DE602004028907D1 - Als kinaseinhibitoren geeignete verbindungen auf thiazolylbasis - Google Patents
Als kinaseinhibitoren geeignete verbindungen auf thiazolylbasisInfo
- Publication number
- DE602004028907D1 DE602004028907D1 DE602004028907T DE602004028907T DE602004028907D1 DE 602004028907 D1 DE602004028907 D1 DE 602004028907D1 DE 602004028907 T DE602004028907 T DE 602004028907T DE 602004028907 T DE602004028907 T DE 602004028907T DE 602004028907 D1 DE602004028907 D1 DE 602004028907D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- thiazolyl
- kinaseinhibitors
- basis
- kinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44541003P | 2003-02-06 | 2003-02-06 | |
PCT/US2004/003879 WO2004071440A2 (en) | 2003-02-06 | 2004-02-06 | Thiazolyl-based compounds useful as kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004028907D1 true DE602004028907D1 (de) | 2010-10-14 |
Family
ID=32869361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004028907T Expired - Lifetime DE602004028907D1 (de) | 2003-02-06 | 2004-02-06 | Als kinaseinhibitoren geeignete verbindungen auf thiazolylbasis |
Country Status (6)
Country | Link |
---|---|
US (2) | US7169771B2 (de) |
EP (1) | EP1594854B1 (de) |
AT (1) | ATE479667T1 (de) |
DE (1) | DE602004028907D1 (de) |
ES (1) | ES2349532T3 (de) |
WO (1) | WO2004071440A2 (de) |
Families Citing this family (42)
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US7265138B2 (en) * | 2003-02-10 | 2007-09-04 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
RS20050789A (sr) | 2003-05-01 | 2008-04-04 | Bristol-Myers Squibb Company, | Aril-supstituisana jedinjenja pirazol-amida pogodna za primenu kao inhibitori kinaze |
GB0329572D0 (en) | 2003-12-20 | 2004-01-28 | Astrazeneca Ab | Amide derivatives |
US7652146B2 (en) | 2004-02-06 | 2010-01-26 | Bristol-Myers Squibb Company | Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors |
US7491725B2 (en) * | 2004-02-06 | 2009-02-17 | Bristol-Myers Squibb Company | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors |
US20050215795A1 (en) * | 2004-02-06 | 2005-09-29 | Bang-Chi Chen | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors |
TWI338004B (en) * | 2004-02-06 | 2011-03-01 | Bristol Myers Squibb Co | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors |
TW200628156A (en) * | 2004-11-04 | 2006-08-16 | Bristol Myers Squibb Co | Combination of a SRC kinase inhibitor and a BCR-ABL inhibitor for the treatment of proliferative diseases |
AU2005311251A1 (en) * | 2004-12-01 | 2006-06-08 | Devgen Nv | 5-carboxamido substituted thiazole derivatives that interact with ion channels, in particular with ion channels from the Kv family |
BRPI0607307A2 (pt) * | 2005-01-26 | 2009-08-25 | Irm Llc | compostos e composições como inibidores de proteìna cinase |
US20060178388A1 (en) * | 2005-02-04 | 2006-08-10 | Wrobleski Stephen T | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
KR101142283B1 (ko) * | 2005-03-11 | 2012-05-07 | 스미또모 가가꾸 가부시끼가이샤 | 2-아미노티아졸 카르복사미드 유도체의 신규한 제조방법 |
JP5149003B2 (ja) | 2005-06-21 | 2013-02-20 | 三井化学アグロ株式会社 | アミド誘導体ならびに該化合物を含有する殺虫剤 |
WO2007138110A2 (en) * | 2006-06-01 | 2007-12-06 | Devgen N.V. | Compounds that interact with ion channels, in particular with ion channels from the kv family |
US20100022541A1 (en) * | 2006-09-25 | 2010-01-28 | Sonia Escaich | Chemical inhibitors of bacterial heptose synthesis, methods for their preparation and biological applications of said inhibitors |
CN101616667A (zh) | 2006-10-27 | 2009-12-30 | 百时美施贵宝公司 | 可用作激酶抑制剂的杂环酰胺化合物 |
EP2099794B1 (de) * | 2006-12-20 | 2013-05-15 | Bristol-Myers Squibb Company | Als kinasehemmer geeignete thiazolylverbindungen |
US7737149B2 (en) | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
CA2703106C (en) | 2007-10-24 | 2015-12-01 | Astellas Pharma Inc. | Azolecarboxamide derivatives as trka inhibitors |
WO2009132310A1 (en) * | 2008-04-25 | 2009-10-29 | Wisconsin Alumni Research Foundation | Inhibitors of udp-galactopyranose mutase thwart mycobacterial growth |
JP6073677B2 (ja) | 2009-06-12 | 2017-02-01 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 縮合複素環式化合物およびそれらの使用 |
CA2784807C (en) * | 2009-12-29 | 2021-12-14 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
US9290485B2 (en) | 2010-08-04 | 2016-03-22 | Novartis Ag | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides |
US9382239B2 (en) | 2011-11-17 | 2016-07-05 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-Jun-N-terminal kinase (JNK) |
RU2495430C1 (ru) * | 2012-03-29 | 2013-10-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Астраханская государственная академия" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО АГМА Минздравсоцразвития России) | Способ оценки эффективности терапии хронического миелолейкоза |
RU2495427C1 (ru) * | 2012-07-04 | 2013-10-10 | Федеральное бюджетное учреждение науки "Уфимский научно-исследовательский институт медицины труда и экологии человека" | Способ прогнозирования ответа на химиотерапию при хроническом лимфолейкозе |
EP2909194A1 (de) | 2012-10-18 | 2015-08-26 | Dana-Farber Cancer Institute, Inc. | Hemmer der cyclinabhängigen kinase 7 (cdk7) |
WO2014063054A1 (en) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof |
USRE48175E1 (en) | 2012-10-19 | 2020-08-25 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
US20140179712A1 (en) | 2012-12-21 | 2014-06-26 | Astrazeneca Ab | Pharmaceutical formulation of n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide |
US20160264551A1 (en) | 2013-10-18 | 2016-09-15 | Syros Pharmaceuticals, Inc. | Heteroaromatic compounds useful for the treatment of prolferative diseases |
EP3057956B1 (de) | 2013-10-18 | 2021-05-05 | Dana-Farber Cancer Institute, Inc. | Polycyclische inhibitoren der cyclin-dependent-kinase 7 (cdk7) |
WO2015164604A1 (en) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged janus kinase inhibitors and uses thereof |
WO2015164614A1 (en) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Janus kinase inhibitors and uses thereof |
WO2016105528A2 (en) | 2014-12-23 | 2016-06-30 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
US10550121B2 (en) | 2015-03-27 | 2020-02-04 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
AU2016276963C1 (en) | 2015-06-12 | 2021-08-05 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
EP4019515A1 (de) | 2015-09-09 | 2022-06-29 | Dana-Farber Cancer Institute, Inc. | Hemmer von cyclinabhängigen kinasen |
WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
US10080757B2 (en) | 2016-03-11 | 2018-09-25 | Wisconsin Alumni Research Foundation | Inhibitors of UDP-galactopyranose mutase |
AU2019265268C1 (en) * | 2018-05-09 | 2022-08-04 | Lg Chem, Ltd. | Novel compound exhibiting enteropeptidase inhibitory activity |
TWI815137B (zh) | 2018-06-15 | 2023-09-11 | 漢達生技醫藥股份有限公司 | 尼洛替尼十二烷基硫酸鹽之結晶 |
Family Cites Families (23)
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US4200750A (en) | 1977-01-07 | 1980-04-29 | Westwood Pharmaceuticals Inc. | 4-Substituted imidazo [1,2-a]quinoxalines |
US5739135A (en) | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
US6262096B1 (en) | 1997-11-12 | 2001-07-17 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
SI0928790T1 (en) | 1998-01-02 | 2003-06-30 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
ID28959A (id) | 1998-12-04 | 2001-07-19 | Bristol Myers Squibb Co | Turunan-turunan 3-tersubstitusi-4-arilkinolin-2-on sebagai modulator saluran kalium |
ES2209831T3 (es) | 1999-02-22 | 2004-07-01 | Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) | Epotilonas modificadas en c-21. |
US6548529B1 (en) | 1999-04-05 | 2003-04-15 | Bristol-Myers Squibb Company | Heterocyclic containing biphenyl aP2 inhibitors and method |
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
WO2000062778A1 (en) | 1999-04-15 | 2000-10-26 | Bristol-Myers Squibb Co. | Cyclic protein tyrosine kinase inhibitors |
WO2001010865A1 (fr) | 1999-08-06 | 2001-02-15 | Takeda Chemical Industries, Ltd. | INHIBITEURS DE p38MAP KINASE |
SE9904177D0 (sv) | 1999-11-18 | 1999-11-18 | Astra Ab | Novel compounds |
MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
US6906067B2 (en) | 1999-12-28 | 2005-06-14 | Bristol-Myers Squibb Company | N-heterocyclic inhibitors of TNF-α expression |
US20020065270A1 (en) | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
MY138097A (en) | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
EP1268474A2 (de) * | 2000-03-30 | 2003-01-02 | Takeda Chemical Industries, Ltd. | Substituierte 1,3-thiazol-verbindungen, ihre herstellung und verwendung |
US20020137755A1 (en) | 2000-12-04 | 2002-09-26 | Bilodeau Mark T. | Tyrosine kinase inhibitors |
EP1392684B1 (de) | 2001-06-01 | 2006-09-13 | Vertex Pharmaceuticals Incorporated | Thiazolverbindungen, die sich als inhibitoren von proteinkinasen eignen |
HN2002000156A (es) * | 2001-07-06 | 2003-11-27 | Inc Agouron Pharmaceuticals | Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización. |
PL368035A1 (en) | 2001-08-31 | 2005-03-21 | Bristol-Myers Squibb Company | Compositions and methods for the treatment of cancer |
US6916813B2 (en) | 2001-12-10 | 2005-07-12 | Bristol-Myers Squibb Co. | (1-phenyl-2-heteoaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase |
-
2004
- 2004-02-06 DE DE602004028907T patent/DE602004028907D1/de not_active Expired - Lifetime
- 2004-02-06 ES ES04709122T patent/ES2349532T3/es not_active Expired - Lifetime
- 2004-02-06 AT AT04709122T patent/ATE479667T1/de not_active IP Right Cessation
- 2004-02-06 US US10/773,790 patent/US7169771B2/en active Active
- 2004-02-06 EP EP04709122A patent/EP1594854B1/de not_active Expired - Lifetime
- 2004-02-06 WO PCT/US2004/003879 patent/WO2004071440A2/en active Application Filing
-
2006
- 2006-12-04 US US11/633,337 patent/US7323482B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US7169771B2 (en) | 2007-01-30 |
EP1594854A4 (de) | 2007-07-18 |
WO2004071440A2 (en) | 2004-08-26 |
EP1594854A2 (de) | 2005-11-16 |
WO2004071440A3 (en) | 2004-12-09 |
ATE479667T1 (de) | 2010-09-15 |
ES2349532T3 (es) | 2011-01-04 |
US7323482B2 (en) | 2008-01-29 |
US20040220233A1 (en) | 2004-11-04 |
EP1594854B1 (de) | 2010-09-01 |
US20070093537A1 (en) | 2007-04-26 |
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