DE602004027792D1 - Indazolamide mit analgetischer wirkung - Google Patents

Indazolamide mit analgetischer wirkung

Info

Publication number
DE602004027792D1
DE602004027792D1 DE602004027792T DE602004027792T DE602004027792D1 DE 602004027792 D1 DE602004027792 D1 DE 602004027792D1 DE 602004027792 T DE602004027792 T DE 602004027792T DE 602004027792 T DE602004027792 T DE 602004027792T DE 602004027792 D1 DE602004027792 D1 DE 602004027792D1
Authority
DE
Germany
Prior art keywords
indazolamides
analgetic effect
analgetic
effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004027792T
Other languages
English (en)
Inventor
Maria Alessandra Alisi
Nicola Cazzolla
Angelo Guglielmotti
Guido Furlotti
Giuseppe Luna
Lorenzo Polenzani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Angelini Acraf SpA
Original Assignee
Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aziende Chimiche Riunite Angelini Francesco ACRAF SpA filed Critical Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
Publication of DE602004027792D1 publication Critical patent/DE602004027792D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602004027792T 2003-02-18 2004-01-26 Indazolamide mit analgetischer wirkung Expired - Lifetime DE602004027792D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000287A ITMI20030287A1 (it) 2003-02-18 2003-02-18 Indazolammidi dotate di attivita' analgesica metodo, per
PCT/EP2004/000647 WO2004074275A1 (en) 2003-02-18 2004-01-26 Indazolamides with analgesic activity

Publications (1)

Publication Number Publication Date
DE602004027792D1 true DE602004027792D1 (de) 2010-08-05

Family

ID=32894157

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004027792T Expired - Lifetime DE602004027792D1 (de) 2003-02-18 2004-01-26 Indazolamide mit analgetischer wirkung

Country Status (23)

Country Link
US (2) US7632849B2 (de)
EP (1) EP1594859B1 (de)
JP (1) JP4724651B2 (de)
KR (1) KR101108222B1 (de)
CN (2) CN101139341B (de)
AR (1) AR043186A1 (de)
AT (1) ATE471934T1 (de)
AU (1) AU2004213104B2 (de)
CA (1) CA2511984C (de)
DE (1) DE602004027792D1 (de)
DK (1) DK1594859T3 (de)
EA (1) EA009077B1 (de)
ES (1) ES2345983T3 (de)
GE (1) GEP20074075B (de)
HK (1) HK1079199A1 (de)
IL (1) IL169285A (de)
IT (1) ITMI20030287A1 (de)
MX (1) MXPA05008730A (de)
PL (1) PL215870B1 (de)
PT (1) PT1594859E (de)
SI (1) SI1594859T1 (de)
UA (1) UA79537C2 (de)
WO (1) WO2004074275A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
GEP20094638B (en) * 2004-06-15 2009-03-10 Pfizer Benzimidazolone carboxylic acid derivatives
EA022505B1 (ru) 2008-03-25 2016-01-29 Эффектис Фармасьютиклз Аг Новые p2x7r антагонисты и их применение
US8815892B2 (en) 2008-03-25 2014-08-26 Affectis Pharmaceuticals Ag P2X7R antagonists and their use
PT2243772E (pt) * 2009-04-14 2012-03-28 Affectis Pharmaceuticals Ag Novos antagonistas de p2x7r e sua utilização
PL2817301T3 (pl) 2012-02-21 2016-05-31 Acraf Zastosowanie związków 1H-indazolo-3-karboksyamidowych jako inhibitorów kinazy syntazy glikogenu 3-beta
EP2817302B1 (de) 2012-02-21 2015-12-30 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. 1h-indazol-3-carboxamid-verbindungen als glycogen-synthase-kinase 3-beta inhibitoren
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
JP6064062B2 (ja) 2013-03-15 2017-01-18 ファイザー・インク Ampkを活性化させるインダゾール化合物
CN112135821B (zh) 2018-05-07 2024-05-31 方济各安吉利克化学联合股份有限公司 作为糖原合酶激酶3β抑制剂的1H-吲唑-3-甲酰胺化合物
CN109336890B (zh) * 2018-11-17 2020-03-20 重庆文理学院 一种吲唑类衍生物的合成方法及抗肿瘤应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705175A (en) * 1969-04-01 1972-12-05 Egyt Gyogyszervegyeszeti Gyar Indazole-3-carboxylic amides
IL117438A (en) * 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
KR19990022096A (ko) * 1995-05-31 1999-03-25 쇼다 오사무 모노시클릭 아미노기를 갖는 인다졸 유도체
WO1997017208A1 (en) * 1995-11-08 1997-05-15 Toray Industries, Inc. Direct drawing type waterless planographic original form plate
ES2151743T3 (es) 1996-08-16 2001-01-01 Smithkline Beecham Plc Procedimiento para la preparacion de n-((1-n-butil-4-piperidinil)metil)-3,4-dihidro-2h-(1,3)-oxazino(3,2-a)indol-10-carboxamida y las sales y productos intermedios en el procedimiento.
IT1291569B1 (it) 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
US6407103B2 (en) * 1998-04-21 2002-06-18 Bristol-Myers Squibb Pharma Company Indeno [1,2-c] pyrazol-4-ones and their uses
EP1071668B1 (de) * 1998-04-21 2009-06-03 Bristol-Myers Squibb Pharma Company 5-aminoindeno[1,2-c]pyrazol-4-one als antitumor- und wachstumshemmende mittel

Also Published As

Publication number Publication date
ITMI20030287A1 (it) 2004-08-19
IL169285A (en) 2012-08-30
PL377236A1 (pl) 2006-01-23
EA009077B1 (ru) 2007-10-26
AU2004213104B2 (en) 2010-07-08
US20100048907A1 (en) 2010-02-25
WO2004074275A1 (en) 2004-09-02
CA2511984C (en) 2011-01-18
GEP20074075B (en) 2007-03-26
ES2345983T3 (es) 2010-10-07
MXPA05008730A (es) 2005-09-20
SI1594859T1 (sl) 2010-10-29
AU2004213104A1 (en) 2004-09-02
JP4724651B2 (ja) 2011-07-13
ATE471934T1 (de) 2010-07-15
EA200501164A1 (ru) 2005-12-29
CN1742004A (zh) 2006-03-01
EP1594859B1 (de) 2010-06-23
KR20050101541A (ko) 2005-10-24
US8519139B2 (en) 2013-08-27
CA2511984A1 (en) 2004-09-02
EP1594859A1 (de) 2005-11-16
UA79537C2 (en) 2007-06-25
JP2006517932A (ja) 2006-08-03
KR101108222B1 (ko) 2012-02-08
US7632849B2 (en) 2009-12-15
CN100347168C (zh) 2007-11-07
CN101139341A (zh) 2008-03-12
AR043186A1 (es) 2005-07-20
US20060052417A1 (en) 2006-03-09
DK1594859T3 (da) 2010-10-11
PT1594859E (pt) 2010-07-23
PL215870B1 (pl) 2014-02-28
HK1079199A1 (en) 2006-03-31
CN101139341B (zh) 2010-12-08

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