DE60037817D1 - Identifizierung genetischer marker des biologischen alters und des metabolismus - Google Patents

Identifizierung genetischer marker des biologischen alters und des metabolismus

Info

Publication number
DE60037817D1
DE60037817D1 DE60037817T DE60037817T DE60037817D1 DE 60037817 D1 DE60037817 D1 DE 60037817D1 DE 60037817 T DE60037817 T DE 60037817T DE 60037817 T DE60037817 T DE 60037817T DE 60037817 D1 DE60037817 D1 DE 60037817D1
Authority
DE
Germany
Prior art keywords
organ
tissue
cell
gene expression
subjects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60037817T
Other languages
English (en)
Inventor
Richard H Weindruch
Tomas A Prolla
Cheol-Koo Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of DE60037817D1 publication Critical patent/DE60037817D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE60037817T 1999-08-12 2000-08-08 Identifizierung genetischer marker des biologischen alters und des metabolismus Expired - Lifetime DE60037817D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14854099P 1999-08-12 1999-08-12
US17823200P 2000-01-26 2000-01-26
US21192300P 2000-06-16 2000-06-16
PCT/US2000/021603 WO2001012851A2 (en) 1999-08-12 2000-08-08 Identification of genetic markers of biological age and metabolism

Publications (1)

Publication Number Publication Date
DE60037817D1 true DE60037817D1 (de) 2008-03-06

Family

ID=27386702

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60037817T Expired - Lifetime DE60037817D1 (de) 1999-08-12 2000-08-08 Identifizierung genetischer marker des biologischen alters und des metabolismus

Country Status (7)

Country Link
US (3) US6569624B1 (de)
EP (1) EP1200629B1 (de)
AT (1) ATE384137T1 (de)
AU (1) AU782102B2 (de)
CA (1) CA2381777C (de)
DE (1) DE60037817D1 (de)
WO (1) WO2001012851A2 (de)

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US6960439B2 (en) 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
US7452664B2 (en) 1999-12-15 2008-11-18 Massachusetts Institute Of Technology Methods for identifying agents which alter histone protein acetylation
US8642284B1 (en) 1999-12-15 2014-02-04 Massachusetts Institute Of Technology Methods for identifying agents that alter NAD-dependent deacetylation activity of a SIR2 protein
AU2461201A (en) * 1999-12-23 2001-07-03 Regents Of The University Of California, The Interventions to mimic the effects of calorie restriction
US6406853B1 (en) 1999-12-23 2002-06-18 The Regents Of The University Of California Interventions to mimic the effects of calorie restriction
US7118873B2 (en) 2000-12-12 2006-10-10 The University Of Connecticut Polynucleotides encoding cellular transporters and methods of use thereof
US7572575B2 (en) 2000-12-13 2009-08-11 Massachusetts Institute Of Technology SIR2 activity
WO2002074911A2 (en) * 2001-03-19 2002-09-26 Wisconsin Alumni Research Foundation Identification of gene expression alterations underlying the aging process in mammals
EP1406489A4 (de) * 2001-06-22 2005-08-24 Univ California Eukaryontische gene, die an der regulation des lebensalters als erwachsener beteiligt sind
AU2002345839A1 (en) * 2001-06-26 2003-03-03 Wisconsin Alumni Research Foundation Gene expression alterations underlying the retardation of aging by caloric restriction in mammals
US20050071088A1 (en) * 2001-08-13 2005-03-31 Landfield Philip W Gene expression profile biomarkers and therapeutic targets for brain aging and age-related cognitive impairment
EP1451345A4 (de) * 2001-08-15 2006-03-01 Elixir Pharmaceuticals Inc Mit alter assoziierte marker
CN102402650A (zh) 2001-11-09 2012-04-04 生命技术公司 利用基因表达分布图识别、监控和治疗疾病以及鉴定生物学状态
WO2003099781A2 (en) * 2002-05-24 2003-12-04 Boehringer Ingelheim Pharmaceuticals, Inc. METHODS FOR THE IDENTIFICATION OF IKKα FUNCTION AND OTHER GENES USEFUL FOR TREATMENT OF INFLAMMATORY DISEASES
EP1581624A4 (de) * 2002-08-09 2007-01-24 Univ California An der regulation der lebensdauer von erwachsenen beteiligte eukaryontische gene
FR2847269B1 (fr) * 2002-11-19 2006-07-28 Coletica Procede d'identification d'une modification eventuelle d'au moins un parametre biologique mettant en oeuvre des cellules vivantes jeunes et agees
US20070048301A1 (en) * 2002-11-26 2007-03-01 Bodary-Winter Sarah C Compositions and methods for the treatment of immune related diseases
US20040191775A1 (en) * 2003-03-12 2004-09-30 Spindler Stephen R. Methods of analyzing genes affected by caloric restriction or caloric restriction mimetics
US20050250156A1 (en) * 2003-10-31 2005-11-10 Shebuski Ronald J Detection of acute myocardial infarction biomarkers
US20070275108A1 (en) * 2003-12-19 2007-11-29 Geesamen Bard J Life Span Managment
US20050266438A1 (en) * 2004-03-16 2005-12-01 The Regents Of The University Of California Genetic networks regulated by attenuated GH/IGF1 signaling and caloric restriction
US7273453B2 (en) * 2004-04-12 2007-09-25 Frank Shallenberger Method for analyzing the biological age of a subject
US20050228237A1 (en) * 2004-04-12 2005-10-13 Frank Shallenberger Method for analyzing the biological age of a subject
WO2005123955A2 (en) * 2004-06-09 2005-12-29 Children's Medical Center Corporation Methods and compositions for modifying gene regulation and dna damage in ageing
WO2006087767A1 (ja) * 2005-02-15 2006-08-24 Yugenkaisha Japan Tsusyo 体力年齢測定システム
US20070099830A1 (en) 2005-04-21 2007-05-03 Massachusetts Institute Of Technology Sirt4 activities
US7960605B2 (en) 2006-03-17 2011-06-14 BioMaker Pharmaceuticals, Inc. Methods for testing for caloric restriction (CR) mimetics
ATE536425T1 (de) * 2006-10-13 2011-12-15 Metabolon Inc Mit metabolischem alter verbundene biomarker und verfahren zur verwendung davon
AU2008217662A1 (en) * 2007-02-23 2008-08-28 Progenika Biopharma, S.A. Method and product for "in vitro" genotyping with application in anti-aging medicine
US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
US7666137B2 (en) * 2008-04-10 2010-02-23 Frank Shallenberger Method for analyzing mitochondrial function
BRPI0913578A2 (pt) 2008-05-14 2017-06-06 Dermtech Int diagnose de melanoma e lentigo solar por análise de ácido nucléico
CN102177253A (zh) * 2008-08-28 2011-09-07 德玛泰克国际公司 测定皮肤样品的年龄范围
CA2754392A1 (en) * 2009-03-11 2010-09-16 Nestec S.A. Tissue-specific aging biomarkers
US20110091081A1 (en) * 2009-10-16 2011-04-21 General Electric Company Method and system for analyzing the expression of biomarkers in cells in situ in their tissue of origin
US8320655B2 (en) * 2009-10-16 2012-11-27 General Electric Company Process and system for analyzing the expression of biomarkers in cells
US8824769B2 (en) * 2009-10-16 2014-09-02 General Electric Company Process and system for analyzing the expression of biomarkers in a cell
EP2499260B1 (de) * 2009-11-10 2017-08-23 Nestec S.A. Herzalterungs-biomarker und verfahren zu ihrer verwendung
WO2011149981A2 (en) 2010-05-24 2011-12-01 Nse Products, Inc. Oral formulations for counteracting effects of aging
WO2013027191A1 (en) 2011-08-25 2013-02-28 Novartis Ag Methods and compositions using fgf23 fusion polypeptides
US8652518B2 (en) 2012-04-15 2014-02-18 Jahahreeh Finley Compositions and methods for the prevention and treatment of diseases or conditions associated with oxidative stress, inflammation, and metabolic dysregulation
FR2993282B1 (fr) * 2012-07-13 2017-11-10 Expanscience Lab Procede d'identification de marqueurs moleculaires de la peau d'enfant
WO2016201246A1 (en) * 2015-06-12 2016-12-15 President And Fellows Of Harvard College Compositions and methods for maintaining splicing fidelity
WO2019074615A2 (en) * 2017-09-14 2019-04-18 OneSkin Technologies, Inc. IN VITRO METHODS FOR DISCOVERING THERAPEUTIC COMPOUNDS FOR THE SKIN USING SKIN AGING BIOMARKERS
CA3090785A1 (en) 2018-02-14 2019-08-22 John Daniel Dobak Iii Novel gene classifiers and uses thereof in non-melanoma skin cancers
US11578373B2 (en) 2019-03-26 2023-02-14 Dermtech, Inc. Gene classifiers and uses thereof in skin cancers
US11227691B2 (en) 2019-09-03 2022-01-18 Kpn Innovations, Llc Systems and methods for selecting an intervention based on effective age
US11250337B2 (en) 2019-11-04 2022-02-15 Kpn Innovations Llc Systems and methods for classifying media according to user negative propensities

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744300A (en) * 1993-03-24 1998-04-28 Geron Corporation Methods and reagents for the identification and regulation of senescence-related genes
US6087102A (en) * 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6406853B1 (en) 1999-12-23 2002-06-18 The Regents Of The University Of California Interventions to mimic the effects of calorie restriction

Also Published As

Publication number Publication date
US20080254464A1 (en) 2008-10-16
EP1200629A2 (de) 2002-05-02
AU782102B2 (en) 2005-07-07
WO2001012851A2 (en) 2001-02-22
EP1200629B1 (de) 2008-01-16
US20030157526A1 (en) 2003-08-21
CA2381777A1 (en) 2001-02-22
US6569624B1 (en) 2003-05-27
ATE384137T1 (de) 2008-02-15
WO2001012851A3 (en) 2001-08-23
AU6528900A (en) 2001-03-13
CA2381777C (en) 2011-10-04

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