DE60103560D1 - Prozess zur herstellung von paclitaxel - Google Patents

Prozess zur herstellung von paclitaxel

Info

Publication number
DE60103560D1
DE60103560D1 DE60103560T DE60103560T DE60103560D1 DE 60103560 D1 DE60103560 D1 DE 60103560D1 DE 60103560 T DE60103560 T DE 60103560T DE 60103560 T DE60103560 T DE 60103560T DE 60103560 D1 DE60103560 D1 DE 60103560D1
Authority
DE
Germany
Prior art keywords
producing paclitaxel
paclitaxel
producing
preparation
deacetylbaccatine iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60103560T
Other languages
English (en)
Other versions
DE60103560T2 (de
Inventor
Arturo Battaglia
Paolo Dambruoso
Andrea Guerrini
Ezio Bombardelli
Alessandro Pontiroli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Publication of DE60103560D1 publication Critical patent/DE60103560D1/de
Application granted granted Critical
Publication of DE60103560T2 publication Critical patent/DE60103560T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60103560T 2000-12-06 2001-12-03 Prozess zur herstellung von paclitaxel Expired - Lifetime DE60103560T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI20002654 2000-12-06
IT2000MI002654A IT1319682B1 (it) 2000-12-06 2000-12-06 Procedimento di sintesi del paclitaxel.
PCT/EP2001/014084 WO2002046177A1 (en) 2000-12-06 2001-12-03 A process for the preparation of paclitaxel

Publications (2)

Publication Number Publication Date
DE60103560D1 true DE60103560D1 (de) 2004-07-01
DE60103560T2 DE60103560T2 (de) 2004-09-16

Family

ID=11446197

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60103560T Expired - Lifetime DE60103560T2 (de) 2000-12-06 2001-12-03 Prozess zur herstellung von paclitaxel

Country Status (23)

Country Link
US (1) US6768012B2 (de)
EP (1) EP1339703B1 (de)
JP (1) JP2004515497A (de)
KR (1) KR100846891B1 (de)
CN (1) CN1286828C (de)
AT (1) ATE267820T1 (de)
AU (2) AU3453502A (de)
CA (1) CA2430814C (de)
CZ (1) CZ300024B6 (de)
DE (1) DE60103560T2 (de)
DK (1) DK1339703T3 (de)
ES (1) ES2221656T3 (de)
HK (1) HK1063052A1 (de)
HU (1) HU229373B1 (de)
IL (2) IL156331A0 (de)
IT (1) IT1319682B1 (de)
NO (1) NO328505B1 (de)
PL (1) PL195121B1 (de)
PT (1) PT1339703E (de)
RU (1) RU2276147C2 (de)
SK (1) SK286616B6 (de)
TR (1) TR200401435T4 (de)
WO (1) WO2002046177A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319682B1 (it) * 2000-12-06 2003-10-23 Indena Spa Procedimento di sintesi del paclitaxel.
ITMI20012185A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
WO2004068930A2 (en) * 2003-02-04 2004-08-19 Natural Pharmaceuticals Inc. Method and composition for preparing a compound using a benzolating agent essentially free of ring chlorination
CN1303077C (zh) * 2004-01-16 2007-03-07 桂林晖昂生化药业有限责任公司 合成紫杉烷的制备工艺
ITMI20050614A1 (it) * 2005-04-12 2006-10-13 Indena Spa Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
DK1854799T3 (da) * 2006-05-12 2011-07-18 Indena Spa Fremgangsmåde til fremstilling af et taxanderivat
CN102887876B (zh) * 2012-02-15 2015-11-25 浙江大学宁波理工学院 一种改进的多西紫杉醇的半合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US5917062A (en) 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
US6020507A (en) 1998-03-02 2000-02-01 Bristol-Myers Squibb Company Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile
IT1319682B1 (it) * 2000-12-06 2003-10-23 Indena Spa Procedimento di sintesi del paclitaxel.

Also Published As

Publication number Publication date
RU2276147C2 (ru) 2006-05-10
NO20032558L (no) 2003-06-05
NO328505B1 (no) 2010-03-08
AU3453502A (en) 2002-06-18
US6768012B2 (en) 2004-07-27
ITMI20002654A1 (it) 2002-06-06
KR100846891B1 (ko) 2008-07-17
SK286616B6 (sk) 2009-02-05
PL366120A1 (en) 2005-01-24
IL156331A (en) 2006-10-31
PT1339703E (pt) 2004-08-31
EP1339703B1 (de) 2004-05-26
CN1286828C (zh) 2006-11-29
TR200401435T4 (tr) 2004-08-23
DK1339703T3 (da) 2004-09-27
US20040049060A1 (en) 2004-03-11
HK1063052A1 (en) 2004-12-10
AU2002234535B2 (en) 2006-02-02
ATE267820T1 (de) 2004-06-15
JP2004515497A (ja) 2004-05-27
CN1509277A (zh) 2004-06-30
NO20032558D0 (no) 2003-06-05
SK6972003A3 (en) 2003-11-04
CA2430814A1 (en) 2002-06-13
IT1319682B1 (it) 2003-10-23
DE60103560T2 (de) 2004-09-16
CZ300024B6 (cs) 2009-01-14
WO2002046177A1 (en) 2002-06-13
KR20030055332A (ko) 2003-07-02
PL195121B1 (pl) 2007-08-31
HUP0500615A2 (hu) 2005-11-28
IL156331A0 (en) 2004-01-04
ES2221656T3 (es) 2005-01-01
EP1339703A1 (de) 2003-09-03
HU229373B1 (hu) 2013-11-28
CZ20031534A3 (cs) 2003-08-13
CA2430814C (en) 2009-04-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC