DE60128551D1 - Geladene verbindungen mit einer nukleinsäure-bindenden einheit sowie deren verwendungen - Google Patents
Geladene verbindungen mit einer nukleinsäure-bindenden einheit sowie deren verwendungenInfo
- Publication number
- DE60128551D1 DE60128551D1 DE60128551T DE60128551T DE60128551D1 DE 60128551 D1 DE60128551 D1 DE 60128551D1 DE 60128551 T DE60128551 T DE 60128551T DE 60128551 T DE60128551 T DE 60128551T DE 60128551 D1 DE60128551 D1 DE 60128551D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- nucleic acid
- acid binding
- binding unit
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18993000P | 2000-03-16 | 2000-03-16 | |
PCT/US2001/008252 WO2001074898A2 (en) | 2000-03-16 | 2001-03-14 | Charged compounds comprising a nucleic acid binding moiety and uses therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60128551D1 true DE60128551D1 (de) | 2007-07-05 |
Family
ID=22699352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60128551T Expired - Lifetime DE60128551D1 (de) | 2000-03-16 | 2001-03-14 | Geladene verbindungen mit einer nukleinsäure-bindenden einheit sowie deren verwendungen |
Country Status (11)
Country | Link |
---|---|
US (2) | US6555693B2 (de) |
EP (1) | EP1265921B1 (de) |
JP (1) | JP2003529609A (de) |
KR (1) | KR20030043785A (de) |
CN (1) | CN1427839A (de) |
AT (1) | ATE362940T1 (de) |
AU (1) | AU7681401A (de) |
CA (1) | CA2403537A1 (de) |
DE (1) | DE60128551D1 (de) |
HK (1) | HK1052190A1 (de) |
WO (1) | WO2001074898A2 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7078536B2 (en) * | 2001-03-14 | 2006-07-18 | Genesoft Pharmaceuticals, Inc. | Charged compounds comprising a nucleic acid binding moiety and uses therefor |
DE60128551D1 (de) * | 2000-03-16 | 2007-07-05 | Genesoft Inc | Geladene verbindungen mit einer nukleinsäure-bindenden einheit sowie deren verwendungen |
WO2002088119A1 (en) * | 2001-04-26 | 2002-11-07 | Genesoft Pharmaceuticals, Inc | Halogen-substituted thienyl compounds |
US7129261B2 (en) | 2001-05-31 | 2006-10-31 | Medarex, Inc. | Cytotoxic agents |
WO2002101007A2 (en) * | 2001-06-13 | 2002-12-19 | Genesoft Pharmaceuticals, Inc | Antipathogenic benzamide compounds |
US6777425B2 (en) | 2001-06-13 | 2004-08-17 | Genesoft Pharmaceuticals, Inc. | Isoquinoline compounds having antiinfective activity |
GB0130868D0 (en) | 2001-12-24 | 2002-02-06 | Univ Strathclyde | New compounds |
US7498349B2 (en) | 2002-08-02 | 2009-03-03 | Genesoft Pharmaceuticals, Inc. | Biaryl compounds having anti-infective activity |
EP1562931A2 (de) * | 2002-10-25 | 2005-08-17 | Genesoft Pharmaceuticals, Inc. | Biarylverbindungen mitantiinfektionswirkung |
EP1587529A4 (de) * | 2002-12-10 | 2009-08-12 | Oscient Pharmaceuticals Corp | Antibakterielle verbindungen mit(pyrrolcarboxamid)-(benzamid)-(imidazolcarboxamid)-motiv |
US7691962B2 (en) * | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
EP1747021B1 (de) * | 2004-05-19 | 2015-09-09 | E. R. Squibb & Sons, L.L.C. | Selbstimmolative verbinder und arzneimittelkonjugate |
AU2006214031A1 (en) * | 2005-02-18 | 2006-08-24 | Medarex, Inc. | Human monoclonal antibodies to prostate specific membrane antigen (PSMA) |
US7714016B2 (en) * | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
CN101312748A (zh) * | 2005-09-26 | 2008-11-26 | 梅达莱克斯公司 | 抗体-药物轭合物和使用方法 |
ES2375843T3 (es) | 2005-10-26 | 2012-03-06 | Medarex, Inc. | Procedimientos y compuestos para la preparación de an�?logos de cc-1065. |
WO2007059404A2 (en) | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
GB0619325D0 (en) * | 2006-09-30 | 2006-11-08 | Univ Strathclyde | New compounds |
TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
WO2008103693A2 (en) | 2007-02-21 | 2008-08-28 | Medarex, Inc. | Chemical linkers with single amino acids and conjugates thereof |
TWI510241B (zh) | 2010-02-18 | 2015-12-01 | Vtv Therapeutice Llc | 苯基-雜芳基衍生物及其使用方法 |
US9650421B2 (en) | 2011-09-02 | 2017-05-16 | Northwestern University | Self-assembled nanostructures |
US10131682B2 (en) | 2012-11-24 | 2018-11-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules |
US10464955B2 (en) | 2014-02-28 | 2019-11-05 | Hangzhou Dac Biotech Co., Ltd. | Charged linkers and their uses for conjugation |
CN104845967B (zh) | 2015-04-15 | 2020-12-11 | 苏州新海生物科技股份有限公司 | 寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用 |
TN2017000483A1 (en) | 2015-05-20 | 2019-04-12 | Amgen Inc | Triazole agonists of the apj receptor. |
CN113350518A (zh) | 2015-07-12 | 2021-09-07 | 杭州多禧生物科技有限公司 | 与细胞结合分子的共轭偶联的桥连接体 |
US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
WO2017192485A1 (en) | 2016-05-03 | 2017-11-09 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the apj receptor |
WO2018047148A1 (en) | 2016-09-12 | 2018-03-15 | Novartis Ag | Compounds for the inhibition of mirna |
NZ752394A (en) | 2016-11-14 | 2021-07-30 | Hangzhou Dac Biotech Co Ltd | Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers |
US10689367B2 (en) | 2016-11-16 | 2020-06-23 | Amgen Inc. | Triazole pyridyl compounds as agonists of the APJ receptor |
US11020395B2 (en) | 2016-11-16 | 2021-06-01 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the APJ receptor |
WO2018097945A1 (en) | 2016-11-16 | 2018-05-31 | Amgen Inc. | Heteroaryl-substituted triazoles as apj receptor agonists |
MA46824A (fr) | 2016-11-16 | 2019-09-25 | Amgen Inc | Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj |
EP3541792B1 (de) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazol-furan-verbindungen als agonisten des apj-rezeptors |
WO2018093579A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Triazole phenyl compounds as agonists of the apj receptor |
MA50509A (fr) | 2017-11-03 | 2021-06-02 | Amgen Inc | Agonistes de triazole fusionnés du récepteur apj |
WO2019213006A1 (en) | 2018-05-01 | 2019-11-07 | Amgen Inc. | Substituted pyrimidinones as agonists of the apj receptor |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN85103908A (zh) | 1985-07-16 | 1986-11-05 | 法米塔利·卡洛·埃尔巴有限公司 | 制备4′-表多克索红菌素的新方法 |
GB8517922D0 (en) | 1985-07-16 | 1985-08-21 | Erba Farmitalia | Carboxamido derivatives |
US5049579A (en) | 1986-05-20 | 1991-09-17 | Farmitalia Carlo Erba, S.R.L. | Site specific alkylating agents |
US5310752A (en) | 1986-05-20 | 1994-05-10 | Farmitalia Carlo Erba Spa | Site specific alkylating agents |
GB8612218D0 (en) | 1986-05-20 | 1986-06-25 | Erba Farmitalia | Site specific alkylating agents |
CA1308516C (en) | 1987-07-06 | 1992-10-06 | J. William Lown | Oligopeptide anticancer and antiviral agents |
AU1224392A (en) | 1991-02-06 | 1992-09-07 | Synphar Laboratories, Inc. | Oligopeptide antiretroviral agents |
IT1247878B (it) | 1991-02-15 | 1995-01-05 | Menarini Farma Ind | Derivati poli-4-aminopirrol-2-carbossiamidici,processi di preparazione e composizioni farmaceutiche che li contengono |
IT1262921B (it) | 1992-01-10 | 1996-07-22 | Federico Arcamone | Agenti antitumorali analoghi di oligopeptidi pirrol-amidinici retroversi processi di preparazione e prodotti farmaceutici che li contengono |
IT1271456B (it) | 1993-03-01 | 1997-05-28 | Menarini Farma Ind | Composti pirrol-amidinici, e loro sali farmaceuticamente accettabili, processi di preparazione e composizioni farmaceutiche che li contengono |
IT1263089B (it) | 1993-04-26 | 1996-07-24 | Menarini Farma Ind | Composti pirrol-amidinici, processi di preparazione e composizioni farmaceutiche che li contengono. |
AU7380294A (en) | 1993-08-06 | 1995-02-28 | Synphar Laboratories, Inc. | Oligopeptide antiretroviral agents |
US5698674A (en) | 1994-04-13 | 1997-12-16 | The Regents Of The University Of California | Triheterocyclic peptides capable of binding the minor and major grooves of DNA |
EP0711768B1 (de) | 1994-05-31 | 2002-02-13 | Mitsui Chemicals, Inc. | Benzimidazol-derivate |
GB9416005D0 (en) | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Peptidic compounds analogous to distamycin a and process for their preparation |
US5502068A (en) | 1995-01-31 | 1996-03-26 | Synphar Laboratories, Inc. | Cyclopropylpyrroloindole-oligopeptide anticancer agents |
US5801155A (en) | 1995-04-03 | 1998-09-01 | Epoch Pharmaceuticals, Inc. | Covalently linked oligonucleotide minor grove binder conjugates |
GB2310207A (en) * | 1996-02-15 | 1997-08-20 | Pharmacia Spa | Antiviral ureido derivatives of substituted heterocyclic compounds |
JP2002515897A (ja) | 1996-02-26 | 2002-05-28 | カリフォルニア・インスティチュート・オブ・テクノロジー | 特異的ポリアミドdna−結合リガンドの設計、合成、および使用 |
WO1998037066A1 (en) | 1996-02-26 | 1998-08-27 | California Institute Of Technology | Improved polyamides for binding in the minor groove of double stranded dna |
CN1260006A (zh) | 1996-02-26 | 2000-07-12 | 加利福尼亚州技术学院 | 双链dna和杂环低聚物之间复合物的形成 |
EP1023288A1 (de) | 1996-02-26 | 2000-08-02 | California Institute Of Technology | Stereochemische kontrolle der dna-bindungsaffinität, sequenz-spezifität und orientierungspräferenz von chiralen hairinpolyamiden an den kleinen graben |
US6635417B1 (en) * | 1996-07-31 | 2003-10-21 | California Institute Of Technology | Complex formation between DSDNA and oligomer of cyclic heterocycles |
US6090947A (en) * | 1996-02-26 | 2000-07-18 | California Institute Of Technology | Method for the synthesis of pyrrole and imidazole carboxamides on a solid support |
CA2286232A1 (en) * | 1997-04-06 | 1998-11-05 | California Institute Of Technology | Dna-binding pyrrole and imidazole polyamide derivatives |
ATE251913T1 (de) | 1997-05-21 | 2003-11-15 | Univ Leland Stanford Junior | Zusammensetzung und verfahren zur verzögerung des transports durch biologische membranen |
US6562859B1 (en) | 1997-12-04 | 2003-05-13 | The United States Of America As Represented By The Department Of Health And Human Services | Ureido derivatives of poly-4-amino-2-carboxy-1-methyl pyrrole compounds for inhibition of inflammation |
DE19805431A1 (de) | 1998-02-11 | 1999-08-12 | Merck Patent Gmbh | Heteroaromatische Oligoamide als Affinitätsliganden |
GB9806689D0 (en) | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents |
UA60365C2 (uk) * | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
GB9812211D0 (en) | 1998-06-05 | 1998-08-05 | Pharmacia & Upjohn Spa | Cinnamoyl distamycin analogous derivatives,process for their preparation,and their use as antitumor agents |
US6099947A (en) | 1998-06-05 | 2000-08-08 | Maeta Techno-Research, Inc. | Hybrid material and method of manufacturing the same |
WO2000040605A2 (en) | 1999-01-08 | 2000-07-13 | California Institute Of Technology | Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids |
DE60128551D1 (de) * | 2000-03-16 | 2007-07-05 | Genesoft Inc | Geladene verbindungen mit einer nukleinsäure-bindenden einheit sowie deren verwendungen |
-
2001
- 2001-03-14 DE DE60128551T patent/DE60128551D1/de not_active Expired - Lifetime
- 2001-03-14 KR KR1020027012164A patent/KR20030043785A/ko not_active Application Discontinuation
- 2001-03-14 JP JP2001572587A patent/JP2003529609A/ja active Pending
- 2001-03-14 US US09/808,729 patent/US6555693B2/en not_active Expired - Fee Related
- 2001-03-14 EP EP01954573A patent/EP1265921B1/de not_active Expired - Lifetime
- 2001-03-14 WO PCT/US2001/008252 patent/WO2001074898A2/en active IP Right Grant
- 2001-03-14 CN CN01809034A patent/CN1427839A/zh active Pending
- 2001-03-14 CA CA002403537A patent/CA2403537A1/en not_active Abandoned
- 2001-03-14 AT AT01954573T patent/ATE362940T1/de not_active IP Right Cessation
- 2001-03-16 AU AU7681401A patent/AU7681401A/xx active Pending
-
2003
- 2003-06-18 HK HK03104396.9A patent/HK1052190A1/zh unknown
-
2006
- 2006-07-14 US US11/487,164 patent/US7301037B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2003529609A (ja) | 2003-10-07 |
WO2001074898A8 (en) | 2002-04-11 |
CN1427839A (zh) | 2003-07-02 |
US20020065227A1 (en) | 2002-05-30 |
AU7681401A (en) | 2001-10-15 |
EP1265921A1 (de) | 2002-12-18 |
WO2001074898A3 (en) | 2003-01-16 |
US20070105135A1 (en) | 2007-05-10 |
CA2403537A1 (en) | 2001-10-11 |
US6555693B2 (en) | 2003-04-29 |
WO2001074898A2 (en) | 2001-10-11 |
ATE362940T1 (de) | 2007-06-15 |
KR20030043785A (ko) | 2003-06-02 |
HK1052190A1 (zh) | 2003-10-03 |
EP1265921B1 (de) | 2007-05-23 |
US7301037B2 (en) | 2007-11-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |