DE602006020754D1 - Carbamatverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren - Google Patents
Carbamatverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibierenInfo
- Publication number
- DE602006020754D1 DE602006020754D1 DE602006020754T DE602006020754T DE602006020754D1 DE 602006020754 D1 DE602006020754 D1 DE 602006020754D1 DE 602006020754 T DE602006020754 T DE 602006020754T DE 602006020754 T DE602006020754 T DE 602006020754T DE 602006020754 D1 DE602006020754 D1 DE 602006020754D1
- Authority
- DE
- Germany
- Prior art keywords
- vla
- leukocyte adhesion
- compounds
- adhesion mediated
- carbamate compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- AIDS & HIV (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72235505P | 2005-09-29 | 2005-09-29 | |
PCT/US2006/038113 WO2007041324A1 (en) | 2005-09-29 | 2006-09-28 | Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006020754D1 true DE602006020754D1 (de) | 2011-04-28 |
Family
ID=37591849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006020754T Active DE602006020754D1 (de) | 2005-09-29 | 2006-09-28 | Carbamatverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren |
Country Status (11)
Country | Link |
---|---|
US (3) | US7727996B2 (de) |
EP (1) | EP1940827B1 (de) |
JP (2) | JP5081828B2 (de) |
CN (1) | CN101273035A (de) |
AT (1) | ATE502031T1 (de) |
AU (1) | AU2006297180A1 (de) |
BR (1) | BRPI0616643A2 (de) |
CA (2) | CA2851103A1 (de) |
DE (1) | DE602006020754D1 (de) |
WO (1) | WO2007041324A1 (de) |
ZA (1) | ZA200803016B (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1144388B1 (de) * | 1999-01-22 | 2010-01-13 | Elan Pharmaceuticals, Inc. | Acyl derivate zur behandlung von krankheiten die in zusammenhang mit vla-4 stehen |
WO2007041324A1 (en) | 2005-09-29 | 2007-04-12 | Elan Pharmaceuticals, Inc. | Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4 |
KR20080059268A (ko) * | 2005-09-29 | 2008-06-26 | 엘란 파마슈티칼스, 인크. | Vla-4에 의해 매개되는 백혈구 부착을 억제하는피리미디닐 아미드 화합물 |
WO2007101165A1 (en) * | 2006-02-27 | 2007-09-07 | Elan Pharmaceuticals, Inc. | Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4 |
US8367836B2 (en) * | 2009-04-27 | 2013-02-05 | Elan Pharmaceuticals, Inc. | Pyridinone antagonists of alpha-4 integrins |
WO2011020874A1 (en) | 2009-08-20 | 2011-02-24 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy |
AU2017234010A1 (en) * | 2016-03-14 | 2018-09-27 | Millennium Pharmaceuticals, Inc. | Methods of treating or preventing graft versus host disease |
WO2019070827A1 (en) * | 2017-10-04 | 2019-04-11 | Celgene Corporation | PROCESSES FOR THE PREPARATION OF CIS-4 [2 - {(3S, 4R) -3-FLUOROOXAN-4-YL] AMINO) -8- (2,4,6-TRICHLOROANILINO) -9H-PURIN-9-YL] -1 -MÉTHYLCYCLOHEXANE-1-carboxamide |
EP4284947A1 (de) | 2021-01-29 | 2023-12-06 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Verfahren zur beurteilung des risikos der entwicklung progressiver multifokaler leukoenzephalopathie bei patienten mit vla-4-antagonisten |
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US408A (en) * | 1837-09-25 | Machine for | ||
DE2525656A1 (de) | 1974-06-19 | 1976-01-15 | Sandoz Ag | Verfahren zur herstellung neuer heterocyclischer verbindungen |
US4096255A (en) | 1974-11-08 | 1978-06-20 | Mitsubishi Chemical Industries Limited | N2 -naphthalenesulfonyl-L-argininamides, and pharmaceutical salts, compositions and methods |
US4104392A (en) | 1974-11-08 | 1978-08-01 | Mitsubishi Chemical Industries Ltd. | N2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof, and antithrombotic compositions and methods employing them |
US4070457A (en) | 1974-11-08 | 1978-01-24 | Mitsubishi Chemical Industries Ltd. | N2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
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US4041156A (en) | 1974-11-08 | 1977-08-09 | Mitsubishi Chemical Industries Limited | N2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
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US4046876A (en) | 1974-11-08 | 1977-09-06 | Mitsubishi Chemical Industries Limited | N2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
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-
2006
- 2006-09-28 WO PCT/US2006/038113 patent/WO2007041324A1/en active Application Filing
- 2006-09-28 BR BRPI0616643-1A patent/BRPI0616643A2/pt not_active IP Right Cessation
- 2006-09-28 CA CA2851103A patent/CA2851103A1/en not_active Abandoned
- 2006-09-28 CN CNA200680035707XA patent/CN101273035A/zh active Pending
- 2006-09-28 US US11/541,205 patent/US7727996B2/en not_active Expired - Fee Related
- 2006-09-28 CA CA2624524A patent/CA2624524C/en not_active Expired - Fee Related
- 2006-09-28 AU AU2006297180A patent/AU2006297180A1/en not_active Abandoned
- 2006-09-28 EP EP06804266A patent/EP1940827B1/de active Active
- 2006-09-28 JP JP2008533682A patent/JP5081828B2/ja not_active Expired - Fee Related
- 2006-09-28 AT AT06804266T patent/ATE502031T1/de not_active IP Right Cessation
- 2006-09-28 ZA ZA200803016A patent/ZA200803016B/xx unknown
- 2006-09-28 DE DE602006020754T patent/DE602006020754D1/de active Active
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2009
- 2009-10-15 US US12/579,828 patent/US8158642B2/en not_active Expired - Fee Related
-
2010
- 2010-04-13 US US12/759,419 patent/US8367688B2/en not_active Expired - Fee Related
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2012
- 2012-07-19 JP JP2012160870A patent/JP2012197319A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20100113434A1 (en) | 2010-05-06 |
CN101273035A (zh) | 2008-09-24 |
US8367688B2 (en) | 2013-02-05 |
US8158642B2 (en) | 2012-04-17 |
JP2009510103A (ja) | 2009-03-12 |
EP1940827B1 (de) | 2011-03-16 |
BRPI0616643A2 (pt) | 2011-06-28 |
JP5081828B2 (ja) | 2012-11-28 |
JP2012197319A (ja) | 2012-10-18 |
WO2007041324A1 (en) | 2007-04-12 |
US7727996B2 (en) | 2010-06-01 |
CA2851103A1 (en) | 2007-04-12 |
ZA200803016B (en) | 2009-10-28 |
CA2624524C (en) | 2014-07-08 |
ATE502031T1 (de) | 2011-04-15 |
US20070129390A1 (en) | 2007-06-07 |
EP1940827A1 (de) | 2008-07-09 |
CA2624524A1 (en) | 2007-04-12 |
AU2006297180A1 (en) | 2007-04-12 |
US20100261715A1 (en) | 2010-10-14 |
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