DE60044515D1 - Azithromycinmonohydrat - Google Patents

Azithromycinmonohydrat

Info

Publication number
DE60044515D1
DE60044515D1 DE60044515T DE60044515T DE60044515D1 DE 60044515 D1 DE60044515 D1 DE 60044515D1 DE 60044515 T DE60044515 T DE 60044515T DE 60044515 T DE60044515 T DE 60044515T DE 60044515 D1 DE60044515 D1 DE 60044515D1
Authority
DE
Germany
Prior art keywords
azithromycin
monohydrate
stable
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60044515T
Other languages
English (en)
Inventor
Victor Centellas
Rafael Garcia
Marta Poch
Jose Diago
Johannes Ludescher
Immaculada Bosch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9915218.3A external-priority patent/GB9915218D0/en
Priority claimed from GBGB9915216.7A external-priority patent/GB9915216D0/en
Priority claimed from GBGB9930059.2A external-priority patent/GB9930059D0/en
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of DE60044515D1 publication Critical patent/DE60044515D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60044515T 1999-06-29 2000-06-27 Azithromycinmonohydrat Expired - Fee Related DE60044515D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9915218.3A GB9915218D0 (en) 1999-06-29 1999-06-29 Organic compounds
GBGB9915216.7A GB9915216D0 (en) 1999-06-29 1999-06-29 Organic compounds
GBGB9930059.2A GB9930059D0 (en) 1999-12-20 1999-12-20 Organic compounds

Publications (1)

Publication Number Publication Date
DE60044515D1 true DE60044515D1 (de) 2010-07-15

Family

ID=27269768

Family Applications (3)

Application Number Title Priority Date Filing Date
DE60029589T Expired - Lifetime DE60029589T2 (de) 1999-06-29 2000-06-27 Verfahren zur herstellung von azithromycin
DE60044515T Expired - Fee Related DE60044515D1 (de) 1999-06-29 2000-06-27 Azithromycinmonohydrat
DE20023815U Expired - Lifetime DE20023815U1 (de) 1999-06-29 2000-06-27 Azithromycin enthaltende Zusammensetzungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60029589T Expired - Lifetime DE60029589T2 (de) 1999-06-29 2000-06-27 Verfahren zur herstellung von azithromycin

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE20023815U Expired - Lifetime DE20023815U1 (de) 1999-06-29 2000-06-27 Azithromycin enthaltende Zusammensetzungen

Country Status (10)

Country Link
US (1) US6703372B1 (de)
EP (2) EP1189915B1 (de)
JP (2) JP4703924B2 (de)
KR (1) KR100700475B1 (de)
AT (2) ATE334136T1 (de)
AU (1) AU5820400A (de)
DE (3) DE60029589T2 (de)
ES (2) ES2346782T3 (de)
HR (1) HRP20010956B1 (de)
WO (1) WO2001000640A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
DE60026718T2 (de) 2000-07-25 2006-11-16 Laboratorio Silanes, S.A. De C.V. Einstufiges verfahren zur herstellung von 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle(11.2.11)hexadeca-1(2)-en-8-ona undeine neue form von 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin a
ES2172417B1 (es) * 2000-07-31 2003-09-16 Sint Quimica Sa Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden.
CZ303343B6 (cs) * 2000-11-27 2012-08-08 Sandoz Ag Zpusob prípravy azithromycinu ve forme monohydrátu
HRP20010301A2 (en) * 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
EP1671979B1 (de) * 2001-05-22 2008-08-13 Pfizer Products Inc. Neue Kristallforme von Azithromycin
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
EA007618B1 (ru) 2001-05-22 2006-12-29 Пфайзер Продактс Инк. Кристаллический полуторогидрат азитромицина, содержащая его фармацевтическая композиция и способ лечения на его основе
BR0215175A (pt) * 2001-12-21 2004-12-28 Pfizer Prod Inc Métodos para a granulação úmida de azitromicina
EP1479687A4 (de) * 2002-02-26 2006-01-04 Meiji Seika Kaisha Neues 15gliedriges cyclisches azalid, neues 16gliedriges cyclisches diazalidderivat und verfahren zu deren herstellung
EP1490382A4 (de) * 2002-04-03 2007-09-12 Hanmi Pharm Ind Co Ltd Verfahren zur herstellung von azithromycin und dabei verwendetes kristallines 9-desoxo-9a-aza-9a-homoerythromycin-a-hydrat
ITMI20021209A1 (it) * 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza
GB0214277D0 (en) * 2002-06-20 2002-07-31 Biochemie Gmbh Organic compounds
US6855813B2 (en) 2002-07-19 2005-02-15 Alembic Limited Process for the preparation of azithromycin monohydrate
HRP20020614A2 (en) * 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
GB0224197D0 (en) * 2002-10-17 2002-11-27 Biochemie Gmbh Organic compounds
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
US7572773B2 (en) * 2003-07-24 2009-08-11 Pliva Hrvatska D.O.O. Single dose fast dissolving azithromycin
US20060189800A1 (en) * 2003-07-24 2006-08-24 Mitsuru Ohkubo Indolopyrrolocabazole derivative and antitumor agent
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
WO2006055663A2 (en) * 2004-11-17 2006-05-26 Smithkline Beecham Corporation The use of novel antibacterial compounds
CN101177441B (zh) * 2007-12-05 2012-05-23 浙江耐司康药业有限公司 一种稳定的阿奇霉素一水合物结晶的制备方法
CN101445532B (zh) * 2008-12-30 2011-09-21 广东东阳光药业有限公司 阿奇霉素一水合物结晶的制备方法
BRPI1009823A2 (pt) 2009-03-13 2019-09-24 Da Volterra Assistance Publique Hopitaux De Paris E Univ Paris Diderot Paris 7 "composição compreendendo um sistema de dispensação de droga, conjunto de uma primeira e uma segunda composição, e, kit."
CN102417531B (zh) * 2011-12-20 2014-06-11 浙江国邦药业有限公司 一种阿奇霉素一水合物的制备方法
CN105030704B (zh) * 2015-06-29 2018-09-07 石药集团欧意药业有限公司 阿奇霉素片剂及其制备方法
CN110684056B (zh) * 2018-07-05 2021-07-13 青岛农业大学 一种阿奇霉素中间体的化学合成方法
CN114516895A (zh) * 2020-11-19 2022-05-20 江苏威奇达药业有限公司 一种阿奇霉素胺结晶方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA835204B (en) * 1982-07-19 1985-02-27 Pfizer N-methyl 11-aza-10-deoxo-10-dihydroerythromycin a,intermediates therefor and processes for their preparation
UA27040C2 (uk) * 1987-07-09 2000-02-28 Пфайзер Інк. Кристалічhий дигідрат азитроміциhу та спосіб одержаhhя кристалічhого дигідрату азитроміциhу
ES2122905B1 (es) 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
GB9705323D0 (en) 1997-03-14 1997-04-30 Biochemie Sa Organic compounds
KR100378434B1 (ko) * 1997-07-08 2003-03-29 바이오케미 에스.에이. 에리트로마이신 ａ 옥심 용매화물
PT102130A (pt) 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
CA2245398C (en) * 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
GB9824580D0 (en) 1998-11-10 1999-01-06 Biochemie Sa Organic compounds

