DE602005002776D1 - Verfahren zur Herstellung von 1,3-Dihydro-2H-3-Benzazepin-2-on und Anwendung zur Herstellung von Ivabradine und ihren pharmazeutischen annehmbaren Salzen - Google Patents

Verfahren zur Herstellung von 1,3-Dihydro-2H-3-Benzazepin-2-on und Anwendung zur Herstellung von Ivabradine und ihren pharmazeutischen annehmbaren Salzen

Info

Publication number
DE602005002776D1
DE602005002776D1 DE602005002776T DE602005002776T DE602005002776D1 DE 602005002776 D1 DE602005002776 D1 DE 602005002776D1 DE 602005002776 T DE602005002776 T DE 602005002776T DE 602005002776 T DE602005002776 T DE 602005002776T DE 602005002776 D1 DE602005002776 D1 DE 602005002776D1
Authority
DE
Germany
Prior art keywords
preparation
ivabradine
benzazepin
dihydro
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005002776T
Other languages
English (en)
Other versions
DE602005002776T2 (de
Inventor
Jean-Michel Lerestif
Jean-Pierre Lecouve
Daniel Brigot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Publication of DE602005002776D1 publication Critical patent/DE602005002776D1/de
Application granted granted Critical
Publication of DE602005002776T2 publication Critical patent/DE602005002776T2/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE602005002776T 2004-04-13 2005-02-21 Verfahren zur Herstellung von 1,3-Dihydro-2H-3-Benzazepin-2-on und Anwendung zur Herstellung von Ivabradine und ihren pharmazeutischen annehmbaren Salzen Active DE602005002776T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0403829 2004-04-13
FR0403829A FR2868776B1 (fr) 2004-04-13 2004-04-13 Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (2)

Publication Number Publication Date
DE602005002776D1 true DE602005002776D1 (de) 2007-11-22
DE602005002776T2 DE602005002776T2 (de) 2008-08-28

Family

ID=34941960

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005002776T Active DE602005002776T2 (de) 2004-04-13 2005-02-21 Verfahren zur Herstellung von 1,3-Dihydro-2H-3-Benzazepin-2-on und Anwendung zur Herstellung von Ivabradine und ihren pharmazeutischen annehmbaren Salzen

Country Status (33)

Country Link
US (1) US7074920B2 (de)
EP (1) EP1589014B1 (de)
JP (2) JP4511970B2 (de)
KR (1) KR100636500B1 (de)
CN (1) CN1332951C (de)
AR (1) AR047686A1 (de)
AT (1) ATE375339T1 (de)
AU (1) AU2005200860B2 (de)
BR (1) BRPI0500478B8 (de)
CA (1) CA2496721C (de)
CY (1) CY1107101T1 (de)
DE (1) DE602005002776T2 (de)
DK (1) DK1589014T3 (de)
EA (1) EA007744B1 (de)
ES (1) ES2294652T3 (de)
FR (1) FR2868776B1 (de)
GE (1) GEP20074137B (de)
HK (1) HK1079776A1 (de)
HR (1) HRP20070503T3 (de)
MA (1) MA27599A1 (de)
ME (1) ME01402B (de)
MX (1) MXPA05003695A (de)
MY (1) MY141223A (de)
NO (1) NO329438B1 (de)
NZ (1) NZ538327A (de)
PL (1) PL1589014T3 (de)
PT (1) PT1589014E (de)
RS (1) RS50546B (de)
SG (1) SG116573A1 (de)
SI (1) SI1589014T1 (de)
UA (1) UA81772C2 (de)
WO (1) WO2005111026A1 (de)
ZA (1) ZA200501467B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
US8212026B2 (en) 2007-05-30 2012-07-03 Ind-Swift Laboratories Limited Process for the preparation of ivabradine hydrochloride and polymorph thereof
WO2010072409A1 (en) 2008-12-22 2010-07-01 Krka, D. D., Novo Mesto Process for preparation of ivabradine
EP2902384B1 (de) 2010-02-12 2017-11-08 KRKA, D.D., Novo Mesto Form von ivabradin-hydrochlorid
FR2956401B1 (fr) * 2010-02-17 2012-02-03 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2984320B1 (fr) * 2011-12-20 2013-11-29 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490369A (en) * 1981-05-19 1984-12-25 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Benzazepine derivatives, their pharmaceutical compositions and method of use
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3242599A1 (de) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3418270A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3519735A1 (de) * 1985-06-01 1986-12-04 Dr. Karl Thomae Gmbh, 7950 Biberach Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) * 1985-06-01 1990-01-03 Dr. Karl Thomae GmbH Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JP2568416B2 (ja) * 1986-11-04 1997-01-08 大塚製薬株式会社 ヒドロフルオレン誘導体
JPH0495078A (ja) * 1990-08-08 1992-03-27 Nippon Shoji Kk ピリミドン誘導体の製造法、そのための中間体
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
TW279860B (de) * 1993-11-12 1996-07-01 Ciba Geigy Ag
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Also Published As

Publication number Publication date
MA27599A1 (fr) 2005-11-01
WO2005111026A1 (fr) 2005-11-24
HRP20070503T3 (en) 2007-12-31
HK1079776A1 (en) 2006-04-13
EP1589014B1 (de) 2007-10-10
ME01402B (de) 2010-05-07
BRPI0500478B8 (pt) 2021-05-25
KR20060042120A (ko) 2006-05-12
DK1589014T3 (da) 2008-02-25
CA2496721C (fr) 2010-09-07
CN1332951C (zh) 2007-08-22
BRPI0500478B1 (pt) 2019-04-02
MXPA05003695A (es) 2006-01-24
ES2294652T3 (es) 2008-04-01
SG116573A1 (en) 2005-11-28
NZ538327A (en) 2005-11-25
US20050227962A1 (en) 2005-10-13
PL1589014T3 (pl) 2008-01-31
GEP20074137B (en) 2007-06-25
NO20050885D0 (no) 2005-02-18
JP4511970B2 (ja) 2010-07-28
AR047686A1 (es) 2006-02-01
PT1589014E (pt) 2007-12-13
ZA200501467B (en) 2005-11-30
CY1107101T1 (el) 2012-10-24
BRPI0500478A (pt) 2005-11-16
NO20050885L (no) 2005-10-14
EP1589014A1 (de) 2005-10-26
AU2005200860A1 (en) 2005-10-27
FR2868776A1 (fr) 2005-10-14
RS50546B (sr) 2010-05-07
EA007744B1 (ru) 2006-12-29
SI1589014T1 (sl) 2008-02-29
JP2010043096A (ja) 2010-02-25
DE602005002776T2 (de) 2008-08-28
AU2005200860B2 (en) 2010-08-05
NO329438B1 (no) 2010-10-18
MY141223A (en) 2010-03-31
ATE375339T1 (de) 2007-10-15
KR100636500B1 (ko) 2006-10-18
CN1683342A (zh) 2005-10-19
FR2868776B1 (fr) 2008-04-18
CA2496721A1 (fr) 2005-10-13
US7074920B2 (en) 2006-07-11
EA200500237A1 (ru) 2005-10-27
JP2005298479A (ja) 2005-10-27
UA81772C2 (uk) 2008-02-11

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