DE60041773D1 - Der effekt von steroiden auf ndma-rezeptoren beruht auf der zusammensetzung der untereinheiten - Google Patents

Der effekt von steroiden auf ndma-rezeptoren beruht auf der zusammensetzung der untereinheiten

Info

Publication number
DE60041773D1
DE60041773D1 DE60041773T DE60041773T DE60041773D1 DE 60041773 D1 DE60041773 D1 DE 60041773D1 DE 60041773 T DE60041773 T DE 60041773T DE 60041773 T DE60041773 T DE 60041773T DE 60041773 D1 DE60041773 D1 DE 60041773D1
Authority
DE
Germany
Prior art keywords
subunit
receptors
nmda
modulator
candidate modulator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60041773T
Other languages
English (en)
Inventor
David H Farb
Shelley Russek
Ming-Kuei Jang
Terrell Gibbs
Nader Yaghoubi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston University
Original Assignee
Boston University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22540293&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60041773(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boston University filed Critical Boston University
Application granted granted Critical
Publication of DE60041773D1 publication Critical patent/DE60041773D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
DE60041773T 1999-08-31 2000-08-31 Der effekt von steroiden auf ndma-rezeptoren beruht auf der zusammensetzung der untereinheiten Expired - Lifetime DE60041773D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15180299P 1999-08-31 1999-08-31
PCT/US2000/023985 WO2001016601A1 (en) 1999-08-31 2000-08-31 Effect of steroids on nmda receptors depends on subunit composition

Publications (1)

Publication Number Publication Date
DE60041773D1 true DE60041773D1 (de) 2009-04-23

Family

ID=22540293

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60041773T Expired - Lifetime DE60041773D1 (de) 1999-08-31 2000-08-31 Der effekt von steroiden auf ndma-rezeptoren beruht auf der zusammensetzung der untereinheiten

Country Status (7)

Country Link
US (1) US6623933B1 (de)
EP (1) EP1212618B1 (de)
AT (1) ATE425459T1 (de)
AU (1) AU782250B2 (de)
CA (1) CA2383047A1 (de)
DE (1) DE60041773D1 (de)
WO (1) WO2001016601A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1347763A4 (de) * 2000-11-06 2005-10-12 Univ Boston Neuraktive steroidderivate und verfahren zu ihrer verwendung
AUPR731901A0 (en) * 2001-08-28 2001-09-20 Goodchild, Colin Stanley Method of treatment
DK2523666T3 (en) 2010-01-14 2016-04-04 Asarina Pharma Ab A pharmaceutical composition comprising 3-beta-hydroxy-5-alpha-pregnan-20-one with improved storage and solubility properties
CZ305733B6 (cs) * 2014-08-26 2016-02-24 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Amfifilní sloučeniny s neuroprotektivními účinky
CN108148106A (zh) * 2016-12-05 2018-06-12 江苏恩华络康药物研发有限公司 一类水溶性别孕烯醇酮衍生物及其用途
CN114957445B (zh) * 2022-05-31 2023-09-19 陕西脉元生物科技有限公司 一种nmdar nr1亚基、nmdar的突变体及其构建方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2110934A1 (en) * 1992-12-11 1994-06-12 Robert L. Foldes Human cns receptors of the nmda-r1 family
JPH08509607A (ja) * 1993-04-20 1996-10-15 ザ ソールク インスチチュート バイオテクノロジー／インダストリアル アソシエイツ，インコーポレイテッド ヒトｎ−メチル−ｄ−アスパラギン酸受容体サブユニット、これをコードする核酸およびその用途
JP4313435B2 (ja) * 1995-07-24 2009-08-12 トラスティーズ オブ ボストン ユニバーシティー プレグネノロンサルフェート誘導体によるｎｍｄａレセプター活性の抑制
US5888996A (en) 1995-07-26 1999-03-30 Trustees Of Boston University Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity
CA2398250A1 (en) * 2000-02-01 2001-08-09 Agy Therapeutics, Inc. Interaction of nmda receptor with protein tyrosine phosphatase

Also Published As

Publication number Publication date
WO2001016601A1 (en) 2001-03-08
AU782250B2 (en) 2005-07-14
US6623933B1 (en) 2003-09-23
EP1212618B1 (de) 2009-03-11
EP1212618A4 (de) 2005-04-06
CA2383047A1 (en) 2001-03-08
EP1212618A1 (de) 2002-06-12
AU7098100A (en) 2001-03-26
ATE425459T1 (de) 2009-03-15

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DE60041773D1 (de) Der effekt von steroiden auf ndma-rezeptoren beruht auf der zusammensetzung der untereinheiten
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Legal Events

Date Code Title Description
8363 Opposition against the patent