Also Published As

Publication number Publication date
EP1712556A1 (de) 2006-10-18
US6703372B1 (en) 2004-03-09
KR20020016862A (ko) 2002-03-06
WO2001000640A1 (en) 2001-01-04
DE20023815U1 (de) 2006-06-08
ATE469910T1 (de) 2010-06-15
ES2346782T3 (es) 2010-10-20
JP2011126894A (ja) 2011-06-30
JP2003503417A (ja) 2003-01-28
EP1189915B1 (de) 2006-07-26
ATE334136T1 (de) 2006-08-15
DE60029589D1 (de) 2006-09-07
HRP20010956B1 (en) 2010-09-30
AU5820400A (en) 2001-01-31
DE60029589T2 (de) 2007-07-19
ES2267549T3 (es) 2007-03-16
EP1189915A1 (de) 2002-03-27
KR100700475B1 (ko) 2007-03-28
JP4703924B2 (ja) 2011-06-15
HRP20010956A2 (en) 2003-08-31
EP1712556B1 (de) 2010-06-02

Similar Documents

Publication Publication Date Title
DE60044515D1 (de) Azithromycinmonohydrat
TR200000520A3 (tr) 4-Fenil-piridin türevleri.
NO20020684L (no) 3(5)-aminopyrazolderivater, fremgangsmåtet for deres fremstilling og deres anvendelse som antitumormidler
BR0013570B1 (pt) controlador de umidade.
BR0014932B1 (pt) conjunto de retenção.
DE69919255D1 (de) Graviervorrichtung
DE60022833D1 (de) Kugellager
ATE204279T1 (de) Diaza-spiro(3,5)nonan-derivate
ZA200004983B (en) Lightweight draft arm.
ITRM990493A0 (it) Dispositivo di comando manuale, in particolare per l'accelerazione.
ID22243A (id) Amplifier penguatan tinggi
ES1041879Y (es) Abanico ambientador.
ES1039438Y (es) Expositor-expendedor perfeccionado.
ES1040429Y (es) Ambientador perfeccionado.
ES1043641Y (es) Flexometro perfeccionado.
ES1041199Y (es) Biberon perfeccionado.
ES1043442Y (es) Aparato ambientador.
ITRM990553A0 (it) Electroprophylaxis (elettroprofilassi).
ES1041259Y (es) Juguete perfeccionado.
ES1039739Y (es) Muñeca perfeccionada.
ES1039562Y (es) Muñeco perfeccionado.
ES1041532Y (es) Muñeco perfeccionado.
ES1040223Y (es) Muñeco perfeccionado.
ES1041227Y (es) Muñeco perfeccionado.
ES1039937Y (es) Muñeca perfeccionada.

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee