidin-2,7-dion

Info

Publication number
DE602007012247D1
DE602007012247D1 DE602007012247T DE602007012247T DE602007012247D1 DE 602007012247 D1 DE602007012247 D1 DE 602007012247D1 DE 602007012247 T DE602007012247 T DE 602007012247T DE 602007012247 T DE602007012247 T DE 602007012247T DE 602007012247 D1 DE602007012247 D1 DE 602007012247D1
Authority
DE
Germany
Prior art keywords
thiazola4
dupryidin
dion
ribofuranosyl
deoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007012247T
Other languages
English (en)
Inventor
Gregory J Haley
Joseph R Lennox
Alan Xin Xiang
Stephen E Webber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anadys Pharmaceuticals Inc
Original Assignee
Anadys Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anadys Pharmaceuticals Inc filed Critical Anadys Pharmaceuticals Inc
Publication of DE602007012247D1 publication Critical patent/DE602007012247D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
DE602007012247T 2006-06-22 2007-06-21 Prodrugs von 5-amino-3-(3'-deoxy-beta-d-ribofuranosyl)-thiazolä4,5-düpyrimidin-2,7-dion Active DE602007012247D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81557606P 2006-06-22 2006-06-22
PCT/US2007/071830 WO2007150002A2 (en) 2006-06-22 2007-06-21 PRODRUGS OF 5-AMINO-3-(3'-DEOXY-β-D-RIBOFURANOSYL)-THIAZOLO[4,5-d] PYRIMIDIN-2,7-DIONE

Publications (1)

Publication Number Publication Date
DE602007012247D1 true DE602007012247D1 (de) 2011-03-10

Family

ID=38834404

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007012247T Active DE602007012247D1 (de) 2006-06-22 2007-06-21 Prodrugs von 5-amino-3-(3'-deoxy-beta-d-ribofuranosyl)-thiazolä4,5-düpyrimidin-2,7-dion

Country Status (16)

Country Link
US (1) US7709448B2 (de)
EP (1) EP2034834B1 (de)
JP (1) JP5345527B2 (de)
KR (1) KR101461604B1 (de)
CN (1) CN101516192B (de)
AR (1) AR061580A1 (de)
AT (1) ATE496924T1 (de)
AU (1) AU2007260828B2 (de)
BR (1) BRPI0713680A2 (de)
CA (1) CA2655904C (de)
DE (1) DE602007012247D1 (de)
HK (1) HK1126353A1 (de)
IL (1) IL196107A0 (de)
MX (1) MX2008016518A (de)
TW (1) TWI418561B (de)
WO (1) WO2007150002A2 (de)

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US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
EA200801404A1 (ru) 2005-11-21 2008-10-30 Анадис Фармасьютикалз, Инк. Новый способ получения 5-амино-3н-тиазоло[4,5-d]пиримидин-2-она
DE602007012881D1 (en) * 2006-07-18 2011-04-14 Anadys Pharmaceuticals Inc Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen
BRPI0717741A2 (pt) * 2006-10-17 2014-04-08 Anadys Pharmaceuticals Inc Compostos e respectivos método de preparação, método de redução de composto de sulfonil substituído, composição farmacêutica método de tratamento ou prevenção de doença
US20110166092A1 (en) * 2007-08-20 2011-07-07 Anadys Pharmaceuticals, Inc. Dosing methods for treating disease
CN104402945A (zh) * 2014-11-27 2015-03-11 苏州乔纳森新材料科技有限公司 一种3-脱氧-1,2-o-异丙叉-d-呋喃木糖的合成方法
KR20230113824A (ko) * 2014-12-08 2023-08-01 에프. 호프만-라 로슈 아게 바이러스 감염의 치료 또는 예방을 위한 3-치환된 5-아미노-6H-티아졸로[4,5-d]피리미딘-2,7-다이온화합물
EP3695837A1 (de) * 2015-03-16 2020-08-19 F. Hoffmann-La Roche AG Kombinierte behandlung mit einem tlr7-agonisten und einem hbv-capsid-anordnungsinhibitor
CN107743491B (zh) 2015-05-08 2020-08-21 豪夫迈·罗氏有限公司 用于治疗和预防病毒感染的新的氧硫杂环戊烷甲酸及其衍生物
EP4001283A1 (de) * 2015-05-12 2022-05-25 F. Hoffmann-La Roche AG Substituiertes aminothiazolpyrimidindion zur behandlung und prophylaxe einer virusinfektion
JP6839104B2 (ja) * 2015-06-30 2021-03-03 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ウイルス感染の治療及び予防のための新規な置換アミノチアゾロピリミジンジオン
AU2018205994B2 (en) 2017-01-06 2021-09-09 F. Hoffmann-La Roche Ag Process for the preparation of 3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds

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Also Published As

Publication number Publication date
WO2007150002A2 (en) 2007-12-27
WO2007150002A3 (en) 2008-09-12
US20080032999A1 (en) 2008-02-07
CA2655904A1 (en) 2007-12-27
AU2007260828B2 (en) 2013-03-07
ATE496924T1 (de) 2011-02-15
EP2034834B1 (de) 2011-01-26
EP2034834A4 (de) 2010-03-24
TWI418561B (zh) 2013-12-11
JP5345527B2 (ja) 2013-11-20
BRPI0713680A2 (pt) 2012-10-23
AU2007260828A1 (en) 2007-12-27
JP2009541349A (ja) 2009-11-26
MX2008016518A (es) 2009-01-19
CA2655904C (en) 2014-11-18
TW200823226A (en) 2008-06-01
CN101516192B (zh) 2012-09-19
US7709448B2 (en) 2010-05-04
EP2034834A2 (de) 2009-03-18
AR061580A1 (es) 2008-09-03
KR20090033876A (ko) 2009-04-06
CN101516192A (zh) 2009-08-26
HK1126353A1 (de) 2009-09-04
IL196107A0 (en) 2009-09-01
KR101461604B1 (ko) 2014-11-18

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