DE60115461D1 - Trägerlösung für verglasbare konzentrationen von gefrierschutzmitteln und gefrierschutzmittel-mischungen - Google Patents
Trägerlösung für verglasbare konzentrationen von gefrierschutzmitteln und gefrierschutzmittel-mischungenInfo
- Publication number
- DE60115461D1 DE60115461D1 DE60115461T DE60115461T DE60115461D1 DE 60115461 D1 DE60115461 D1 DE 60115461D1 DE 60115461 T DE60115461 T DE 60115461T DE 60115461 T DE60115461 T DE 60115461T DE 60115461 D1 DE60115461 D1 DE 60115461D1
- Authority
- DE
- Germany
- Prior art keywords
- solutions
- glazable
- freezer
- concentrations
- carrier solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 230000008014 freezing Effects 0.000 title 1
- 238000007710 freezing Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000004017 vitrification Methods 0.000 abstract 3
- 239000008365 aqueous carrier Substances 0.000 abstract 2
- 239000002577 cryoprotective agent Substances 0.000 abstract 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 abstract 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22169100P | 2000-07-31 | 2000-07-31 | |
| US221691P | 2000-07-31 | ||
| PCT/US2001/023853 WO2002009516A2 (en) | 2000-07-31 | 2001-07-30 | Carrier solution for vitrifiable concentrations of cryoprotectants, and cryoprotectant mixtures |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60115461D1 true DE60115461D1 (de) | 2006-01-05 |
| DE60115461T2 DE60115461T2 (de) | 2006-06-08 |
Family
ID=22828916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60115461T Expired - Lifetime DE60115461T2 (de) | 2000-07-31 | 2001-07-30 | Trägerlösung für verglasbare konzentrationen von gefrierschutzmitteln und gefrierschutzmittel-mischungen |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6869757B2 (de) |
| EP (1) | EP1311155B1 (de) |
| AT (1) | ATE311104T1 (de) |
| AU (1) | AU2001288229A1 (de) |
| CA (1) | CA2388544C (de) |
| DE (1) | DE60115461T2 (de) |
| WO (1) | WO2002009516A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6869757B2 (en) * | 2000-07-31 | 2005-03-22 | 21St Century Medicine, Inc. | Advantageous carrier solution for vitrifiable concentrations of cryoprotectants, and compatible cryoprotectant mixtures |
| US6949335B2 (en) * | 1999-11-30 | 2005-09-27 | 21St Century Medicine, Inc. | Polyglycerol and lactose compositions for the protection of living systems from states of reduced metabolism |
| US7250292B2 (en) * | 2000-01-26 | 2007-07-31 | 21St Century Medicine | Hypertonic reduction of chilling injury |
| US8679735B2 (en) | 2003-09-16 | 2014-03-25 | 21St Century Medicine Inc. | Methods and compositions for the cryopreservation of organs |
| EP2811827A1 (de) * | 2012-02-08 | 2014-12-17 | University of Warwick | Gefrierkonservierung von zellen in abwesenheit von verglasung induzierenden mitteln |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01106826A (ja) * | 1987-10-21 | 1989-04-24 | Terumo Corp | 血液保存液組成物 |
| CA2051092C (en) * | 1990-09-12 | 2002-07-23 | Stephen A. Livesey | Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions |
| AU672775B2 (en) * | 1992-01-21 | 1996-10-17 | Cobe Laboratories Inc. | Method of freezing cells and cell-like materials |
| CA2256714A1 (en) * | 1996-05-29 | 1997-12-04 | Victor Bronshtein | Loading and unloading of permeating protectants for cell, tissue, and organ cryopreservation by vitrification |
| US5879875A (en) * | 1996-06-14 | 1999-03-09 | Biostore New Zealand | Compositions and methods for the preservation of living tissues |
| CA2257497A1 (en) * | 1996-06-14 | 1997-12-18 | Philippa M. Wiggins | Compositions and methods for the preservation of living tissues |
| JP2002516254A (ja) * | 1998-05-26 | 2002-06-04 | ライフセル コーポレイション | ヒト赤血球の低温保存 |
| ATE313259T1 (de) * | 1998-09-21 | 2006-01-15 | 21St Century Medicine Inc | Verbesserte kälteschutzlösungen |
| US6194137B1 (en) * | 1999-04-13 | 2001-02-27 | Organ Recovery Systems, Inc. | Method of cryopreservation of blood vessels by vitrification |
| EP1242558B1 (de) * | 1999-11-30 | 2015-01-28 | 21st Century Medicine | Verhinderung von eiskristallbildung mit hilfe von polyglycerin |
| US6869757B2 (en) * | 2000-07-31 | 2005-03-22 | 21St Century Medicine, Inc. | Advantageous carrier solution for vitrifiable concentrations of cryoprotectants, and compatible cryoprotectant mixtures |
| US20020045156A1 (en) * | 2000-05-16 | 2002-04-18 | Mehmet Toner | Microinjection of cryoprotectants for preservation of cells |
-
2001
- 2001-07-27 US US09/916,396 patent/US6869757B2/en not_active Expired - Lifetime
- 2001-07-30 AT AT01967949T patent/ATE311104T1/de not_active IP Right Cessation
- 2001-07-30 DE DE60115461T patent/DE60115461T2/de not_active Expired - Lifetime
- 2001-07-30 WO PCT/US2001/023853 patent/WO2002009516A2/en active IP Right Grant
- 2001-07-30 AU AU2001288229A patent/AU2001288229A1/en not_active Abandoned
- 2001-07-30 EP EP01967949A patent/EP1311155B1/de not_active Expired - Lifetime
- 2001-07-30 CA CA2388544A patent/CA2388544C/en not_active Expired - Lifetime
-
2005
- 2005-03-11 US US11/078,214 patent/US7741018B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6869757B2 (en) | 2005-03-22 |
| AU2001288229A1 (en) | 2002-02-13 |
| WO2002009516A3 (en) | 2002-06-13 |
| DE60115461T2 (de) | 2006-06-08 |
| EP1311155A2 (de) | 2003-05-21 |
| EP1311155B1 (de) | 2005-11-30 |
| WO2002009516A2 (en) | 2002-02-07 |
| ATE311104T1 (de) | 2005-12-15 |
| US20020076687A1 (en) | 2002-06-20 |
| US20050153272A1 (en) | 2005-07-14 |
| US7741018B2 (en) | 2010-06-22 |
| CA2388544C (en) | 2011-02-22 |
| CA2388544A1 (en) | 2002-02-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |