DE60123117D1 - Verwendung von alpha-halogenacryloyl-distamycin derivaten zur herstellung eines medikaments zur behandlung von krebs - Google Patents

Verwendung von alpha-halogenacryloyl-distamycin derivaten zur herstellung eines medikaments zur behandlung von krebs

Info

Publication number
DE60123117D1
DE60123117D1 DE60123117T DE60123117T DE60123117D1 DE 60123117 D1 DE60123117 D1 DE 60123117D1 DE 60123117 T DE60123117 T DE 60123117T DE 60123117 T DE60123117 T DE 60123117T DE 60123117 D1 DE60123117 D1 DE 60123117D1
Authority
DE
Germany
Prior art keywords
alpha
treatment
halogenacryloyl
medicament
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60123117T
Other languages
English (en)
Other versions
DE60123117T2 (de
Inventor
Camilla Fowst
Franzanne Vreeland
Cristina Geroni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nerviano Medical Sciences SRL
Pharmacia and Upjohn Co LLC
Original Assignee
Nerviano Medical Sciences SRL
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nerviano Medical Sciences SRL, Pharmacia and Upjohn Co LLC filed Critical Nerviano Medical Sciences SRL
Application granted granted Critical
Publication of DE60123117D1 publication Critical patent/DE60123117D1/de
Publication of DE60123117T2 publication Critical patent/DE60123117T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
DE60123117T 2000-10-02 2001-09-21 Verwendung von alpha-halogenacryloyl-distamycin derivaten zur herstellung eines medikaments zur behandlung von krebs Expired - Lifetime DE60123117T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US676770 2000-10-02
US09/676,770 US6576612B1 (en) 2000-10-02 2000-10-02 Antitumor therapy comprising distamycin derivatives
PCT/EP2001/010988 WO2002028389A1 (en) 2000-10-02 2001-09-21 Antitumor therapy comprising distamycin derivatives

Publications (2)

Publication Number Publication Date
DE60123117D1 true DE60123117D1 (de) 2006-10-26
DE60123117T2 DE60123117T2 (de) 2007-02-08

Family

ID=24715919

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60123117T Expired - Lifetime DE60123117T2 (de) 2000-10-02 2001-09-21 Verwendung von alpha-halogenacryloyl-distamycin derivaten zur herstellung eines medikaments zur behandlung von krebs

Country Status (24)

Country Link
US (2) US6576612B1 (de)
EP (1) EP1345604B1 (de)
JP (1) JP2004510734A (de)
KR (1) KR100827560B1 (de)
CN (1) CN1468099A (de)
AT (1) ATE339202T1 (de)
AU (2) AU2162202A (de)
BR (1) BR0114389A (de)
CA (1) CA2424116A1 (de)
CZ (1) CZ299686B6 (de)
DE (1) DE60123117T2 (de)
EA (1) EA006295B1 (de)
EE (1) EE05241B1 (de)
ES (1) ES2267841T3 (de)
HU (1) HUP0301247A2 (de)
IL (1) IL154755A0 (de)
MX (1) MXPA03002824A (de)
MY (1) MY134690A (de)
NO (1) NO20031410L (de)
PE (1) PE20020487A1 (de)
PL (1) PL363926A1 (de)
SK (1) SK5032003A3 (de)
WO (1) WO2002028389A1 (de)
ZA (1) ZA200303405B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0015446D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015447D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives
US20070249651A1 (en) * 2001-06-20 2007-10-25 Nerviano Medical Sciences S.R.I. Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
US6969592B2 (en) * 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy
ES2299692T3 (es) * 2002-04-02 2008-06-01 Nerviano Medical Sciences S.R.L. Terapia combinada contra tumores que comprende derivados de distmicina acriloil sustituido y radioterapia.
AU2003288263A1 (en) * 2002-10-16 2004-05-04 Pharmacia Italia S.P.A. Use of substituted acrylolyl distamycin derivatives in combination with demethylating agents, in the treatment of cancer
DK1975158T3 (da) * 2005-12-27 2011-10-24 Ct Nac Investigaciones Oncologicas Cnio Hidtil ukendte pyrrolderivater med histondeacetylase-inhibitoraktivitet
MD36Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare
MD24Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare
MD35Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare
MD23Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
GB9615692D0 (en) * 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9806689D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9928703D0 (en) * 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives

Also Published As

Publication number Publication date
CA2424116A1 (en) 2002-04-11
PE20020487A1 (es) 2002-05-23
SK5032003A3 (en) 2003-08-05
WO2002028389A1 (en) 2002-04-11
PL363926A1 (en) 2004-11-29
KR100827560B1 (ko) 2008-05-07
DE60123117T2 (de) 2007-02-08
NO20031410D0 (no) 2003-03-27
JP2004510734A (ja) 2004-04-08
US7399748B2 (en) 2008-07-15
EE200300129A (et) 2003-06-16
CZ2003909A3 (cs) 2003-08-13
EP1345604B1 (de) 2006-09-13
ATE339202T1 (de) 2006-10-15
KR20030096222A (ko) 2003-12-24
CZ299686B6 (cs) 2008-10-22
HUP0301247A2 (hu) 2003-09-29
CN1468099A (zh) 2004-01-14
AU2162202A (en) 2002-04-15
MY134690A (en) 2007-12-31
EE05241B1 (et) 2009-12-15
AU2002221622B2 (en) 2007-05-17
ES2267841T3 (es) 2007-03-16
US6576612B1 (en) 2003-06-10
ZA200303405B (en) 2004-05-03
IL154755A0 (en) 2003-10-31
US20040006023A1 (en) 2004-01-08
EP1345604A1 (de) 2003-09-24
EA006295B1 (ru) 2005-10-27
MXPA03002824A (es) 2003-07-14
NO20031410L (no) 2003-03-27
BR0114389A (pt) 2004-02-03
EA200300427A1 (ru) 2003-10-30

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