DE602006012816D1 - Tifizierung von zellulären folat vitamin rezeptoren - Google Patents

Tifizierung von zellulären folat vitamin rezeptoren

Info

Publication number
DE602006012816D1
DE602006012816D1 DE602006012816T DE602006012816T DE602006012816D1 DE 602006012816 D1 DE602006012816 D1 DE 602006012816D1 DE 602006012816 T DE602006012816 T DE 602006012816T DE 602006012816 T DE602006012816 T DE 602006012816T DE 602006012816 D1 DE602006012816 D1 DE 602006012816D1
Authority
DE
Germany
Prior art keywords
folat
tification
cellular
vitamin receptors
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006012816T
Other languages
English (en)
Inventor
Philip Stewart Low
Lynn C Hartmann
Christopher Paul Leamon
Phil Ronald Ellis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mayo Foundation for Medical Education and Research
Purdue Research Foundation
Endocyte Inc
Original Assignee
Mayo Foundation for Medical Education and Research
Purdue Research Foundation
Endocyte Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation for Medical Education and Research, Purdue Research Foundation, Endocyte Inc filed Critical Mayo Foundation for Medical Education and Research
Publication of DE602006012816D1 publication Critical patent/DE602006012816D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE602006012816T 2005-03-30 2006-03-30 Tifizierung von zellulären folat vitamin rezeptoren Active DE602006012816D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66643005P 2005-03-30 2005-03-30
PCT/US2006/011376 WO2006105141A1 (en) 2005-03-30 2006-03-30 Method for cancer prognosis using cellular folate vitamin receptor quantification

Publications (1)

Publication Number Publication Date
DE602006012816D1 true DE602006012816D1 (de) 2010-04-22

Family

ID=36754569

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006012816T Active DE602006012816D1 (de) 2005-03-30 2006-03-30 Tifizierung von zellulären folat vitamin rezeptoren

Country Status (10)

Country Link
US (1) US20090081710A1 (de)
EP (2) EP2199796A1 (de)
JP (1) JP2008537778A (de)
CN (1) CN101203759A (de)
AT (1) ATE460668T1 (de)
AU (1) AU2006230219A1 (de)
CA (1) CA2602585A1 (de)
DE (1) DE602006012816D1 (de)
RU (1) RU2007139912A (de)
WO (1) WO2006105141A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE427948T1 (de) 2001-04-24 2009-04-15 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
AU2003243226A1 (en) 2002-05-15 2003-12-02 Endocyte, Inc. Vitamin-mitomycin conjugates
DK1592457T3 (da) 2003-01-27 2012-10-22 Endocyte Inc Folat-vinblastin-konjugat som lægemiddel
EP3101034A1 (de) 2004-02-12 2016-12-07 Morphotek, Inc. Monoklonale, spezifisch an folatrezeptor-alpha bindende antikörper
WO2006012527A1 (en) 2004-07-23 2006-02-02 Endocyte, Inc. Bivalent linkers and conjugates thereof
EP1863816B1 (de) 2005-03-16 2014-06-25 Endocyte, Inc. Synthese und aufreinigung von pteroinsäure und konjugaten davon
EP1879922A2 (de) 2005-04-22 2008-01-23 Morphotek, Inc. Antikörper mit immuneffektoraktivität, die in alpha-positive folatrezeptorzellen internalisiert werden
CN103893778A (zh) 2005-08-19 2014-07-02 恩多塞特公司 多药物配体缀合物
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
NZ599239A (en) 2007-03-14 2013-10-25 Endocyte Inc Binding ligand linked drug delivery conjugates of tubulysins
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
AU2008268432B2 (en) 2007-06-25 2015-01-15 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
JP2011500835A (ja) 2007-10-25 2011-01-06 エンドサイト，インコーポレイテッド チューブリシン類および調製プロセス
JP2013501224A (ja) * 2009-07-31 2013-01-10 エンドサイト，インク． 葉酸を標的とした診断及び処置
EP3196212B1 (de) 2010-02-24 2020-06-03 ImmunoGen, Inc. Immunkonjugate die einen folat-rezeptor-1-antikörper beinhalten
WO2012061759A2 (en) * 2010-11-05 2012-05-10 Morphotek Inc. Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers
CN103403552B (zh) * 2010-11-12 2016-01-06 恩多塞特公司 治疗癌症的方法
EA028805B1 (ru) * 2011-04-01 2018-01-31 Иммьюноджен, Инк. Способы повышения эффективности folr1 терапии рака
PL2731972T3 (pl) 2011-07-15 2018-06-29 Eisai R&D Management Co., Ltd. Przeciwciała skierowane przeciwko receptorowi folianowemu alfa i ich zastosowania
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
KR20200079565A (ko) 2012-08-31 2020-07-03 이뮤노젠 아이엔씨 엽산 수용체 1의 검출을 위한 진단성 검정 및 키트
CN102861020A (zh) * 2012-09-25 2013-01-09 上海交通大学医学院附属仁济医院 叶酸在制备预防大肠腺瘤初发药物中的应用
CA2887727A1 (en) 2012-10-16 2014-04-24 Endocyte, Inc. Drug delivery conjugates containing unnatural amino acids and methods for using
US20140154702A1 (en) * 2012-11-30 2014-06-05 Endocyte, Inc. Methods For Treating Cancer Using Combination Therapies
HUE055856T2 (hu) 2013-08-30 2021-12-28 Immunogen Inc Antitestek és vizsgálatok a folsavreceptor 1 kimutatására
KR102115217B1 (ko) * 2013-10-08 2020-05-26 이뮤노젠 아이엔씨 항-folr1 면역접합체 투여 레지멘
ES2860173T3 (es) 2013-11-19 2021-10-04 Purdue Research Foundation Método de selección de pacientes para inflamación
JP6246030B2 (ja) * 2014-03-12 2017-12-13 東芝メディカルシステムズ株式会社 病理染色装置及び病理染色方法
AU2016323968B2 (en) 2015-09-17 2023-07-06 Immunogen, Inc. Therapeutic combinations comprising anti-FOLR1 immunoconjugates
US11313868B2 (en) 2016-06-14 2022-04-26 Board Of Regents, The University Of Texas System Methods of detecting anti-folic acid antibodies and uses thereof
CN106483282B (zh) * 2016-09-29 2018-08-31 北京世纪沃德生物科技有限公司 一种抗原稳定剂及其制备方法与应用
WO2018098277A1 (en) 2016-11-23 2018-05-31 Eisai R&D Management Co., Ltd Anti-folate receptor alpha antibodies and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5989838A (en) 1992-03-11 1999-11-23 Institute Of Virology, Slovak Academy Of Sciences Immunological methods of detecting MN proteins and MN polypeptides
US6218529B1 (en) * 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
US5846739A (en) 1995-12-05 1998-12-08 Wisconsin Alumni Research Foundation Immunohistochemical detection assay for carcinoma proliferative status
US6358682B1 (en) * 1998-01-26 2002-03-19 Ventana Medical Systems, Inc. Method and kit for the prognostication of breast cancer
CZ304942B6 (cs) * 2000-03-31 2015-02-04 Purdue Research Foundation Léčivo pro zvyšování specifické eliminace populace tumorových buněk a farmaceutický prostředek obsahující konjugát fosfát-FITC nebo fosfát-dinitrofenyl
DK1434603T3 (da) 2001-09-28 2010-04-26 Purdue Research Foundation Fremgangsmåde til behandling ved anvendelse af ligand-immunogen-konjugater
EP1496934A4 (de) 2002-04-19 2006-08-02 Endocyte Inc Adjuvante verbesserte immunotherapie
AU2003243226A1 (en) 2002-05-15 2003-12-02 Endocyte, Inc. Vitamin-mitomycin conjugates
DK1592457T3 (da) * 2003-01-27 2012-10-22 Endocyte Inc Folat-vinblastin-konjugat som lægemiddel

Also Published As

Publication number Publication date
AU2006230219A1 (en) 2006-10-05
EP2199796A1 (de) 2010-06-23
EP1864133B1 (de) 2010-03-10
US20090081710A1 (en) 2009-03-26
CN101203759A (zh) 2008-06-18
ATE460668T1 (de) 2010-03-15
WO2006105141A1 (en) 2006-10-05
JP2008537778A (ja) 2008-09-25
EP1864133A1 (de) 2007-12-12
CA2602585A1 (en) 2006-10-05
RU2007139912A (ru) 2009-05-10

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Legal Events

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