DE602004020218D1 - Feedback resistante mevalonate kinase - Google Patents

Feedback resistante mevalonate kinase

Info

Publication number
DE602004020218D1
DE602004020218D1 DE602004020218T DE602004020218T DE602004020218D1 DE 602004020218 D1 DE602004020218 D1 DE 602004020218D1 DE 602004020218 T DE602004020218 T DE 602004020218T DE 602004020218 T DE602004020218 T DE 602004020218T DE 602004020218 D1 DE602004020218 D1 DE 602004020218D1
Authority
DE
Germany
Prior art keywords
mevalonate kinase
feedback resistant
resistant mevalonate
vectors
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004020218T
Other languages
English (en)
Inventor
Renyunan Bai
Markus Huembelin
Martin Lehmann
Rual Lopez-Ulibarri
Markus Wyss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of DE602004020218D1 publication Critical patent/DE602004020218D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE602004020218T 2003-06-12 2004-06-10 Feedback resistante mevalonate kinase Expired - Lifetime DE602004020218D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03012294 2003-06-12
PCT/CH2004/000353 WO2004111214A1 (en) 2003-06-12 2004-06-10 Feedback-resistant mevalonate kinases

Publications (1)

Publication Number Publication Date
DE602004020218D1 true DE602004020218D1 (de) 2009-05-07

Family

ID=33547583

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004020218T Expired - Lifetime DE602004020218D1 (de) 2003-06-12 2004-06-10 Feedback resistante mevalonate kinase

Country Status (9)

