DE60102151D1 - Neue thiochromanderivate und ihre verwendung als thrombininhibitoren - Google Patents

Neue thiochromanderivate und ihre verwendung als thrombininhibitoren

Info

Publication number
DE60102151D1
DE60102151D1 DE60102151T DE60102151T DE60102151D1 DE 60102151 D1 DE60102151 D1 DE 60102151D1 DE 60102151 T DE60102151 T DE 60102151T DE 60102151 T DE60102151 T DE 60102151T DE 60102151 D1 DE60102151 D1 DE 60102151D1
Authority
DE
Germany
Prior art keywords
thiochrome
derivatives
new
thrombine
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60102151T
Other languages
English (en)
Other versions
DE60102151T2 (de
Inventor
Kjell Andersson
Tord Inghardt
Olle Karlsson
Marcel Linschoten
Jan-Erik Nystroem
Gunnel Sunden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE60102151D1 publication Critical patent/DE60102151D1/de
Application granted granted Critical
Publication of DE60102151T2 publication Critical patent/DE60102151T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
DE60102151T 2000-05-16 2001-05-14 Neue thiochromanderivate und ihre verwendung als thrombininhibitoren Expired - Fee Related DE60102151T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0001803 2000-05-16
SE0001803A SE0001803D0 (sv) 2000-05-16 2000-05-16 New compounds i
PCT/SE2001/001052 WO2001087879A1 (en) 2000-05-16 2001-05-14 New thiochromane derivatives and their use as thrombin inhibitors

Publications (2)

Publication Number Publication Date
DE60102151D1 true DE60102151D1 (de) 2004-04-01
DE60102151T2 DE60102151T2 (de) 2004-09-16

Family

ID=20279688

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60102151T Expired - Fee Related DE60102151T2 (de) 2000-05-16 2001-05-14 Neue thiochromanderivate und ihre verwendung als thrombininhibitoren

Country Status (18)

Country Link
US (1) US6716834B2 (de)
EP (1) EP1283837B1 (de)
JP (1) JP2003533522A (de)
KR (1) KR100874393B1 (de)
CN (1) CN1196696C (de)
AR (1) AR028068A1 (de)
AT (1) ATE260273T1 (de)
AU (2) AU2001256931B2 (de)
BR (1) BR0110794A (de)
CA (1) CA2407222A1 (de)
DE (1) DE60102151T2 (de)
IL (2) IL152396A0 (de)
MX (1) MXPA02010711A (de)
NO (1) NO323829B1 (de)
NZ (1) NZ522133A (de)
SE (1) SE0001803D0 (de)
WO (1) WO2001087879A1 (de)
ZA (1) ZA200208805B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9804313D0 (sv) * 1998-12-14 1998-12-14 Astra Ab New compounds
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201659D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7524354B2 (en) * 2005-07-07 2009-04-28 Research Foundation Of State University Of New York Controlled synthesis of highly monodispersed gold nanoparticles
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030
UY31923A (es) * 2008-06-23 2010-01-29 Astrazeneca Ab Nuevos heterociclos para su uso como inhibidores de trombina
CN103819464B (zh) * 2014-03-11 2015-10-07 南京工业大学 硫色满类化合物及其合成方法和制备抗真菌药物的应用
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178398B (en) 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
GB2161801B (en) 1984-07-17 1987-10-07 Erba Farmitalia N-imidazolyl derivatives and process for their preparation
HU192646B (en) 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
ZA86746B (en) 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
ZA897514B (en) 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
TW201303B (de) 1990-07-05 1993-03-01 Hoffmann La Roche
CA2075154A1 (en) 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
SE9102462D0 (sv) 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
CZ333492A3 (en) 1991-11-12 1993-09-15 Lilly Co Eli Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
AU663169B2 (en) 1992-03-04 1995-09-28 Gyogyszerkutato Intezet Kft New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof
TW223629B (de) 1992-03-06 1994-05-11 Hoffmann La Roche
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (de) 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterozyklische Thrombinhemmer
TW394760B (en) 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
AU1025795A (en) 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
ZA951617B (en) 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5510369A (en) 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
MX9706069A (es) 1995-02-17 1997-10-31 Basf Ag Nuevos inhibidores de la trombina.
AU698911B2 (en) 1995-04-04 1998-11-12 Merck & Co., Inc. Thrombin inhibitors
US5629324A (en) 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
TWI238827B (en) 1995-12-21 2005-09-01 Astrazeneca Ab Prodrugs of thrombin inhibitors
US6080767A (en) 1996-01-02 2000-06-27 Aventis Pharmaceuticals Products Inc. Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
WO1997033576A1 (en) 1996-03-12 1997-09-18 Bristol-Myers Squibb Company Carbamyl guanidine and amidine prodrugs
SE9601556D0 (sv) 1996-04-24 1996-04-24 Astra Ab New pharmaceutical formulation of a thrombin inhibitor for parenteral use
JP4328387B2 (ja) * 1996-05-01 2009-09-09 オーソ―マクニール・フアーマシユーチカル・インコーポレーテツド 血栓形成疾患の処置のためのピロリジン、ピペリジン及びヘキサヒドロアゼピンのカルボキサミド誘導体
SE9602263D0 (sv) * 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
AU3496297A (en) 1996-06-25 1998-01-14 Eli Lilly And Company Anticoagulant agents
KR20000022532A (ko) 1996-06-27 2000-04-25 오노 야꾸힝 고교 가부시키가이샤 아릴(설파이드, 설폭시드 및 설폰)유도체 및 이를 활성 성분으로 함유하는 약물
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
AR013084A1 (es) * 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
WO1998057934A1 (en) 1997-06-19 1998-12-23 The Du Pont Merck Pharmaceutical Company (AMIDINO)6-MEMBERED AROMATICS AS FACTOR Xa INHIBITORS
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
SE9804313D0 (sv) * 1998-12-14 1998-12-14 Astra Ab New compounds
KR100639274B1 (ko) * 1999-01-13 2006-10-27 아스트라제네카 아베 신규 아미디노벤질아민 유도체 및 트롬빈 억제제로서의 용도
AR023819A1 (es) 1999-05-03 2002-09-04 Astrazeneca Ab FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION

Also Published As

Publication number Publication date
NO323829B1 (no) 2007-07-09
ATE260273T1 (de) 2004-03-15
US20030220317A1 (en) 2003-11-27
CN1196696C (zh) 2005-04-13
MXPA02010711A (es) 2003-03-10
JP2003533522A (ja) 2003-11-11
CN1441799A (zh) 2003-09-10
NZ522133A (en) 2004-11-26
ZA200208805B (en) 2004-02-09
EP1283837A1 (de) 2003-02-19
KR20030001507A (ko) 2003-01-06
NO20025504L (no) 2002-11-15
CA2407222A1 (en) 2001-11-22
AU5693101A (en) 2001-11-26
WO2001087879A1 (en) 2001-11-22
AU2001256931B2 (en) 2005-08-04
BR0110794A (pt) 2003-05-06
AR028068A1 (es) 2003-04-23
US6716834B2 (en) 2004-04-06
KR100874393B1 (ko) 2008-12-17
IL152396A0 (en) 2003-05-29
NO20025504D0 (no) 2002-11-15
SE0001803D0 (sv) 2000-05-16
EP1283837B1 (de) 2004-02-25
DE60102151T2 (de) 2004-09-16
IL152396A (en) 2009-07-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee