DE60039683D1 - Verwendung eines adenovirusvektors zur transduktion von synovialen zellen - Google Patents
Verwendung eines adenovirusvektors zur transduktion von synovialen zellenInfo
- Publication number
- DE60039683D1 DE60039683D1 DE60039683T DE60039683T DE60039683D1 DE 60039683 D1 DE60039683 D1 DE 60039683D1 DE 60039683 T DE60039683 T DE 60039683T DE 60039683 T DE60039683 T DE 60039683T DE 60039683 D1 DE60039683 D1 DE 60039683D1
- Authority
- DE
- Germany
- Prior art keywords
- adenovirus
- transduction
- tissue tropism
- adenovirus vector
- synovial cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
- C12N9/1211—Thymidine kinase (2.7.1.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
- C12N2710/10352—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Physical Education & Sports Medicine (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99200624 | 1999-03-04 | ||
PCT/NL2000/000133 WO2000052186A1 (en) | 1999-03-04 | 2000-03-03 | Means and methods for fibroblast-like or macrophage-like cell transduction |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60039683D1 true DE60039683D1 (de) | 2008-09-11 |
Family
ID=8239945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60039683T Expired - Lifetime DE60039683D1 (de) | 1999-03-04 | 2000-03-03 | Verwendung eines adenovirusvektors zur transduktion von synovialen zellen |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1159438B1 (de) |
JP (1) | JP4683727B2 (de) |
AT (1) | ATE403006T1 (de) |
AU (1) | AU776067B2 (de) |
CA (1) | CA2364499C (de) |
DE (1) | DE60039683D1 (de) |
WO (1) | WO2000052186A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6929946B1 (en) | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
US6869936B1 (en) | 1999-03-04 | 2005-03-22 | Crucell Holland B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
PT1818408E (pt) * | 1999-05-17 | 2011-11-15 | Crucell Holland Bv | Adenovírus recombinante do serótipo ad11 |
US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
EP1067188A1 (de) * | 1999-07-08 | 2001-01-10 | Introgene B.V. | Infektion mit chimärischen Adenoviren der Zellen die für den Adenoviren Serotyp 5 Coxsacki Adenoviren Rezeptor (CAR) negativ sind |
ES2256302T3 (es) | 2000-08-10 | 2006-07-16 | Crucell Holland B.V. | Vectores adenovirales para la transduccion de condrocitos. |
US20040033605A1 (en) * | 2000-09-20 | 2004-02-19 | Menzo Havenga | Gene delivery vectors provided with a tissue tropism for dendritic cells |
WO2002029073A2 (en) * | 2000-10-06 | 2002-04-11 | Crucell Holland B.V. | Gene delivery vectors for stem cells |
EP1195440A1 (de) * | 2000-10-06 | 2002-04-10 | Introgene B.V. | Genverabreichung-Vektoren für Stammzellen |
US6905678B2 (en) | 2001-07-07 | 2005-06-14 | Crucell Holland B.V. | Gene delivery vectors with cell type specificity for mesenchymal stem cells |
EP1279738A1 (de) * | 2001-07-06 | 2003-01-29 | Crucell Holland B.V. | Für mesenchymale Stammzellen spezifische Gen-Transfer-Vektoren |
AU2003271738C1 (en) | 2002-04-25 | 2008-04-17 | Crucell Holland B.V. | Stable adenoviral vectors and methods for propagation thereof |
EP1553983A2 (de) | 2002-10-23 | 2005-07-20 | Crucell Holland B.V. | Einstellung für rekombinante adenovirus-basierte impfstoffe |
US20080153083A1 (en) | 2003-10-23 | 2008-06-26 | Crucell Holland B.V. | Settings for recombinant adenoviral-based vaccines |
EP2258850B1 (de) | 2002-12-17 | 2013-07-17 | Crucell Holland B.V. | Rekombinanter virus-basierter malaria impfstoff |
AU2014236207B2 (en) | 2013-03-14 | 2019-05-23 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions |
CA3000462C (en) | 2015-10-05 | 2024-04-02 | Salk Institute For Biological Studies | Synthetic adenoviruses with tropism to damaged tissue for use in promoting wound repair and tissue regeneration |
CA3013637A1 (en) | 2016-02-23 | 2017-08-31 | Salk Institute For Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
CN117384961A (zh) | 2016-02-23 | 2024-01-12 | 萨克生物研究学院 | 对病毒动力学影响最小的治疗性腺病毒中的外源基因表达 |
WO2018111767A1 (en) | 2016-12-12 | 2018-06-21 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
WO2018125970A1 (en) * | 2016-12-30 | 2018-07-05 | Salk Institute For Biological Studies | Synthetic adenoviruses targeting bone tissue and uses thereof |
CN111094577A (zh) | 2017-05-26 | 2020-05-01 | 埃皮森特Rx股份有限公司 | 携带转基因的重组腺病毒 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2723697B1 (fr) * | 1994-08-17 | 1996-09-20 | Rhone Poulenc Rorer Sa | Methode de traitement de la restenose par la therapie genique |
US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
IL122614A0 (en) * | 1995-06-15 | 1998-08-16 | Introgene Bv | Packaging systems for human recombinant adenovirus to be used in gene therapy |
EP1616961A1 (de) * | 1995-11-28 | 2006-01-18 | Genvec, Inc. | Vektoren und Methoden zum Gentransfer in Zellen |
US20030017138A1 (en) * | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
IL133032A (en) * | 1998-11-20 | 2007-06-03 | Introgene Bv | Adenoviral gene delivery vectors provided with a tissue tropism for smooth muscle cells and /or endothelial cells |
EP1020529B1 (de) * | 1998-11-20 | 2005-06-01 | Crucell Holland B.V. | Genverabreichende Vektoren mit Gewebetropismus für glatte Muskelzellen und/oder Endothelzellen |
-
2000
- 2000-03-03 WO PCT/NL2000/000133 patent/WO2000052186A1/en active Search and Examination
- 2000-03-03 AU AU29488/00A patent/AU776067B2/en not_active Ceased
- 2000-03-03 EP EP00908116A patent/EP1159438B1/de not_active Expired - Lifetime
- 2000-03-03 DE DE60039683T patent/DE60039683D1/de not_active Expired - Lifetime
- 2000-03-03 CA CA002364499A patent/CA2364499C/en not_active Expired - Fee Related
- 2000-03-03 AT AT00908116T patent/ATE403006T1/de not_active IP Right Cessation
- 2000-03-03 JP JP2000602796A patent/JP4683727B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2364499A1 (en) | 2000-09-08 |
JP4683727B2 (ja) | 2011-05-18 |
EP1159438A1 (de) | 2001-12-05 |
JP2002537816A (ja) | 2002-11-12 |
AU776067B2 (en) | 2004-08-26 |
ATE403006T1 (de) | 2008-08-15 |
CA2364499C (en) | 2008-12-23 |
WO2000052186A1 (en) | 2000-09-08 |
EP1159438B1 (de) | 2008-07-30 |
AU2948800A (en) | 2000-09-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |