DE60041773D1 - Der effekt von steroiden auf ndma-rezeptoren beruht auf der zusammensetzung der untereinheiten - Google Patents
Der effekt von steroiden auf ndma-rezeptoren beruht auf der zusammensetzung der untereinheitenInfo
- Publication number
- DE60041773D1 DE60041773D1 DE60041773T DE60041773T DE60041773D1 DE 60041773 D1 DE60041773 D1 DE 60041773D1 DE 60041773 T DE60041773 T DE 60041773T DE 60041773 T DE60041773 T DE 60041773T DE 60041773 D1 DE60041773 D1 DE 60041773D1
- Authority
- DE
- Germany
- Prior art keywords
- subunit
- receptors
- nmda
- modulator
- candidate modulator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000003431 steroids Chemical class 0.000 title 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 4
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 4
- 102000005962 receptors Human genes 0.000 abstract 3
- 108020003175 receptors Proteins 0.000 abstract 3
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 1
- 239000002858 neurotransmitter agent Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15180299P | 1999-08-31 | 1999-08-31 | |
PCT/US2000/023985 WO2001016601A1 (en) | 1999-08-31 | 2000-08-31 | Effect of steroids on nmda receptors depends on subunit composition |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60041773D1 true DE60041773D1 (de) | 2009-04-23 |
Family
ID=22540293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60041773T Expired - Lifetime DE60041773D1 (de) | 1999-08-31 | 2000-08-31 | Der effekt von steroiden auf ndma-rezeptoren beruht auf der zusammensetzung der untereinheiten |
Country Status (7)
Country | Link |
---|---|
US (1) | US6623933B1 (de) |
EP (1) | EP1212618B1 (de) |
AT (1) | ATE425459T1 (de) |
AU (1) | AU782250B2 (de) |
CA (1) | CA2383047A1 (de) |
DE (1) | DE60041773D1 (de) |
WO (1) | WO2001016601A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1347763A4 (de) * | 2000-11-06 | 2005-10-12 | Univ Boston | Neuraktive steroidderivate und verfahren zu ihrer verwendung |
AUPR731901A0 (en) * | 2001-08-28 | 2001-09-20 | Goodchild, Colin Stanley | Method of treatment |
DK2523666T3 (en) | 2010-01-14 | 2016-04-04 | Asarina Pharma Ab | A pharmaceutical composition comprising 3-beta-hydroxy-5-alpha-pregnan-20-one with improved storage and solubility properties |
CZ305733B6 (cs) * | 2014-08-26 | 2016-02-24 | Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. | Amfifilní sloučeniny s neuroprotektivními účinky |
CN108148106A (zh) * | 2016-12-05 | 2018-06-12 | 江苏恩华络康药物研发有限公司 | 一类水溶性别孕烯醇酮衍生物及其用途 |
CN114957445B (zh) * | 2022-05-31 | 2023-09-19 | 陕西脉元生物科技有限公司 | 一种nmdar nr1亚基、nmdar的突变体及其构建方法和应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2110934A1 (en) * | 1992-12-11 | 1994-06-12 | Robert L. Foldes | Human cns receptors of the nmda-r1 family |
JPH08509607A (ja) * | 1993-04-20 | 1996-10-15 | ザ ソールク インスチチュート バイオテクノロジー/インダストリアル アソシエイツ,インコーポレイテッド | ヒトn−メチル−d−アスパラギン酸受容体サブユニット、これをコードする核酸およびその用途 |
JP4313435B2 (ja) * | 1995-07-24 | 2009-08-12 | トラスティーズ オブ ボストン ユニバーシティー | プレグネノロンサルフェート誘導体によるnmdaレセプター活性の抑制 |
US5888996A (en) | 1995-07-26 | 1999-03-30 | Trustees Of Boston University | Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity |
CA2398250A1 (en) * | 2000-02-01 | 2001-08-09 | Agy Therapeutics, Inc. | Interaction of nmda receptor with protein tyrosine phosphatase |
-
2000
- 2000-08-31 AU AU70981/00A patent/AU782250B2/en not_active Ceased
- 2000-08-31 CA CA002383047A patent/CA2383047A1/en not_active Abandoned
- 2000-08-31 WO PCT/US2000/023985 patent/WO2001016601A1/en active IP Right Grant
- 2000-08-31 US US09/652,345 patent/US6623933B1/en not_active Expired - Fee Related
- 2000-08-31 AT AT00959706T patent/ATE425459T1/de not_active IP Right Cessation
- 2000-08-31 EP EP00959706A patent/EP1212618B1/de not_active Revoked
- 2000-08-31 DE DE60041773T patent/DE60041773D1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2001016601A1 (en) | 2001-03-08 |
AU782250B2 (en) | 2005-07-14 |
US6623933B1 (en) | 2003-09-23 |
EP1212618B1 (de) | 2009-03-11 |
EP1212618A4 (de) | 2005-04-06 |
CA2383047A1 (en) | 2001-03-08 |
EP1212618A1 (de) | 2002-06-12 |
AU7098100A (en) | 2001-03-26 |
ATE425459T1 (de) | 2009-03-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |