DE602006009901D1 - Verfahren zur herstellung von 7-ethyl-10-hydroxycamptothecin - Google Patents

Verfahren zur herstellung von 7-ethyl-10-hydroxycamptothecin

Info

Publication number
DE602006009901D1
DE602006009901D1 DE602006009901T DE602006009901T DE602006009901D1 DE 602006009901 D1 DE602006009901 D1 DE 602006009901D1 DE 602006009901 T DE602006009901 T DE 602006009901T DE 602006009901 T DE602006009901 T DE 602006009901T DE 602006009901 D1 DE602006009901 D1 DE 602006009901D1
Authority
DE
Germany
Prior art keywords
ethyl
hydroxycamptothecin
preparation
temperature
pyrano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006009901T
Other languages
English (en)
Inventor
Ilpo Laitinen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fermion Oy
Original Assignee
Fermion Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fermion Oy filed Critical Fermion Oy
Publication of DE602006009901D1 publication Critical patent/DE602006009901D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602006009901T 2005-02-07 2006-02-06 Verfahren zur herstellung von 7-ethyl-10-hydroxycamptothecin Active DE602006009901D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65017505P 2005-02-07 2005-02-07
PCT/FI2006/000034 WO2006082279A1 (en) 2005-02-07 2006-02-06 Process for the manufacturing of 7-ethyl-10-hydroxy camptothecin

Publications (1)

Publication Number Publication Date
DE602006009901D1 true DE602006009901D1 (de) 2009-12-03

Family

ID=36588759

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006009901T Active DE602006009901D1 (de) 2005-02-07 2006-02-06 Verfahren zur herstellung von 7-ethyl-10-hydroxycamptothecin

Country Status (9)

Country Link
US (1) US7910737B2 (de)
EP (1) EP1846412B1 (de)
JP (1) JP5133705B2 (de)
AT (1) ATE446299T1 (de)
CA (1) CA2591081C (de)
DE (1) DE602006009901D1 (de)
ES (1) ES2333462T3 (de)
PL (1) PL1846412T3 (de)
WO (1) WO2006082279A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5133705B2 (ja) 2005-02-07 2013-01-30 フェルミオン オサケ ユキチュア ７−エチル−１０−ヒドロキシカンプトテシンの製造方法
JP5133703B2 (ja) * 2005-02-08 2013-01-30 フェルミオン オサケ ユキチュア ［１，４’］ビピペリジニル−１’−カルボニルクロリドまたはその塩酸塩の製造方法
EP1928883B1 (de) * 2005-02-08 2013-10-30 Fermion Oy Verfahren zur herstellung von irinotecanhydrochlorid
TWI375678B (en) 2005-06-09 2012-11-01 Yakult Honsha Kk A method of preparation of a tricyclic ketone
EP2082741A1 (de) * 2005-09-20 2009-07-29 Scinopharm Singapore Pte, Ltd. Neue Kristallform von Irinotecan-Hydrochlorid
WO2009002489A2 (en) 2007-06-25 2008-12-31 Scinopharm Taiwan Ltd. Crystalline polymorph of 7-ethyl-10-hydroxycamptothecin
WO2012032531A1 (en) * 2010-09-06 2012-03-15 Avra Laboratories Pvt. Ltd. Process for the manufacture of irinotecan hydrochloride by total synthesis
KR101327720B1 (ko) * 2013-02-15 2013-11-11 제일약품주식회사 이리노테칸의 제조방법
EA032135B1 (ru) * 2014-10-22 2019-04-30 Вивэситас Онколоджи Инк. Способы и системы для синтеза аналогов камптотецина

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US182990A (en) * 1876-10-10 Improvement in corner-finish for rooms
US103309A (en) * 1870-05-24 Improvement in machines for burring wool
US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS6019790A (ja) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US4894456A (en) * 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5053512A (en) * 1987-04-14 1991-10-01 Research Triangle Institute Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
IL117684A (en) * 1995-04-07 2002-02-10 Pharmacia & Upjohn Inc Intermediates and Process for Production of History of Kempotocin (CPT-11) and Related Compounds
KR20010072228A (ko) * 1998-08-05 2001-07-31 추후제출 위장 독성이 감소된 캠프토테신 유도체의 용도
TWI245768B (en) * 2001-02-21 2005-12-21 Yakult Honsha Kk Process for synthesizing camptothecin related compound(s)
KR20040091083A (ko) 2002-03-01 2004-10-27 파마시아 이탈리아 에스.피.에이. 이리노테칸 히드로클로라이드의 결정성 다형체
JP3839813B2 (ja) 2002-04-17 2006-11-01 ファルマシア コーポレイション カンプトテシン誘導体の調製に有用な化合物
US20050267141A1 (en) 2004-05-28 2005-12-01 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives
WO2006016203A1 (en) 2004-08-09 2006-02-16 Shilpa Medicare Limited An improved process for the preparation of irinotecan hydrochloride trihydrate
JP5133705B2 (ja) 2005-02-07 2013-01-30 フェルミオン オサケ ユキチュア ７−エチル−１０−ヒドロキシカンプトテシンの製造方法

Also Published As

Publication number Publication date
ES2333462T3 (es) 2010-02-22
PL1846412T3 (pl) 2010-03-31
JP5133705B2 (ja) 2013-01-30
US7910737B2 (en) 2011-03-22
US20080103309A1 (en) 2008-05-01
EP1846412B1 (de) 2009-10-21
WO2006082279A1 (en) 2006-08-10
CA2591081A1 (en) 2006-08-10
EP1846412A1 (de) 2007-10-24
JP2008529993A (ja) 2008-08-07
ATE446299T1 (de) 2009-11-15
CA2591081C (en) 2014-10-28

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