Country Link
US (1) US7422884B2 (de)
EP (1) EP1631664B1 (de)
JP (1) JP4643569B2 (de)
KR (1) KR101190897B1 (de)
CN (1) CN1806042B (de)
AT (1) ATE426662T1 (de)
DE (1) DE602004020218D1 (de)
ES (1) ES2323175T3 (de)
WO (1) WO2004111214A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8338155B2 (en) 2004-12-14 2012-12-25 Dsm Ip Assets B.V. Modified mevalonate kinase with reduced feedback inhibition
CN101218352B (zh) 2005-03-18 2013-09-04 米克罗比亚公司 产油酵母和真菌中类胡萝卜素的产生
BRPI0716954B1 (pt) 2006-09-26 2024-04-30 The Regents Of The University Of California Microrganismos geneticamente modificados capazes de produzir um isoprenóide
WO2008042338A2 (en) 2006-09-28 2008-04-10 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
JP2009000046A (ja) * 2007-06-21 2009-01-08 Hitachi Zosen Corp トチュウのメバロン酸経路の酵素をコードする遺伝子
MX2010006576A (es) 2007-12-13 2010-10-15 Danisco Us Inc Composiciones y metodos para producir isopreno.
MX2010011706A (es) 2008-04-23 2011-03-15 Danisco Us Inc Variantes de isopreno-sintasa para produccion microbiana mejorada de isopreno.
EP2157174A1 (de) 2008-08-12 2010-02-24 DSM IP Assets B.V. Erhöhte Produktion von Pantothenate (Vitamin B5)
MY169163A (en) * 2008-09-15 2019-02-19 Danisco Us Inc Increased isoprene production using the archaeal lower mevalonate pathway
EP2421966A2 (de) 2009-04-23 2012-02-29 Danisco US Inc. Dreidimensionale struktur von isopren-synthase und verwendung davon zur erzeugung von varianten
EP2336310A1 (de) 2009-12-16 2011-06-22 Isobionics B.V. Valencensynthase
MX349121B (es) 2010-06-02 2017-07-12 Evolva Inc Produccion recombinante de esteviol glucosidos.
WO2012014228A1 (en) 2010-07-28 2012-02-02 Abhishek Narain Singh A method to by-pass allosteric domain activity of an enzyme so as to alter its feedback or feed-forward inhibition or activation
WO2012019169A1 (en) * 2010-08-06 2012-02-09 Danisco Us Inc. Production of isoprene under neutral ph conditions
JP2014502148A (ja) 2010-10-27 2014-01-30 ダニスコ・ユーエス・インク イソプレン生産の向上を目的としたイソプレン合成酵素変異体
WO2012175574A1 (en) 2011-06-21 2012-12-27 Dsm Ip Assets B.V. Increased pantothenate (vitamin b5) production
EP2537926A1 (de) 2011-06-21 2012-12-26 Isobionics B.V. Valencensynthase
WO2012175575A2 (en) 2011-06-21 2012-12-27 Dsm Ip Assets B.V. Increased vitamin b5 production
WO2013022799A1 (en) 2011-08-05 2013-02-14 Danisco Us Inc. PRODUCTION OF ISOPRENOIDS UNDER NEUTRAL pH CONDITIONS
EP3009508B1 (de) 2011-08-08 2020-11-25 Evolva SA Rekombinante herstellung von steviolglykosiden
CN103205432B (zh) * 2012-01-11 2015-06-10 安徽医科大学第一附属医院 弥散型浅表性光线性汗孔角化症(dsap)相关基因
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
JP6379112B2 (ja) 2013-02-06 2018-08-22 エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． レバウディオサイドｄおよびレバウディオサイドｍの改良された産生方法
KR20150128705A (ko) 2013-02-11 2015-11-18 에볼바 에스아 재조합 숙주에서 스테비올 글리코시드의 효율적인 생성
RU2014112066A (ru) 2014-03-28 2015-10-10 Адзиномото Ко., Инк. Способ получения мономерного изопрена
SG10201901007PA (en) 2014-08-11 2019-03-28 Evolva Sa Production of steviol glycosides in recombinant hosts
SG11201701677UA (en) 2014-09-09 2017-04-27 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2016120486A1 (en) 2015-01-30 2016-08-04 Evolva Sa Production of steviol glycosides in recombinant hosts
CA2979931A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
AU2016307066A1 (en) 2015-08-07 2018-02-08 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2017178632A1 (en) 2016-04-13 2017-10-19 Evolva Sa Production of steviol glycosides in recombinant hosts
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
CN110100006A (zh) 2016-11-07 2019-08-06 埃沃尔瓦公司 重组宿主中甜菊糖苷的生产
NL2018457B1 (en) 2017-03-02 2018-09-21 Isobionics B V Santalene Synthase
NL2019473B1 (en) 2017-09-01 2019-03-11 Isobionics B V Terpene Synthase producing patchoulol and elemol, and preferably also pogostol
KR102092075B1 (ko) * 2017-10-27 2020-03-23 경상대학교산학협력단 MmMVK-메발론산 복합체의 3차원 결정 구조 및 기질저해 저항성 돌연변이 메발론산 인산화효소
KR20200095534A (ko) 2017-12-07 2020-08-10 지머젠 인코포레이티드 발효에 의한 (6e)-8-히드록시제라니올의 제조를 위해 조작된 생합성 경로
CA3086490A1 (en) 2017-12-21 2019-06-27 Zymergen Inc. Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI250210B (en) 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
WO2002099095A2 (en) * 2001-06-06 2002-12-12 Roche Vitamins Ag Improved isoprenoid production

Also Published As

Publication number Publication date
EP1631664A1 (de) 2006-03-08
US7422884B2 (en) 2008-09-09
ATE426662T1 (de) 2009-04-15
CN1806042A (zh) 2006-07-19
ES2323175T3 (es) 2009-07-08
JP4643569B2 (ja) 2011-03-02
US20070141685A1 (en) 2007-06-21
KR20060022692A (ko) 2006-03-10
JP2007523612A (ja) 2007-08-23
KR101190897B1 (ko) 2012-10-12
WO2004111214A1 (en) 2004-12-23
EP1631664B1 (de) 2009-03-25
CN1806042B (zh) 2012-07-04

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Legal Events

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