DE602004001397D1 - Spirosubstituierte pyrrolopyrimidine - Google Patents

Spirosubstituierte pyrrolopyrimidine

Info

Publication number: DE602004001397D1
Authority: DE; Germany
Prior art keywords: cathepsin; formula; spirosubstituted; pyrrolopyrimidines; compounds
Prior art date: 2003-02-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE602004001397T

Other languages

English (en)

Other versions

DE602004001397T2 (de

Inventor

Osamu Irie

Genji Iwasaki

Keiichi Masuya

Takahiro Miyake

Naoki Teno

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Novartis AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-02-28

Filing date

2004-02-27

Publication date

2006-08-10

2004-02-27 Application filed by Novartis AG filed Critical Novartis AG

2006-08-10 Publication of DE602004001397D1 publication Critical patent/DE602004001397D1/de

2007-04-26 Application granted granted Critical

2007-04-26 Publication of DE602004001397T2 publication Critical patent/DE602004001397T2/de

2024-02-28 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

DE602004001397T 2003-02-28 2004-02-27 Spirosubstituierte pyrrolopyrimidine Expired - Fee Related DE602004001397T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0304640		2003-02-28
GBGB0304640.6A GB0304640D0 (en)	2003-02-28	2003-02-28	Organic compounds
PCT/EP2004/001982 WO2004076455A1 (en)	2003-02-28	2004-02-27	Spiro-substituted pyrrolopyrimidines

Publications (2)

Publication Number	Publication Date
DE602004001397D1 true DE602004001397D1 (de)	2006-08-10
DE602004001397T2 DE602004001397T2 (de)	2007-04-26

Family

ID=9953876

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE602004001397T Expired - Fee Related DE602004001397T2 (de)	2003-02-28	2004-02-27	Spirosubstituierte pyrrolopyrimidine

Country Status (18)

Country	Link
US (2)	US7531546B2 (de)
EP (1)	EP1601677B1 (de)
JP (1)	JP2006519207A (de)
CN (1)	CN100341876C (de)
AT (1)	ATE331718T1 (de)
AU (1)	AU2004215648B2 (de)
BR (1)	BRPI0407919A (de)
CA (1)	CA2517035A1 (de)
CY (1)	CY1105637T1 (de)
DE (1)	DE602004001397T2 (de)
DK (1)	DK1601677T3 (de)
ES (1)	ES2268633T3 (de)
GB (1)	GB0304640D0 (de)
HK (1)	HK1089156A1 (de)
MX (1)	MXPA05009157A (de)
PL (1)	PL378469A1 (de)
PT (1)	PT1601677E (de)
WO (1)	WO2004076455A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0201980D0 (sv)	2002-06-24	2002-06-24	Astrazeneca Ab	Novel compounds
JP2009507800A (ja)	2005-09-09	2009-02-26	ユーロ−セルティークエス．エイ．	縮合およびスピロ環化合物ならびにその使用
KR101415861B1 (ko) *	2005-12-05	2014-07-04	인사이트 코포레이션	락탐 화합물 및 이를 사용하는 방법
US20090099157A1 (en) *	2007-02-15	2009-04-16	Ameriks Michael K	Tetrahydro-pyrazolo-pyridine thioether modulators of cathepsin s
US20080269241A1 (en) *	2007-02-15	2008-10-30	Darin Allen	Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20080207683A1 (en) *	2007-02-15	2008-08-28	Darin Allen	Biaryl-substituted tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20090118274A1 (en) *	2007-02-15	2009-05-07	Darin Allen	Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20080200454A1 (en) *	2007-02-15	2008-08-21	Ameriks Michael K	Carbon-linked tetrahydro-pyrazolo-pyridine modulators of cathepsin s
CN101678011B (zh) *	2007-05-16	2012-07-18	默沙东公司	螺氮茚酮化合物
EP2268647B1 (de)	2008-03-21	2017-01-25	The General Hospital Corporation	Verbindungen und zusammensetzungen für den nachweis und die behandlung von morbus alzheimer und verwandten erkrankungen
JP5677425B2 (ja)	2009-06-29	2015-02-25	インサイト・コーポレイションＩｎｃｙｔｅＣｏｒｐｏｒａｔｉｏｎ	Ｐｉ３ｋ阻害剤としてのピリミジノン
WO2011075643A1 (en)	2009-12-18	2011-06-23	Incyte Corporation	Substituted heteroaryl fused derivatives as pi3k inhibitors
CA2796311A1 (en)	2010-04-14	2011-10-20	Incyte Corporation	Fused derivatives as pi3k.delta. inhibitors
WO2011163195A1 (en)	2010-06-21	2011-12-29	Incyte Corporation	Fused pyrrole derivatives as pi3k inhibitors
EP2655374B1 (de)	2010-12-20	2019-10-23	Incyte Holdings Corporation	N-(1-(substituierte phenyl)ethyl)-9h-purin-6-amine als pi3k-hemmer
WO2012125629A1 (en)	2011-03-14	2012-09-20	Incyte Corporation	Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
US9126948B2 (en)	2011-03-25	2015-09-08	Incyte Holdings Corporation	Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
KR102507287B1 (ko)	2011-09-02	2023-03-07	인사이트 홀딩스 코포레이션	Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
AR090548A1 (es)	2012-04-02	2014-11-19	Incyte Corp	Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
JP6172143B2 (ja) *	2012-04-17	2017-08-02	アステラス製薬株式会社	含窒素二環式芳香族へテロ環化合物
CN104903313B (zh) *	2012-10-16	2017-12-29	爱尔兰詹森科学公司	Rsv抗病毒化合物
WO2014145576A2 (en)	2013-03-15	2014-09-18	Northwestern University	Substituted pyrrolo(2,3-d)pyrimidines for the treatment of cancer
TWI671299B (zh)	2014-04-14	2019-09-11	愛爾蘭商健生科學愛爾蘭無限公司	作為ｒｓｖ抗病毒化合物之螺脲化合物
US10077277B2 (en)	2014-06-11	2018-09-18	Incyte Corporation	Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
PE20180129A1 (es)	2015-02-27	2018-01-18	Incyte Corp	Sales de inhibidor de pi3k y procesos de preparacion
US10537552B2 (en)	2015-05-05	2020-01-21	Carafe Drug Innovation, Llc	Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers
US9988401B2 (en)	2015-05-11	2018-06-05	Incyte Corporation	Crystalline forms of a PI3K inhibitor
US9732097B2 (en)	2015-05-11	2017-08-15	Incyte Corporation	Process for the synthesis of a phosphoinositide 3-kinase inhibitor
CN107935908A (zh) *	2016-10-12	2018-04-20	上海科胜药物研发有限公司	一种尼达尼布（nintedanib）的制备方法及其中间体
WO2019190117A1 (ko)	2018-03-28	2019-10-03	한림제약(주)	2-시아노피리미딘-4-일 카르바메이트 혹은 유레아 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
WO2024092040A1 (en) *	2022-10-26	2024-05-02	Protego Biopharma, Inc.	Spirocycle containing bicyclic heteroaryl compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1265897A1 (de) *	2000-03-20	2002-12-18	Axys Pharmaceuticals, Inc.	Nicht-amidine enthaltende protease inhibitoren
GB0121033D0 (en) *	2001-08-30	2001-10-24	Novartis Ag	Organic compounds
PE20050068A1 (es) *	2003-02-06	2005-03-11	Novartis Ag	2-cianopirrolopirimidinas como inhibidores de la catepsina s

2003
- 2003-02-28 GB GBGB0304640.6A patent/GB0304640D0/en not_active Ceased
2004
- 2004-02-27 WO PCT/EP2004/001982 patent/WO2004076455A1/en active IP Right Grant
- 2004-02-27 PT PT04715273T patent/PT1601677E/pt unknown
- 2004-02-27 MX MXPA05009157A patent/MXPA05009157A/es active IP Right Grant
- 2004-02-27 CN CNB2004800054716A patent/CN100341876C/zh not_active Expired - Fee Related
- 2004-02-27 AU AU2004215648A patent/AU2004215648B2/en not_active Ceased
- 2004-02-27 DK DK04715273T patent/DK1601677T3/da active
- 2004-02-27 PL PL378469A patent/PL378469A1/pl not_active Application Discontinuation
- 2004-02-27 US US10/547,184 patent/US7531546B2/en not_active Expired - Fee Related
- 2004-02-27 EP EP04715273A patent/EP1601677B1/de not_active Expired - Lifetime
- 2004-02-27 AT AT04715273T patent/ATE331718T1/de not_active IP Right Cessation
- 2004-02-27 CA CA002517035A patent/CA2517035A1/en not_active Abandoned
- 2004-02-27 ES ES04715273T patent/ES2268633T3/es not_active Expired - Lifetime
- 2004-02-27 DE DE602004001397T patent/DE602004001397T2/de not_active Expired - Fee Related
- 2004-02-27 BR BRPI0407919-1A patent/BRPI0407919A/pt not_active IP Right Cessation
- 2004-02-27 JP JP2006501973A patent/JP2006519207A/ja active Pending
2006
- 2006-06-01 HK HK06106349A patent/HK1089156A1/xx not_active IP Right Cessation
- 2006-09-28 CY CY20061101408T patent/CY1105637T1/el unknown
2009
- 2009-03-30 US US12/413,996 patent/US20090186889A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CY1105637T1 (el)	2010-12-22
CA2517035A1 (en)	2004-09-10
EP1601677A1 (de)	2005-12-07
WO2004076455A1 (en)	2004-09-10
AU2004215648B2 (en)	2007-10-11
EP1601677B1 (de)	2006-06-28
US7531546B2 (en)	2009-05-12
CN100341876C (zh)	2007-10-10
JP2006519207A (ja)	2006-08-24
GB0304640D0 (en)	2003-04-02
ATE331718T1 (de)	2006-07-15
ES2268633T3 (es)	2007-03-16
MXPA05009157A (es)	2005-10-20
BRPI0407919A (pt)	2006-03-01
AU2004215648A1 (en)	2004-09-10
CN1753895A (zh)	2006-03-29
US20060258690A1 (en)	2006-11-16
US20090186889A1 (en)	2009-07-23
PT1601677E (pt)	2006-11-30
HK1089156A1 (en)	2006-11-24
DK1601677T3 (da)	2006-10-30
DE602004001397T2 (de)	2007-04-26
PL378469A1 (pl)	2006-04-03

Legal Events

Date	Code	Title	Description
2007-07-19	8364	No opposition during term of opposition
2010-05-20	8328	Change in the person/name/address of the agent	Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336
2012-01-19	R119	Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee	Ref document number: 1601677 Country of ref document: EP Effective date: 20110901
2012-01-31	R082	Change of representative	Ref document number: 1601677 Country of ref document: EP Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN, DE

Publication	Publication Date	Title
DE602004001397D1 (de)	2006-08-10	Spirosubstituierte pyrrolopyrimidine
GB0220187D0 (en)	2002-10-09	Organic compounds
GB0121033D0 (en)	2001-10-24	Organic compounds
PL367821A1 (en)	2005-03-07	Cysteine protease inhibitors with 2-cyano-4-amino-pyrimidine structure and cathepsin k inhibitory activity for the treatment of inflammations and other diseases
NO20044038L (no)	2004-09-28	Glutaminylbaserte DRIV-inhibitorer
GB0223040D0 (en)	2002-11-13	Therapeutic compounds
EP1562897A4 (de)	2007-06-27	Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer
NO20030895D0 (no)	2003-02-26	Ny anvendelse av dipeptidyl peptidase IV inhibitorer
EP1689233A4 (de)	2007-08-29	Bicyclische mek-hemmer und verfahren zu ihrer verwendung
RS20050070A (en)	2007-06-04	Use of 1kb kinase inhibitors for the treatment of pain
UY28310A1 (es)	2004-11-30	Pirazoles como inhibidores de factor de necrosis tumoral
DK1641454T3 (da)	2009-02-09	Pyrazolo[3,4-B]pyridin-6-oner som GSK-3-hæmmere
ITMI20031311A1 (it)	2004-12-28	Formulazioni per il trattamento di disturbi artrosici.
ECSP044989A (es)	2004-04-28	Inhibidores de proteasa de cisteina con estructura de 2-ciano-4-amino-pirimidina y actividad inhibidora de catepsina k para el tratamiento de inflamaciones y otras enfermedades
MXPA05006296A (es)	2005-08-29	Uso de tiazolobenzoheterociclos para el tratamiento de la esclerosis multiple.
ITMI20030258A1 (it)	2004-08-14	Composizioni per il trattamento di ferite corneali
MY140242A (en)	2009-12-31	BICYCLIC 6-ALKYLIDENE-PENEMS AS ß-LACTAMASES INHIBITORS