DE602005006840D1 - 1,2,3,3a;8,8a-hexahydro-2,7a-diazacyclopentaäaüinden-7-onderivate, die sich an neuronale nikotinische acetylcholinspezifische rezeptorstellen binden und zur modulation der cholinergen funktion und zur behandlung von suchterkrankungen eignen - Google Patents

1,2,3,3a;8,8a-hexahydro-2,7a-diazacyclopentaäaüinden-7-onderivate, die sich an neuronale nikotinische acetylcholinspezifische rezeptorstellen binden und zur modulation der cholinergen funktion und zur behandlung von suchterkrankungen eignen

Info

Publication number: DE602005006840D1
Authority: DE; Germany
Prior art keywords: onderivates; diazacyclopentaaeindene; cholinergen; hexahydro; modulating
Prior art date: 2004-12-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE602005006840T

Other languages

English (en)

Inventor

Brian Thomas O'neill

Kristen Procko

Daniel Yohannes

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Products Inc

Original Assignee

Pfizer Products Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-07

Filing date

2005-11-30

Publication date

2008-06-26

2005-11-30 Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc

2008-06-26 Publication of DE602005006840D1 publication Critical patent/DE602005006840D1/de

Status Expired - Fee Related legal-status Critical Current

2025-12-01 Anticipated expiration legal-status Critical

Links

208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
201000010099 disease Diseases 0.000 title 1
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
241000208125 Nicotiana Species 0.000 abstract 1
235000002637 Nicotiana tabacum Nutrition 0.000 abstract 1
230000006949 cholinergic function Effects 0.000 abstract 1
230000000926 neurological effect Effects 0.000 abstract 1
229960002715 nicotine Drugs 0.000 abstract 1
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
208000020016 psychiatric disease Diseases 0.000 abstract 1
UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Psychiatry (AREA)
Psychology (AREA)
Addiction (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DE602005006840T 2004-12-07 2005-11-30 1,2,3,3a;8,8a-hexahydro-2,7a-diazacyclopentaäaüinden-7-onderivate, die sich an neuronale nikotinische acetylcholinspezifische rezeptorstellen binden und zur modulation der cholinergen funktion und zur behandlung von suchterkrankungen eignen Expired - Fee Related DE602005006840D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US63389804P	2004-12-07	2004-12-07
PCT/IB2005/003730 WO2006061711A1 (en)	2004-12-07	2005-11-30	1, 2, 3, 3a, 8, 8a-hexahydro-2, 7a-diada-cyclopenta [a] inden-7-one derivatives which bind to neuronal nicotinic acetylcholine specific receptor sites and are useful in modulating cholinergic function and in the treatment of addictive disorders

Publications (1)

Publication Number	Publication Date
DE602005006840D1 true DE602005006840D1 (de)	2008-06-26

Family

ID=35901719

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE602005006840T Expired - Fee Related DE602005006840D1 (de)	2004-12-07	2005-11-30	1,2,3,3a;8,8a-hexahydro-2,7a-diazacyclopentaäaüinden-7-onderivate, die sich an neuronale nikotinische acetylcholinspezifische rezeptorstellen binden und zur modulation der cholinergen funktion und zur behandlung von suchterkrankungen eignen

Country Status (8)

Country	Link
US (1)	US20090093512A1 (de)
EP (1)	EP1824852B1 (de)
JP (1)	JP2008523045A (de)
AT (1)	ATE395348T1 (de)
CA (1)	CA2591330A1 (de)
DE (1)	DE602005006840D1 (de)
ES (1)	ES2306250T3 (de)
WO (1)	WO2006061711A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102007036068A1 (de) *	2007-08-01	2009-02-05	Wacker Chemie Ag	Verfahren zur Herstellung von Alkyl-methoxymethyl-trimethylsilanylmethylaminen
SG172217A1 (en) *	2008-12-16	2011-07-28	Hoffmann La Roche	Process for the preparation of pyrollidine-3-carboxylic acids
GB201121128D0 (en) *	2011-12-08	2012-01-18	Dow Corning	Treatment of filler with silane
GB201121124D0 (en) *	2011-12-08	2012-01-18	Dow Corning	Hydrolysable silanes
JP6440625B2 (ja)	2012-11-14	2018-12-19	ザ・ジョンズ・ホプキンス・ユニバーシティー	精神***病を処置するための方法および組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69735891T2 (de) *	1996-10-30	2006-12-14	Pfizer Inc.	Pyridon-kondensierte azabicyclische- oder cytisinderivate, ihre herstellung und verwendung in der suchttherapie
CA2330576A1 (en) *	1998-04-29	1999-11-04	Pfizer Products Inc.	Substituted benzazocines as nicotine-binding inhibitors

2005
- 2005-11-30 DE DE602005006840T patent/DE602005006840D1/de not_active Expired - Fee Related
- 2005-11-30 CA CA002591330A patent/CA2591330A1/en not_active Abandoned
- 2005-11-30 EP EP05811074A patent/EP1824852B1/de not_active Not-in-force
- 2005-11-30 ES ES05811074T patent/ES2306250T3/es active Active
- 2005-11-30 JP JP2007545013A patent/JP2008523045A/ja not_active Withdrawn
- 2005-11-30 AT AT05811074T patent/ATE395348T1/de not_active IP Right Cessation
- 2005-11-30 US US11/814,168 patent/US20090093512A1/en not_active Abandoned
- 2005-11-30 WO PCT/IB2005/003730 patent/WO2006061711A1/en active IP Right Grant

Also Published As

Publication number	Publication date
EP1824852B1 (de)	2008-05-14
CA2591330A1 (en)	2006-06-15
US20090093512A1 (en)	2009-04-09
ATE395348T1 (de)	2008-05-15
ES2306250T3 (es)	2008-11-01
WO2006061711A1 (en)	2006-06-15
EP1824852A1 (de)	2007-08-29
JP2008523045A (ja)	2008-07-03

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Legal Events

Date	Code	Title	Description
2009-06-04	8364	No opposition during term of opposition
2010-09-16	8339	Ceased/non-payment of the annual fee