DE60142838D1 - Pharmazeutisch aktive benzsulfonamidderivate als inhibitoren von protein-jun-kinasen - Google Patents

Pharmazeutisch aktive benzsulfonamidderivate als inhibitoren von protein-jun-kinasen

Info

Publication number
DE60142838D1
DE60142838D1 DE60142838T DE60142838T DE60142838D1 DE 60142838 D1 DE60142838 D1 DE 60142838D1 DE 60142838 T DE60142838 T DE 60142838T DE 60142838 T DE60142838 T DE 60142838T DE 60142838 D1 DE60142838 D1 DE 60142838D1
Authority
DE
Germany
Prior art keywords
derivatives
substituted
formula
benzsulfonamide
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60142838T
Other languages
English (en)
Inventor
Serge Halazy
Dennis Church
Montserrat Camps
Jean-Pierre Gotteland
Thomas Rueckle
Marco Biamonte
Stephen Arkinstall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SA
Original Assignee
Merck Serono SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono SA filed Critical Merck Serono SA
Application granted granted Critical
Publication of DE60142838D1 publication Critical patent/DE60142838D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
DE60142838T 2000-09-27 2001-09-27 Pharmazeutisch aktive benzsulfonamidderivate als inhibitoren von protein-jun-kinasen Expired - Lifetime DE60142838D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00810888A EP1193256A1 (de) 2000-09-27 2000-09-27 Pharmazeutisch aktive Benzolsulfonamidderivate als JNK-Proteininhibitoren
PCT/IB2001/001773 WO2002026711A1 (en) 2000-09-27 2001-09-27 Pharmaceutically active benzsulfonamide derivatives as inhibitors of protein junkinases

Publications (1)

Publication Number Publication Date
DE60142838D1 true DE60142838D1 (de) 2010-09-30

Family

ID=8174938

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60142838T Expired - Lifetime DE60142838D1 (de) 2000-09-27 2001-09-27 Pharmazeutisch aktive benzsulfonamidderivate als inhibitoren von protein-jun-kinasen

Country Status (14)

Country Link
US (2) US7417058B2 (de)
EP (2) EP1193256A1 (de)
JP (1) JP4927303B2 (de)
AT (1) ATE478048T1 (de)
AU (2) AU2001287992B9 (de)
CA (1) CA2420568C (de)
CY (1) CY1110904T1 (de)
DE (1) DE60142838D1 (de)
DK (1) DK1320526T3 (de)
ES (1) ES2347136T3 (de)
IL (2) IL154964A0 (de)
PT (1) PT1320526E (de)
SI (1) SI1320526T1 (de)
WO (1) WO2002026711A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1193268A1 (de) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmazeutisch aktive Sulfonamidderivate mit sowohl lipophilen als auch ionisierbaren Gruppen als Inhibitoren von Protein-JunKinasen
EP1193256A1 (de) 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmazeutisch aktive Benzolsulfonamidderivate als JNK-Proteininhibitoren
EP1193267A1 (de) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmazeutisch wirksame hydrophile Sulfonamidderivate zur Verwendung als Proteinjunkinasehemmer
CA2454662A1 (en) * 2001-07-23 2003-02-06 Fos Holding S.A. Device for separating the epithelium layer from the surface of the cornea of an eye
ES2318041T3 (es) * 2001-07-23 2009-05-01 Laboratoires Serono Sa Derivados de arilsulfonamida como inhibidores de c-jun quinasas (jnk) n-terminales.
ATE383356T1 (de) * 2002-04-25 2008-01-15 Serono Lab Piperazinbenzothiazole als wirkstoffe in der behandlung von ischämien und krankheiten des zns- systems
ES2385219T3 (es) * 2003-09-12 2012-07-19 Merck Serono Sa Derivados de sulfonamida para el tratamiento de diabetes
US20060094753A1 (en) * 2004-10-29 2006-05-04 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases
US7803824B2 (en) * 2004-10-29 2010-09-28 Alcon, Inc. Use of inhibitors of Jun N-terminal kinases to treat glaucoma
AU2011265521B8 (en) * 2005-07-15 2014-05-22 Merck Serono Sa JNK inhibitors for the treatment of endometreosis
US20070260951A1 (en) * 2006-05-03 2007-11-08 Texas Instruments Incorporated Uncompromised standard input set-up time with improved enable input set-up time characteristics in a storage circuit
EP2280001B1 (de) * 2008-04-24 2014-10-15 Msd K.K. Hemmer für langkettige fettsäuren verlängerndes enzym mit arylsulfonylderivat als wirkstoff
US8828924B2 (en) * 2009-05-14 2014-09-09 University Of Maryland, Baltimore Methods of treating a diabetic embryopathy
WO2011060321A1 (en) 2009-11-16 2011-05-19 Chdi, Inc. Transglutaminase tg2 inhibitors, pharmaceutical compositions, and methods of use thereof
MX347889B (es) 2010-09-03 2017-05-17 Forma Tm Llc * Compuestos y composiciones novedosos para la inhibición de nampt.
KR20140027366A (ko) 2011-05-04 2014-03-06 포르마 티엠, 엘엘씨. Nampt의 억제를 위한 신규 화합물 및 조성물
US8889716B2 (en) 2011-05-10 2014-11-18 Chdi Foundation, Inc. Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof
KR101592068B1 (ko) 2013-11-08 2016-02-05 순천향대학교 산학협력단 플라즈마 아포리포프로테인 h를 포함하는 아스피린 과민성 호흡계 질환 및 아스피린 내성 천식 구별 진단용 마커 및 구별 진단용 키트
EP3946301A4 (de) * 2019-04-02 2023-08-09 The University of Chicago Remodiline für atemwegsremodellierung und organfibrose
US20230133406A1 (en) * 2021-08-18 2023-05-04 Chemocentryx, Inc. Aryl Sulfonyl (Hydroxy) Piperidines as CCR6 Inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3812144A (en) * 1969-03-10 1974-05-21 Ciba Geigy Corp Derivatives of p-aminoalkylbenzene sulfonamide
FR2553414B1 (fr) * 1983-10-18 1986-08-14 Choay Sa Nouveaux benzenesulfonamides n-cyclises, leur procede de preparation et leur utilisation comme substance active de compositions pharmaceutiques
US5744320A (en) 1995-06-07 1998-04-28 Promega Corporation Quenching reagents and assays for enzyme-mediated luminescence
US6043083A (en) * 1997-04-28 2000-03-28 Davis; Roger J. Inhibitors of the JNK signal transduction pathway and methods of use
DE19743435A1 (de) * 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
CN1332943C (zh) * 1998-07-08 2007-08-22 萨诺费－阿文蒂斯德国有限公司 硫取代的磺酰基氨基羧酸n－芳基酰胺,其制备方法、用途以及含有该化合物的药物制剂
EP1088821A1 (de) * 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Pharmazeutisch wirksamer Sulfonamid Derivate
EP1193256A1 (de) 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmazeutisch aktive Benzolsulfonamidderivate als JNK-Proteininhibitoren
EP1193267A1 (de) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmazeutisch wirksame hydrophile Sulfonamidderivate zur Verwendung als Proteinjunkinasehemmer
EP1193268A1 (de) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmazeutisch aktive Sulfonamidderivate mit sowohl lipophilen als auch ionisierbaren Gruppen als Inhibitoren von Protein-JunKinasen

Also Published As

Publication number Publication date
JP2004523475A (ja) 2004-08-05
SI1320526T1 (sl) 2010-11-30
US8008341B2 (en) 2011-08-30
EP1193256A1 (de) 2002-04-03
DK1320526T3 (da) 2010-10-18
IL154964A (en) 2010-11-30
IL154964A0 (en) 2003-10-31
ES2347136T3 (es) 2010-10-26
AU8799201A (en) 2002-04-08
JP4927303B2 (ja) 2012-05-09
AU2001287992B9 (en) 2006-09-28
CA2420568A1 (en) 2002-04-04
US20080255222A1 (en) 2008-10-16
US7417058B2 (en) 2008-08-26
EP1193256A8 (de) 2002-08-28
PT1320526E (pt) 2010-09-02
EP1320526A1 (de) 2003-06-25
CY1110904T1 (el) 2015-06-10
ATE478048T1 (de) 2010-09-15
EP1320526B1 (de) 2010-08-18
US20040053917A1 (en) 2004-03-18
CA2420568C (en) 2010-09-21
WO2002026711A1 (en) 2002-04-04
AU2001287992B2 (en) 2006-05-04

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