DE602004023926D1 - Selektive spirocyclische glucocorticoid-rezeptor-modulatoren - Google Patents
Selektive spirocyclische glucocorticoid-rezeptor-modulatorenInfo
- Publication number
- DE602004023926D1 DE602004023926D1 DE602004023926T DE602004023926T DE602004023926D1 DE 602004023926 D1 DE602004023926 D1 DE 602004023926D1 DE 602004023926 T DE602004023926 T DE 602004023926T DE 602004023926 T DE602004023926 T DE 602004023926T DE 602004023926 D1 DE602004023926 D1 DE 602004023926D1
- Authority
- DE
- Germany
- Prior art keywords
- glucocorticoid receptor
- selective
- spirocyclic
- receptor modulators
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940117965 Glucocorticoid receptor modulator Drugs 0.000 title 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 102000003676 Glucocorticoid Receptors Human genes 0.000 abstract 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46478403P | 2003-04-23 | 2003-04-23 | |
PCT/US2004/012102 WO2004093805A2 (en) | 2003-04-23 | 2004-04-19 | Selective spirocyclic glucocorticoid receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004023926D1 true DE602004023926D1 (de) | 2009-12-17 |
Family
ID=33310953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004023926T Expired - Lifetime DE602004023926D1 (de) | 2003-04-23 | 2004-04-19 | Selektive spirocyclische glucocorticoid-rezeptor-modulatoren |
Country Status (9)
Country | Link |
---|---|
US (1) | US7662846B2 (de) |
EP (1) | EP1617806B1 (de) |
JP (1) | JP4739191B2 (de) |
CN (1) | CN1809347A (de) |
AT (1) | ATE447575T1 (de) |
AU (1) | AU2004232301B2 (de) |
CA (1) | CA2522946A1 (de) |
DE (1) | DE602004023926D1 (de) |
WO (1) | WO2004093805A2 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003214879B2 (en) | 2002-01-22 | 2008-02-07 | The Regents Of The University Of California | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof |
WO2007025303A2 (en) | 2005-08-26 | 2007-03-01 | The Regents Of The University Of California | Non-steroidal antiandrogens |
CN101511802A (zh) * | 2006-09-13 | 2009-08-19 | 阿斯利康(瑞典)有限公司 | 螺唑烷酮化合物及其作为代谢型谷氨酸受体增效剂的用途 |
EP2097385B1 (de) | 2006-10-23 | 2012-08-01 | Merck Sharp & Dohme Corp. | 2-[1-phenyl-5-hydroxy- oder methoxy-4alpha-methylhexahydrocyclopenta[f]indazol-5-yl]ethylphenylderivate als glucocorticoidrezeptorliganden |
AR066191A1 (es) * | 2007-03-22 | 2009-08-05 | Schering Corp | Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona |
CA2714607A1 (en) * | 2008-02-26 | 2009-09-03 | Merck Sharp & Dohme Corp. | Hexahydrocyclopentyl[f]indazole carboxamides and derivatives thereof as selective glucocorticoid receptor modulators |
JP2011513409A (ja) * | 2008-03-06 | 2011-04-28 | メルク・シャープ・エンド・ドーム・コーポレイション | 選択的グルココルチコイドレセプターモジュレーターとしてのヘキサヒドロシクロペンチル[f]インダゾールスルホンアミドおよびこれらの誘導体 |
WO2011117881A2 (en) | 2010-03-22 | 2011-09-29 | Council Of Scientific & Industrial Research | Substituted cyclohexane-1, 3-dione compounds, process for preparation thereof and its applications |
JP5737114B2 (ja) * | 2011-09-29 | 2015-06-17 | Jsr株式会社 | 化合物、重合体及びフォトレジスト組成物 |
JP5737211B2 (ja) * | 2012-02-23 | 2015-06-17 | Jsr株式会社 | 液浸上層膜形成用組成物及びレジストパターン形成方法 |
WO2013047044A1 (ja) * | 2011-09-29 | 2013-04-04 | Jsr株式会社 | 液浸露光用膜形成組成物、重合体、化合物及びレジストパターン形成方法 |
EA202190271A1 (ru) * | 2018-07-20 | 2021-06-07 | Грюненталь Гмбх | Замещенные триазолохиноксалиновые производные |
US10981918B2 (en) * | 2018-07-20 | 2021-04-20 | Grünenthal GmbH | Further substituted triazolo quinoxaline derivatives |
AU2020211303A1 (en) | 2019-01-22 | 2021-07-15 | Akribes Biomedical Gmbh | Selective Glucocorticoid Receptor Modifiers for treating impaired skin wound healing |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4349559A (en) * | 1981-02-19 | 1982-09-14 | Sterling Drug Inc. | Anti-inflammatory spiro-2H-indene-[2,3']-3H-pyrazolo[4",5":7',6']naphtho[2,1-b]pyran-1,3-dione derivatives |
US4412995A (en) * | 1981-02-19 | 1983-11-01 | Sterling Drug Inc. | Pentacyclic phenylpyrazole compounds as anti-inflammatory agents |
AU2003214879B2 (en) * | 2002-01-22 | 2008-02-07 | The Regents Of The University Of California | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof |
WO2003086294A2 (en) | 2002-04-11 | 2003-10-23 | Merck & Co., Inc. | 1h-benzo[f]indazol-5-yl derivatives as selective glucocorticoid receptor modulators |
US6875828B2 (en) * | 2002-09-04 | 2005-04-05 | Univation Technologies, Llc | Bimodal polyolefin production process and films therefrom |
CA2499150A1 (en) * | 2002-09-20 | 2004-04-01 | Merck & Co., Inc. | Octahydro-2-h-naphtho[1,2-f] indole-4-carboxamide derivatives as selective glucocorticoid receptor modulators |
AU2004216182B2 (en) * | 2003-02-25 | 2008-11-20 | Merck Sharp & Dohme Corp. | Selective non-steroidal glucocorticoid receptor modulators |
-
2004
- 2004-04-19 CA CA002522946A patent/CA2522946A1/en not_active Abandoned
- 2004-04-19 CN CNA200480017051XA patent/CN1809347A/zh active Pending
- 2004-04-19 JP JP2006513140A patent/JP4739191B2/ja not_active Expired - Fee Related
- 2004-04-19 AT AT04760029T patent/ATE447575T1/de not_active IP Right Cessation
- 2004-04-19 DE DE602004023926T patent/DE602004023926D1/de not_active Expired - Lifetime
- 2004-04-19 EP EP04760029A patent/EP1617806B1/de not_active Expired - Lifetime
- 2004-04-19 WO PCT/US2004/012102 patent/WO2004093805A2/en active Application Filing
- 2004-04-19 US US10/551,933 patent/US7662846B2/en not_active Expired - Fee Related
- 2004-04-19 AU AU2004232301A patent/AU2004232301B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP1617806B1 (de) | 2009-11-04 |
CA2522946A1 (en) | 2004-11-04 |
AU2004232301B2 (en) | 2009-11-12 |
EP1617806A2 (de) | 2006-01-25 |
ATE447575T1 (de) | 2009-11-15 |
AU2004232301A1 (en) | 2004-11-04 |
CN1809347A (zh) | 2006-07-26 |
WO2004093805A3 (en) | 2005-12-08 |
JP2006524251A (ja) | 2006-10-26 |
US20060217563A1 (en) | 2006-09-28 |
JP4739191B2 (ja) | 2011-08-03 |
EP1617806A4 (de) | 2006-11-02 |
US7662846B2 (en) | 2010-02-16 |
WO2004093805A2 (en) | 2004-11-04 |
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