DE602004020769D1 - Aufreinigung von her-2-varianten - Google Patents

Aufreinigung von her-2-varianten

Info

Publication number: DE602004020769D1
Authority: DE; Germany
Prior art keywords: purification; provides; chromatography; variant; variants
Prior art date: 2003-06-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

DE602004020769T

Other languages

English (en)

Inventor

Marie Eskling

Klaus Gregorius Nielsen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

BN ImmunoTherapeutics Inc

Original Assignee

BN ImmunoTherapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-25

Filing date

2004-06-24

Publication date

2009-06-04

2004-06-24 Application filed by BN ImmunoTherapeutics Inc filed Critical BN ImmunoTherapeutics Inc

2009-06-04 Publication of DE602004020769D1 publication Critical patent/DE602004020769D1/de

Status Active legal-status Critical Current

2024-06-25 Anticipated expiration legal-status Critical

Links

238000000746 purification Methods 0.000 title abstract 3
101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 title abstract 2
102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 title abstract 2
238000000034 method Methods 0.000 abstract 3
238000005571 anion exchange chromatography Methods 0.000 abstract 2
238000001597 immobilized metal affinity chromatography Methods 0.000 abstract 2
238000001542 size-exclusion chromatography Methods 0.000 abstract 2
241000238631 Hexapoda Species 0.000 abstract 1
238000011026 diafiltration Methods 0.000 abstract 1
102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 abstract 1
108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 abstract 1
239000001963 growth medium Substances 0.000 abstract 1
230000002163 immunogen Effects 0.000 abstract 1
YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies

DE602004020769T 2003-06-25 2004-06-24 Aufreinigung von her-2-varianten Active DE602004020769D1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US48231503P	2003-06-25	2003-06-25
DKPA200300954		2003-06-25
PCT/DK2004/000451 WO2004113377A1 (en)	2003-06-25	2004-06-24	Purification of her-2 variants

Publications (1)

Publication Number	Publication Date
DE602004020769D1 true DE602004020769D1 (de)	2009-06-04

Family

ID=33542436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE602004020769T Active DE602004020769D1 (de)	2003-06-25	2004-06-24	Aufreinigung von her-2-varianten

Country Status (12)

Country	Link
EP (2)	EP1641819B1 (de)
JP (1)	JP4579912B2 (de)
AT (1)	ATE429447T1 (de)
AU (1)	AU2004249362B2 (de)
CA (1)	CA2530233C (de)
DE (1)	DE602004020769D1 (de)
DK (1)	DK1641819T3 (de)
ES (1)	ES2325584T3 (de)
MX (1)	MXPA05013389A (de)
NO (1)	NO20055948L (de)
NZ (1)	NZ544017A (de)
WO (1)	WO2004113377A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EA008827B1 (ru)	2003-06-25	2007-08-31	Фармекса А/С	Очистка вариантов her-2
US20080253993A1 (en) *	2005-03-31	2008-10-16	Pharmexa A/S	Immunogenic Egfr Peptides Comprising Foreign T Cell Stimulating Epitope
CA2665068C (en) *	2006-10-06	2016-01-05	Bn Immunotherapeutics Inc.	Methods for treating cancer with mva
CN116438456A (zh) *	2020-09-11	2023-07-14	格里姆普斯生物股份有限公司	用于疾病检测/诊断、分期、监测和治疗的离体蛋白酶活性检测

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6080409A (en) *	1995-12-28	2000-06-27	Dendreon Corporation	Immunostimulatory method
ES2222728T3 (es)	1998-10-05	2005-02-01	Pharmexa A/S	Procedimiento de vacunacion terapeutica.
MXPA01007721A (es) *	1999-01-29	2003-07-14	Corixa Corp	Proteinas de fusion her-2/neu.
MXPA04009809A (es) *	2002-04-11	2004-12-13	Amgen Inc	Moleculas de tirosina cinasa del receptor her-2 y uso de las mismas.

2004
- 2004-06-24 AU AU2004249362A patent/AU2004249362B2/en not_active Ceased
- 2004-06-24 WO PCT/DK2004/000451 patent/WO2004113377A1/en active Application Filing
- 2004-06-24 ES ES04738948T patent/ES2325584T3/es active Active
- 2004-06-24 DK DK04738948T patent/DK1641819T3/da active
- 2004-06-24 JP JP2006515732A patent/JP4579912B2/ja not_active Expired - Fee Related
- 2004-06-24 EP EP04738948A patent/EP1641819B1/de active Active
- 2004-06-24 AT AT04738948T patent/ATE429447T1/de active
- 2004-06-24 NZ NZ544017A patent/NZ544017A/en not_active IP Right Cessation
- 2004-06-24 CA CA2530233A patent/CA2530233C/en not_active Expired - Fee Related
- 2004-06-24 DE DE602004020769T patent/DE602004020769D1/de active Active
- 2004-06-24 EP EP09005519A patent/EP2090586A1/de not_active Withdrawn
- 2004-06-24 MX MXPA05013389A patent/MXPA05013389A/es unknown
2005
- 2005-12-14 NO NO20055948A patent/NO20055948L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP1641819B1 (de)	2009-04-22
NZ544017A (en)	2008-04-30
ATE429447T1 (de)	2009-05-15
AU2004249362A1 (en)	2004-12-29
MXPA05013389A (es)	2006-03-17
CA2530233A1 (en)	2004-12-29
WO2004113377A1 (en)	2004-12-29
DK1641819T3 (da)	2009-08-03
ES2325584T3 (es)	2009-09-09
EP1641819A1 (de)	2006-04-05
CA2530233C (en)	2012-09-11
AU2004249362B2 (en)	2011-08-25
EP2090586A1 (de)	2009-08-19
NO20055948L (no)	2005-12-14
JP4579912B2 (ja)	2010-11-10
JP2007523615A (ja)	2007-08-23

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Legal Events

Date	Code	Title	Description
2010-05-12	8364	No opposition during term of opposition