DE60117857D1 - Kontrollierte freisetzung von anti-arrhythmica aus einem biodegradierbaren hydrogel für die lokale anwendung am herzen - Google Patents

Kontrollierte freisetzung von anti-arrhythmica aus einem biodegradierbaren hydrogel für die lokale anwendung am herzen

Info

Publication number
DE60117857D1
DE60117857D1 DE60117857T DE60117857T DE60117857D1 DE 60117857 D1 DE60117857 D1 DE 60117857D1 DE 60117857 T DE60117857 T DE 60117857T DE 60117857 T DE60117857 T DE 60117857T DE 60117857 D1 DE60117857 D1 DE 60117857D1
Authority
DE
Germany
Prior art keywords
heart
controlled release
drugs
arrhythmica
local application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60117857T
Other languages
English (en)
Inventor
C Philbrook
W Burns
C Skinner
J Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of DE60117857D1 publication Critical patent/DE60117857D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/624—Nanocapsules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60117857T 2000-12-27 2001-12-27 Kontrollierte freisetzung von anti-arrhythmica aus einem biodegradierbaren hydrogel für die lokale anwendung am herzen Expired - Lifetime DE60117857D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25836900P 2000-12-27 2000-12-27
PCT/US2001/049617 WO2002051383A2 (en) 2000-12-27 2001-12-27 Controlled release of anti-arrhythmic agents from a biodegradable polyethylene oxide hydrogel for local application to the heart

Publications (1)

Publication Number Publication Date
DE60117857D1 true DE60117857D1 (de) 2006-05-04

Family

ID=22980272

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60117857T Expired - Lifetime DE60117857D1 (de) 2000-12-27 2001-12-27 Kontrollierte freisetzung von anti-arrhythmica aus einem biodegradierbaren hydrogel für die lokale anwendung am herzen

Country Status (8)

Country Link
US (1) US7022343B2 (de)
EP (1) EP1347756B1 (de)
JP (1) JP2004518664A (de)
AT (1) ATE319423T1 (de)
AU (1) AU2002231175A1 (de)
CA (1) CA2433861A1 (de)
DE (1) DE60117857D1 (de)
WO (1) WO2002051383A2 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8795242B2 (en) * 1994-05-13 2014-08-05 Kensey Nash Corporation Resorbable polymeric device for localized drug delivery
US7963997B2 (en) 2002-07-19 2011-06-21 Kensey Nash Corporation Device for regeneration of articular cartilage and other tissue
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
MXPA03002769A (es) * 2000-09-29 2003-07-28 Solvay Pharm Bv Formulacion farmaceutica de liberacion sostenida e independiente de la densidad ionica.
EP1551368A1 (de) * 2002-06-28 2005-07-13 Genzyme Corporation Gesteuerte verabreichung von antiarrhythmica
CA2496364A1 (en) * 2002-08-20 2004-03-04 Exactech, Inc. Composition for the carrying and delivery of bone growth inducing material and methods for producing and applying the composition
US7217254B2 (en) 2002-09-20 2007-05-15 Genzyme Corporation Multi-pressure biocompatible agent delivery device and method
US20060093673A1 (en) * 2003-06-27 2006-05-04 Coury Arthur J Controlled release of anti-arrhythmic agents
US7517914B2 (en) * 2005-04-04 2009-04-14 Boston Scientificscimed, Inc. Controlled degradation materials for therapeutic agent delivery
CA2609456C (en) * 2005-05-25 2014-04-29 Massachusetts Institute Of Technology Localized delivery of cardiac inotropic agents
EP1903934A2 (de) * 2005-06-06 2008-04-02 Solvay Pharmaceuticals GmbH Werkzeug zur steuerung des risikos von atypischer ventrikulärer tachykardie
US8974542B2 (en) 2006-06-27 2015-03-10 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions
US9090737B2 (en) * 2007-11-13 2015-07-28 Surmodics, Inc. Viscous terpolymers as drug delivery platform
WO2009065065A1 (en) * 2007-11-15 2009-05-22 Ceramoptec Industries, Inc. Pegylated liposomal formulations for photodynamic treatment of inflammatory diseases
FR2930149B1 (fr) * 2008-04-17 2011-02-18 Sanofi Aventis Association de dronedarone avec au moins un diuretique, son application en therapeutique
JP2011518785A (ja) * 2008-04-17 2011-06-30 サノフイ−アベンテイス 心血管入院または死亡の予防に用いる薬剤を調製するためのドロネダロンの使用
EP2116239A1 (de) * 2008-04-29 2009-11-11 Sanofi-Aventis Verfahren zur Verwaltung von Risiken in Zusammenhang mit der Zunahme von Serumkreatinin bei der Dronedaron-Behandlung
US8562586B2 (en) * 2008-08-26 2013-10-22 Massachusetts Institute Of Technology Devices and systems for local delivery of inotropic agents to the epicardium
EP2344329B1 (de) 2008-10-02 2012-12-05 Mylan Inc. Verfahren zur herstellung eines mehrlagigen klebstofflaminats
US8974808B2 (en) * 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
US8951546B2 (en) 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
US20100168807A1 (en) * 2008-12-23 2010-07-01 Burton Kevin W Bioactive terpolymer compositions and methods of making and using same
US20100158978A1 (en) * 2008-12-23 2010-06-24 Peter Markland Bioactive spray coating compositions and methods of making and uses thereof
US9480643B2 (en) 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
US9415197B2 (en) 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
WO2011057133A1 (en) 2009-11-09 2011-05-12 Spotlight Technology Partners Llc Fragmented hydrogels
CA2780294C (en) 2009-11-09 2018-01-16 Spotlight Technology Partners Llc Polysaccharide based hydrogels
TWI508726B (zh) 2009-12-21 2015-11-21 Gilead Sciences Inc 治療心房纖維性顫動之方法
US9993441B2 (en) 2009-12-30 2018-06-12 Surmodics, Inc. Controlled release matrix barrier structure for subcutaneous medical devices
EP2364703A1 (de) * 2010-03-12 2011-09-14 Sanofi Verwendung von Dronedaron oder eines pharmazeutische zulässigen Salzes davon zur Herstellung eines Medikaments zur Verabreichung kurz nach einer Amiodaroneinstellung
US8602215B2 (en) 2010-06-30 2013-12-10 Sanofi Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation
WO2012023024A2 (en) * 2010-08-17 2012-02-23 Lupin Limited Controlled release formulations of dronedarone
US8920921B2 (en) 2010-08-30 2014-12-30 Surmodics Pharmaceuticals, Inc. Terpolymer blends and their use as pressure-sensitive adhesives
EA201492173A1 (ru) * 2012-05-22 2015-04-30 Санофи Дронедарон для применения при лейшманиозе, в составах и комбинациях для применения при лейшманиозе
WO2015021044A1 (en) * 2013-08-05 2015-02-12 University Of Rochester Compositions and methods for stimuli-responsive release of a therapeutic agent
US11847932B2 (en) 2017-09-07 2023-12-19 Intuitive Surgical Operations, Inc. Modified animal organs for use in surgical simulators
US10799138B2 (en) 2018-04-05 2020-10-13 University Of Maryland, Baltimore Method of administering sotalol IV/switch
US11344518B2 (en) 2018-08-14 2022-05-31 AltaThera Pharmaceuticals LLC Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame
US11696902B2 (en) 2018-08-14 2023-07-11 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
US11610660B1 (en) 2021-08-20 2023-03-21 AltaThera Pharmaceuticals LLC Antiarrhythmic drug dosing methods, medical devices, and systems
US10512620B1 (en) 2018-08-14 2019-12-24 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4243775A (en) 1978-11-13 1981-01-06 American Cyanamid Company Synthetic polyester surgical articles
ATE37983T1 (de) 1982-04-22 1988-11-15 Ici Plc Mittel mit verzoegerter freigabe.
US5387419A (en) * 1988-03-31 1995-02-07 The University Of Michigan System for controlled release of antiarrhythmic agents
EP0649637A1 (de) 1988-08-24 1995-04-26 SLEPIAN, Marvin J. Werkstoff zum endoluminalen Verpflastern und Abdichten
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
WO1993017669A1 (en) 1992-02-28 1993-09-16 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5650447A (en) 1992-08-24 1997-07-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitric oxide-releasing polymers to treat restenosis and related disorders
US5800373A (en) 1995-03-23 1998-09-01 Focal, Inc. Initiator priming for improved adherence of gels to substrates
AU6446794A (en) 1993-03-15 1994-10-11 Board Of Regents Of The University Of Michigan, The System for controlled release of antiarrhythmic agents
CA2215309C (en) 1995-03-23 2008-11-25 Focal, Inc. Redox and photoinitiator systems for priming for improved adherence of gels to substrates
US5900245A (en) * 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US5779673A (en) 1995-06-26 1998-07-14 Focal, Inc. Devices and methods for application of intraluminal photopolymerized gels
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
WO1998041154A1 (en) 1997-03-20 1998-09-24 Focal, Inc. Biodegradable tissue retractor
US6197324B1 (en) 1997-12-18 2001-03-06 C. R. Bard, Inc. System and methods for local delivery of an agent
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6605294B2 (en) * 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
WO2002016442A2 (en) * 2000-08-22 2002-02-28 Purdue Research Foundation Microparticle composition and method
EP1379197A4 (de) 2001-03-23 2009-06-03 Durect Corp Abgabe von arzneimitteln von vorrichtungen mit verzögerter freisetzung, die in myokardgewebe oder im perikardraum implantiert sind

Also Published As

Publication number Publication date
CA2433861A1 (en) 2002-07-04
WO2002051383A2 (en) 2002-07-04
AU2002231175A1 (en) 2002-07-08
WO2002051383A3 (en) 2003-03-06
ATE319423T1 (de) 2006-03-15
US20020150622A1 (en) 2002-10-17
US7022343B2 (en) 2006-04-04
EP1347756B1 (de) 2006-03-08
EP1347756A2 (de) 2003-10-01
JP2004518664A (ja) 2004-06-24

Similar Documents

Publication Publication Date Title
DE60117857D1 (de) Kontrollierte freisetzung von anti-arrhythmica aus einem biodegradierbaren hydrogel für die lokale anwendung am herzen
Gulati et al. Titania nanopores with dual micro-/nano-topography for selective cellular bioactivity
Wnek et al. Encyclopedia of biomaterials and biomedical engineering
DE60124142D1 (de) Chirurgisches instrument
EP0875218A3 (de) Wirkstoffhaltige poröse Metallprothesen
WO2007075981A3 (en) Devices, systems and methods for retracting, lifting, compressing, supporting or repositioning tissues or anatomical structures
ITRM20020596A0 (it) Protesi vascolare ad impianto con tecnica combinata, laparoscopica edendovascolare, per la cura degli aneurismi dell'aorta addominale, e co
CY1105998T1 (el) Βελτιωμενη ενδοπροθετικη διαταξη
EP2286799A3 (de) Mikrokugeln zur aktiven Embolisation
EP2281828A3 (de) Modifiziertes Erythropoietin enthaltende Zusammensetzungen
HUP0001818A2 (hu) A szem első kamrájában alkalmazható szabályzott felszabadulású gyógyszerhatóanyagok
EP1525859A3 (de) Selbstexpandierbarer Stent und Stenteinbringungssystem zur Behandlung von Gefässerkrankungen
EP0784487A1 (de) Ein präparat und ein verfahren zur gewebevermehrung
DE60235775D1 (de) Intraluminale Vorrichtung mit einer therapeutisches-mittel enthaltenden Beschichtung
DE60025202D1 (de) Mit polymer beschichtete okklusionsvorrichtung und verfahren zu ihrer herstellung
WO2001003607A3 (en) Aneurysm closure device assembly
WO2005097186A3 (en) Bioactive stents for type ii diabetics and methods for use thereof
ATE282439T1 (de) Thermoreversibles polymer für intralumenalimplantate
WO2005034852A3 (en) Protein biomaterials and biocoacervates and methods of making and using thereof
ATE26584T1 (de) In-vivo abbaubares polypeptid und dessen anwendung zur verzoegerten freigabe von medikamenten.
ATE418357T1 (de) Myokardiales leitungsbefestigungssystem
EP2415423A3 (de) Stenkatheteranordnung mit einer lösbaren Stenthalteverbindung
EE03004B1 (et) Tselluloosi sisaldava teraviljaekstrakti valmistamise meetod
DE60238335D1 (de) Gerüstprodukt für die konstruktion von menschlichem knochengewebe, verfahren zu seiner herstellung
CA2640743A1 (en) Pharmaceutical composition of microspheres for preventing diabetic limb amputation

Legal Events

Date Code Title Description
8332 No legal effect for de