DE602004015277D1 - Substituierte-1-phthalazinamine als vr-1-antagonisten - Google Patents
Substituierte-1-phthalazinamine als vr-1-antagonistenInfo
- Publication number
- DE602004015277D1 DE602004015277D1 DE602004015277T DE602004015277T DE602004015277D1 DE 602004015277 D1 DE602004015277 D1 DE 602004015277D1 DE 602004015277 T DE602004015277 T DE 602004015277T DE 602004015277 T DE602004015277 T DE 602004015277T DE 602004015277 D1 DE602004015277 D1 DE 602004015277D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- antagonists
- phthalazineamins
- substituted
- inflammation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 230000004054 inflammatory process Effects 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0310726.5A GB0310726D0 (en) | 2003-05-09 | 2003-05-09 | Therapeutic agents |
| PCT/GB2004/001942 WO2004099177A1 (en) | 2003-05-09 | 2004-05-04 | Substituted-1-phthalazinamines as vr-1 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004015277D1 true DE602004015277D1 (de) | 2008-09-04 |
Family
ID=9957782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004015277T Expired - Fee Related DE602004015277D1 (de) | 2003-05-09 | 2004-05-04 | Substituierte-1-phthalazinamine als vr-1-antagonisten |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7329659B2 (de) |
| EP (1) | EP1625119B1 (de) |
| JP (1) | JP2006525984A (de) |
| CN (1) | CN1816541A (de) |
| AT (1) | ATE402166T1 (de) |
| AU (1) | AU2004236014A1 (de) |
| CA (1) | CA2524622A1 (de) |
| DE (1) | DE602004015277D1 (de) |
| GB (1) | GB0310726D0 (de) |
| WO (1) | WO2004099177A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7759337B2 (en) * | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
| CA2599778A1 (en) * | 2005-03-05 | 2006-09-14 | Bayer Healthcare Ag | Use of hydroxy tetrahydro-naphtalene derivates for the treatment of respiratory diseases |
| TWI392670B (zh) * | 2006-06-22 | 2013-04-11 | Ucb Pharma Gmbh | 經取代的２-胺基萘滿之於製造用於預防、減緩及／或治療各種類型疼痛之藥物上的用途 |
| JP2010501593A (ja) * | 2006-08-24 | 2010-01-21 | セレネックス， インコーポレイテッド | イソキノリン、キナゾリンおよびフタラジン誘導体 |
| US8044041B2 (en) | 2006-11-15 | 2011-10-25 | Forest Laboratories Holdings Limited | Phthalazine derivatives as inhibitors of protein kinase |
| EP2116618A1 (de) | 2008-05-09 | 2009-11-11 | Agency for Science, Technology And Research | Diagnose und Behandlung des Kawasaki-Syndroms |
| WO2010042649A2 (en) | 2008-10-10 | 2010-04-15 | Amgen Inc. | PHTHALAZINE COMPOUNDS AS p38 MAP KINASE MODULATORS AND METHODS OF USE THEREOF |
| US8772481B2 (en) | 2008-10-10 | 2014-07-08 | Amgen Inc. | Aza- and diaza-phthalazine compounds as P38 map kinase modulators and methods of use thereof |
| US8546388B2 (en) * | 2008-10-24 | 2013-10-01 | Purdue Pharma L.P. | Heterocyclic TRPV1 receptor ligands |
| WO2018130443A1 (de) | 2017-01-10 | 2018-07-19 | Bayer Aktiengesellschaft | Heterocyclen-derivate als schädlingsbekämpfungsmittel |
| TWI820231B (zh) | 2018-10-11 | 2023-11-01 | 德商拜耳廠股份有限公司 | 用於製備經取代咪唑衍生物之方法 |
| BR112022026904A2 (pt) | 2020-07-02 | 2023-01-24 | Bayer Ag | Derivados de heterocicleno como agentes de controle de pragas |
| WO2022026465A1 (en) * | 2020-07-28 | 2022-02-03 | Mirati Therapeutics, Inc. | Sos1 inhibitors |
| DE102022104759A1 (de) | 2022-02-28 | 2023-08-31 | SCi Kontor GmbH | Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3240781A (en) | 1965-01-06 | 1966-03-15 | Vantorex Ltd | 1-lower alkyl-4-anilinophthalazines |
| GB1293565A (en) | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| GB9707693D0 (en) | 1997-04-16 | 1997-06-04 | Smithkline Beecham Plc | Novel method of treatment |
| RS63204A (en) | 2002-01-17 | 2006-10-27 | Neurogen Corporation | Substituted quinazolin-4-ylamine analogues as modulators of capsaicin |
| ATE493987T1 (de) | 2002-05-22 | 2011-01-15 | Amgen Inc | Aminopyrimidin-derivate zur verwendung als vanilloid-rezeptor-liganden zur behandlung von schmerzen |
-
2003
- 2003-05-09 GB GBGB0310726.5A patent/GB0310726D0/en not_active Ceased
-
2004
- 2004-04-05 US US10/555,235 patent/US7329659B2/en not_active Expired - Fee Related
- 2004-05-04 DE DE602004015277T patent/DE602004015277D1/de not_active Expired - Fee Related
- 2004-05-04 CN CNA2004800191817A patent/CN1816541A/zh active Pending
- 2004-05-04 CA CA002524622A patent/CA2524622A1/en not_active Abandoned
- 2004-05-04 AU AU2004236014A patent/AU2004236014A1/en not_active Abandoned
- 2004-05-04 JP JP2006506223A patent/JP2006525984A/ja not_active Withdrawn
- 2004-05-04 EP EP04731058A patent/EP1625119B1/de active Active
- 2004-05-04 AT AT04731058T patent/ATE402166T1/de not_active IP Right Cessation
- 2004-05-04 WO PCT/GB2004/001942 patent/WO2004099177A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| GB0310726D0 (en) | 2003-06-11 |
| CA2524622A1 (en) | 2004-11-18 |
| US7329659B2 (en) | 2008-02-12 |
| JP2006525984A (ja) | 2006-11-16 |
| US20060229307A1 (en) | 2006-10-12 |
| WO2004099177A1 (en) | 2004-11-18 |
| CN1816541A (zh) | 2006-08-09 |
| EP1625119B1 (de) | 2008-07-23 |
| EP1625119A1 (de) | 2006-02-15 |
| AU2004236014A1 (en) | 2004-11-18 |
| ATE402166T1 (de) | 2008-08-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE0101387D0 (sv) | Novel compounds | |
| CY1107850T1 (el) | Παραγωγα θειαδιαζολυλοπιπεραζiνης mε χρησιμοτητα στην αποτροπη ή στην αγωγη εναντι tου αλγους | |
| DK1678166T3 (da) | Proteinkinaseinhibitorer | |
| ATE381537T1 (de) | Formanilid-derivative als beta2-adrenorezeptor- agonisten | |
| ATE371656T1 (de) | Heteroaryl-pyrimidinderivate als jak-inhibitoren | |
| CY1109242T1 (el) | Θεραπευτικοι παραγοντες χρησιμοι για θεραπεια πονου | |
| ATE307810T1 (de) | Imidazol-2-carbonsäureamid derivate als raf- kinase-inhibitoren | |
| PT1263724E (pt) | Novos compostos | |
| DE602004015277D1 (de) | Substituierte-1-phthalazinamine als vr-1-antagonisten | |
| WO2005056524A3 (en) | Therapeutic agents useful for treating pain | |
| PL376324A1 (en) | Piperazinyl and diazapanyl benzamides and benzthioamides | |
| SE0302116D0 (sv) | Novel compounds | |
| EA200501703A1 (ru) | Применение производных азетидинкарбоксамида в терапии | |
| SE0302573D0 (sv) | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof | |
| SE0104250D0 (sv) | Heterocyclic compounds | |
| NO20043115L (no) | Substituerte diketopiperaziner som oksytocin antagonister | |
| TW200504029A (en) | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof | |
| ATE485822T1 (de) | Phenylaminopyridine und phenylaminopyrazine | |
| SE0203070D0 (en) | Novel compounds | |
| SE0301699D0 (sv) | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof | |
| GEP20053590B (en) | Phenyl Heterocyclyl Ether Derivatives as Serotonin Re-Uptake Inhibitors | |
| MY140653A (en) | Substituted diketopiperazines and their use as oxytocyn antagonists | |
| SE0300105D0 (sv) | Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof | |
| ITMI20042475A1 (it) | Uso di derivati tiazolidinonici come agenti terapeutici | |
| SE0104326D0 (sv) | Therapeutic heterocycles |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |