DE60034699D1 - Verfahren zur herstellung von fumagillin - Google Patents

Verfahren zur herstellung von fumagillin

Info

Publication number: DE60034699D1
Authority: DE; Germany
Prior art keywords: fumagillin; production; salt; liberation; preparation
Prior art date: 1999-06-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60034699T

Other languages

English (en)

Other versions

DE60034699T2 (de

Inventor

Gyula Farkas

Andrea Gyorbiro

Istvan Hermecz

Kalman Simon

Anna Szabo

Arpadne Vasvari

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Sanofi Aventis France

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-11

Filing date

2000-06-06

Publication date

2007-06-14

2000-06-06 Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France

2007-06-14 Publication of DE60034699D1 publication Critical patent/DE60034699D1/de

2008-01-17 Application granted granted Critical

2008-01-17 Publication of DE60034699T2 publication Critical patent/DE60034699T2/de

2020-06-07 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

NGGMYCMLYOUNGM-UHFFFAOYSA-N (-)-fumagillin Natural products O1C(CC=C(C)C)C1(C)C1C(OC)C(OC(=O)C=CC=CC=CC=CC(O)=O)CCC21CO2 NGGMYCMLYOUNGM-UHFFFAOYSA-N 0.000 title abstract 2
NGGMYCMLYOUNGM-CSDLUJIJSA-N fumagillin Chemical compound C([C@H]([C@H]([C@@H]1[C@]2(C)[C@H](O2)CC=C(C)C)OC)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O)C[C@@]21CO2 NGGMYCMLYOUNGM-CSDLUJIJSA-N 0.000 title abstract 2
229960000936 fumagillin Drugs 0.000 title abstract 2
230000001476 alcoholic effect Effects 0.000 abstract 1
OLRILZDTQKZQIG-PNLOCOOESA-N n-cyclohexylcyclohexanamine;(2e,4e,6e,8e)-10-[[(3r,4s,5s,6r)-5-methoxy-4-[(2r,3r)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid Chemical compound C1CCCCC1NC1CCCCC1.C([C@H]([C@H]([C@@H]1[C@]2(C)[C@H](O2)CC=C(C)C)OC)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O)C[C@@]21CO2 OLRILZDTQKZQIG-PNLOCOOESA-N 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE60034699T 1999-06-11 2000-06-06 Verfahren zur herstellung von fumagillin Expired - Lifetime DE60034699T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
HU9901943A HUP9901943A2 (hu)	1999-06-11	1999-06-11	Eljárás fumagillin előállítására
HU9901943P		1999-06-11
PCT/HU2000/000054 WO2000076994A2 (en)	1999-06-11	2000-06-06	Process for the preparation of fumagillin

Publications (2)

Publication Number	Publication Date
DE60034699D1 true DE60034699D1 (de)	2007-06-14
DE60034699T2 DE60034699T2 (de)	2008-01-17

Family

ID=89998483

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60034699T Expired - Lifetime DE60034699T2 (de)	1999-06-11	2000-06-06	Verfahren zur herstellung von fumagillin

Country Status (13)

Country	Link
US (1)	US6521764B1 (de)
EP (1)	EP1230238B1 (de)
JP (1)	JP3923798B2 (de)
AT (1)	ATE361292T1 (de)
AU (1)	AU5416600A (de)
CA (1)	CA2374639C (de)
CY (1)	CY1106728T1 (de)
DE (1)	DE60034699T2 (de)
DK (1)	DK1230238T3 (de)
ES (1)	ES2284500T3 (de)
HU (2)	HUP9901943A2 (de)
PT (1)	PT1230238E (de)
WO (1)	WO2000076994A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0820229A2 (pt) *	2007-11-28	2017-05-09	A Stevenson Cheri	conjugados de análogos de fumagilina biodegradáveis biocompatíveis
CN105622593B (zh) *	2016-02-25	2018-06-26	中国农业科学院蜜蜂研究所	一种烟曲霉素的提取方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE36735C (de)			L. ET1ENNE in Paris, 99 Avenue Parmentier	Rohrverbindung
DD36735A (de) *
AT193076B (de)	1953-12-17	1957-11-25	Abbott Lab	Verfahren zur Herstellung von neuen Salzen des Fumagillins
AT281289B (de)	1968-01-17	1970-05-11	Chinoin Gyogyszer Es Vegyeszet	Verfahren zur Herstellung eines neuen Fumagillinsalzes
US5328930A (en)	1993-03-01	1994-07-12	Emory University	Treatment of microsporidial and acanthamoeba keratoconjunctivitis with topical fumagillin

1999
- 1999-06-11 HU HU9901943A patent/HUP9901943A2/hu unknown
2000
- 2000-06-06 DE DE60034699T patent/DE60034699T2/de not_active Expired - Lifetime
- 2000-06-06 CA CA002374639A patent/CA2374639C/en not_active Expired - Fee Related
- 2000-06-06 AU AU54166/00A patent/AU5416600A/en not_active Abandoned
- 2000-06-06 JP JP2001503852A patent/JP3923798B2/ja not_active Expired - Fee Related
- 2000-06-06 HU HU0201574A patent/HU227695B1/hu unknown
- 2000-06-06 DK DK00938947T patent/DK1230238T3/da active
- 2000-06-06 AT AT00938947T patent/ATE361292T1/de active
- 2000-06-06 ES ES00938947T patent/ES2284500T3/es not_active Expired - Lifetime
- 2000-06-06 US US10/009,116 patent/US6521764B1/en not_active Expired - Lifetime
- 2000-06-06 PT PT00938947T patent/PT1230238E/pt unknown
- 2000-06-06 EP EP00938947A patent/EP1230238B1/de not_active Expired - Lifetime
- 2000-06-06 WO PCT/HU2000/000054 patent/WO2000076994A2/en active IP Right Grant
2007
- 2007-07-13 CY CY20071100934T patent/CY1106728T1/el unknown

Also Published As

Publication number	Publication date
JP3923798B2 (ja)	2007-06-06
CA2374639A1 (en)	2000-12-21
PT1230238E (pt)	2007-06-22
HUP0201574A3 (en)	2003-08-28
WO2000076994A3 (en)	2001-02-08
HU227695B1 (en)	2011-12-28
CA2374639C (en)	2008-07-15
WO2000076994A2 (en)	2000-12-21
HUP9901943A2 (hu)	2001-12-28
US6521764B1 (en)	2003-02-18
ATE361292T1 (de)	2007-05-15
JP2003502324A (ja)	2003-01-21
EP1230238B1 (de)	2007-05-02
ES2284500T3 (es)	2007-11-16
CY1106728T1 (el)	2012-05-23
EP1230238A2 (de)	2002-08-14
AU5416600A (en)	2001-01-02
HUP0201574A2 (en)	2002-08-28
DK1230238T3 (da)	2007-08-13
HU9901943D0 (en)	1999-08-30
DE60034699T2 (de)	2008-01-17

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Legal Events

Date	Code	Title	Description
2008-05-21	8364	No opposition during term of opposition